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Author : Neil R. Sims
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (893 download)
Download or read book Energy Metabolism, Oxidative Stress and Neuronal Degeneration in Alzheimer's Disease written by Neil R. Sims and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Fei Yin
Publisher : Frontiers Media SA
ISBN 13 : 2889452530
Total Pages : 161 pages
Book Rating : 4.8/5 (894 download)
Download or read book The Metabolic-Inflammatory Axis in Brain Aging and Neurodegeneration written by Fei Yin and published by Frontiers Media SA. This book was released on 2017-08-16 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: Impairment of energy metabolism is a hallmark of brain aging and several neurodegenerative diseases, such as the Alzheimer’s disease (AD). Age- and disease-related hypometabolism is commonly associated with oxidative stress and they are both regarded as major contributors to the decline in synaptic plasticity and cognition. Neuroinflammatory changes, entailing microglial activation and elevated expression of inflammatory cytokines, also correlate with age-related cognitive decline. It is still under debate whether the mitochondrial dysfunction-induced metabolic deficits or the microglia activation-mediated neuroinflammation is the initiator of the cognitive changes in aging and AD. Nevertheless, multiple lines of evidence support the notion that mitochondrial dysfunction and chronic inflammation exacerbate each other, and these mechanistic diversities have cellular redox dysregulation as a common denominator. This research topic focuses on the role of a metabolic-inflammatory axis encompassing the bioenergetic activity, brain inflammatory responses and their redox regulation in healthy brain aging and neurodegenerative diseases. Dynamic interactions among these systems are reviewed in terms of their causative or in-tandem occurrence and how the systemic environment, –e.g., insulin resistance, diabetes, and systemic inflammation–, impacts on brain function.
Author : John P. Blass
Publisher :
ISBN 13 :
Total Pages : 472 pages
Book Rating : 4.X/5 (4 download)
Download or read book Oxidative/energy Metabolism in Neurodegenerative Disorders written by John P. Blass and published by . This book was released on 1999 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is solid evidence of abnormalities in oxidative / energy metabolism with neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. The papers contained in this book are an attempt to move studies in this area to a deeper, more mechanistic level.
Author : Francisco Gonzalez-Lima
Publisher : Springer Science & Business Media
ISBN 13 : 1475799365
Total Pages : 294 pages
Book Rating : 4.4/5 (757 download)
Download or read book Cytochrome Oxidase in Neuronal Metabolism and Alzheimer’s Disease written by Francisco Gonzalez-Lima and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is based on an international symposium titled "Cytochrome oxidase in energy metabolism and Alzheimer's disease," held as a satellite to the 27th meeting of the Society for Neuroscience, New Orleans, 1997. The symposium was dedicated in honor of Dr. Margaret T. T. Wong-Riley because, in our opinion, the cytochrome oxidase histo chemical method introduced by Dr. Wong-Riley in 1979 was the most significant break through to map energy metabolism in the entire brain since the 2-deoxyglucose method introduced by Dr. Louis Sokoloff and colleagues in 1977. Both of these metabolic map ping techniques have made monumental contributions to brain research by allowing an integral view of brain activity. They have also developed into various specialized tech niques, including applications to the human brain. One of these new applications, which is described in detail in this book, is the quantitative cytochrome oxidase cytochemical method used to study Alzheimer's disease. The objective of this book is to describe the role of cytochrome oxidase in neuronal metabolism and Alzheimer's disease. Whether genetic or environmental, the pathogenesis of Alzheimer's disease involves a cascade of multiple intracellular events, eventually re sulting in failure of oxidative energy metabolism. Could impairment of cytochrome oxi dase in energy metabolism initiate the degenerative process? Cytochrome oxidase function and dysfunction are discussed in relationship to neuronal energy metabolism, neurodegen eration, and Alzheimer's disease. The book is made up of 10 chapters, divided into three major parts.
Author : G. Ali Qureshi
Publisher : Elsevier
ISBN 13 : 0080489494
Total Pages : 795 pages
Book Rating : 4.0/5 (84 download)
Download or read book Oxidative Stress and Neurodegenerative Disorders written by G. Ali Qureshi and published by Elsevier. This book was released on 2007-03-22 with total page 795 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders. * Contains the latest information on the subject of neurodegenerative disorders* Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems
Author : David Baglietto-Vargas
Publisher : Frontiers Media SA
ISBN 13 : 2889746720
Total Pages : 173 pages
Book Rating : 4.8/5 (897 download)
Download or read book Metabolic Alterations in Neurodegenerative Disorders written by David Baglietto-Vargas and published by Frontiers Media SA. This book was released on 2022-03-14 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (136 download)
Download or read book The Metabolic-Inflammatory Axis in Brain Aging and Neurodegeneration written by and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Impairment of energy metabolism is a hallmark of brain aging and several neurodegenerative diseases, such as the Alzheimer's disease (AD). Age- and disease-related hypometabolism is commonly associated with oxidative stress and they are both regarded as major contributors to the decline in synaptic plasticity and cognition. Neuroinflammatory changes, entailing microglial activation and elevated expression of inflammatory cytokines, also correlate with age-related cognitive decline. It is still under debate whether the mitochondrial dysfunction-induced metabolic deficits or the microglia activation-mediated neuroinflammation is the initiator of the cognitive changes in aging and AD. Nevertheless, multiple lines of evidence support the notion that mitochondrial dysfunction and chronic inflammation exacerbate each other, and these mechanistic diversities have cellular redox dysregulation as a common denominator. This research topic focuses on the role of a metabolic-inflammatory axis encompassing the bioenergetic activity, brain inflammatory responses and their redox regulation in healthy brain aging and neurodegenerative diseases. Dynamic interactions among these systems are reviewed in terms of their causative or in-tandem occurrence and how the systemic environment, -e.g., insulin resistance, diabetes, and systemic inflammation-, impacts on brain function.
Author : Yuan Luo
Publisher : CRC Press
ISBN 13 : 1420026550
Total Pages : 524 pages
Book Rating : 4.4/5 (2 download)
Download or read book Oxidative Stress and Age-Related Neurodegeneration written by Yuan Luo and published by CRC Press. This book was released on 2005-11-21 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidative Stress and Age-Related Neurodegeneration brings together researchers from a variety of fields to compare normal aging and disease-related neurodegeneration in terms of susceptibility to and effects of oxidative stress. They address how these effects can be attenuated, and examine whether antioxidants and natural micronutrients, such as those found in Gingko biloba, green tea, blueberries, and grape seed extract, can play a role. The book includes various ways research is getting to the core of neurodegenerative disease, including the use of proteomics, comparisons to related diseases, and examinations at the cellular and molecular levels.
Author : Fushun Wang
Publisher : Frontiers Media SA
ISBN 13 : 2832505201
Total Pages : 202 pages
Book Rating : 4.8/5 (325 download)
Download or read book Natural Products and Brain Energy Metabolism: Astrocytes in Neurodegenerative Diseases, Volume I written by Fushun Wang and published by Frontiers Media SA. This book was released on 2022-11-11 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lawrence H. Lash
Publisher : Elsevier
ISBN 13 : 1483218619
Total Pages : 527 pages
Book Rating : 4.4/5 (832 download)
Download or read book Mitochondrial Dysfunction written by Lawrence H. Lash and published by Elsevier. This book was released on 2013-10-22 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.
Author : Ralph N. Martins
Publisher : John Wiley & Sons
ISBN 13 : 1119356776
Total Pages : 544 pages
Book Rating : 4.1/5 (193 download)
Download or read book Neurodegeneration and Alzheimer's Disease written by Ralph N. Martins and published by John Wiley & Sons. This book was released on 2019-04-26 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the impact of diet, exercise, genetics, and hormones on the risk and development of Alzheimer’s and other neurogenerative diseases Diet is widely known to impact on neurological function. Nevertheless, academic texts discussing this relationship are relatively few in number. This book therefore fills an important gap in the current literature. Opening with an overview of neurodegenerative diseases, particularly Alzheimer’s disease, the text then focuses on explaining the means by which glycemic control and lipid metabolism – and associated nutritional and lifestyle variables – may factor into such disorders’ prevention and treatment. An international group of experts in the fields of food science and neurodegeneration have contributed chapters that examine Alzheimer’s disease within a broad range of contexts. Offering dietary, genetic, and hormonal perspectives, the authors explore topics ranging from sugar consumption to digestive fermentation, and Alzheimer’s disease animal models to the cognition-enhancing effects of physical exercise. Also included are overviews of the latest research into current and developing methods of treatment and diagnosis, as well as differential diagnostics. This groundbreaking book: Explores how glucose metabolism, insulin resistance, lipid metabolism, and high intake of refined carbohydrates are linked to Alzheimer's disease Discusses how genetic makeup can impact risk of Alzheimer’s and Parkinson’s disease Examines cognitive changes in neurodegeneration, lists current tests for determining cognitive impairment, and provides information concerning differential diagnosis Discusses potential advantages of increasing antioxidant and micronutrient intake Reviews hormonal influences on neurodegeneration Examines the links between protein intake and Alzheimer’s disease. Neurodegeneration and Alzheimer's Disease is an essential resource for researchers, medical practitioners, dietitians, and students with an interest in neurological diseases and their diagnosis and risk factors, as well as diet-related conditions such as diabetes and obesity. Lifestyle and diet influence neurodegeneration risk, and a better understanding of this evidence amongst health professionals will hopefully lead to greater public awareness of how to reduce the likelihood of these widespread conditions.
Author : Irene Ceballos-Picot
Publisher : Springer Science & Business Media
ISBN 13 : 3662225166
Total Pages : 391 pages
Book Rating : 4.6/5 (622 download)
Download or read book The Role of Oxidative Stress in Neuronal Death written by Irene Ceballos-Picot and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines current knowledge and recent advances in the study of fundamental processes involved in neuronal death, particularly oxidative stress as a causal agent or risk factor. The author presents discussion of oxidative stress in neuronal apoptosis and its role in the neuropathogenesis of age-related neurodegenerative diseases exemplified by Alzheimer's disease, Parkinson's disease and Amyotrophic Lateral Sclerosis.
Author : Domenico Praticὸ
Publisher : Springer Science & Business Media
ISBN 13 : 1627035982
Total Pages : 234 pages
Book Rating : 4.6/5 (27 download)
Download or read book Studies on Alzheimer's Disease written by Domenico Praticὸ and published by Springer Science & Business Media. This book was released on 2013-09-21 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume systematically reviews the basic science and clinical knowledge of the role of free radicals and antioxidants, collectively known as “oxidative stress,” in the pathology of Alzheimer’s disease. It describes the most current diagnostic tools, laboratory methods and technology, and suggests ways of prevention and treatment to emphasize the concept of the bench-to-bedside approach. Studies on Alzheimer’s Disease provides thorough coverage of emerging technology and medical applications including discussions of biomarkers and antioxidants as therapeutic agents, and several more relevant aspects. In addition, this book promotes the concept of using biomarkers representative of oxidative stress reactions and free-radical damageand describes the effects of antioxidants in treating disease in clinical trials. This content is invaluable to both researchers and clinicians studying the development of and treating patients with Alzheimer’s Disease.
Author : Sigrid C. Veasey
Publisher : Springer Science & Business Media
ISBN 13 : 1603273425
Total Pages : 224 pages
Book Rating : 4.6/5 (32 download)
Download or read book Oxidative Neural Injury written by Sigrid C. Veasey and published by Springer Science & Business Media. This book was released on 2009-05-28 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Twenty-five years ago, Earl R. Stadtman, PhD discovered that specific enzymes regulating metabolism can be inactivated by oxidation [1]. He later showed that age-related oxidative modification contributes, at least in part, to age-related loss of function of the enzymes [2, 3]. Dr. Stadtman broke the ground for a new field of study to discover how oxidative stress contributes in significant ways to age-related cellular dysfunction and protein accumulation and that oxidation in the aging brain influences Alzheimer’s disease, ischemia-reperfusion injury, amyotrophic lateral sclerosis, and lifespan [4–6]. Today, his research and mentorship have positively influenced the work of hundreds of scientists in this field. We dedicate this book to Dr. Earl R. Stadtman (1912–2008), in celebration of his passion for science and his superior collaborative and mentorship skills. This book is comprised of three sections. The first describes the valuable roles reactive oxygen species (ROS) and reactive nitrogen species (RNS) play in cellular biology. The second section provides an overview of redox imbalance injury with effects on mitochondria, signaling, endoplasmic reticular function, and on aging in general. The third section takes these mechanisms to neurodegenerative disorders and provides a state-of-the-art look at the roles redox imbalances play in age-related susceptibility to disease and in the disease processes. In the first section we attempt to answer a question posed by Dr. Stadtman, ‘‘Why have cells selected reactive oxygen species to regulate cell signaling events’’ [7].
Author : Paolo Zatta
Publisher : World Scientific
ISBN 13 : 9789812796691
Total Pages : 546 pages
Book Rating : 4.7/5 (966 download)
Download or read book Metal Ions and Neurodegenerative Disorders written by Paolo Zatta and published by World Scientific. This book was released on 2003 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidative stress have been described in association with neurons, neurofibrillary tangles and senile plaques in Alzheimer''s disease, including advanced glycation end products and free carbonyl oxidation. Oxidative damage and antioxidant responses are now well characterized, but sources of damaging free radicals are yet to be fully understood. Evidences of alteration in metal ions metabolism have been reported in various diseases like Alzheimer''s, Wilson, Menkes, Prion, Pick, Huntington disease, epilepsy and other pathological events. Thus, metal ions play a pivotal role in neurodegenerative phenomena. Chelation therapy is still in the early days of its development, but research in this area could lead to new products that could revolutionize treatment. Two international conferences on OC Metals and the Brain: From Neurochemistry to NeurodegenerationOCO (Padova, Italy, 2000 and Fez, Morocco, 2002) were recently held to discuss the role of metal ions in neurophysiopathology. A third will be held in 2005 in Johannesburg, South Africa. This book follows the same train of thought as those conferences, in order to highlight the unquestionable importance of metal ions in the research on the neurophysiopathology of neurodegenerative diseases. The excellent reputation of the scientists who have contributed to this project ensures the quality of the chapters presented here, and hopefully this will help spur new research initiatives in the field, which is still in its infancy. Contents: Metal-Catalyzed Redox Activity in Neurodegenerative Disease (M A Taddeo et al.); Aluminum and Central Nervous System Morphology in Hemodialysis (E Reusche); Transition Metals, Oxidation, Lipoproteins, and Amyloid-: Major Players in Alzheimer''s Disease (A Kontush); Molecular Basis of Copper Transport: Cellular and Physiological Functions of Menkes and Wilson Disease Proteins (ATP7A and ATP7B) (D R Kramer et al.); Copper-Zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis (M B Yim et al.); Copper and Prion Disease (J Sasson & D Brown); Metallothioneins in Neurodegeneration (M Aschner et al.); Iron and Neurodegeneration (S L Grab & J R Connor); Iron, Neuromelanin, and -Synuclein in Neuropathogenesis of Parkinson''s Disease (K L Double et al.); Iron and Epilepsy (W-Y Ong et al.); Role of Iron Metabolism in Multiple Sclerosis (M J Kotze et al.); Neuroprotective Effects of Lithium (S Ermidiou-Pollet & S Pollet); and other articles. Readership: Academics, graduate students and researchers in neurology, psychiatry, neuroscience and environmental health."
Download or read book The Role of Energy Metabolism in the Pathogenesis of Alzheimer's Disease written by and published by . This book was released on 1908 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In Alzheimer's disease, neuronal degeneration due to apoptosis has been linked to overexpression and aberrant amyloidogenic processing of the amyloid precursor protein (APP), as well as to bioenergetic defects characterized by deficits in the electron transport chain's cytochrome c oxidase (COX) which leads to the genera ion of radical oxygen species. Inhibition of oxidative energy metabolism increased the amyloidogenic processing of APP, which led to neurotoxicity. Overexpression of APP in cultured normal human muscle fibres caused a specific decrease in COX activity, followed by ultrastructural abnormalities of mitochondria. We have demonstrated, using the yeast two-hybrid system, that APP interacts with COX subunit 1 (COX I), and that this interaction involves the extracellular domain of APP. We demonstrated that APP caused specific deficits in COX activity, induced the production of radical oxygen species and lipid peroxidation, and enhanced neuronal apoptosis. However, anti-oxidant enzyme activity was variable, and probably represented a compensatory reaction to elevated oxygen radicals. To directly interact with COY, APP must be targeted to, and localized in, mitochondria. This possibility was tested with an ' in vitro' mitochondrial import assay which showed that APP is transported to mitochondria in an energy-dependent manner. Furthermore, dual fluorescence microscopy with chimeric APP-green fluorescent protein, and immunoelectron microscopy, demonstrated the presence of endogenous APP and B-amyloid peptide (the neurotoxic cleavage product of APP) in mitochondria of postmortem human brain tissue, with increased levels of B-amyloid peptide in AD brains compared to non-AD brains. (Abstract shortened by UMI.).
Author : Abhai Kumar
Publisher : CRC Press
ISBN 13 : 1000282740
Total Pages : 631 pages
Book Rating : 4.0/5 (2 download)
Download or read book Antioxidants and Functional Foods for Neurodegenerative Disorders written by Abhai Kumar and published by CRC Press. This book was released on 2021-01-07 with total page 631 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are a growing problem across the world’s aging population. Oxidative stress in the brain plays a central role in a common pathophysiology of these diseases. This book presents scientific research on the potential of antioxidant therapy in the prevention and treatment of neurodegenerative disorders. This book outlines the roles of oxidative stress and diabetes mellitus in neurodegeneration, describes the molecular mechanisms of neurodegenerative disorders including the roles of environmental pollutants and inflammatory responses, and explores mitochondrial dysfunction. It then describes the protective abilities of antioxidants – including vitamin D, tocotrienol and coenzyme Q10 – against neurodegeneration. The book demonstrates the therapeutic potential of ketogenic diets, and highlights the roles of medicinal plants, phytopharmaceuticals, traditional medicines and food nutrients in neuroprotection. Key Features: Explains damage caused by numerous neurodegenerative disorders and the possible protection offered by antioxidants and functional foods. Describes molecular mechanisms of neurodegeneration by oxidative stress, advancing age, diabetes and mitochondrial dysfunctions. Demonstrates protection offered by nutraceuticals, antioxidants, botanical extracts and functional foods. The book contains twenty-three chapters divided into six sections written by leading researchers. This book is essential reading for health professionals, dietitians, food and nutrition scientists and anyone wanting to improve their knowledge of etiology of neurodegenerative diseases.
