Emulsions and Nanosuspensions for the Formulation of Poorly Soluble Drugs

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Publisher : CRC Press
ISBN 13 : 9783887630690
Total Pages : 410 pages
Book Rating : 4.6/5 (36 download)

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Book Synopsis Emulsions and Nanosuspensions for the Formulation of Poorly Soluble Drugs by : Rainer H. Müller

Download or read book Emulsions and Nanosuspensions for the Formulation of Poorly Soluble Drugs written by Rainer H. Müller and published by CRC Press. This book was released on 1998 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explore possible new approaches for overcoming poorly soluble drugs - a challenge to drug formulation work and an increasing problem. Many newly developed drugs are poorly soluble, very often simultaneously in aqueous and in organic media. Emulsions and Nanosuspensions for the Formulation of Poorly Soluble Drugs aims to: review the possibilities, limitations and future perspectives of emulsions as drug carriers considering technology from other than the phamaceutical industry (i.e food industry). show the production technology of nanosuspensions, explain the special dissolution properties (i.e. increased saturation solubility) and increased dissolution velocity (theory), and cover the possible applications. present the theory of high pressure homogenization and high pressure extrusion in dispersion techniques, including examples of applications and size measurements in concentrated dispersions.

Emulsions and Nanosuspensions for the Formulation of Poorly Soluble Drugs

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Publisher :
ISBN 13 : 9783804750203
Total Pages : 396 pages
Book Rating : 4.7/5 (52 download)

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Book Synopsis Emulsions and Nanosuspensions for the Formulation of Poorly Soluble Drugs by : Rainer H. Müller

Download or read book Emulsions and Nanosuspensions for the Formulation of Poorly Soluble Drugs written by Rainer H. Müller and published by . This book was released on 1998 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Submicron Emulsions in Drug Targeting and Delivery

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Publisher : CRC Press
ISBN 13 : 1000717550
Total Pages : 353 pages
Book Rating : 4.0/5 (7 download)

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Book Synopsis Submicron Emulsions in Drug Targeting and Delivery by : S Benita

Download or read book Submicron Emulsions in Drug Targeting and Delivery written by S Benita and published by CRC Press. This book was released on 2019-08-16 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is anticipated that submicron emulsion and lipid suspension will find numerous and novel medical applications in the near future. The purpose of this multi-authore book is to provide the reader with an up-to-date general overview of submicron emulsions and lipid suspensions (solid lipid nanoparticles) as well as to emphasize the various methods of preparation, characerization, evaluation and potential applications in various therapeutic areas. Leading authors have contributed to this unique book which contains all state of the art and detailed knowledge related to the physico-chemical, pharmaceutical and medical aspects of these most interesting but complex dosage forms, thus making this information easily available to the reader. This book will be of interest to scientists working in the field of drug delivery and targeting in universities as well as in the pharmaceutical, food, cosmetic, veterinary and chemical industries.

Drug Delivery Strategies for Poorly Water-Soluble Drugs

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 1118444671
Total Pages : 543 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Drug Delivery Strategies for Poorly Water-Soluble Drugs by : Dionysios Douroumis

Download or read book Drug Delivery Strategies for Poorly Water-Soluble Drugs written by Dionysios Douroumis and published by John Wiley & Sons. This book was released on 2012-12-19 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many newly proposed drugs suffer from poor water solubility, thus presenting major hurdles in the design of suitable formulations for administration to patients. Consequently, the development of techniques and materials to overcome these hurdles is a major area of research in pharmaceutical companies. Drug Delivery Strategies for Poorly Water-Soluble Drugs provides a comprehensive overview of currently used formulation strategies for hydrophobic drugs, including liposome formulation, cyclodextrin drug carriers, solid lipid nanoparticles, polymeric drug encapsulation delivery systems, self–microemulsifying drug delivery systems, nanocrystals, hydrosol colloidal dispersions, microemulsions, solid dispersions, cosolvent use, dendrimers, polymer- drug conjugates, polymeric micelles, and mesoporous silica nanoparticles. For each approach the book discusses the main instrumentation, operation principles and theoretical background, with a focus on critical formulation features and clinical studies. Finally, the book includes some recent and novel applications, scale-up considerations and regulatory issues. Drug Delivery Strategies for Poorly Water-Soluble Drugs is an essential multidisciplinary guide to this important area of drug formulation for researchers in industry and academia working in drug delivery, polymers and biomaterials.

Early Drug Development

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Publisher : John Wiley & Sons
ISBN 13 : 3527801774
Total Pages : 816 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis Early Drug Development by : Fabrizio Giordanetto

Download or read book Early Drug Development written by Fabrizio Giordanetto and published by John Wiley & Sons. This book was released on 2018-06-15 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: This one-stop reference systematically covers key aspects in early drug development that are directly relevant to the discovery phase and are required for first-in-human studies. Its broad scope brings together critical knowledge from many disciplines, ranging from process technology to pharmacology to intellectual property issues. After introducing the overall early development workflow, the critical steps of early drug development are described in a sequential and enabling order: the availability of the drug substance and that of the drug product, the prediction of pharmacokinetics and -dynamics, as well as that of drug safety. The final section focuses on intellectual property aspects during early clinical development. The emphasis throughout is on recent case studies to exemplify salient points, resulting in an abundance of practice-oriented information that is usually not available from other sources. Aimed at medicinal chemists in industry as well as academia, this invaluable reference enables readers to understand and navigate the challenges in developing clinical candidate molecules that can be successfully used in phase one clinical trials.

Encyclopedia of Colloid and Interface Science

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Publisher : Springer
ISBN 13 : 9783642206641
Total Pages : 0 pages
Book Rating : 4.2/5 (66 download)

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Book Synopsis Encyclopedia of Colloid and Interface Science by : Tharwat Tadros

Download or read book Encyclopedia of Colloid and Interface Science written by Tharwat Tadros and published by Springer. This book was released on 2013-06-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: An authoritative and comprehensive reference relevant to all scientists and engineers in the field. This encyclopedia not only helps chemistry, materials science and physics researchers to understand the principles, but also provides practicing engineers with the necessary information for implementing practical applications, such as Food and agrochemicals Polymers and ceramics Cosmetics and detergents Paints and coatings Pharmaceuticals and drug delivery In addition, the encyclopedia is an important reference for industrial chemists and chemical engineers faced with a multitude of industrial systems of a colloidal nature. As wide as the range of applications that colloid and interface science has is the range of scientific disciplines that contribute to research and development in this field. These encompass chemistry, physics, biology and mathematics as well as nanoscience and nanotechnology. The encyclopedia provides easy-to-digest information for meeting these interdisciplinary challenges. While providing numerous concise definitions of key terms, the encyclopedia also features more than forty in-depth essays on topics ranging from Agrochemical Formulations to Zeta Potential. All entries are cross-referenced and include selected references to original literature as well as synonyms.

Nanoemulsions

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Publisher : Academic Press
ISBN 13 : 0128118393
Total Pages : 665 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Nanoemulsions by : Seid Mahdi Jafari

Download or read book Nanoemulsions written by Seid Mahdi Jafari and published by Academic Press. This book was released on 2018-02-24 with total page 665 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoemulsions: Formulation, Applications, and Characterization provides detailed information on the production, application and characterization of food nanoemulsion as presented by experts who share a wealth of experience. Those involved in the nutraceutical, pharmaceutical and cosmetic industries will find this a useful reference as it addresses findings related to different preparation and formulation methods of nanoemulsions and their application in different fields and products. As the last decade has seen a major shift from conventional emulsification processes towards nanoemulsions that both increase the efficiency and stability of emulsions and improve targeted drug and nutraceutical delivery, this book is a timely resource. Summarizes general aspects of food nanoemulsions and their formulation Provides detailed information on the production, application, and characterization of food nanoemulsion Reveals the potential of nanoemulsions, as well as their novel applications in functional foods, nutraceutical products, delivery systems, and cosmetic formulations Explains preparation of nanoemulsions by both low- and high-energy methods

Insecticides Design Using Advanced Technologies

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Publisher : Springer Science & Business Media
ISBN 13 : 3540469079
Total Pages : 320 pages
Book Rating : 4.5/5 (44 download)

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Book Synopsis Insecticides Design Using Advanced Technologies by : Isaac Ishaaya

Download or read book Insecticides Design Using Advanced Technologies written by Isaac Ishaaya and published by Springer Science & Business Media. This book was released on 2007-02-15 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Among the highlights of this book are the use of nanotechnology to increase potency of available insecticides, the use of genetic engineering techniques for controlling insect pests, the development of novel insecticides that bind to unique biochemical receptors, the exploration of natural products as a source for environmentally acceptable insecticides, and the use of insect genomics and cell lines for determining biological and biochemical modes of action of new insecticides.

Water-Insoluble Drug Formulation

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Author :
Publisher : CRC Press
ISBN 13 : 1351646826
Total Pages : 781 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Water-Insoluble Drug Formulation by : Ron Liu

Download or read book Water-Insoluble Drug Formulation written by Ron Liu and published by CRC Press. This book was released on 2018-03-12 with total page 781 pages. Available in PDF, EPUB and Kindle. Book excerpt: Properties and Formulation: From Theory to Real-World Application Scientists have attributed more than 40 percent of the failures in new drug development to poor biopharmaceutical properties, particularly water insolubility. Issues surrounding water insolubility can postpone or completely derail important new drug development. Even the much-needed reformulation of currently marketed products can be significantly affected by these challenges. More recently it was reported that the percentage increased to 90% for the candidates of new chemical entities in the discovery stage and 75% for compounds under development. In the most comprehensive resource on the topic, this third edition of Water-Insoluble Drug Formulation brings together a distinguished team of experts to provide the scientific background and step-by-step guidance needed to deal with solubility issues in drug development. Twenty-three chapters systematically describe the detailed discussion on solubility theories, solubility prediction models, the aspects of preformulation, biopharmaceutics, pharmacokinetics, regulatory, and discovery support of water-insoluble drugs to various techniques used in developing delivery systems for water-insoluble drugs. This book includes more than 15 water-insoluble drug delivery systems or technologies, illustrated with case studies and featuring oral and parenteral applications. Highlighting the most current information and data available, this seminal volume reflects the significant progress that has been made in nearly all aspects of this field. The aim of this book is to provide a handy reference for pharmaceutical scientists in the handling of formulation issues related to water-insoluble drugs. In addition, this book may be useful to pharmacy and chemistry undergraduate students and pharmaceutical and biopharmaceutical graduate students to enhance their knowledge in the techniques of drug solubilization and dissolution enhancement.

Water-Insoluble Drug Formulation

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Author :
Publisher : CRC Press
ISBN 13 : 9781574911053
Total Pages : 676 pages
Book Rating : 4.9/5 (11 download)

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Book Synopsis Water-Insoluble Drug Formulation by : Ron Liu

Download or read book Water-Insoluble Drug Formulation written by Ron Liu and published by CRC Press. This book was released on 2000-09-30 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: Delivering drugs in a water-insoluble formulation is a critical matter in therapeutic drug development. However, because a drug molecule has to be water soluble to be readily delivered to the cellular membrane while retaining its hydrophobic properties, issues surrounding water insolubility can postpone - or completely derail - important new drug development. Even much needed reformulation of currently marketed products can be significantly affected by these issues. This book systematically describes the techniques used for water-insoluble formulations, providing step-by-step guidance as well as scientific background on drug and water properties and how they contribute to solubilization and dissolution. A world-class team of experts discusses how these issues are viewed - and solved - by key industry and R&D institutions. This book provides a handy reference for pharmaceutical scientists in the handling of formulation issues related to water-insoluble drugs. In addition, this book may be useful to pharmacy and chemistry undergraduate students, and pharmaceutical and biopharmaceutical graduate students, to enhance their knowledge in the techniques of drug solubilization and dissolution enhancement.

Pharmaceutical Emulsions and Suspensions

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Publisher : CRC Press
ISBN 13 : 9780824703042
Total Pages : 660 pages
Book Rating : 4.7/5 (3 download)

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Book Synopsis Pharmaceutical Emulsions and Suspensions by : Françoise Nielloud

Download or read book Pharmaceutical Emulsions and Suspensions written by Françoise Nielloud and published by CRC Press. This book was released on 2000-02-25 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analyzes construction of experiments, focusing on variables, models, matrices, and reproducibility. This timely reference systematically examines the basic concepts and theoretical issues, methodologies for experiment and measurement, and practical health applications of emulsions and dispersions-describing formulation problems and identifying potential carriers for the delivery or targeting of new drugs. Evaluates anionic, cationic, and nonionic surfactants as dispersing, emulsifying, foaming, penetrating, and wetting agents. Written by more than 20 international researchers, Pharmaceutical Emulsions and Suspensions discusses uses of macroemulsions and (submicron) microemulsions illuminates delivery devices such as microparticles, nanospheres, liposomes, and mixed micelles investigates the application of self-emulsifying drug delivery systems (SEDDS) introduces techniques for increasing drug solubility with nanosuspensions addresses stabilization, flocculation, and coagulation problems in pharmaceutical and cosmetic suspensions surveys drug delivery by way of dermatological, follicular, and ocular routes explains the pharmacodynamics, bioavailability, and pharmacokinetics in the drug formulation development process compares and contrasts monomeric and micellar adsorption at oil-water interfaces and more! Containing over 1800 references, tables, equations, drawings, and micrographs, Pharmaceutical Emulsions and Suspensions is an ideal resource for pharmacists; physical, surface, colloid, cosmetic, food, and agricultural chemists; and upper-level undergraduate and graduate students in these disciplines.

Formulating Poorly Water Soluble Drugs

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1461411440
Total Pages : 656 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Formulating Poorly Water Soluble Drugs by : Robert O. Williams III

Download or read book Formulating Poorly Water Soluble Drugs written by Robert O. Williams III and published by Springer Science & Business Media. This book was released on 2011-12-04 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is intended to provide the reader with a breadth of understanding regarding the many challenges faced with the formulation of poorly water-soluble drugs as well as in-depth knowledge in the critical areas of development with these compounds. Further, this book is designed to provide practical guidance for overcoming formulation challenges toward the end goal of improving drug therapies with poorly water-soluble drugs. Enhancing solubility via formulation intervention is a unique opportunity in which formulation scientists can enable drug therapies by creating viable medicines from seemingly undeliverable molecules. With the ever increasing number of poorly water-soluble compounds entering development, the role of the formulation scientist is growing in importance. Also, knowledge of the advanced analytical, formulation, and process technologies as well as specific regulatory considerations related to the formulation of these compounds is increasing in value. Ideally, this book will serve as a useful tool in the education of current and future generations of scientists, and in this context contribute toward providing patients with new and better medicines.

Nanodispersions for Drug Delivery

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Publisher : CRC Press
ISBN 13 : 135104754X
Total Pages : 400 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Nanodispersions for Drug Delivery by : Raj K. Keservani

Download or read book Nanodispersions for Drug Delivery written by Raj K. Keservani and published by CRC Press. This book was released on 2018-09-24 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume addresses efforts to overcome the shortcomings of conventional dosage forms by exploiting the principles of nanoscience to deliver drugs for medical treatment. Nanodispersions are an important aspect because they possess globules/particles in sizes usually below 1000 nm in which the drug is dispersed in a continuous medium employing surface-active agents as stabilizers. With chapters written by experienced scientists and researchers in the field, this volume provides an abundance of information on various aspects of nanodispersions for drug delivery. The book is divided into several sections: nanoemulsions, nanosuspensions, and diverse dispersed systems. The chapters detail what nanodispersions have demonstrated in the past and what they are expoected to continue to do in the future as the technology further evolves. Key features: • Provides an overview of nanoemulsions for drug delivery • Introduces the general principles, classification, and methods of preparation of nanoemulsion-based drug delivery systems • Presents information relevant to specific routes of applications of nanoemulsions • Looks at the various aspects of nanosuspensions, including their formulation components, preparation methods, unique features, methods of characterization, and applications in various routes of administration • Explores nanomicellar approaches for drug delivery • Discusses the preparation, applications, and clinical considerations of nanogels for drug delivery

Modified-Release Drug Delivery Technology

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Author :
Publisher : CRC Press
ISBN 13 : 0824708695
Total Pages : 1021 pages
Book Rating : 4.8/5 (247 download)

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Book Synopsis Modified-Release Drug Delivery Technology by : Michael J. Rathbone

Download or read book Modified-Release Drug Delivery Technology written by Michael J. Rathbone and published by CRC Press. This book was released on 2002-11-07 with total page 1021 pages. Available in PDF, EPUB and Kindle. Book excerpt: Describing formulation challenges and their solutions in the design, development, and commercialization of modified-release drugs delivery systems, this book contains eighty papers that review recent developments in design and manufacturing techniques. It includes detailed descriptions of extended release drug products for the oral, nasal, ophthalmic, pulmonary, vaginal, dermal and transdermal pathways. With the exception of the final section addressing regulatory issues, each section covers a particular route for drug delivery and opens with an overview of the anatomical, physiological, and pharmaceutical basics of each route before moving on to cover specific technologies.

Novel Drug Delivery Technologies

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Author :
Publisher : Springer Nature
ISBN 13 : 9811336423
Total Pages : 448 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Novel Drug Delivery Technologies by : Ambikanandan Misra

Download or read book Novel Drug Delivery Technologies written by Ambikanandan Misra and published by Springer Nature. This book was released on 2020-02-12 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: The application of drug delivery is a valuable, cost-effective lifecycle management resource. By endowing drugs with new and innovative therapeutic benefits, drug delivery systems extend products’ profitable lifecycle, giving pharmaceutical companies competitive and financial advantages, and providing patients with improved medications. Formulation development is now being used to create new dosage forms for existing products, which not only reduces the time and expense involved in new drug development, but also helps with regard to patent protection and bypassing existing patents. Today’s culture demands convenience, a major factor determining adherence to drug therapy. Over the past few years, patient convenience-oriented research in the field of drug delivery has yielded a range of innovative drug-delivery options. As a result, various drug-delivery systems, including medicated chewing gums, oral dispersible tablets, medicated lozenges and lollipops, have now hit the market and are very popular. These dosage forms offer a highly convenient way to dose medications, not only for special population groups with swallowing difficulties, such as children and the elderly, but for the general populace as well. This book provides valuable insights into a number of formulation design approaches that are currently being used, or could be used, to provide new benefits from existing drug molecules.

Pharmaceutical Suspensions

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1441910875
Total Pages : 337 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Pharmaceutical Suspensions by : Alok K. Kulshreshtha

Download or read book Pharmaceutical Suspensions written by Alok K. Kulshreshtha and published by Springer Science & Business Media. This book was released on 2009-11-05 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: The suspension dosage form has long been used for poorly soluble active ingre- ents for various therapeutic indications. Development of stable suspensions over the shelf life of the drug product continues to be a challenge on many fronts. A good understanding of the fundamentals of disperse systems is essential in the development of a suitable pharmaceutical suspension. The development of a s- pension dosage form follows a very complicated path. The selection of the proper excipients (surfactants, viscosity imparting agents etc.) is important. The particle size distribution in the finished drug product dosage form is a critical parameter that significantly impacts the bioavailability and pharmacokinetics of the product. Appropriate analytical methodologies and instruments (chromatographs, visco- ters, particle size analyzers, etc.) must be utilized to properly characterize the s- pension formulation. The development process continues with a successful scale-up of the manufacturing process. Regulatory agencies around the world require cli- cal trials to establish the safety and efficacy of the drug product. All of this devel- ment work should culminate into a regulatory filing in accordance with the regulatory guidelines. Pharmaceutical Suspensions, From Formulation Development to Manufacturing, in its organization, follows the development approach used widely in the pharmaceutical industry. The primary focus of this book is on the classical disperse system – poorly soluble active pharmaceutical ingredients s- pended in a suitable vehicle.

Physicochemical Principles of Pharmacy

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Author :
Publisher : Pharmaceutical Press
ISBN 13 : 0857111744
Total Pages : 665 pages
Book Rating : 4.8/5 (571 download)

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Book Synopsis Physicochemical Principles of Pharmacy by : Alexander T Florence

Download or read book Physicochemical Principles of Pharmacy written by Alexander T Florence and published by Pharmaceutical Press. This book was released on 2015-12-01 with total page 665 pages. Available in PDF, EPUB and Kindle. Book excerpt: This 6th edition of the established textbook covers every aspect of drug properties from the design of dosage forms to their delivery by all routes to sites of action in the body.