Biodefense in the Age of Synthetic Biology

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Author :
Publisher : National Academies Press
ISBN 13 : 0309465184
Total Pages : 189 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Biodefense in the Age of Synthetic Biology by : National Academies of Sciences, Engineering, and Medicine

Download or read book Biodefense in the Age of Synthetic Biology written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-01-05 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific advances over the past several decades have accelerated the ability to engineer existing organisms and to potentially create novel ones not found in nature. Synthetic biology, which collectively refers to concepts, approaches, and tools that enable the modification or creation of biological organisms, is being pursued overwhelmingly for beneficial purposes ranging from reducing the burden of disease to improving agricultural yields to remediating pollution. Although the contributions synthetic biology can make in these and other areas hold great promise, it is also possible to imagine malicious uses that could threaten U.S. citizens and military personnel. Making informed decisions about how to address such concerns requires a realistic assessment of the capabilities that could be misused. Biodefense in the Age of Synthetic Biology explores and envisions potential misuses of synthetic biology. This report develops a framework to guide an assessment of the security concerns related to advances in synthetic biology, assesses the levels of concern warranted for such advances, and identifies options that could help mitigate those concerns.

Emerging Policy Issues in Synthetic Biology

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Author :
Publisher : OCDE
ISBN 13 : 9789264208414
Total Pages : 0 pages
Book Rating : 4.2/5 (84 download)

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Book Synopsis Emerging Policy Issues in Synthetic Biology by : Organization for Economic Cooperation and Development

Download or read book Emerging Policy Issues in Synthetic Biology written by Organization for Economic Cooperation and Development and published by OCDE. This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetic biology is at such an early stage of development that there is no uniform agreement as yet about what it actually is. To some, it represents a natural extension of genetic engineering, and therefore is "business as usual". For others, it is a way to bring mass manufacturing out from the decades of biotechnology research. Currently the discipline is limited by the ability to synthesise DNA cost-effectively but this is a technical barrier that it is anticipated will be overcome. Synthetic biology raises a number of policy issues around R&D funding, company investment, PPP arrangements and innovative financing, infrastructure requirements, education and training, intellectual property (IP), regulation, and public engagement. In preparation for the continuing development and greater use of synthetic biology, some countries have started to prepare synthetic biology technical roadmaps and a global roadmap for the medium term would be an extremely useful policy tool. Technical roadmaps could both identify likely future policy requirements, and be a useful vehicle in public engagement.

The Science and Applications of Synthetic and Systems Biology

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Publisher : National Academies Press
ISBN 13 : 0309219396
Total Pages : 570 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis The Science and Applications of Synthetic and Systems Biology by : Institute of Medicine

Download or read book The Science and Applications of Synthetic and Systems Biology written by Institute of Medicine and published by National Academies Press. This book was released on 2011-12-30 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.

Emerging Threats of Synthetic Biology and Biotechnology

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Author :
Publisher : Springer Nature
ISBN 13 : 940242086X
Total Pages : 233 pages
Book Rating : 4.4/5 (24 download)

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Book Synopsis Emerging Threats of Synthetic Biology and Biotechnology by : Benjamin D. Trump

Download or read book Emerging Threats of Synthetic Biology and Biotechnology written by Benjamin D. Trump and published by Springer Nature. This book was released on 2021 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetic biology is a field of biotechnology that is rapidly growing in various applications, such as in medicine, environmental sustainability, and energy production. However these technologies also have unforeseen risks and applications to humans and the environment. This open access book presents discussions on risks and mitigation strategies for these technologies including biosecurity, or the potential of synthetic biology technologies and processes to be deliberately misused for nefarious purposes. The book presents strategies to prevent, mitigate, and recover from 'dual-use concern' biosecurity challenges that may be raised by individuals, rogue states, or non-state actors. Several key topics are explored including opportunities to develop more coherent and scalable approaches to govern biosecurity from a laboratory perspective up to the international scale and strategies to prevent potential health and environmental hazards posed by deliberate misuse of synthetic biology without stifling innovation. The book brings together the expertise of top scholars in synthetic biology and biotechnology risk assessment, management, and communication to discuss potential biosecurity governing strategies and offer perspectives for collaboration in oversight and future regulatory guidance.

Preparing for Future Products of Biotechnology

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Publisher : National Academies Press
ISBN 13 : 0309452058
Total Pages : 231 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Preparing for Future Products of Biotechnology by : National Academies of Sciences, Engineering, and Medicine

Download or read book Preparing for Future Products of Biotechnology written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-07-28 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Between 1973 and 2016, the ways to manipulate DNA to endow new characteristics in an organism (that is, biotechnology) have advanced, enabling the development of products that were not previously possible. What will the likely future products of biotechnology be over the next 5â€"10 years? What scientific capabilities, tools, and/or expertise may be needed by the regulatory agencies to ensure they make efficient and sound evaluations of the likely future products of biotechnology? Preparing for Future Products of Biotechnology analyzes the future landscape of biotechnology products and seeks to inform forthcoming policy making. This report identifies potential new risks and frameworks for risk assessment and areas in which the risks or lack of risks relating to the products of biotechnology are well understood.

Globalization, Biosecurity, and the Future of the Life Sciences

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Publisher : National Academies Press
ISBN 13 : 0309164753
Total Pages : 316 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Globalization, Biosecurity, and the Future of the Life Sciences by : National Research Council

Download or read book Globalization, Biosecurity, and the Future of the Life Sciences written by National Research Council and published by National Academies Press. This book was released on 2006-06-07 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical advances have made it possible to identify and manipulate features of living organisms in useful ways-leading to improvements in public health, agriculture, and other areas. The globalization of scientific and technical expertise also means that many scientists and other individuals around the world are generating breakthroughs in the life sciences and related technologies. The risks posed by bioterrorism and the proliferation of biological weapons capabilities have increased concern about how the rapid advances in genetic engineering and biotechnology could enable the production of biological weapons with unique and unpredictable characteristics. Globalization, Biosecurity, and the Future of Life Sciences examines current trends and future objectives of research in public health, life sciences, and biomedical science that contain applications relevant to developments in biological weapons 5 to 10 years into the future and ways to anticipate, identify, and mitigate these dangers.

Intelligence, Biosecurity and Bioterrorism

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Author :
Publisher : Springer
ISBN 13 : 113751700X
Total Pages : 303 pages
Book Rating : 4.1/5 (375 download)

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Book Synopsis Intelligence, Biosecurity and Bioterrorism by : Patrick F. Walsh

Download or read book Intelligence, Biosecurity and Bioterrorism written by Patrick F. Walsh and published by Springer. This book was released on 2018-09-18 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores how potential bio-threats and risks may evolve post 9/11 given the rapid changes in biotechnology and synthetic biology. It also explores what role intelligence communities can play in understanding threats and risks. It argues that although bio-threats and risks are largely low probability and high impact in nature, intelligence in ‘Five Eyes’ countries remain insufficiently prepared to understand them. This book identifies key areas where intelligence reforms need to take place including a more strategic and systematic collaboration between national security/law enforcement intelligence and the scientific community. It is aimed at intelligence analysts, those in the scientific community working on health security threats, policy makers and researchers working on biosecurity and bioterrorism threats and risks.

Plant Synthetic Biology

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Author :
Publisher : Humana
ISBN 13 : 9781071617908
Total Pages : 298 pages
Book Rating : 4.6/5 (179 download)

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Book Synopsis Plant Synthetic Biology by : Matias D. Zurbriggen

Download or read book Plant Synthetic Biology written by Matias D. Zurbriggen and published by Humana. This book was released on 2022-02-22 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides methods on different aspects and applications on plants, algae, photosynthetic bacteria, synthetic construct design, and multiplex cloning. Chapters cover multiple aspects of synthetic metabolic, photosynthetic systems, metabolic and signaling pathways, advanced engineering of metabolic networks, isolation of organelles and co-culture of microorganisms, and methods for the on command manipulation of the relative stability of proteins. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Plant Synthetic Biology: Methods and Protocols aims to be a useful resource for both researchers starting to explore novel experimental avenues as well as for experts willing to expand their portfolio of tools and strategies.

Innovation, Dual Use, and Security

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Publisher : MIT Press
ISBN 13 : 0262017172
Total Pages : 367 pages
Book Rating : 4.2/5 (62 download)

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Book Synopsis Innovation, Dual Use, and Security by : Jonathan B. Tucker

Download or read book Innovation, Dual Use, and Security written by Jonathan B. Tucker and published by MIT Press. This book was released on 2012 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in disciplines such as biotechnology, nanotechnology, and neuropharmacology entail a "dual-use dilemma" because they promise benefits for human health and welfare yet pose the risk of misuse for hostile purposes. The emerging field of synthetic genomics, for example, can produce custom DNA molecules for life-saving drugs but also makes possible the creation of deadly viral agents for biological warfare or terrorism. The challenge for policymakers is to prevent the misuse of these new technologies without forgoing their benefits . Innovation, Dual Use, and Security offers a systematic approach for managing the dual-use dilemma. The book presents a "decision framework" for assessing the security risks of emerging technologies and fashioning governance strategies to manage those risks. This framework is applied to fourteen contemporary case studies, including synthetic genomics, DNA shuffling and directed evolution, combinatorial chemistry, protein engineering, immunological modulation, and aerosol vaccines. The book also draws useful lessons from two historical cases: the development of the V-series nerve agents in Britain and the use and misuse of LSD by the U.S. Army and the CIA. Innovation, Dual Use, and Security offers a comprehensive, multifaceted introduction to the challenges of governing dual-use technologies in an era of rapid innovation. The book will be of interest to government officials and other practitioners as well as to students and scholars in security studies, science and technology studies, biology, and chemistry.

Science and Security in a Post 9/11 World

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Author :
Publisher : National Academies Press
ISBN 13 : 0309111919
Total Pages : 136 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Science and Security in a Post 9/11 World by : National Research Council

Download or read book Science and Security in a Post 9/11 World written by National Research Council and published by National Academies Press. This book was released on 2007-11-10 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on a series of regional meetings on university campuses with officials from the national security community and academic research institutions, this report identifies specific actions that should be taken to maintain a thriving scientific research environment in an era of heightened security concerns. Actions include maintaining the open exchange of scientific information, fostering a productive environment for international scholars in the U.S., reexamining federal definitions of sensitive but unclassified research, and reviewing policies on deemed export controls. The federal government should establish a standing entity, preferably a Science and Security Commission, that would review policies regarding the exchange of information and the participation of foreign-born scientists and students in research.

Synthetic Biology 2020: Frontiers in Risk Analysis and Governance

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Author :
Publisher : Springer Nature
ISBN 13 : 3030272648
Total Pages : 434 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Synthetic Biology 2020: Frontiers in Risk Analysis and Governance by : Benjamin D. Trump

Download or read book Synthetic Biology 2020: Frontiers in Risk Analysis and Governance written by Benjamin D. Trump and published by Springer Nature. This book was released on 2019-11-28 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetic biology offers powerful remedies for some of the world’s most intractable problems, but these solutions are clouded by uncertainty and risk that few strategies are available to address. The incentives for continued development of this emerging technology are prodigious and obvious, and the public deserves assurances that all potential downsides are duly considered and minimized accordingly. Incorporating social science analysis within the innovation process may impose constraints, but its simultaneous support in making the end products more acceptable to society at large should be considered a worthy trade-off. Contributing authors in this volume represent diverse perspectives related to synthetic biology’s social sciences, and reflect on different areas of risk analysis and governance that have developed for the field. Such perspectives include leading scholarly discussion pertaining to risk assessment, governance, ethics, and communication. The chapters of this volume note that while the first twenty years of synthetic biology development have focused strongly on technological innovation and product development, the next twenty should emphasize the synergy between developers, policymakers, and publics to generate the most beneficial, well governed, and transparent technologies and products possible. Many chapters in this volume provide new data and approaches that demonstrate the feasibility for multi-stakeholder efforts involving policymakers, regulators, industrial developers, workers, experts, and societal representatives to share responsibilities in the production of effective and acceptable governance in the face of uncertain risk probabilities. A full consideration of such perspectives may prevent a world of draconian regulations based on an insufficient or incomplete understanding of the science that underpins synthetic biology, as well as any hesitancy or fear by the public to adopt its eventual products.

Biotechnology Research in an Age of Terrorism

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Publisher : National Academies Press
ISBN 13 : 0309089778
Total Pages : 164 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Biotechnology Research in an Age of Terrorism by : National Research Council

Download or read book Biotechnology Research in an Age of Terrorism written by National Research Council and published by National Academies Press. This book was released on 2004-03-02 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years much has happened to justify an examination of biological research in light of national security concerns. The destructive application of biotechnology research includes activities such as spreading common pathogens or transforming them into even more lethal forms. Policymakers and the scientific community at large must put forth a vigorous and immediate response to this challenge. This new book by the National Research Council recommends that the government expand existing regulations and rely on self-governance by scientists rather than adopt intrusive new policies. One key recommendation of the report is that the government should not attempt to regulate scientific publishing but should trust scientists and journals to screen their papers for security risks, a task some journals have already taken up. With biological information and tools widely distributed, regulating only U.S. researchers would have little effect. A new International Forum on Biosecurity should encourage the adoption of similar measures around the world. Seven types of risky studies would require approval by the Institutional Biosafety Committees that already oversee recombinant DNA research at some 400 U.S. institutions. These "experiments of concern" include making an infectious agent more lethal and rendering vaccines powerless.

Expertise Under Scrutiny

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Publisher : Springer
ISBN 13 : 3030205320
Total Pages : 177 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Expertise Under Scrutiny by : Myriam Merad

Download or read book Expertise Under Scrutiny written by Myriam Merad and published by Springer. This book was released on 2019-07-17 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the challenges that confront leaders in government and industry when making decisions in the areas of environmental health and safety. Today, decision making demands transparency, robustness, and resiliency. However thoughtfully they are devised, decisions made by governments and enterprises can often trigger immediate, passionate public response. Expertise Under Scrutiny shows how leaders can establish organizational decision making processes that yield valid, workable choices even in fast-changing and uncertain conditions. The first part of the book examines the organizational decision making process, describing the often-contentious environment in which important environmental health and safety decisions are made, and received. The authors review the roles of actors and experts in the decision making process. The book goes on to address such topics as: · The roles of actors and experts in the decision making process · Ethics and analytics as drivers of good decisions · Why managing problems in safety, security, environment, and health Part II offers an outline for adopting a formal decision support structure, including the use of decision support tools. It includes a chapter devoted to ELECTRE (ELimination and Choice Expressing Reality), a multi-criteria decision analysis system. The book concludes with an insightful appraisal and analysis of the expertise, structure and resources needed for navigating well-supported, risk-informed decisions in our 21st Century world. Expertise Under Scrutiny benefits a broad audience of students, academics, researchers, and working professionals in management and related disciplines, especially in the field of environmental health and safety.

The Fourth Industrial Revolution

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Publisher : Crown Currency
ISBN 13 : 1524758876
Total Pages : 194 pages
Book Rating : 4.5/5 (247 download)

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Book Synopsis The Fourth Industrial Revolution by : Klaus Schwab

Download or read book The Fourth Industrial Revolution written by Klaus Schwab and published by Crown Currency. This book was released on 2017-01-03 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: World-renowned economist Klaus Schwab, Founder and Executive Chairman of the World Economic Forum, explains that we have an opportunity to shape the fourth industrial revolu­tion, which will fundamentally alter how we live and work. Schwab argues that this revolution is different in scale, scope and complexity from any that have come before. Characterized by a range of new technologies that are fusing the physical, digital and biological worlds, the developments are affecting all disciplines, economies, industries and governments, and even challenging ideas about what it means to be human. Artificial intelligence is already all around us, from supercomputers, drones and virtual assistants to 3D printing, DNA sequencing, smart thermostats, wear­able sensors and microchips smaller than a grain of sand. But this is just the beginning: nanomaterials 200 times stronger than steel and a million times thinner than a strand of hair and the first transplant of a 3D printed liver are already in development. Imagine “smart factories” in which global systems of manu­facturing are coordinated virtually, or implantable mobile phones made of biosynthetic materials. The fourth industrial revolution, says Schwab, is more significant, and its ramifications more profound, than in any prior period of human history. He outlines the key technologies driving this revolution and discusses the major impacts expected on government, business, civil society and individu­als. Schwab also offers bold ideas on how to harness these changes and shape a better future—one in which technology empowers people rather than replaces them; progress serves society rather than disrupts it; and in which innovators respect moral and ethical boundaries rather than cross them. We all have the opportunity to contribute to developing new frame­works that advance progress.

Bio-Inspired Innovation and National Security

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Author :
Publisher : NDU Press
ISBN 13 : 1780390408
Total Pages : 356 pages
Book Rating : 4.7/5 (83 download)

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Book Synopsis Bio-Inspired Innovation and National Security by : National Defense University

Download or read book Bio-Inspired Innovation and National Security written by National Defense University and published by NDU Press. This book was released on 2010-10 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the vital importance of the emerging area of biotechnology and its role in defense planning and policymaking, no definitive book has been written on the topic for the defense policymaker, the military student, and the private-sector bioscientist interested in the "emerging opportunities market" of national security. This edited volume is intended to help close this gap and provide the necessary backdrop for thinking strategically about biology in defense planning and policymaking. This volume is about applications of the biological sciences, here called "biologically inspired innovations," to the military. Rather than treating biology as a series of threats to be dealt with, such innovations generally approach the biological sciences as a set of opportunities for the military to gain strategic advantage over adversaries. These opportunities range from looking at everything from genes to brains, from enhancing human performance to creating renewable energy, from sensing the environment around us to harnessing its power.

The Cobra Event

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Publisher : Ballantine Books
ISBN 13 : 0345498135
Total Pages : 449 pages
Book Rating : 4.3/5 (454 download)

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Book Synopsis The Cobra Event by : Richard Preston

Download or read book The Cobra Event written by Richard Preston and published by Ballantine Books. This book was released on 2007-04-10 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cobra Event is set in motion one spring morning in New York City, when a seventeen-year-old student wakes up feeling vaguely ill. Hours later she is having violent seizures, blood is pouring out of her nose, and she has begun a hideous process of self-cannibalization. Soon, other gruesome deaths of a similar nature have been discovered, and the Centers for Disease Control sends a forensic pathologist to investigate. What she finds precipitates a federal crisis. The details of this story are fictional, but they are based on a scrupulously thorough inquiry into the history of biological weapons and their use by civilian and military terrorists. Richard Preston's sources include members of the FBI and the United States military, public health officials, intelligence officers in foreign governments, and scientists who have been involved in the testing of strategic bioweapons. The accounts of what they have seen and what they expect to happen are chilling. The Cobra Event is a dramatic, heart-stopping account of a very real threat, told with the skill and authority that made Preston's The Hot Zone an internationally acclaimed bestseller.

BioBuilder

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Publisher : "O'Reilly Media, Inc."
ISBN 13 : 1491907533
Total Pages : 293 pages
Book Rating : 4.4/5 (919 download)

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Book Synopsis BioBuilder by : Natalie Kuldell PhD.

Download or read book BioBuilder written by Natalie Kuldell PhD. and published by "O'Reilly Media, Inc.". This book was released on 2015-06-22 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today’s synthetic biologists are in the early stages of engineering living cells to help treat diseases, sense toxic compounds in the environment, and produce valuable drugs. With this manual, you can be part of it. Based on the BioBuilder curriculum, this valuable book provides open-access, modular, hands-on lessons in synthetic biology for secondary and post-secondary classrooms and laboratories. It also serves as an introduction to the field for science and engineering enthusiasts. Developed at MIT in collaboration with award-winning high school teachers, BioBuilder teaches the foundational ideas of the emerging synthetic biology field, as well as key aspects of biological engineering that researchers are exploring in labs throughout the world. These lessons will empower teachers and students to explore and be part of solving persistent real-world challenges. Learn the fundamentals of biodesign and DNA engineering Explore important ethical issues raised by examples of synthetic biology Investigate the BioBuilder labs that probe the design-build-test cycle Test synthetic living systems designed and built by engineers Measure several variants of an enzyme-generating genetic circuit Model "bacterial photography" that changes a strain’s light sensitivity Build living systems to produce purple or green pigment Optimize baker’s yeast to produce ?-carotene