Emerging Roles For Hippocampal Adult Neural Stem Cells In Memory

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Emerging Roles for Hippocampal Adult Neural Stem Cells in Memory

Author : Aaron R. Friedman
Publisher : Biota Publishing
ISBN 13 : 1615044779
Total Pages : 41 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis Emerging Roles for Hippocampal Adult Neural Stem Cells in Memory by : Aaron R. Friedman

Download or read book Emerging Roles for Hippocampal Adult Neural Stem Cells in Memory written by Aaron R. Friedman and published by Biota Publishing. This book was released on 2013-12-01 with total page 41 pages. Available in PDF, EPUB and Kindle. Book excerpt: Approximately 50 years ago, newly generated neurons were discovered in the adult hippocampus of the rat brain. This discovery contradicted a key principle in mammalian developmental neurobiology—that all the neurons of the brain are made during early development—and led to intensive study to find out how new neurons are generated and how the process of neurogenesis is regulated. Since then, a unique population of adult neural stem cells has been identified, and many of the molecular pathways that control their self-renewal, proliferation, and cell fate have been elucidated. However, the presence of new neurons in the adult brain also poses intriguing functional questions that have, as yet, gone largely unanswered. Why is adult neurogenesis restricted to select brain regions? What functional benefit do these new cells confer? Indeed, the field of adult neurogenesis offers a unique opportunity to study naïve neurons as they mature, form connections with existing neural networks, and begin to participate in information processing. We review the basics of adult NSC biology and the maturation of newborn neurons. In particular, we focus on new neurons in the hippocampus, and how they contribute to function in this key memory-forming structure of the brain.

Adult Neurogenesis in the Hippocampus

Author : Juan J. Canales
Publisher : Academic Press
ISBN 13 : 0128019921
Total Pages : 298 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Adult Neurogenesis in the Hippocampus by : Juan J. Canales

Download or read book Adult Neurogenesis in the Hippocampus written by Juan J. Canales and published by Academic Press. This book was released on 2016-05-23 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurogenesis in the adult brain has emerged as one of the most dynamic and rapidly moving fields in modern neuroscience research. The implications of adult neurogenesis for health and well-being are wide-ranging, with findings in this area having distinct relevance for treatment and rehabilitation in neurology and psychopathology. Adult Neurogenesis in the Hippocampus addresses these implications by providing an up-to-date account on how neurogenesis in the adult hippocampus contributes to critical psychological and physiological processes, such as learning and memory, and how it is modified by life experiences, such as aging, environmental enrichment, exercise, and dieting. The book also provides the most current reviews of how adult hippocampal neurogenesis influences the pathogenesis of mood disorders, addiction, and key neurological disorders. This book is the ideal resource for researchers and advanced graduates seeking focused knowledge on the role of adult neurogenesis in brain health and disease. Provides a unique overview of how adult hippocampal neurogenesis contributes to adaptive processes, brain psychopathology, and disease Includes state-of-the-art reviews by leading world experts in adult neurogenesis

Neuronal Networks of the Hippocampus

Author : Roger D. Traub
Publisher : Cambridge University Press
ISBN 13 : 0521364817
Total Pages : 306 pages
Book Rating : 4.5/5 (213 download)

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Book Synopsis Neuronal Networks of the Hippocampus by : Roger D. Traub

Download or read book Neuronal Networks of the Hippocampus written by Roger D. Traub and published by Cambridge University Press. This book was released on 1991-05-31 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: The questions of how a large population of neurons in the brain functions, how synchronized firing of neurons is achieved, and what factors regulate how many and which neurons fire under different conditions form the central theme of this book. Important neurological techniques for the physiological reconstruction of a large biological neural network are presented.

The Hippocampus

Author : Ales Stuchlik
Publisher : BoD – Books on Demand
ISBN 13 : 1789233569
Total Pages : 180 pages
Book Rating : 4.7/5 (892 download)

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Book Synopsis The Hippocampus by : Ales Stuchlik

Download or read book The Hippocampus written by Ales Stuchlik and published by BoD – Books on Demand. This book was released on 2018-07-11 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: The hippocampus is an important brain region, a true central hub for memory of various kinds and other processes. Neuropsychiatric disorders such as Alzheimer's disease, drug addiction, and schizophrenia are characterized by hippocampal alterations. The dentate gyrus of the hippocampus is a site exhibiting adult neurogenesis. This book covers the topic of the hippocampus from various perspectives. It discusses adult neurogenesis, effect of enriched environments on hippocampal plasticity, and long-term potentiation-associated gene expression. The book also addresses multiscale representations of complex environments and strategies in the hippocampus-dependent spatial tasks. Finally, insight into the hippocampus as a link between negative affect and relapse to psychostimulants is provided. The book collects evidence of various hippocampal functions in healthy and disordered brain.

The Neurobiology of Olfaction

Author : Anna Menini
Publisher : CRC Press
ISBN 13 : 9781420071993
Total Pages : 448 pages
Book Rating : 4.0/5 (719 download)

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Book Synopsis The Neurobiology of Olfaction by : Anna Menini

Download or read book The Neurobiology of Olfaction written by Anna Menini and published by CRC Press. This book was released on 2009-11-24 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Overview of Advances in Olfaction The common belief is that human smell perception is much reduced compared with other mammals, so that whatever abilities are uncovered and investigated in animal research would have little significance for humans. However, new evidence from a variety of sources indicates this traditional view is likely overly simplistic. The Neurobiology of Olfaction provides a thorough analysis of the state-of-the-science in olfactory knowledge and research, reflecting the growing interest in the field. Authors from some of the most respected laboratories in the world explore various aspects of olfaction, including genetics, behavior, olfactory systems, odorant receptors, odor coding, and cortical activity. Until recently, almost all animal research in olfaction was carried out on orthonasal olfaction (inhalation). It is only in recent years, especially in human flavor research, that evidence has begun to be obtained regarding the importance of retronasal olfaction (exhalation). These studies are beginning to demonstrate that retronasal smell plays a large role to play in human behavior. Highlighting common principles among various species – including humans, insects, Xenopus laevis (African frog), and Caenorhabditis elegans (nematodes) – this highly interdisciplinary book contains chapters about the most recent discoveries in odor coding from the olfactory epithelium to cortical centers. It also covers neurogenesis in the olfactory epithelium and olfactory bulb. Each subject-specific chapter is written by a top researcher in the field and provides an extensive list of reviews and original articles for students and scientists interested in further readings.

Memory, Amnesia, and the Hippocampal System

Author : Neal J. Cohen
Publisher : MIT Press
ISBN 13 : 9780262531320
Total Pages : 1182 pages
Book Rating : 4.5/5 (313 download)

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Book Synopsis Memory, Amnesia, and the Hippocampal System by : Neal J. Cohen

Download or read book Memory, Amnesia, and the Hippocampal System written by Neal J. Cohen and published by MIT Press. This book was released on 1993 with total page 1182 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this sweeping synthesis, Neal J. Cohen and Howard Eichenbaum bring together converging findings from neuropsychology, neuroscience, and cognitive science that provide the critical clues and constraints for developing a more comprehensive understanding of memory. Specifically, they offer a cognitive neuroscience theory of memory that accounts for the nature of memory impairment exhibited in human amnesia and animal models of amnesia, that specifies the functional role played by the hippocampal system in memory, and that provides further understanding of the componential structure of memory.The authors' central thesis is that the hippocampal system mediates a capacity for declarative memory, the kind of memory that in humans supports conscious recollection and the explicit and flexible expression of memories. They argue that this capacity emerges from a representation of critical relations among items in memory, and that such a relational representation supports the ability to make inferences and generalizations from memory, and to manipulate and flexibly express memory in countless ways. In articulating such a description of the fundamental nature of declarative representation and of the mnemonic capabilities to which it gives rise, the authors' theory constitutes a major extension and elaboration of the earlier procedural-declarative account of memory.Support for this view is taken from a variety of experimental studies of amnesia in humans, nonhuman primates, and rodents. Additional support is drawn from observations concerning the neuroanatomy and neurophysiology of the hippocampal system. The data taken from divergent literatures are shown to converge on the central theme of hippocampal involvement in declarative memory across species and across behavioral paradigms.

Handbook of the Psychology of Aging

Author : K Warner Schaie
Publisher : Academic Press
ISBN 13 : 9780123808837
Total Pages : 434 pages
Book Rating : 4.8/5 (88 download)

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Book Synopsis Handbook of the Psychology of Aging by : K Warner Schaie

Download or read book Handbook of the Psychology of Aging written by K Warner Schaie and published by Academic Press. This book was released on 2010-12-21 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of the Psychology of Aging, Seventh Edition, provides a basic reference source on the behavioral processes of aging for researchers, graduate students, and professionals. It also provides perspectives on the behavioral science of aging for researchers and professionals from other disciplines. The book is organized into four parts. Part 1 reviews key methodological and analytical issues in aging research. It examines some of the major historical influences that might provide explanatory mechanisms for a better understanding of cohort and period differences in psychological aging processes. Part 2 includes chapters that discuss the basics and nuances of executive function; the history of the morphometric research on normal brain aging; and the neural changes that occur in the brain with aging. Part 3 deals with the social and health aspects of aging. It covers the beliefs that individuals have about how much they can control various outcomes in their life; the impact of stress on health and aging; and the interrelationships between health disparities, social class, and aging. Part 4 discusses the emotional aspects of aging; family caregiving; and mental disorders and legal capacities in older adults. Contains all the main areas of psychological gerontological research in one volume Entire section on neuroscience and aging Begins with a section on theory and methods Edited by one of the father of gerontology (Schaie) and contributors represent top scholars in gerontology

Adult Neurogenesis

Author : Gerd Kempermann
Publisher : Oxford University Press, USA
ISBN 13 : 9780195179712
Total Pages : 464 pages
Book Rating : 4.1/5 (797 download)

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Book Synopsis Adult Neurogenesis by : Gerd Kempermann

Download or read book Adult Neurogenesis written by Gerd Kempermann and published by Oxford University Press, USA. This book was released on 2006 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of adult neurogenesis and of stem cells in the brain has changed our view of the mature brain. Though we now know that the adult brain can make new neurons, it normally does so only in two privileged regions, the olfactory bulb and the hippocampus. Yet stem cells, which have the potential to produce new neurons, can be found throughout the adult brain. So why does the brain not make wider use of its potential for neurogenesis? And what is the function of new neurons and of neural stem cells in areas where they occur? After all, the brain regenerates poorly and many neurological and psychiatric disorders are chronic because cell replacement has not taken place. This is the first comprehensive, integrated account of one of the most exciting areas of neuroscience. It begins with the historical background and discusses theories of adult neurogenesis and neural stem cell biology in the context of learning and memory processes as well as structural plasticity. It describes in detail neurogenesis in the adult hippocampus and olfactory system and then surveys the regulatory, functional, and comparative aspects, concluding with a chapter on the provocative hypotheses that link failing adult neurogenesis with such diseases as temporal lobe epilepsy, major depression, brain tumors, and dementias. For graduate students, investigators, and clinicians in the neurosciences, developmental biology, and stem cell research, this book is a unique resource that sifts through the evidence for exciting scientific ideas and fosters a realistic view of the therapeutic possibilities for the use of stem cells in the adult brain.

The CA3 Region of the Hippocampus: How is it? What is it for? How does it do it?

Author : Enrico Cherubini
Publisher : Frontiers Media SA
ISBN 13 : 2889196313
Total Pages : 167 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis The CA3 Region of the Hippocampus: How is it? What is it for? How does it do it? by : Enrico Cherubini

Download or read book The CA3 Region of the Hippocampus: How is it? What is it for? How does it do it? written by Enrico Cherubini and published by Frontiers Media SA. This book was released on 2015-08-19 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: The CA3 hippocampal region receives information from the entorhinal cortex either directly from the perforant path or indirectly from the dentate gyrus via the mossy fibers (MFs). According to their specific targets (principal/mossy cells or interneurons), MFs terminate with large boutons or small filopodial extensions, respectively. MF-CA3 synapses are characterized by a low probability of release and pronounced frequency-dependent facilitation. In addition MF terminals are endowed with mGluRs that regulate their own release. We will describe the intrinsic membrane properties of pyramidal cells, which can sometimes fire in bursts, together with the geometry of their dendritic arborization. The single layer of pyramidal cells is quite distinct from the six-layered neocortical arrangement. The resulting aligned dendrites provides the substrate for laminated excitatory inputs. They also underlie a precise, diversity of inhibitory control which we will also describe in detail. The CA3 region has an especially rich internal connectivity, with recurrent excitatory and inhibitory loops. In recent years both in vivo and in vitro studies have allowed to better understand functional properties of the CA3 auto-associative network and its role in information processing. This circuit is implicated in encoding spatial representations and episodic memories. It generates physiological population synchronies, including gamma, theta and sharp-waves that are presumed to associate firing in selected assemblies of cells in different behavioral conditions. The CA3 region is susceptible to neurodegeneration during aging and after stresses such as infection or injury. Loss of some CA3 neurones has striking effects on mossy fiber inputs and can facilitate the generation of pathologic synchrony within the CA3 micro-circuit. The aim of this special topic is to bring together experts on the cellular and molecular mechanisms regulating the wiring properties of the CA3 hippocampal microcircuit in both physiological and pathological conditions, synaptic plasticity, behavior and cognition.We will particularly emphasize the dual glutamatergic and GABAergic phenotype of MF-CA3 synapses at early developmental stages and the steps that regulate the integration of newly generated neurons into the adult dentate gyrus-CA3 circuit.

Neurogenesis and Neural Plasticity

Author : Catherine Belzung
Publisher : Springer Science & Business Media
ISBN 13 : 364236232X
Total Pages : 447 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Neurogenesis and Neural Plasticity by : Catherine Belzung

Download or read book Neurogenesis and Neural Plasticity written by Catherine Belzung and published by Springer Science & Business Media. This book was released on 2014-07-08 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume brings together authors working on a wide range of topics to provide an up to date account of the underlying mechanisms and functions of neurogenesis and synaptogenesis in the adult brain. With an increasing understanding of the role of neurogenesis and synaptogenesis it is possible to envisage improvements or novel treatments for a number of diseases and the possibility of harnessing these phenomena to reduce the impact of ageing and to provide mechanisms to repair the brain.

Cognitive Enhancement

Author : Kathleen M. Kantak
Publisher : Springer
ISBN 13 : 3319165224
Total Pages : 470 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Cognitive Enhancement by : Kathleen M. Kantak

Download or read book Cognitive Enhancement written by Kathleen M. Kantak and published by Springer. This book was released on 2015-05-14 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the behavioral and neurobiological issues relevant for drug development, reviews evidence for an innovative approach for drug discovery and presents perspectives on multiple special topics ranging from therapeutic drug use in children, emerging technologies and non-pharmacological approaches to cognitive enhancement.

Neuroscience in the 21st Century

Author : Donald W. Pfaff
Publisher : Springer
ISBN 13 : 9781493934737
Total Pages : 0 pages
Book Rating : 4.9/5 (347 download)

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Book Synopsis Neuroscience in the 21st Century by : Donald W. Pfaff

Download or read book Neuroscience in the 21st Century written by Donald W. Pfaff and published by Springer. This book was released on 2016-10-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimer’s and other dementias. Because neuroscience takes the etiology of disease—the complex interplay between biological, psychological, and sociocultural factors—as its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States’ Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising around 150 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21st Century in its second edition serves as a comprehensive resource to students and researchers alike.

Neuroepigenomics in Aging and Disease

Author : Raul Delgado-Morales
Publisher : Springer
ISBN 13 : 3319538896
Total Pages : 525 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Neuroepigenomics in Aging and Disease by : Raul Delgado-Morales

Download or read book Neuroepigenomics in Aging and Disease written by Raul Delgado-Morales and published by Springer. This book was released on 2017-05-18 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetic mechanisms (DNA modifications, histone alterations and non-coding RNAs) are crucial for transcriptional regulation and alterations of the “physiological epigenome” are increasingly associated with human diseases. During the last decade the emerging field of neuroepigenomics have started to impact tremendously in areas such learning and memory, addiction or neurodegeneration. This expert volume covers the role of epigenetic molecular mechanism in regulation of central nervous system’s function, one of the most exciting areas of contemporary molecular neuroscience. The book describes the current knowledge on the epigenetic basis of human disease covering the complete lifespan: from neurodevelopment/childhood (Rett Syndrome, Rubinstein-Taybi, autism), adolescence (eating disorders, drug addiction, anxiety), adulthood (depression, schizophrenia, amyotrophic lateral sclerosis, Huntington’s disease) and elderly (Alzheimer’s disease, Parkinson’s disease). The book also covers the three major players on neuroepigenomic mechanisms: histones alterations, DNA modifications and non-coding RNAs, their roles at the molecular and cellular level and the impact of their alterations on neuronal function and behavior. Finally, a special chapter on state-of-the-art technologies helps the reader not only to understand epigenetic driven changes in human cognition and diseases but also the methodology that will help to generate paradigm shifts on our understanding of brain function and the role of the neuroepigenome in human diseases.

The Dentate Gyrus

Author : Helen E. Scharfman
Publisher : Elsevier Science Serials
ISBN 13 : 9780444530158
Total Pages : 787 pages
Book Rating : 4.5/5 (31 download)

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Book Synopsis The Dentate Gyrus by : Helen E. Scharfman

Download or read book The Dentate Gyrus written by Helen E. Scharfman and published by Elsevier Science Serials. This book was released on 2007 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt: A compilation of the fundamentals of the dentate gyrus, an area of the brain of intense scientific interest due to its capacity for plasticity.

Generation of Neurons and Their Integration in Pre-Existing Circuits in the Postnatal Brain: Signalling in Physiological and Regenerative Contexts

Download Generation of Neurons and Their Integration in Pre-Existing Circuits in the Postnatal Brain: Signalling in Physiological and Regenerative Contexts PDF Online Free

Author : Helena Mira
Publisher : Frontiers Media SA
ISBN 13 : 2889639886
Total Pages : 150 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Generation of Neurons and Their Integration in Pre-Existing Circuits in the Postnatal Brain: Signalling in Physiological and Regenerative Contexts by : Helena Mira

Download or read book Generation of Neurons and Their Integration in Pre-Existing Circuits in the Postnatal Brain: Signalling in Physiological and Regenerative Contexts written by Helena Mira and published by Frontiers Media SA. This book was released on 2020-09-03 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Neurobiology of Chemical Communication

Author : Carla Mucignat-Caretta
Publisher : CRC Press
ISBN 13 : 1466553413
Total Pages : 614 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Neurobiology of Chemical Communication by : Carla Mucignat-Caretta

Download or read book Neurobiology of Chemical Communication written by Carla Mucignat-Caretta and published by CRC Press. This book was released on 2014-02-14 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intraspecific communication involves the activation of chemoreceptors and subsequent activation of different central areas that coordinate the responses of the entire organism—ranging from behavioral modification to modulation of hormones release. Animals emit intraspecific chemical signals, often referred to as pheromones, to advertise their presence to members of the same species and to regulate interactions aimed at establishing and regulating social and reproductive bonds. In the last two decades, scientists have developed a greater understanding of the neural processing of these chemical signals. Neurobiology of Chemical Communication explores the role of the chemical senses in mediating intraspecific communication. Providing an up-to-date outline of the most recent advances in the field, it presents data from laboratory and wild species, ranging from invertebrates to vertebrates, from insects to humans. The book examines the structure, anatomy, electrophysiology, and molecular biology of pheromones. It discusses how chemical signals work on different mammalian and non-mammalian species and includes chapters on insects, Drosophila, honey bees, amphibians, mice, tigers, and cattle. It also explores the controversial topic of human pheromones. An essential reference for students and researchers in the field of pheromones, this is also an ideal resource for those working on behavioral phenotyping of animal models and persons interested in the biology/ecology of wild and domestic species.

Gray's Surgical Anatomy E-Book

Author : Peter Prof. Brennan
Publisher : Elsevier Health Sciences
ISBN 13 : 0702073881
Total Pages : 672 pages
Book Rating : 4.7/5 (2 download)

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Book Synopsis Gray's Surgical Anatomy E-Book by : Peter Prof. Brennan

Download or read book Gray's Surgical Anatomy E-Book written by Peter Prof. Brennan and published by Elsevier Health Sciences. This book was released on 2019-11-05 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written and edited by expert surgeons in collaboration with a world-renowned anatomist, this exquisitely illustrated reference consolidates surgical, anatomical and technical knowledge for the entire human body in a single volume. Part of the highly respected Gray’s ‘family,’ this new resource brings to life the applied anatomical knowledge that is critically important in the operating room, with a high level of detail to ensure safe and effective surgical practice. Gray’s Surgical Anatomy is unique in the field: effectively a textbook of regional anatomy, a dissection manual, and an atlas of operative procedures – making it an invaluable resource for surgeons and surgical trainees at all levels of experience, as well as students, radiologists, and anatomists. Brings you expert content written by surgeons for surgeons, with all anatomical detail quality assured by Lead Co-Editor and Gray’s Anatomy Editor-in-Chief, Professor Susan Standring. Features superb colour photographs from the operating room, accompanied by detailed explanatory artwork and figures from the latest imaging modalities - plus summary tables, self-assessment questions, and case-based scenarios – making it an ideal reference and learning package for surgeons at all levels. Reflects contemporary practice with chapters logically organized by anatomical region, designed for relevance to surgeons across a wide range of subspecialties, practice types, and clinical settings – and aligned to the requirements of current trainee curricula. Maximizes day-to-day practical application with references to core surgical procedures throughout, as well as the ‘Tips and Anatomical Hazards’ from leading international surgeons. Demonstrates key anatomical features and relationships that are essential for safe surgical practice - using brand-new illustrations, supplemented by carefully selected contemporary artwork from the most recent edition of Gray’s Anatomy and other leading publications. Integrates essential anatomy for robotic and minimal access approaches, including laparoscopic and endoscopic techniques. Features dedicated chapters describing anatomy of lumbar puncture, epidural anaesthesia, peripheral nerve blocks, echocardiographic anatomy of the heart, and endoscopic anatomy of the gastrointestinal tract – as well as a unique overview of human factors and minimizing error in the operating room, essential non-technical skills for improving patient outcomes and safety.