Emerging Challenges Of Cardiovascular And Metabolic Dysfunctions In Cardio Oncology From Bench To Bedside

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Emerging Challenges of Cardiovascular and Metabolic Dysfunctions in Cardio-oncology: From Bench to Bedside

Author : Canan G. Nebigil
Publisher : Frontiers Media SA
ISBN 13 : 2889660958
Total Pages : 127 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Emerging Challenges of Cardiovascular and Metabolic Dysfunctions in Cardio-oncology: From Bench to Bedside by : Canan G. Nebigil

Download or read book Emerging Challenges of Cardiovascular and Metabolic Dysfunctions in Cardio-oncology: From Bench to Bedside written by Canan G. Nebigil and published by Frontiers Media SA. This book was released on 2020-10-27 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Cardio-Oncology: From Bench to Bedside

Author : Jun-ichi Abe
Publisher : Frontiers Media SA
ISBN 13 : 288945875X
Total Pages : 113 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Cardio-Oncology: From Bench to Bedside by : Jun-ichi Abe

Download or read book Cardio-Oncology: From Bench to Bedside written by Jun-ichi Abe and published by Frontiers Media SA. This book was released on 2019-05-17 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardio-oncology is a medical subspecialty concerned with the diagnosis and treatment of cardiovascular disease (CVD) and organ failure mediated by micro- to macro-circulation defects in cancer patients and survivors. The risk of CVD in cancer survivors is eight times higher than the general population, and the relative risk of coronary artery disease and heart failure (HF) is 10 times and 15 times higher, respectively, compared to their siblings without cancer. It is important to note that cancer treatments including chemotherapy and radiation can lead to both short- (< 1 year) and long-term (> 5 years) cardiovascular complications. Previously, Dr. Edward T.H. Yeh initiated the MD Anderson Practice (MAP) project, and published 16 MAPs to provide the current best practice we considered at UT MD Anderson. As shown in these MAPs, one of the key issues of cardio-oncology practice and science is how we can allow cancer patients to receive maximum and uninterrupted treatments for cancer while protecting them from cancer therapy-mediated cardiovascular complications. Therefore, it is crucial to understand not only pathophysiology of CVD, but also mechanistic insights of how each cancer treatment can control cancer growth and metastasis. Without having the profound knowledge in the pathophysiological, clinical and epidemiologic aspects of cardiovascular complications of existing cancer therapy, it is impossible to establish the strong evidence-based strategies and approaches for both short- and long-term cardiovascular complications after cancer treatment. In addition, we believe that cardio-oncology science should not be restricted to deal with the side effects of each specific cancer drug, because many common cardiovascular phenotypes among the different cancer treatments are also observed. This Research Topic provides a comprehensive overview from both of the current research and practice, and a platform for obtaining the logical and up-to-date treatment and prevention of CVD in cancer patients and survivors.

Advances & Innovations in Heart Failure (AIHF)

Author : HK Chopra
Publisher : Jaypee Brothers Medical Publishers
ISBN 13 : 9389587891
Total Pages : 995 pages
Book Rating : 4.3/5 (895 download)

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Book Synopsis Advances & Innovations in Heart Failure (AIHF) by : HK Chopra

Download or read book Advances & Innovations in Heart Failure (AIHF) written by HK Chopra and published by Jaypee Brothers Medical Publishers. This book was released on 2020-02-28 with total page 995 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heart failure is a serious condition caused by the heart failing to pump enough blood around the body at the right pressure. It usually occurs because the heart muscle has become too weak or stiff to work properly, most commonly caused by heart attack, high blood pressure or cardiomyopathy (heart disease). This textbook is a comprehensive guide to the latest advances in the diagnosis and management of heart failure. Comprising nearly 1000 pages, the book features 15 sections, beginning with discussion on clinical issues of heart failure, followed by imaging techniques. Each of the following sections covers a different disorder or disease that subsequently may lead to heart failure. Topics include coronary artery disease, stroke, arrhythmia, hypertension, nutritional aspects, cardio-oncology, and much more. The book concludes with rehabilitation, legal aspects, and future directions. Authored by internationally recognised experts in the field, the text is further enhanced by clinical photographs, diagrams and tables. Key points Comprehensive guide to latest advances in diagnosis and management of heart failure Extensive text comprising nearly 1000 pages covering numerous associated disorders and diseases Internationally recognised editor and author team Highly illustrated with clinical photographs, diagrams and tables

ASE’s Comprehensive Strain Imaging, E-Book

Author : Thomas H. Marwick
Publisher : Elsevier Health Sciences
ISBN 13 : 0323759483
Total Pages : 256 pages
Book Rating : 4.3/5 (237 download)

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Book Synopsis ASE’s Comprehensive Strain Imaging, E-Book by : Thomas H. Marwick

Download or read book ASE’s Comprehensive Strain Imaging, E-Book written by Thomas H. Marwick and published by Elsevier Health Sciences. This book was released on 2021-05-01 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Strain imaging (also known as speckle-tracking echocardiography or STE) is a rapidly growing, affordable, and versatile cardiac imaging technology of great interest to clinicians in both inpatient and outpatient settings. ASE's Comprehensive Strain Imaging is the first reference designed to help you master a wide range of strain imaging/STE applications, including screening, diagnosis, treatment, and follow up. Written and edited by a team of international experts from the American Society of Echocardiography (ASE), this new resource provides the information you need to optimize imaging acquisition and analysis using this important new echocardiography method. Covers step-by-step techniques on how to use strain imaging with expert tips on nuances, pitfalls, and clinical decision making. Discusses the growing range of strain imaging applications for assessing diastolic function, atrial function, heart failure, arterial disease, valve disease, hypertrophy, and other common cardiovascular conditions. Provides up-to-date information on screening and follow up of patients who receive cardio-toxic oncologic agents during cancer treatment and evaluation of patients with cardiomyopathy, heart failure, arterial disease, valve disease, implantable pacemakers, pericardial disease, hypertrophy, ischemic disease, and chest radiation. Includes more than 150 images using the latest strain imaging technology, as well as videos that depict evaluation and monitoring of patients with cardiomyopathies. Addresses future applications, including elastography.

Targeted Therapies in Breast Cancer

Author : Gw Sledge
Publisher : Clinical Pub
ISBN 13 : 9781846920660
Total Pages : 0 pages
Book Rating : 4.9/5 (26 download)

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Book Synopsis Targeted Therapies in Breast Cancer by : Gw Sledge

Download or read book Targeted Therapies in Breast Cancer written by Gw Sledge and published by Clinical Pub. This book was released on 2012-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume updates the reader on selected areas of targeted therapy in breast cancer, with special emphasis on chemoprevention strategies, drug resistance, biomarkers, combination chemotherapy, angiogenesis inhibition and pharmacogenomics in the context of clinical efficacy. This selected review of targeted therapies will guide the reader on effective treatment as part of an integrated programme of patient management.

Introductory Review on Sirtuins in Biology, Aging, and Disease

Author : Leonard Guarente
Publisher : Academic Press
ISBN 13 : 012813500X
Total Pages : 222 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Introductory Review on Sirtuins in Biology, Aging, and Disease by : Leonard Guarente

Download or read book Introductory Review on Sirtuins in Biology, Aging, and Disease written by Leonard Guarente and published by Academic Press. This book was released on 2018-04-20 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration. Covers both the general and specific aspects of sirtuin proteins and their role in biology, aging and disease Presents a top quality collection of leading experts who contribute on a wide range of sirtuin-related topics Ideal resource for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses

Stroke Genetics

Author : Hugh S. Markus
Publisher : Oxford Medical Publications
ISBN 13 : 0198515863
Total Pages : 362 pages
Book Rating : 4.1/5 (985 download)

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Book Synopsis Stroke Genetics by : Hugh S. Markus

Download or read book Stroke Genetics written by Hugh S. Markus and published by Oxford Medical Publications. This book was released on 2003 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stroke is a major cause of death and the major cause of adult neurological disability in most of the world. Despite its importance on a population basis, research into the genetics of stroke has lagged behind that of many other disorders. However, the situation is now changing. Anincreasing number of single gene disorders causing stroke are being described, and there is growing evidence that polygenic factors are important in the risk of apparently "sporadic" stroke.Stroke Genetics provides an up-to-date review of the area, suitable for clinicians treating stroke patients, and both clinical and non-clinical researchers in the field of cerebrovascular disease. The full range of monogenic stroke disorders causing cerebrovascular disease, including ischaemicstroke, intracerebral haemorrhage, aneurysms and arteriovenous malformations, are covered. For each, clinical features, diagnosis, and genetics are described. Increasing evidence suggest that genetic factors are also important for the much more common multifactorial stroke; this evidence isreviewed along with the results of genetic studies in this area. Optimal and novel strategies for investigating multifactorial stroke, including the use of intermediate phenotypes such as intima-media thickness and MRI detected small vessel disease are reviewed. The book concludes by describing apractical approach to investigating patients with stroke for underlying genetic disorders. Also included is a list of useful websites.

Clinical Bioenergetics

Author : Sergej M. Ostojic
Publisher : Academic Press
ISBN 13 : 0128227729
Total Pages : 720 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Clinical Bioenergetics by : Sergej M. Ostojic

Download or read book Clinical Bioenergetics written by Sergej M. Ostojic and published by Academic Press. This book was released on 2020-11-12 with total page 720 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Bioenergetics: From Pathophysiology to Clinical Translation provides recent developments surrounding the etiology and pathophysiology of inherited and acquired energy-delated disorders. Across 40 chapters, world leaders in bioenergetics and mitochondrial medicine discuss novel methodologies designed to identify deficiencies in cellular bioenergetics, as well as the safety and efficacy of emerging management strategies to address poor cellular bioenergetics. Topics discussed include the omics landscape of impaired mitochondrial bioenergetics, hormones, tissue bioenergetics and metabolism in humans. Disease-specific case studies, modes of analysis in clinical bioenergetics, and therapeutic opportunities for impaired bioenergetics, addressing both known treatment pathways and future directions for research, are discussed in-depth. Diseases and Disorders examined include brain injury, chronic fatigue syndrome, psychiatric disorders, pulmonary fibrosis, neurodegenerative disorders, heart failure, chronic kidney disease, obesity, and insulin resistance, among others. Provides a thorough discussion of foundational aspects of bioenergetics and disease, modes of analysis, and treatments for impaired bioenergetics Discusses the role of bioenergetics and treatment pathways in brain injury, chronic fatigue syndrome, psychiatric disorders, pulmonary fibrosis, neurodegenerative disorders, heart failure, chronic kidney disease, obesity, and insulin resistance, among other diseases and disorders Features chapter contributions from international leaders in translational bioenergetics research and clinical practice

Novel Biomarkers for Heart Disease

Author : Michael Lichtenauer
Publisher : MDPI
ISBN 13 : 3039438832
Total Pages : 420 pages
Book Rating : 4.0/5 (394 download)

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Book Synopsis Novel Biomarkers for Heart Disease by : Michael Lichtenauer

Download or read book Novel Biomarkers for Heart Disease written by Michael Lichtenauer and published by MDPI. This book was released on 2020-12-28 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac biomarkers such as troponins and natiuretic peptides have made a great impact on clinical decision making as well as improving our understanding of molecular mechanisms of different disease conditions. However, the biomarkers that are currently in use do not reflect all the multiple disease pathways that are involved in a broad spectrum of cardiac disease conditions ranging from acute coronary syndrome, to heart failure (and heart failure with preserved ejection fraction, HFpEF), to pulmonary hypertension or arrhythmias. In this Special Issue, we will provide an overview of the current developments in the field of biomarker research, beginning with research on molecular pathways and cellular communication (e.g., microRNA) up to the clinical use of biomarkers.

Stem Cells

Author : Ariff Bongso
Publisher : World Scientific
ISBN 13 : 9814289388
Total Pages : 721 pages
Book Rating : 4.8/5 (142 download)

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Book Synopsis Stem Cells by : Ariff Bongso

Download or read book Stem Cells written by Ariff Bongso and published by World Scientific. This book was released on 2011 with total page 721 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cell biology has drawn tremendous interest in recent years as it promises cures for a variety of incurable diseases. This book deals with the basic and clinical aspects of stem cell research and involves work on the full spectrum of stem cells isolated today. It also covers the conversion of stem cell types into a variety of useful tissues which may be used in the future for transplantation therapy. It is thus aimed at undergraduates, postgraduates, scientists, embryologists, doctors, tissue engineers and anyone who wishes to gain some insight into stem cell biology. This book is important as it is comprehensive and covers all aspects of stem cell biology, from basic research to clinical applications. It will have 33 chapters written by renowned stem cell scientists worldwide. It will be up-to-date and all the chapters include self-explanatory figures, color photographs, graphics and tables. It will be easy to read and give the reader a complete understanding and state of the art of the exciting science and its applications.

New Prognostic and Predictive Markers in Cancer Progression

Author : Susan Costantini Alfredo Budillon
Publisher : MDPI
ISBN 13 : 3039439774
Total Pages : 294 pages
Book Rating : 4.0/5 (394 download)

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Book Synopsis New Prognostic and Predictive Markers in Cancer Progression by : Susan Costantini Alfredo Budillon

Download or read book New Prognostic and Predictive Markers in Cancer Progression written by Susan Costantini Alfredo Budillon and published by MDPI. This book was released on 2021-02-12 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers are of critical medical importance for oncologists, allowing them to predict and detect disease and to determine the best course of action for cancer patient care. Prognostic markers are used to evaluate a patient’s outcome and cancer recurrence probability after initial interventions such as surgery or drug treatments and, hence, to select follow-up and further treatment strategies. On the other hand, predictive markers are increasingly being used to evaluate the probability of benefit from clinical intervention(s), driving personalized medicine. Evolving technologies and the increasing availability of “multiomics” data are leading to the selection of numerous potential biomarkers, based on DNA, RNA, miRNA, protein, and metabolic alterations within cancer cells or tumor microenvironment, that may be combined with clinical and pathological data to greatly improve the prediction of both cancer progression and therapeutic treatment responses. However, in recent years, few biomarkers have progressed from discovery to become validated tools to be used in clinical practice. This Special Issue comprises eight review articles and five original studies on novel potential prognostic and predictive markers for different cancer types.

Endocrine and Metabolic Late Effects in Cancer Survivors

Author : Francesco Felicetti (Oncologist)
Publisher :
ISBN 13 : 9783318067903
Total Pages : 162 pages
Book Rating : 4.0/5 (679 download)

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Book Synopsis Endocrine and Metabolic Late Effects in Cancer Survivors by : Francesco Felicetti (Oncologist)

Download or read book Endocrine and Metabolic Late Effects in Cancer Survivors written by Francesco Felicetti (Oncologist) and published by . This book was released on 2021 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book analyzes in detail all aspects related to endocrine and metabolic late effects observed in patients treated for cancer, both in childhood and adulthood. The chapters focusing on the possible pathogenic mechanisms of late effects (i.e., premature aging and chronic inflammation) and on bone health in cancer survivors are particularly interesting and innovative. The volume also deals with hypothalamic-pituitary, thyroid and gonadal disorders, including infertility and how to prevent it. Finally, the relationship between metabolic alterations and cardiovascular diseases in cancer survivors is addressed. Thanks to advances in cancer treatment and supportive care, the five-year survival rate of cancer patients is constantly increasing. However, this undisputable success of medicine has a flip side: the late adverse effects of anticancer therapies. Pediatric oncologists were the first to cope with late complications of treatments, but today also adult oncologists and onco-hematologists recognize the relevance of this issue. Even though late effects observed in cancer survivors can affect any organ or system, endocrine and metabolic dysfunctions are the most frequently reported. Endocrine complications rarely influence life expectancy of cancer survivors, but they can significantly impact morbidity and quality of life. Among endocrine adverse effects, severe hypothalamic damage may be considered the most harmful in survivors, leading to morbid obesity, propensity to metabolic syndrome and cardiovascular disease. This book aims to disseminate the knowledge about endocrine and metabolic adverse effects of cancer therapies and about survivorship care. Since the number of cancer survivors is steadily growing in the general population, this publication is intended not only for endocrinologists but also for oncologists, onco-hematologists, internists, pediatric specialists in those areas and general practitioners, with the aim to better counsel and monitor cancer survivors.

Handbook of Sepsis

Author : W. Joost Wiersinga
Publisher : Springer
ISBN 13 : 3319735063
Total Pages : 264 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Handbook of Sepsis by : W. Joost Wiersinga

Download or read book Handbook of Sepsis written by W. Joost Wiersinga and published by Springer. This book was released on 2018-04-13 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practically oriented book provides an up-to-date overview of all significant aspects of the pathogenesis of sepsis and its management, including within the intensive care unit. Readers will find information on the involvement of the coagulation and endocrine systems during sepsis and on the use of biomarkers to diagnose sepsis and allow early intervention. International clinical practice guidelines for the management of sepsis are presented, and individual chapters focus on aspects such as fluid resuscitation, vasopressor therapy, response to multiorgan failure, antimicrobial therapy, and adjunctive immunotherapy. The closing section looks forward to the coming decade, discussing novel trial designs, sepsis in low- and middle-income countries, and emerging management approaches. The book is internatio nal in scope, with contributions from leading experts worldwide. It will be of value to residents and professionals/practitioners in the fields of infectious diseases and internal medicine, as well as to GPs and medical students.

Porth

Author : Carol Mattson Porth
Publisher :
ISBN 13 : 9781608312986
Total Pages : 0 pages
Book Rating : 4.3/5 (129 download)

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Book Synopsis Porth by : Carol Mattson Porth

Download or read book Porth written by Carol Mattson Porth and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The ESC Textbook of Cardiovascular Medicine

Author : European Society of Cardiology
Publisher : Oxford University Press, USA
ISBN 13 : 0199566992
Total Pages : 1423 pages
Book Rating : 4.1/5 (995 download)

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Book Synopsis The ESC Textbook of Cardiovascular Medicine by : European Society of Cardiology

Download or read book The ESC Textbook of Cardiovascular Medicine written by European Society of Cardiology and published by Oxford University Press, USA. This book was released on 2009-08-27 with total page 1423 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following the structure and format of the ESC core syllabus, this text introduces key concepts in the field of cardiovascular medicine.

Principles of Regenerative Medicine

Author : Anthony Atala
Publisher : Academic Press
ISBN 13 : 0123814235
Total Pages : 1203 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Principles of Regenerative Medicine by : Anthony Atala

Download or read book Principles of Regenerative Medicine written by Anthony Atala and published by Academic Press. This book was released on 2010-12-16 with total page 1203 pages. Available in PDF, EPUB and Kindle. Book excerpt: Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine New discoveries from leading researchers on restoration of diseased tissues and organs

Advances in Regenerative Medicine: Role of Nanotechnology, and Engineering Principles

Author : Venkatram Prasad Shastri
Publisher : Springer Science & Business Media
ISBN 13 : 9048187885
Total Pages : 414 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Advances in Regenerative Medicine: Role of Nanotechnology, and Engineering Principles by : Venkatram Prasad Shastri

Download or read book Advances in Regenerative Medicine: Role of Nanotechnology, and Engineering Principles written by Venkatram Prasad Shastri and published by Springer Science & Business Media. This book was released on 2010-08-14 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes the NATO Advanced Research Workshop (ARW) on “Nanoengineered Systems for Regenerative Medicine” that was organized under the auspices of the NATO Security through Science Program. I would like to thank NATO for supporting this workshop via a grant to the co-directors. The objective of ARW was to explore the various facets of regenerative me- cine and to highlight role of the “the nano-length scale” and “nano-scale systems” in defining and controlling cell and tissue environments. The development of novel tissue regenerative strategies require the integration of new insights emerging from studies of cell-matrix interactions, cellular signalling processes, developmental and systems biology, into biomaterials design, via a systems approach. The chapters in the book, written by the leading experts in their respective disciplines, cover a wide spectrum of topics ranging from stem cell biology, developmental biology, ce- matrix interactions, and matrix biology to surface science, materials processing and drug delivery. We hope the contents of the book will provoke the readership into developing regenerative medicine paradigms that combine these facets into cli- cally translatable solutions. This NATO meeting would not have been successful without the timely help of Dr. Ulrike Shastri, Sanjeet Rangarajan and Ms. Sabine Benner, who assisted in the organization and implementation of various elements of this meeting. Thanks are also due Dr. Fausto Pedrazzini and Ms. Alison Trapp at NATO HQ (Brussels, Belgium). The commitment and persistence of Ms.