Emerging Challenges In Filovirus Infections

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Emerging Challenges in Filovirus Infections

Author : Samuel Ikwaras Okware
Publisher : BoD – Books on Demand
ISBN 13 : 1789855497
Total Pages : 106 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Emerging Challenges in Filovirus Infections by : Samuel Ikwaras Okware

Download or read book Emerging Challenges in Filovirus Infections written by Samuel Ikwaras Okware and published by BoD – Books on Demand. This book was released on 2020-02-12 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the emerging challenges of the filovirus infections Ebola and Marburg virus disease. It reviews the complex ecology and role played by bats and other suspected intermediate hosts, including pigs. Also examined are the challenges for other modes of transmission and early diagnosis and detection. The immunology and pathogenesis of the infections and the impact on the host?s immune systems are discussed. The rare occurrence of Marburg virus infection in pregnancy and the long-term consequences of sexual transmission by survivors is further examined. These discussions have the potential to support future management of outbreaks and guide research for vaccines and medication for Ebola and Marburg disease.

The Emerging Challenges in Transmission and Detection of Filovirus Infections in Developing Countries

Author : Samuel Ikwaras Okware
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)

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Book Synopsis The Emerging Challenges in Transmission and Detection of Filovirus Infections in Developing Countries by : Samuel Ikwaras Okware

Download or read book The Emerging Challenges in Transmission and Detection of Filovirus Infections in Developing Countries written by Samuel Ikwaras Okware and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This chapter reviews the emerging challenges in the transmission and detection of Ebola and Marburg filoviruses since their identification in 1967 and 1976, respectively. Five known highly fatal Ebola species are examined. Ebola outbreaks comprising of 14 EBOV, 7 SUDV, and 4 BDBV infections are reviewed, including the largest West African Ebola outbreak. The ecology of filoviruses and the possible interactions with intermediate hosts and reservoirs is also examined. Evidence that bats are the principal reservoirs of these infections is reviewed. Surveys raise the possibility that other nonhuman primates including dogs may be involved. Challenges on the presumed modes of transmission are discussed with a possibility of droplet and aerosol routes. The discovery of Ebola virus in pigs and its potential impact on the food chain are discussed. The WHO Syndrome Case definition guidelines for diagnosis are examined and shortcomings discussed. However, the early case detection is undermined by the many tropical diseases with similar symptoms. The low positive predictive value for diagnosis based on the antibody antigen assays in outbreaks complicates early isolation and action especially in resource constrained settings. The chapter suggests improvements and areas for further research on the ecology, transmission, and management of filovirus infections.

The Ebola Epidemic in West Africa

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309450063
Total Pages : 137 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis The Ebola Epidemic in West Africa by : National Academies of Sciences, Engineering, and Medicine

Download or read book The Ebola Epidemic in West Africa written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-12-30 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most recent Ebola epidemic that began in late 2013 alerted the entire world to the gaps in infectious disease emergency preparedness and response. The regional outbreak that progressed to a significant public health emergency of international concern (PHEIC) in a matter of months killed 11,310 and infected more than 28,616. While this outbreak bears some unique distinctions to past outbreaks, many characteristics remain the same and contributed to tragic loss of human life and unnecessary expenditure of capital: insufficient knowledge of the disease, its reservoirs, and its transmission; delayed prevention efforts and treatment; poor control of the disease in hospital settings; and inadequate community and international responses. Recognizing the opportunity to learn from the countless lessons of this epidemic, the National Academies of Sciences, Engineering, and Medicine convened a workshop in March 2015 to discuss the challenges to successful outbreak responses at the scientific, clinical, and global health levels. Workshop participants explored the epidemic from multiple perspectives, identified important questions about Ebola that remained unanswered, and sought to apply this understanding to the broad challenges posed by Ebola and other emerging pathogens, to prevent the international community from being taken by surprise once again in the face of these threats. This publication summarizes the presentations and discussions from the workshop.

Emerging Viral Diseases

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309314003
Total Pages : 310 pages
Book Rating : 4.3/5 (93 download)

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Book Synopsis Emerging Viral Diseases by : Institute of Medicine

Download or read book Emerging Viral Diseases written by Institute of Medicine and published by National Academies Press. This book was released on 2015-03-19 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past half century, deadly disease outbreaks caused by novel viruses of animal origin - Nipah virus in Malaysia, Hendra virus in Australia, Hantavirus in the United States, Ebola virus in Africa, along with HIV (human immunodeficiency virus), several influenza subtypes, and the SARS (sudden acute respiratory syndrome) and MERS (Middle East respiratory syndrome) coronaviruses - have underscored the urgency of understanding factors influencing viral disease emergence and spread. Emerging Viral Diseases is the summary of a public workshop hosted in March 2014 to examine factors driving the appearance, establishment, and spread of emerging, re-emerging and novel viral diseases; the global health and economic impacts of recently emerging and novel viral diseases in humans; and the scientific and policy approaches to improving domestic and international capacity to detect and respond to global outbreaks of infectious disease. This report is a record of the presentations and discussion of the event.

Global Infectious Disease Surveillance and Detection

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309111145
Total Pages : 284 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Global Infectious Disease Surveillance and Detection by : Institute of Medicine

Download or read book Global Infectious Disease Surveillance and Detection written by Institute of Medicine and published by National Academies Press. This book was released on 2007-11-11 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early detection is essential to the control of emerging, reemerging, and novel infectious diseases, whether naturally occurring or intentionally introduced. Containing the spread of such diseases in a profoundly interconnected world requires active vigilance for signs of an outbreak, rapid recognition of its presence, and diagnosis of its microbial cause, in addition to strategies and resources for an appropriate and efficient response. Although these actions are often viewed in terms of human public health, they also challenge the plant and animal health communities. Surveillance, defined as "the continual scrutiny of all aspects of occurrence and spread of a disease that are pertinent to effective control", involves the "systematic collection, analysis, interpretation, and dissemination of health data." Disease detection and diagnosis is the act of discovering a novel, emerging, or reemerging disease or disease event and identifying its cause. Diagnosis is "the cornerstone of effective disease control and prevention efforts, including surveillance." Disease surveillance and detection relies heavily on the astute individual: the clinician, veterinarian, plant pathologist, farmer, livestock manager, or agricultural extension agent who notices something unusual, atypical, or suspicious and brings this discovery in a timely way to the attention of an appropriate representative of human public health, veterinary medicine, or agriculture. Most developed countries have the ability to detect and diagnose human, animal, and plant diseases. Global Infectious Disease Surveillance and Detection: Assessing the Challenges-Finding Solutions, Workshop Summary is part of a 10 book series and summarizes the recommendations and presentations of the workshop.

Antiviral Discovery for Highly Pathogenic Emerging Viruses

Author : Rafael Delgado
Publisher : Royal Society of Chemistry
ISBN 13 : 1788015649
Total Pages : 309 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Antiviral Discovery for Highly Pathogenic Emerging Viruses by : Rafael Delgado

Download or read book Antiviral Discovery for Highly Pathogenic Emerging Viruses written by Rafael Delgado and published by Royal Society of Chemistry. This book was released on 2021-12-08 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ideal for drug discovery scientists and medicinal chemists with an interest in antiviral drug discovery and development, this book provides a complete overview of the latest progress in the field, recent advances and the challenges that remain in developing these highly pathogenic agents.

Bats and Viruses

Author : Lin-Fa Wang
Publisher : John Wiley & Sons
ISBN 13 : 1118818733
Total Pages : 402 pages
Book Rating : 4.1/5 (188 download)

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Book Synopsis Bats and Viruses by : Lin-Fa Wang

Download or read book Bats and Viruses written by Lin-Fa Wang and published by John Wiley & Sons. This book was released on 2015-09-08 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Approximately 75% of emerging infectious diseases are zoonoses, and the rate of emergence of zoonotic diseases is on the rise. Bats are being increasingly recognised as an important reservoir of zoonotic viruses of different families, including SARS coronavirus, Nipah virus, Hendra virus and Ebola virus. Understanding bats’ role in emerging zoonotic diseases is crucial to this rapidly expanding area of research. Bats and Viruses: A New Frontier of Emerging Infectious Diseases provides an updated overview of research focusing on bat biology and the role bats play as hosts of many major zoonotic viruses. The text covers bat biology, immunology, and genomics. Chapters also delve into the various major bat-borne virus families, including lyssaviruses, paramyxoviruses, coronaviruses, filoviruses and reoviruses, among others. Edited by leaders in the field, Bats and Viruses: A New Frontier of Emerging Infectious Diseases is a timely, invaluable reference for bat researchers studying microbiology, virology and immunology, as well as infectious disease workers and epidemiologists, among others.

Pregnant in the Time of Ebola

Author : David A. Schwartz
Publisher : Springer
ISBN 13 : 9783319976365
Total Pages : 487 pages
Book Rating : 4.9/5 (763 download)

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Book Synopsis Pregnant in the Time of Ebola by : David A. Schwartz

Download or read book Pregnant in the Time of Ebola written by David A. Schwartz and published by Springer. This book was released on 2019-01-15 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the deadliest Ebola outbreak in history examines its devastating effects on West Africa’s most vulnerable populations: pregnant women and children. Noted experts across disciplines assess health care systems’ responses to the epidemic in Liberia, Guinea, and Sierra Leone, emphasizing key areas such as pregnancy, prenatal services, childbirth, neonatal care, and survivor health among pregnant and non-pregnant women. The 30 chapters hone in on gender-based social issues exacerbated during the outbreak, from violence against women and girls to barriers to female education. At the same time, chapters pinpoint numerous areas for service delivery and policy improvements for more coordinated, effective, and humane actions during future pandemics. A sampling of the topics: Ebola virus disease: perinatal transmission and epidemiology Comprehensive clinical care for children with Ebola virus disease Maternal and reproductive rights: Ebola and the law in Liberia Ebola-related complications for maternal, newborn, and child health service delivery and utilization in Guinea The Ebola epidemic halted female genital cutting in Sierra Leone—temporarily Maternity care for Ebola at Médecins Sans Frontières centers Stigmatization of pregnant women with and without Ebola Exclusion of women and infants from Ebola treatment trials Role of midwives during the Ebola epidemic Pregnant in the Time of Ebola is a powerful resource for public health specialists, anthropologists, social scientists, physicians, epidemiologists, nurses, midwives, and governmental and non-governmental agency staff studying the effects of the epidemic on women and children as a result of the most widespread Ebola outbreak to date.

Ebola and Marburg Viruses

Author : Hans-Dieter Klenk
Publisher : Garland Science
ISBN 13 : 9780954523237
Total Pages : 392 pages
Book Rating : 4.5/5 (232 download)

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Book Synopsis Ebola and Marburg Viruses by : Hans-Dieter Klenk

Download or read book Ebola and Marburg Viruses written by Hans-Dieter Klenk and published by Garland Science. This book was released on 2004 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Ebola and Marburg viruses are a pair of filoviruses that are among the most lethal hemorrhagic viruses on the planet. The authors present a review of past and current research into these pathogens, including 12 papers addressing the structure of the viral proteins; genomic replication; molecular mechanisms of entry; pathogenesis in nonhuman primates, guinea pigs, and mice; virus modulation of innate immunity; and cellular and molecular mechanisms of Ebola pathogenicity and related approaches to vaccine development.

New Drug Development for Known and Emerging Viruses

Author : Helga Rübsamen-Schaeff
Publisher : John Wiley & Sons
ISBN 13 : 3527810706
Total Pages : 530 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis New Drug Development for Known and Emerging Viruses by : Helga Rübsamen-Schaeff

Download or read book New Drug Development for Known and Emerging Viruses written by Helga Rübsamen-Schaeff and published by John Wiley & Sons. This book was released on 2021-11-30 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discusses how to fight Ebola, SARS Corona, and other known or emerging human viruses by building on the successes in antiviral therapy of the past decades Written by leading medicinal chemists from academia and industry, this book discusses the entire field of antiviral drug discovery and development from a medicinal chemistry perspective, focusing on antiviral drugs, targets, and viral disease mechanisms. It provides an outlook on emerging pathogens such as Ebola, Zika, West Nile, Lassa, and includes a chapter on SARS Coronoavirus-2 causing the present pandemic. New Drug Development for Known and Emerging Viruses describes the discovery and development process for antiviral agents for different classes of viruses and targets based on the experiences from the nine human viruses for which approved drugs are on the market (HIV, HCV, Influenza, RSV, HBV, HPV, HCMV, HSV, and VZV). It covers the properties and potential of 20 classes of currently approved antivirals, including combination drugs, and looks at novel antiviral strategies against emerging viruses. Covers the entire field of antiviral drug discovery and development Addresses the need for antiviral drugs to combat major health threats such as Ebola, Zika, West Nile, and SARS Coronavirus-2 Summarizes the successes of the past 15 years in developing ground-breaking medicines against 9 major human viruses, both from the medicinal chemistry and the pharmacological angle Discusses practical and strategic challenges in the drug discovery and development process, including screening technologies, latency, and toxicity issues New Developments in Antiviral Drugs is an important book for medicinal chemists, pharmaceutical chemists, virologists, and epidemiologists, and will be of great interest to those in the ;pharmaceutical industry and public health agencies.

Filoviruses

Author : Jens Kuhn
Publisher : Springer Science & Business Media
ISBN 13 : 3211694951
Total Pages : 410 pages
Book Rating : 4.2/5 (116 download)

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Book Synopsis Filoviruses by : Jens Kuhn

Download or read book Filoviruses written by Jens Kuhn and published by Springer Science & Business Media. This book was released on 2008-05-29 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first comprehensive review of the world literature on filovirus research and provides the most extensive bibliography of the subject yet published. There is special emphasis on foreign literature that has never been summarized. Every aspect of filovirus research, including their history, epidemiology, clinical picture, pathology, molecular biology, and political aspects are reviewed in detail.

Tropical Dermatology E-Book

Author : Steven K Tyring
Publisher : Elsevier Health Sciences
ISBN 13 : 032333914X
Total Pages : 421 pages
Book Rating : 4.3/5 (233 download)

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Book Synopsis Tropical Dermatology E-Book by : Steven K Tyring

Download or read book Tropical Dermatology E-Book written by Steven K Tyring and published by Elsevier Health Sciences. This book was released on 2016-10-17 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: In an increasingly global community, the rapid adaptation of microorganisms has facilitated the return of old communicable diseases and the emergence of new ones. Tropical Dermatology, 2nd Edition, provides a practical, highly illustrated approach to the diagnosis and treatment of a wide range of tropical skin diseases. In a concise and user-friendly format, it offers authoritative coverage of epidemiology, diagnosis, differential diagnosis, pathology, laboratory tests, management, and prevention for both common and rare conditions. Examines the full range of tropical skin diseases in an easy-to-reference format, with consistently organized, templated chapters. Structures clinical guidance by disease rather than by microbe or "bug." Covers the key issues for travelers, important considerations for people working in the tropics, and non-infectious conditions. Provides authoritative guidance for dermatologists, infectious disease specialists, and travel medicine physicians. Includes new chapters on Tungiasis, Ebola and Zika virus. Features updates on emerging diseases and new therapies throughout. Includes brand-new, "hard-to-find" clinical images, for a total of more than 650 full-color illustrations throughout. Integrates the knowledge and experience of new international contributors, including recognized experts in dermatology from the United States, Europe, South America, Africa, and Asia.

AIDS Updates

Author : Samuel Ikwaras Okware
Publisher :
ISBN 13 : 9781839693595
Total Pages : 0 pages
Book Rating : 4.6/5 (935 download)

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Book Synopsis AIDS Updates by : Samuel Ikwaras Okware

Download or read book AIDS Updates written by Samuel Ikwaras Okware and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant progress in HIV prevention and control has been achieved worldwide. This book reviews emerging challenges and new opportunities for prevention. Chapters cover such topics as challenges in the media within the context of advancing technologies and societal perceptions, barriers to antiretroviral treatment and suggestions for improvement, opportunities in nanotechnology-based drug delivery systems, the central role of sexual and reproductive health in consolidating a human rights-based program, and much more. Client-focused models for integrating employment as a social determinant in the HIV/AIDS programs are discussed and recommended.

Current Topics in Tropical Emerging Diseases and Travel Medicine

Author : Alfonso J. Rodriguez-Morales
Publisher : BoD – Books on Demand
ISBN 13 : 1789848245
Total Pages : 179 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Current Topics in Tropical Emerging Diseases and Travel Medicine by : Alfonso J. Rodriguez-Morales

Download or read book Current Topics in Tropical Emerging Diseases and Travel Medicine written by Alfonso J. Rodriguez-Morales and published by BoD – Books on Demand. This book was released on 2018-12-19 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tropical emerging diseases pose a significant risk for the circulation of old and new pathogens in areas previously unknown, also implying the possibility of new morbidities and mortalities and new consequences for naïve populations. Globalization, migration and travel are key factors for tropical diseases, and represent the need for integration of tropical medicine, travel medicine and epidemiology in the understanding of such complex situations. Neglected tropical diseases such as leprosy or Chagas disease, arboviral diseases, HIV, Ebola, and arenaviral infections are just a few examples. This book tries to update significant epidemiological and clinical research in many aspects with a multinational perspective.

Improving Food Safety Through a One Health Approach

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309259363
Total Pages : 418 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Improving Food Safety Through a One Health Approach by : Institute of Medicine

Download or read book Improving Food Safety Through a One Health Approach written by Institute of Medicine and published by National Academies Press. This book was released on 2012-09-10 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Globalization of the food supply has created conditions favorable for the emergence, reemergence, and spread of food-borne pathogens-compounding the challenge of anticipating, detecting, and effectively responding to food-borne threats to health. In the United States, food-borne agents affect 1 out of 6 individuals and cause approximately 48 million illnesses, 128,000 hospitalizations, and 3,000 deaths each year. This figure likely represents just the tip of the iceberg, because it fails to account for the broad array of food-borne illnesses or for their wide-ranging repercussions for consumers, government, and the food industry-both domestically and internationally. A One Health approach to food safety may hold the promise of harnessing and integrating the expertise and resources from across the spectrum of multiple health domains including the human and veterinary medical and plant pathology communities with those of the wildlife and aquatic health and ecology communities. The IOM's Forum on Microbial Threats hosted a public workshop on December 13 and 14, 2011 that examined issues critical to the protection of the nation's food supply. The workshop explored existing knowledge and unanswered questions on the nature and extent of food-borne threats to health. Participants discussed the globalization of the U.S. food supply and the burden of illness associated with foodborne threats to health; considered the spectrum of food-borne threats as well as illustrative case studies; reviewed existing research, policies, and practices to prevent and mitigate foodborne threats; and, identified opportunities to reduce future threats to the nation's food supply through the use of a "One Health" approach to food safety. Improving Food Safety Through a One Health Approach: Workshop Summary covers the events of the workshop and explains the recommendations for future related workshops.

Oxford Textbook of Zoonoses

Author : S.R. Palmer
Publisher : OUP Oxford
ISBN 13 : 9780198570028
Total Pages : 0 pages
Book Rating : 4.5/5 (7 download)

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Book Synopsis Oxford Textbook of Zoonoses by : S.R. Palmer

Download or read book Oxford Textbook of Zoonoses written by S.R. Palmer and published by OUP Oxford. This book was released on 2011-07-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Divided into three sections along the lines of bacteriology, parasitology and virology, this book comprehensively provides a systematic, cross disciplinary approach to the science and control of all zoonoses, written by international specialists in human and veterinary medicine.

Pandemic Outbreaks in the 21st Century

Author : Buddolla Viswanath
Publisher : Elsevier
ISBN 13 : 0323900011
Total Pages : 326 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Pandemic Outbreaks in the 21st Century by : Buddolla Viswanath

Download or read book Pandemic Outbreaks in the 21st Century written by Buddolla Viswanath and published by Elsevier. This book was released on 2021-08-24 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past two decades, several pandemics have ravaged the globe, giving us several lessons on infectious disease epidemiology, the importance of initial detection and characterization of outbreak viruses, the importance of viral epidemic prevention steps, and the importance of modern vaccines. Pandemic Outbreaks in the Twenty-First Century: Epidemiology, Pathogenesis, Prevention, and Treatment summarizes the improvements in the 21st century to overcome / prevent / treat global pandemic with future prospective. Divided into 9 chapters, the book begins with an in-depth introduction to the lessons learned from the first pandemic of the 21st century. It describes the history, present and future in terms of detection, prevention and treatment. Followed by chapters on the outbreak, treatment strategies and clinical management of several infectious diseases like MERS, SARD and COVID 19, Pandemic Outbreaks in the Twenty-First Century: Epidemiology, Pathogenesis, Prevention, and Treatment, presents chapters on immunotherapies and vaccine technologies to combat pandemic outbreak and challenges. The book finishes with a chapter on the current knowledge and technology to control pandemic outbreaks. All are presented in a practical short format, making this volume a valuable resource for very broad academic audience. Provides insight to the lessons learned from past pandemics Gives recommendations, future direction in terms of detection, prevention and treatment of pandemics Guides readers through the status and recent developments of vaccines to overcome or prevent pandemics Shows how to enhance the host innate immunity in infectious diseases Includes a chapter on immunotherapies to combat pandemic outbreaks