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Elliptically Polarized Light For Depth Resolved Diffuse Reflectance Imaging In Biological Tissues
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Book Synopsis Elliptically Polarized Light for Depth Resolved Diffuse Reflectance Imaging in Biological Tissues by : Susmita Sridhar
Download or read book Elliptically Polarized Light for Depth Resolved Diffuse Reflectance Imaging in Biological Tissues written by Susmita Sridhar and published by . This book was released on 2016 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polarization gating imaging is a popular and widely used imaging technique in biomedical optics to sense tissues, deeper volumes, and also selectively probe sub-superficial volumes. Due to the 'polarization memory' effect of polarized light, elliptical polarization gating allows access to tissue layers between those of accessible by linear or circular polarizations. As opposed to the conventional linearly polarized illumination, we focus on polarization gating methods that combine the use of elliptically polarized light to select polarization-maintaining photons and eliminate the background while providing superior contrast and depth information. With gating, it has also become possible to access user-defined depths (dependent on optical properties) in biological tissues with the use of images at different ellipticities. Furthermore, this investigation allowed the application of polarization gating in spectroscopy to selectively quantify the concentration of tissue chromophores at user-desired depths. Polarization gating methods have been validated and demonstrated with in vivo experiments on abnormalities of human skin (nevus, burn scar) and also on the exposed cortex of an anaesthetized rat. Finally, as a first step towards the use of coherent illumination, adding the concept of polarimetry to laser-speckle imaging was demonstrated. Preliminary tests on phantoms (solid and liquid) suggested evidence of the influence of polarization ellipticity on the formation and behaviour of speckles, which could pave the way for more insight in the study of blood flow in tissues.
Book Synopsis Polarized Light in Biomedical Imaging and Sensing by : Jessica C. Ramella-Roman
Download or read book Polarized Light in Biomedical Imaging and Sensing written by Jessica C. Ramella-Roman and published by Springer Nature. This book was released on 2022-11-14 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on biomedical applications of polarized light, covering instrumentation and modeling specific to the field. This will be the first book, written by leading researchers in the field, to tackle this important topic. Readers will learn the fundamentals of polarized light transport and how to develop instrumentation for clinical and preclinical studies. They will also become familiar with the latest advancement in data analysis and image processing for a variety of medical applications. The book is dedicated specifically to the biomedical community, including scientists, engineers, and physicians working on the development of instrumentation for clinical and preclinical use. Emphasizes biomedical imaging and sensing; Describes new computational approaches with examples; Provides detailed descriptions of novel instrumentation.
Book Synopsis Polarized Light Propagation in Biological Tissue and Tissue Phantoms by :
Download or read book Polarized Light Propagation in Biological Tissue and Tissue Phantoms written by and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Imaging through biologic tissue relies on the discrimination of weakly scattered from multiply scattered photons. The degree of polarization can be used as the discrimination criterion by which to reject multiply scattered photons. Polarized light propagation through biologic tissue is typically studied using tissue phantoms consisting of dilute aqueous suspensions of microsphere. We show that, although such phantoms are designed to match the macroscopic scattering properties of tissue (i.e. the scattering coefficient, [mu]3, and scattering anisotropy, g), they do not accurately represent biologic tissue for polarization-sensitive studies. In common tissue phantoms, such as dilute Intralipid and dilute 1-[mu]m-diameter polystyrene microsphere suspensions, we find that linearly polarized light is depolarized more quickly than circularly polarized light. In dense tissue, however, where scatterers are often located in close proximity to one another, circularly polarized light is depolarized similar to or more quickly than linearly polarized light. We also demonstrate that polarized light propagates differently in dilute versus densely packed microsphere suspensions, which may account for the differences seen between polarized light propagation in common dilute tissue phantoms versus dense biologic tissue.
Book Synopsis Optical Polarization in Biomedical Applications by : Valery V. Tuchin
Download or read book Optical Polarization in Biomedical Applications written by Valery V. Tuchin and published by Springer Science & Business Media. This book was released on 2006-10-12 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Polarization in Biomedical Applications introduces key developments in optical polarization methods for quantitative studies of tissues, while presenting the theory of polarization transfer in a random medium as a basis for the quantitative description of polarized light interaction with tissues. This theory uses the modified transfer equation for Stokes parameters and predicts the polarization structure of multiple scattered optical fields. The backscattering polarization matrices (Jones matrix and Mueller matrix) important for noninvasive medical diagnostic are introduced. The text also describes a number of diagnostic techniques such as CW polarization imaging and spectroscopy, polarization microscopy and cytometry. As a new tool for medical diagnosis, optical coherent polarization tomography is analyzed. The monograph also covers a range of biomedical applications, among them cataract and glaucoma diagnostics, glucose sensing, and the detection of bacteria.
Book Synopsis Shedding the Polarized Light on Biological Tissues by : Igor Meglinski
Download or read book Shedding the Polarized Light on Biological Tissues written by Igor Meglinski and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the early-stage detection of cancer using polarized light. It discusses the diverse properties of the light (temporal and spatial coherence, polarization, fluorescence, etc.) that can be used non-invasively as an optical technique for recognizing precancerous lesions, which could become a reliable and accurate method for cancer screening. The search for the effective means for cancer screening is of particular interest to scientific and medical communities, because cancer takes its toll around the globe with no respect for age or gender. Early detection of the disease is a key factor in increasing the survival rate and patients' quality of life.
Book Synopsis A Study on the Use of Polarized Light in Application to Noninvasive Tissue Diagnoistics by : Yanfang Li
Download or read book A Study on the Use of Polarized Light in Application to Noninvasive Tissue Diagnoistics written by Yanfang Li and published by . This book was released on 2005 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this dissertation, multiple investigations on the implementation and use of polarized light for noninvasive diagnostics in turbid media are reported on and discussed. The first study focuses on the development and construction of an automated Mueller matrix imaging system. In the first investigation, a method was developed to estimate the scattering coefficient contribution as a function of particle size in complex mixtures of polystyrene spheres. A partial least squares approach is used to accurately predict the individual scattering coefficient contributions in phantoms containing 0.2, 0.5, 1, and 2 ưm diameter spheres. It is also shown how scattering type is encoded within the Mueller matrix. In addition, the backscattered Mueller matrix of cultured normal human melanocytes, HEMn-LP, and melanoma cells, WM115 and WM793, are investigated for potential cell characterization. These results indicate that the mitochondria contribute significantly to the backscattering polarization signals. In the second investigation, Mueller matrix imaging is applied for in vitro collagen degradation classification. Four different levels of collagen degradations were imposed on in vitro human dermis via collagenase type IA-s. Polar decomposition of the Mueller matrix was performed to better interpret the image-based measurements for the optical differentiation between the degraded and normal dermis. Combining these results in conjunction with the Mueller matrix elements, the extracted features were analyzed by classification tree to develop an accurate classification model. Such methods may eventually lead to the development of improved diagnostic tools capable of characterizing and distinguishing between tissue abnormalities. The final investigation involves the application of diffuse reflectance polarization imaging to detect glucose concentration levels in highly scattering turbid media. Through the application of partial least squares regression, it is shown that accurate glucose predication in highly scattering media can be achieved. Furthermore, through the use of principal component analysis, the correlation between changes in the scattering coefficient and optical activity in relation to glucose concentration within the polarization image measurements is demonstrated. The findings of this basic research could be potentially extended to biological tissue for the eventual development of a noninvasive physiological glucose monitor.
Book Synopsis Polarized Light Imaging for Assessment of Anisotropy in Turbid Media by : Sanaz Alali
Download or read book Polarized Light Imaging for Assessment of Anisotropy in Turbid Media written by Sanaz Alali and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Assessment of anisotropy has many applications in tissue engineering and early detection of disease such as cancer or stroke. One of the emerging optical technologies for quantifying anisotropy in biological tissues is polarized light imaging. In this technique, the full Mueller matrix of the tissue is measured and then decomposed to yield optical retardance, which is proportional to the tissue anisotropy. The theory of polarized light imaging, its biomedical application and instrumentation are the subject of this thesis. To retrieve more information from the Mueller matrix, a quantitative analysis of generic turbid media's Mueller matrices beyond their decompositions was proposed. Two new metrics based on Mueller matrix were established in this thesis: 1) Tissue depolarization, calculated from the Mueller matrix, can be used to estimate its optical properties, and 2) Symmetry of the off-diagonal elements of a turbid medium's Mueller matrix can be used to detect the axial heterogeneity of anisotropy. Polarized light imaging, followed by Mueller matrix decomposition, was then successfully applied to locate the structural disorders induced by bladder outlet obstruction disease, in ex vivo functioning rat bladders. Motivated by the result of this study and to enable in vivo polarized light measurements of the bladder, a novel thin fiber based polarimetric probe which can measure the full Mueller matrix of the turbid media was suggested. Finally, to enhance the speed of the ex vivo examinations of biological tissues and avoid artifacts, a new rapid benchtop polarized light imaging system based on photoelastic modulators (PEM) and a charge-coupled device (CCD) was proposed and implemented. The demonstrated scheme does not involve using mechanically moving components and thus reduces systematic errors. This imaging system proved to be the fastest high resolution polarimetric characterization tool for imaging turbid media to date.
Book Synopsis Imaging in Dermatology by : Michael R. Hamblin
Download or read book Imaging in Dermatology written by Michael R. Hamblin and published by Academic Press. This book was released on 2016-07-29 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: Imaging in Dermatology covers a large number of topics in dermatological imaging, the use of lasers in dermatology studies, and the implications of using these technologies in research. Written by the experts working in these exciting fields, the book explicitly addresses not only current applications of nanotechnology, but also discusses future trends of these ever-growing and rapidly changing fields, providing clinicians and researchers with a clear understanding of the advantages and challenges of laser and imaging technologies in skin medicine today, along with the cellular and molecular effects of these technologies. Outlines the fundamentals of imaging and lasers for dermatology in clinical and research settings Provides knowledge of current and future applications of dermatological imaging and lasers Coherently structured book written by the experts working in the fields covered
Book Synopsis Introduction to Biophotonics by : Paras N. Prasad
Download or read book Introduction to Biophotonics written by Paras N. Prasad and published by John Wiley & Sons. This book was released on 2004-01-16 with total page 622 pages. Available in PDF, EPUB and Kindle. Book excerpt: Paras Prasad’s text provides a basic knowledge of a broad range of topics so that individuals in all disciplines can rapidly acquire the minimal necessary background for research and development in biophotonics. Introduction to Biophotonics serves as both a textbook for education and training as well as a reference book that aids research and development of those areas integrating light, photonics, and biological systems. Each chapter contains a topic introduction, a review of key data, and description of future directions for technical innovation. Introduction to Biophotonics covers the basic principles of Optics Optical spectroscopy Microscopy Each section also includes illustrated examples and review questions to test and advance the reader’s knowledge. Sections on biosensors and chemosensors, important tools for combating biological and chemical terrorism, will be of particular interest to professionals in toxicology and other environmental disciplines. Introduction to Biophotonics proves a valuable reference for graduate students and researchers in engineering, chemistry, and the life sciences.
Book Synopsis Visualizing Chemistry by : National Research Council
Download or read book Visualizing Chemistry written by National Research Council and published by National Academies Press. This book was released on 2006-06-01 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientists and engineers have long relied on the power of imaging techniques to help see objects invisible to the naked eye, and thus, to advance scientific knowledge. These experts are constantly pushing the limits of technology in pursuit of chemical imagingâ€"the ability to visualize molecular structures and chemical composition in time and space as actual events unfoldâ€"from the smallest dimension of a biological system to the widest expanse of a distant galaxy. Chemical imaging has a variety of applications for almost every facet of our daily lives, ranging from medical diagnosis and treatment to the study and design of material properties in new products. In addition to highlighting advances in chemical imaging that could have the greatest impact on critical problems in science and technology, Visualizing Chemistry reviews the current state of chemical imaging technology, identifies promising future developments and their applications, and suggests a research and educational agenda to enable breakthrough improvements.
Book Synopsis Polarisation: Applications in Remote Sensing by : Shane Cloude
Download or read book Polarisation: Applications in Remote Sensing written by Shane Cloude and published by Oxford University Press. This book was released on 2010 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a monograph concerning the scattering of electromagnetic waves from surfaces to generate information for the purposes of remote sensing. It combines, for the first time, a treatment of two important new ideas, namely information from the orientation or polarisation of the wave and how it can be combined with interferometry.
Book Synopsis Optical Measurements for Scientists and Engineers by : Arthur McClelland
Download or read book Optical Measurements for Scientists and Engineers written by Arthur McClelland and published by Cambridge University Press. This book was released on 2018-04-19 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: An accessible, introductory text explaining how to select, set up and use optical spectroscopy and optical microscopy techniques.
Book Synopsis Handbook of Photonics for Biomedical Engineering by : Aaron H.-P. Ho
Download or read book Handbook of Photonics for Biomedical Engineering written by Aaron H.-P. Ho and published by Springer. This book was released on 2016-09-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanophotonics has emerged rapidly into technological mainstream with the advent and maturity of nanotechnology available in photonics and enabled many new exciting applications in the area of biomedical science and engineering that were unimagined even a few years ago with conventional photonic engineering techniques. Handbook of Nanophotonics in Biomedical Engineering is intended to be a reliable resource to a wealth of information on nanophotonics that can inspire readers by detailing emerging and established possibilities of nanophotonics in biomedical science and engineering applications. This comprehensive reference presents not only the basics of nanophotonics but also explores recent experimental and clinical methods used in biomedical and bioengineering research. Each peer-reviewed chapter of this book discusses fundamental aspects and materials/fabrication issues of nanophotonics, as well as applications in interfaces, cell, tissue, animal studies, and clinical engineering. The organization provides quick access to current issues and trends of nanophotonic applications in biomedical engineering. All students and professionals in applied sciences, materials, biomedical engineering, and medical and healthcare industry will find this essential reference book highly useful.
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2004 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Multiple Light Scattering by : H Van de Hulst
Download or read book Multiple Light Scattering written by H Van de Hulst and published by Elsevier. This book was released on 2012-12-02 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple Light Scattering: Tables, Formulas, and Applications, Volume 1 serves to give concise and handy information related to multiple scattering theory in such a way that the reader would not have to rely on extensive literature on the subject. The book is divided into two parts. Part I: General Theory covers the basic concepts, terms, and notations related to multiple scattering theory; exponential integrals and related functions; reciprocity and detailed balance; different related methods; and homogenous atmospheres with arbitrary phase function and single-scattering albedo. Part II: Isotropic Scattering discusses related concepts such as solutions using the Milne operator; semi-infinite atmospheres; the H-functions; and finite slabs. The text is recommended for practitioners in optics, atmospheric physics, astronomy, and other fields that need a reference book in the subject of multiple light scattering.
Book Synopsis Biomedical Optics by : Lihong V. Wang
Download or read book Biomedical Optics written by Lihong V. Wang and published by John Wiley & Sons. This book was released on 2012-09-26 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: This entry-level textbook, covering the area of tissue optics, is based on the lecture notes for a graduate course (Bio-optical Imaging) that has been taught six times by the authors at Texas A&M University. After the fundamentals of photon transport in biological tissues are established, various optical imaging techniques for biological tissues are covered. The imaging modalities include ballistic imaging, quasi-ballistic imaging (optical coherence tomography), diffusion imaging, and ultrasound-aided hybrid imaging. The basic physics and engineering of each imaging technique are emphasized. A solutions manual is available for instructors; to obtain a copy please email the editorial department at [email protected].
Book Synopsis Journal of the Optical Society of America by :
Download or read book Journal of the Optical Society of America written by and published by . This book was released on 2004 with total page 708 pages. Available in PDF, EPUB and Kindle. Book excerpt:
