Elements Of Human Cancer Madden

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Molecular Biochemical Aspects of Cancer

Author : Undurti N. Das
Publisher : Springer Nature
ISBN 13 : 1071607413
Total Pages : 262 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Molecular Biochemical Aspects of Cancer by : Undurti N. Das

Download or read book Molecular Biochemical Aspects of Cancer written by Undurti N. Das and published by Springer Nature. This book was released on 2020-05-30 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the role of genes, oncogenes, anti-oncogenes, free radicals, PUFAs, anti-oxidants, lipid peroxidation process, telomere, and angiogenesis on the origin of cancer, cell proliferation, and cancer in general. It includes a broad introduction to cancer cells; genes, oncogenes, and anti-oncogenes; and free radicals. In later chapters, it discusses in depth the relationship among free radicals, lipid peroxidation and anti-oxidants in cell proliferation. It also discusses aerobic and anaerobic metabolism and their relationship to cancer, as well as the Warburg effect and its potential in the development of new targets for cancer management. Based on these and other evidences, Molecular Biochemical Aspects of Cancer introduces a novel concept that suggests that selective enhancement of free radical generation in tumor cells could form a strategy to induce apoptosis of cancer cells employing bioactive lipids. It presents a new method of treatment of cancer using in vitro, in vivo and clinical data. This book will interest oncologists, scientists, molecular biologists, life scientists.

Viruses and Human Cancer

Author : Mei Hwei Chang
Publisher : Springer Science & Business Media
ISBN 13 : 3642389651
Total Pages : 293 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Viruses and Human Cancer by : Mei Hwei Chang

Download or read book Viruses and Human Cancer written by Mei Hwei Chang and published by Springer Science & Business Media. This book was released on 2013-09-06 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on oncogenic viruses and related human cancers has advanced rapidly in the past decade. Most articles, however, focus on a specific oncogenic virus and cancer. There is consequently a need for a comprehensive, up-to-date monograph that offers broad and integrated knowledge. Viruses and Human Cancer – From Basic Science to Clinical Prevention is designed to meet this need by providing an advanced overview on the basic and clinical aspects of oncogenic viruses and the human cancers that they cause. Virology, virus-induced inflammation and tissue injuries, oncogenic mechanisms, epidemiology, and current and emerging preventive and therapeutic strategies are all discussed in detail. In addition, the book covers the individual aspects of seven oncogenic viruses, i.e., hepatitis B virus, hepatitis C virus, human papilloma virus, Epstein-Barr virus, human T-cell lymphotropic virus, Kaposi sarcoma-associated herpes virus, and Merkel cell polyomavirus, and the related human cancers.

Morphofunctional Aspects of Tumor Microcirculation

Author : Domenico Ribatti
Publisher : Springer Science & Business Media
ISBN 13 : 940074935X
Total Pages : 122 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Morphofunctional Aspects of Tumor Microcirculation by : Domenico Ribatti

Download or read book Morphofunctional Aspects of Tumor Microcirculation written by Domenico Ribatti and published by Springer Science & Business Media. This book was released on 2012-09-29 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes abnormalities in the blood vessels of tumors, identifying a number of specific tumor endothelial markers, as well as chromosomal abnormalities. Shows how these markers may be used to deliver drugs selectively to the tumor microvasculature.

Biochemical and Molecular Aspects of Selected Cancers

Author : Thomas G. Pretlow
Publisher : Academic Press
ISBN 13 : 1483282058
Total Pages : 457 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Biochemical and Molecular Aspects of Selected Cancers by : Thomas G. Pretlow

Download or read book Biochemical and Molecular Aspects of Selected Cancers written by Thomas G. Pretlow and published by Academic Press. This book was released on 2014-05-10 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemical and Molecular Aspects of Selected Cancers, Volume I provides an overview of important topics and prototypes in cancer research. The book consists of papers provided by outstanding investigators in diverse disciplines in different areas of cancer research. This volume focuses on topics relevant to cancers in humans. It covers such topics as tumor-suppressor genes and human neoplasia; protein kinase C in neoplastic cells; and extracellular matrix interactions with tumor-progressing cells: tumor versus cell type-specific mechanisms. Structural and functional characteristics of human melanoma; steroid hormones and hormone receptors in neoplastic diseases; and patterns and significance of genetic changes in neuroblastomas are expounded as well. Oncologists, biochemists, cytologists, and other researchers in allied fields will find the book invaluable.

Bureau of Plant Industry

Author : United States. Congress. House. Committee on Expenditures in the Department of Agriculture
Publisher :
ISBN 13 :
Total Pages : 134 pages
Book Rating : 4.0/5 ( download)

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Book Synopsis Bureau of Plant Industry by : United States. Congress. House. Committee on Expenditures in the Department of Agriculture

Download or read book Bureau of Plant Industry written by United States. Congress. House. Committee on Expenditures in the Department of Agriculture and published by . This book was released on 1913 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mobile Genetic Elements in Cellular Differentiation, Genome Stability, and Cancer

Author : Tammy A. Morrish
Publisher : Frontiers Media SA
ISBN 13 : 2889453898
Total Pages : 123 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Mobile Genetic Elements in Cellular Differentiation, Genome Stability, and Cancer by : Tammy A. Morrish

Download or read book Mobile Genetic Elements in Cellular Differentiation, Genome Stability, and Cancer written by Tammy A. Morrish and published by Frontiers Media SA. This book was released on 2018-01-16 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human genome, as with the genome of most organisms, is comprised of various types of mobile genetic element derived repeats. Mobile genetic elements that mobilize by an RNA intermediate, include both autonomous and non-autonomous retrotransposons, and mobilize by a “copy and paste” mechanism that relies of the presence of a functional reverse transcriptase activity. The extent to which these different types of elements are actively mobilizing varies among organisms, as revealed with the advent of Next Generation DNA sequencing (NGS). To understand the normal and aberrant mechanisms that impact the mobility of these elements requires a more extensive understanding of how these elements interact with molecular pathways of the cell, including DNA repair, recombination and chromatin. In addition, epigenetic based-mechanisms can also influence the mobility of these elements, likely by transcriptional activation or repression in certain cell types. Studies regarding how mobile genetic elements interface and evolve with these pathways will rely on genomic studies from various model organisms. In addition, the mechanistic details of how these elements are regulated will continue to be elucidated with the use of genetic, biochemical, molecular, cellular, and bioinformatic approaches. Remarkably, the current understanding regarding the biology of these elements in the human genome, suggests these elements may impact developmental biology, including cellular differentiation, neuronal development, and immune function. Thus, aberrant changes in these molecular pathways may also impact disease, including neuronal degeneration, autoimmunity, and cancer.

Infections Causing Human Cancer

Author : Harald zur Hausen
Publisher : John Wiley & Sons
ISBN 13 : 3527609296
Total Pages : 531 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Infections Causing Human Cancer by : Harald zur Hausen

Download or read book Infections Causing Human Cancer written by Harald zur Hausen and published by John Wiley & Sons. This book was released on 2007-09-24 with total page 531 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infections must be thought as one of the most important, if not the most important, risk factors for cancer development in humans. Approximately 15-20% of all cases of cancer around the world are caused by viruses. The establishment of a causal relationship between the presence of specific infective agents and certain types of human cancer represents a key step in the development of novel therapeutic and preventive strategies. In this book, Professor zur Hausen (Nobel Prize in Physiology/Medicine 2008) provides a thorough and comprehensive overview on carcinogenic infective agents -- viruses, bacteria, parasites and protozoons -- as well as their corresponding transforming capacities and mechanisms. The result is an invaluable and instructive reference for all oncologists, microbiologists and molecular biologists working in the area of infections and cancer. The author was among the first scientists to reveal the cervical cancer-inducing mechanisms of human papilloma viruses and isolated HPV16 and HPV18, and, as early as 1976, published the hypothesis that wart viruses play a role in the development of this type of cancer.

RNA Tumor Viruses, Oncogenes, Human Cancer and AIDS: On the Frontiers of Understanding

Author : Philip Furmanski
Publisher : Springer Science & Business Media
ISBN 13 : 1461325838
Total Pages : 430 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis RNA Tumor Viruses, Oncogenes, Human Cancer and AIDS: On the Frontiers of Understanding by : Philip Furmanski

Download or read book RNA Tumor Viruses, Oncogenes, Human Cancer and AIDS: On the Frontiers of Understanding written by Philip Furmanski and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: We stand today on the threshold of a new understanding of cancer. Primarily through the powerful tools of molecular biology, unified hypotheses explaining the origins of the disease are emerging and rapidly being validated. This volume, which presents the latest findings from laboratories throughout the world on the role of RNA tumor viruses in cancer, is a celebration of these achievements and a prediction of further progress leading ultimately to the control of the disease. It is important in this context to recall the natural history or life cycle of RNA cancer virology. From the earliest days of the science, when viruses were first recognized as distinct biologic agents of etiologic significance, their role in cancer was proposed and hotly debated. The critical early discoveries, even those made as recently as 25 years ago, were met with rejection; not skepticism or cautious restraint, but outright rejection. During the 60's, there was a gradual acceptance of the association between viruses and cancer, the result of landmark studies in experimental systems, and this led to a frenzy of activity in the field. There followed another period of doubt and uncertainty, due to the difficulty in attempting to apply directly, and in retrospect inappropriately, the tenets of infectious disease to human cancers, only to have the field resurrected, revitalized and redirected by the explosion of progress in molecular biology and genetics.

New Aspects of Cancer Stem Cell Biology

Author : Ugo Cavallaro
Publisher : MDPI
ISBN 13 : 3039434063
Total Pages : 208 pages
Book Rating : 4.0/5 (394 download)

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Book Synopsis New Aspects of Cancer Stem Cell Biology by : Ugo Cavallaro

Download or read book New Aspects of Cancer Stem Cell Biology written by Ugo Cavallaro and published by MDPI. This book was released on 2020-11-23 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cancer stem cell (CSC) paradigm represents one of the most prominent breakthroughs of the last decades in tumor biology. CSCs are that subpopulation within a tumor that can survive conventional therapies and as a consequence are able to fuel tumor recurrence. Nevertheless, the biological characteristics of CSCs and even their existence, remain the main topic among tumor biologists debates. The difficulty in achieving a better definition of CSC biology may actually be explained by the plasticity of such a cell subpopulation. Indeed, the emerging view is that CSCs represent a dynamic “state” of tumor cells that can acquire stemness-related properties under specific circumstances, rather than referring to a well-defined group of cells. Regardless of their origin, it is clear that designing novel antitumor treatments based on the eradication of CSCs will only be possible upon unraveling the biological mechanisms that underlie their pathogenic role in tumor progression and therapy resistance. The Special Issue on “New aspects of cancer stem cell biology: implications for innovative therapies” aims at highlighting recent insights into CSC features that can make them an attractive target for novel therapeutic strategies.

Emerging and Reemerging Viral Pathogens

Author : Moulay Mustapha Ennaji
Publisher : Academic Press
ISBN 13 : 0128194014
Total Pages : 1170 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Emerging and Reemerging Viral Pathogens by : Moulay Mustapha Ennaji

Download or read book Emerging and Reemerging Viral Pathogens written by Moulay Mustapha Ennaji and published by Academic Press. This book was released on 2019-09-27 with total page 1170 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging and Reemerging Viral Pathogens: Fundamental and Basic Virology Aspects of Human, Animal and Plant Pathogens, Volume One presents new research information on viruses and their impact on the scientific community. It provides a reference book on certain viruses in humans, animals and vegetal, along with a comprehensive discussion on interspecies interactions. The book then looks at the drug, vaccine and bioinformatical strategies that can be used against these viruses, giving the reader a clear understanding of transmission. The book's end goal is to create awareness that the appearance of newly transmissible pathogens is a global risk that requires shared/adoptable policies for prevention and control. - Covers most emerging viral disease in humans, animals and plants - Provides the most advanced tools and techniques in molecular virology and the modeling of viruses - Creates awareness that the appearance of new transmissible pathogens is a global risk - Highlights the need to adopt shared policies for the prevention and control of infectious diseases

Tumor Suppressor Genes in Human Cancer

Author : David E. Fisher
Publisher : Springer Science & Business Media
ISBN 13 : 1592592309
Total Pages : 441 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Tumor Suppressor Genes in Human Cancer by : David E. Fisher

Download or read book Tumor Suppressor Genes in Human Cancer written by David E. Fisher and published by Springer Science & Business Media. This book was released on 2000-10-26 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.

Molecular Signatures of Infectious Agents in Cancer

Author : M. Verma
Publisher : IOS Press
ISBN 13 : 9781586032500
Total Pages : 88 pages
Book Rating : 4.0/5 (325 download)

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Book Synopsis Molecular Signatures of Infectious Agents in Cancer by : M. Verma

Download or read book Molecular Signatures of Infectious Agents in Cancer written by M. Verma and published by IOS Press. This book was released on 2002 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cancer Biomarkers Research Group (CBRG) of the Division of Cancer Prevention (DCP), National Cancer Institute, sponsored a workshop entitled Molecular Signatures of Infectious Agents in Bethesda, Maryland, September 7 - 8, 2000, to identify molecular signatures of infectious agents and to utilize this information for risk assessment and development of prevention strategies against these infectious agents. The specific objectives of the workshop were to review state-of-the-science in detection technology that can identify extraneous genomic insertion in human cancers and to establish future research directions for using the molecular signatures of infectious agents for early detection, risk assessment and prevention of cancer.

The IGF System

Author : Ron G. Rosenfeld
Publisher : Springer Science & Business Media
ISBN 13 : 1592597122
Total Pages : 883 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis The IGF System by : Ron G. Rosenfeld

Download or read book The IGF System written by Ron G. Rosenfeld and published by Springer Science & Business Media. This book was released on 1999-06-01 with total page 883 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been over 40 years since the original report by Salmon and Daughaday demon strating that the ability of GH to stimulate sulfation of cartilage was mediated by a "sulfation factor. " In the ensuing decades, it has become apparent that this "sulfation factor activity" encompasses a complex system ofligands (IGFs), receptors, and carrier proteins that are, in tum, responsible for a wide array of cellular actions. The IGF system has been demonstrated to be critically involved in both intrauterine and postnatal growth, and to have important implications in cancer biology as well, owing to the ability of the IGFs to function in endocrine, paracrine, and autocrine modes and given the wide distri bution of IGFs in virtually every organ system. The contributions to The /GF System reflect the wide span of interest in the IGF system and its implications for normal and abnormal growth and metabolism. The chapters have been divided into four broad sections: I. Molecular biology of the IGF system; II. Bio logical actions of the IGFs; III. IGF physiology; and IV. Clinical aspects of the IGFs. We have made every effort to highlight the major contemporary themes in IGF biology, but as is inevitable in such a fast-moving field, perspectives will continue to change as new information is accumulated.

Clinical and Molecular Aspects of Neurotropic Virus Infection

Author : Donald H. Gilden
Publisher : Springer Science & Business Media
ISBN 13 : 1461316758
Total Pages : 546 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Clinical and Molecular Aspects of Neurotropic Virus Infection by : Donald H. Gilden

Download or read book Clinical and Molecular Aspects of Neurotropic Virus Infection written by Donald H. Gilden and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the summer of 1984, both of us were working with Professor Yechiel Becker in the Laboratory for Molecular Virology at the Hebrew University-Hadassah Medical center in Jerusalem. During a discussion about the increasing number of specialized journals and monographs, Dr. Becker pointed out that none covered both the clinical and molecular aspects of neurotropic virus infections, and he urged us to develop such a book with the help of colleagues who were conducting highly-regarded research in their individual areas related to neurotropic viruses. The responses to our request were gratifying, and each contribution provided both a comprehensive clinical description of the neurologic disease produced by a specific virus and an up-to-date review of the current research in the pathogenesis of the disease, with particular attention given to molecular mechanisms. Most, but not all chapters were written by clinical neurologists who applied basic science strategies and methodologies to the question of how neurotropic viruses produce disease. other chapters were written by virologists known for their longstanding commitment and expertise in the analysis of the pathogenesis of neurotropic virus infections. Thus, this unique monograph should be valuable to all clinicians caring for patients with CNS viral diseases and to "neurovirologists" needing an update of the clinical and molecular pathogenesis of neurotropic virus infections. While this monograph was being prepared, a rapidly expanding literature indicated that the human lenteviruses, human immunodeficiency viruses (HIV) and HTLV-1 were highly neurotropic.

Design and Application of Innovative Local Treatments in Glioblastoma and Other Cancers

Author : Emmanuel Garcion
Publisher : Frontiers Media SA
ISBN 13 : 2889666581
Total Pages : 125 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Design and Application of Innovative Local Treatments in Glioblastoma and Other Cancers by : Emmanuel Garcion

Download or read book Design and Application of Innovative Local Treatments in Glioblastoma and Other Cancers written by Emmanuel Garcion and published by Frontiers Media SA. This book was released on 2021-04-01 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Heat Shock Proteins in Cancer

Author : Stuart K. Calderwood
Publisher : Springer Science & Business Media
ISBN 13 : 1402064012
Total Pages : 399 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Heat Shock Proteins in Cancer by : Stuart K. Calderwood

Download or read book Heat Shock Proteins in Cancer written by Stuart K. Calderwood and published by Springer Science & Business Media. This book was released on 2007-09-09 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.

Novel Aspects of PTHrP Physiopathology

Author : Claudio Luparello
Publisher : Nova Publishers
ISBN 13 : 9781600218576
Total Pages : 380 pages
Book Rating : 4.2/5 (185 download)

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Book Synopsis Novel Aspects of PTHrP Physiopathology by : Claudio Luparello

Download or read book Novel Aspects of PTHrP Physiopathology written by Claudio Luparello and published by Nova Publishers. This book was released on 2007 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: The idea of this book is to attempt to provide an appropriate ground for the discussion of modern PTHrP-related issues, and for the consideration of attentive speculation and comments on current work. It is designed to intersect all the usual lines of disciplines, providing a site for presenting pertinent investigations and for discussing critical questions relevant to the entire field, thus seeking to develop a new focus and new perspectives for all those concerned with PTHrP and its pathobiology.