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Electron Transfer To And Through Peptides And Characterization Of Related Self Assembled Monolayers
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Book Synopsis Electron Transfer to and Through Peptides and Characterization of Related Self-assembled Monolayers by : Federico Polo
Download or read book Electron Transfer to and Through Peptides and Characterization of Related Self-assembled Monolayers written by Federico Polo and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Structure, Stability and Electron Transfer Characteristics of Self-assembled Monolayers Containing Internal Peptide Groups by : Robert Samuel Clegg
Download or read book Structure, Stability and Electron Transfer Characteristics of Self-assembled Monolayers Containing Internal Peptide Groups written by Robert Samuel Clegg and published by . This book was released on 1999 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Characterization of Self-Assembled Monolayers by Low Energy Reactive Ion Scattering: Influences of Terminal Group Composition and Structure on Ion-Surface Interaction by : Yang, Xi
Download or read book Characterization of Self-Assembled Monolayers by Low Energy Reactive Ion Scattering: Influences of Terminal Group Composition and Structure on Ion-Surface Interaction written by Yang, Xi and published by . This book was released on 2007 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: Low energy (tens of eV) polyatomic cations were used as probes for characterization of monolayers of spontaneously chemisorbed thiols on gold. Characteristics including chemical composition, surface order and orientation of the self-assembled monolayers (SAMs) can be derived by monitoring the products of projectile ion neutralization, surface-induced dissociation (SID), and ion-surface reactions. To study the influence of the terminal group chemical structures and orientations of the SAMs on ion-surface interactions, a series of semi-fluorinated alkane thiols with difluoromethylenes buried underneath hydrocarbon terminal groups were examined (CH3CF2CH2− and CH3CH2CF2−). Compared to terminally fluorinated SAMs, they showed more projectile ion neutralization and less internal to vibrational energy deposition into precursor ions. Projectile ion-hydrocarbon reactions decreased significantly when difluoromethylenes are one or two bonds away from the terminal group. Furthermore, ion-surface reaction results on surfaces with odd and even chain lengths suggested that they have similar terminal methyl orientations to their hydrocarbon counterparts. Mixed monolayers of CF3CF2(CH2)14SH (F-SAMs) and CH3(CH2)15SH (H-SAMs) with systematically changing electron transfer, energy deposition and ion-surface reaction were prepared using mixed thiols solution and micro-contact printing (μ-CP). The solution mixture system showed linear variations in electron transfer and energy deposition with different F-SAM surface concentrations, while non-linear changes occur for ion-surface reaction suggesting strong lateral interactions between the two components. These interactions are minimized in theμ-CP system containing domains of each thiol. Energy deposition on the patterned surfaces varies non-linearly with changing F-SAM concentration which differs from the homogenously mixed system. To explore SID with a 90 collision angle, eV SID of a series of protonated peptide ions were performed in an in-line sector Time-Of-Flight (TOF) mass spectrometer. The results were compared to keV collision-induced dissociation (CID) data collected with the same instrument. Fragmentation efficiency for SID was higher than CID for those peptides. In addition to the excellent control over laboratory collision energies with SID, different amount of energy deposition can be achieved when varying surface composition, e.g. using mixed F-SAM/H-SAM. Reactive ion scattering spectrometry (RISS) results provided more in-depth knowledge of low energy ion-surface interactions that will promote usage of RISS as a novel surface characterization technique.
Book Synopsis Stability of and Electron Transfer Through Self-assembled Monolayers of Conformationally Constrained Peptides by :
Download or read book Stability of and Electron Transfer Through Self-assembled Monolayers of Conformationally Constrained Peptides written by and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Handbook of Nanoelectrochemistry by : Mahmood Aliofkhazraei
Download or read book Handbook of Nanoelectrochemistry written by Mahmood Aliofkhazraei and published by Springer. This book was released on 2015-11-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited book is devoted to different electrochemical aspects of nano materials. This comprehensive reference text is basically divided in 3 parts: electrochemical synthesis routes for nanosized materials, electrochemical properties of nano materials and electrochemical characterization methods for nanostructures. The Handbook is a reference work to chemists and materials scientists interested in the nano aspects of electrochemistry. The chapters are written by a number of international experts in the field and the content will assist members of both electrochemical and materials communities to keep abreast of developments in the field.
Book Synopsis The Electronic Structure of Biomolecular Self-Assembled Monolayers by : Matthaeus Anton Wolak
Download or read book The Electronic Structure of Biomolecular Self-Assembled Monolayers written by Matthaeus Anton Wolak and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The studies presented here address the characterization of the electronic structure of various self-assembled monolayers (SAMs) of peptide nucleic acid (PNA) and tetraphenylporphyrin (TPP) SAMs and arrays, formed on gold substrates. PNA is a promising alternative to DNA for bio-sensing applications, as well as for strategies for self-assembly based on nucleic acid hybridization. In recent years charge transfer through PNA molecules was a focus of research due to possible applications in self-assembled molecular circuits and molecular tools. In light of this research it is interesting to investigate the electronic structure of PNA interfaces to gold, a potential electrode material. TPP is, due to its electronic structure, an organic p-type molecular semiconductor. Such a material can provide an alternative to standard micro- and optoelectronic devices and in recent years more attention was paid to semiconducting polymers and organic compounds offering these low-cost and flexible alternatives. Therefore, it is of high importance to investigate the prospect of using modified TPP molecules for the formation of interconnected molecular networks on metallic surfaces. All investigated monolayers were formed from solution in a nitrogen atmosphere inside a homemade glove box. This process allowed for PNA SAM and TPP SAM and array formation on clean Au substrates without the exposure to the ambient atmosphere. Ultraviolet and X-ray photoemission spectroscopy (UPS and XPS) measurements on the resulting PNA SAMs and TPP SAMs and arrays, which were performed in a to the glove box attached vacuum chamber containing a photoemission spectrometer, revealed the hole injection barriers at the interfaces and the interface dipoles. In addition to the UPS and XPS measurements on PNA, electronic structure calculations based on molecular dynamics sampling of the PNA structure were obtained, yielding the HOMO-LUMO gap and the electronic density of states for PNA.
Book Synopsis Electron Transfer Through Self Assembled Synthetic Redox Peptides by :
Download or read book Electron Transfer Through Self Assembled Synthetic Redox Peptides written by and published by . This book was released on 2008 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Intermolecular Interactions in Electron Transfer Through Stretched Helical Peptides by : Daniel Ernesto López Pérez
Download or read book Intermolecular Interactions in Electron Transfer Through Stretched Helical Peptides written by Daniel Ernesto López Pérez and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The helical peptide Cys-Ala-Lys-(Glu-Ala-Ala-Ala-Lys)2-Ala-NH-(CH2)2-SH has been organized forming a self-assembled monolayer on gold (0.602 peptides per nm2), its conductance behavior at stretching conditions being studied using scanning tunnelling microscopy and current sensing atomic force microscopy. The helical conformation of the peptide has been found to play a fundamental role in the conductance. Moreover, variation of the current upon molecular stretching indicates that peptides can be significantly elongated before the conductance drops to zero, the critical elongation being 1.22 ± 0.47 nm. Molecular dynamics simulations of a single peptide in the free state and of a variable number of peptides tethered to a gold surface (i.e. densities ranging from 10.026 to 1.295 peptides per nm2) have indicated that the helical conformation is intrinsically favored in solvated environments while in desolvated environments it is retained because of the fundamental role played by peptide–peptide intermolecular interactions. The structure obtained for the system with 24 tethered peptides, with a density of 0.634 peptides per nm2 is the closest to the experimental one, is in excellent agreement with experimental observations. On the other hand, simulations in which a single molecule is submitted to different compression and stretching processes while the rest remain in the equilibrium have been used to mimic the variation of the tip–substrate distance in experimental measures. Results allowed us to identify the existence, and in some cases coexistence, of intermolecular and intramolecular ionic ladders, suggesting that peptide-mediated electron transfer occurs through the hopping mechanism. Finally, quantum mechanical calculations have been used to investigate the variation of the electronic structure upon compression and stretching deformations.
Book Synopsis Characterization and Modeling of Self-assembled Monolayers for Antifouling and Mediatorless Biosensors by : Hamid Feyzizarnagh
Download or read book Characterization and Modeling of Self-assembled Monolayers for Antifouling and Mediatorless Biosensors written by Hamid Feyzizarnagh and published by . This book was released on 2015 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of nanomaterials to improve biosensor performance has gained a great deal of interest over the past decade. This dissertation research aims to explore the development of antifouling self-assembled monolayers (SAMs) to prevent non-specific adsorption on the working electrode surface of electrochemical sensors. A few organic compounds were studied using electrochemical impedance spectroscopy (EIS) and 3,6-dioxa-8- mercaptooctan-1-ol (DMOL) was selected for this purpose. It has two ether groups in its chain, which are believed to hinder the protein adsorption on the gold electrode surface because of the formation of a hydration layer near the surface through hydrogen bonding between water and DMOL. Another key point in the selection of DMOL is the functional group at the end of its chain that can bind to a gold surface in order to produce a SAM. An aptamer-based hemoglobin sensor modified with DMOL SAM was tested with samples containing other interfering blood proteins and molecules by performing single frequency EIS. Results showed DMOL's ability to reduce the adsorption of non-specific molecules. It was also demonstrated that DMOL was not interfering with the immobilization of the sensing element (aptamer) and the sensing of the target molecules (hemoglobin). Another goal of the research presented here is to investigate the utilization of peptide nanotubes, another interesting class of nanomaterials that mediate the electron transfer between the electrode and the electroactive sites of receptors without any need of using chemical mediators. This avoids the drawbacks of using chemicals such as hydroquinone, which may be toxic to sensing elements or may interfere with the electrochemical reaction of interest. Results obtained from this part suggested that an H2O2 sensor interface modified with peptide nanotubes containing horseradish peroxidase (HRP) shows a comparable electron transfer capability with that of typical chemical mediators. Finally an equivalent circuit modelling approach was proposed, and it was applied to the experimental data obtained from the electrochemical impedance spectroscopy of mercaptoalkanoic acids. A modification to the classical Warburg element in the equivalent circuit was made which shows much better fitting of experimental data than the circuit containing the conventional Warburg element. A non-linear least square algorithm was carried out using the Microsoft Excel Solver add-in to minimize the error (Chi-squared) to fit the model to the experimental data.
Book Synopsis Scanning Probe Microscopy: Characterization, Nanofabrication and Device Application of Functional Materials by : Paula M. Vilarinho
Download or read book Scanning Probe Microscopy: Characterization, Nanofabrication and Device Application of Functional Materials written by Paula M. Vilarinho and published by Springer Science & Business Media. This book was released on 2006-06-15 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the characteristic dimensions of electronic devices continue to shrink, the ability to characterize their electronic properties at the nanometer scale has come to be of outstanding importance. In this sense, Scanning Probe Microscopy (SPM) is becoming an indispensable tool, playing a key role in nanoscience and nanotechnology. SPM is opening new opportunities to measure semiconductor electronic properties with unprecedented spatial resolution. SPM is being successfully applied for nanoscale characterization of ferroelectric thin films. In the area of functional molecular materials it is being used as a probe to contact molecular structures in order to characterize their electrical properties, as a manipulator to assemble nanoparticles and nanotubes into simple devices, and as a tool to pattern molecular nanostructures. This book provides in-depth information on new and emerging applications of SPM to the field of materials science, namely in the areas of characterisation, device application and nanofabrication of functional materials. Starting with the general properties of functional materials the authors present an updated overview of the fundamentals of Scanning Probe Techniques and the application of SPM techniques to the characterization of specified functional materials such as piezoelectric and ferroelectric and to the fabrication of some nano electronic devices. Its uniqueness is in the combination of the fundamental nanoscale research with the progress in fabrication of realistic nanodevices. By bringing together the contribution of leading researchers from the materials science and SPM communities, relevant information is conveyed that allows researchers to learn more about the actual developments in SPM applied to functional materials. This book will contribute to the continuous education and development in the field of nanotechnology.
Book Synopsis Functional Polymer Films, 2 Volume Set by : Wolfgang Knoll
Download or read book Functional Polymer Films, 2 Volume Set written by Wolfgang Knoll and published by John Wiley & Sons. This book was released on 2013-02-12 with total page 1107 pages. Available in PDF, EPUB and Kindle. Book excerpt: Very thin film materials have emerged as a highly interesting and useful quasi 2D-state functionality. They have given rise to numerous applications ranging from protective and smart coatings to electronics, sensors and display technology as well as serving biological, analytical and medical purposes. The tailoring of polymer film properties and functions has become a major research field. As opposed to the traditional treatise on polymer and resin-based coatings, this one-stop reference is the first to give readers a comprehensive view of the latest macromolecular and supramolecular film-based nanotechnology. Bringing together all the important facets and state-of-the-art research, the two well-structured volumes cover film assembly and depostion, functionality and patterning, and analysis and characterization. The result is an in-depth understanding of the phenomena, ordering, scale effects, fabrication, and analysis of polymer ultrathin films. This book will be a valuable addition for Materials Scientists, Polymer Chemists, Surface Scientists, Bioengineers, Coatings Specialists, Chemical Engineers, and Scientists working in this important research field and industry.
Book Synopsis Advances in Bioelectrochemistry Volume 1 by : Frank N. Crespilho
Download or read book Advances in Bioelectrochemistry Volume 1 written by Frank N. Crespilho and published by Springer Nature. This book was released on 2022-04-09 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a collection of chapters on modern bioelectrochemistry, showing different aspects of electron transfer reactions in biological systems and techniques. The chapters cover computer simulation, biomolecules on surfaces, direct and mediated electron transfer, electron transfer kinetics, surface-confined biomolecules, field-effect transistor effects, supramolecular electrochemistry, in situ and operando techniques in bioelectrochemistry. They provide relevant bibliographic information for researchers and students interested in computer simulation involving biomolecules on surfaces, processes of direct and mediated electron transfer kinetics of cytochrome c, surface-confined biomolecules for application in bioelectronics, sensitive devices based on field-effect transistors, insights on supramolecular electrochemistry with recent trends and perspectives and technological innovation on instrumentation applied in operando techniques field.
Book Synopsis Electron Transfer Across Self-assembled Monolayers by : Monica Garcia-Gonzalez
Download or read book Electron Transfer Across Self-assembled Monolayers written by Monica Garcia-Gonzalez and published by . This book was released on 1994 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Films, the Cyclotron and the New Biology by :
Download or read book Molecular Films, the Cyclotron and the New Biology written by and published by . This book was released on 1942 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Effects of Macrocyclic Constraints on Electron Transfer in Peptides by : John R. Horsley
Download or read book The Effects of Macrocyclic Constraints on Electron Transfer in Peptides written by John R. Horsley and published by . This book was released on 2015 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research undertaken in this thesis focuses on electron transfer in peptides constrained into either a 310-helical or a [beta]-strand conformation in order to progress the field of molecular electronics. Chapter One: Natural proteins have evolved to promote electron transfer in many biological processes. However, their complex conformational nature inhibits a thorough investigation, so in order to study electron transfer in proteins, simple peptide models containing redox active moieties present as ideal candidates. Chapter One introduces the importance of secondary structure characteristic to proteins/peptides, and its relevance to electron transfer. The proposed mechanisms responsible for such electron transfer are discussed, along with the various approaches used to further constrain the peptides into their geometric conformations. The methods used to characterize the conformation of all peptides synthesized throughout this thesis are outlined, as are details of the electrochemical techniques used to investigate their electronic properties. A literature review describing several factors that have been shown to influence electron transfer in peptides, and a brief summary of molecular electronics follows. Chapter Two: Two 310-helical peptides were synthesized, one constrained via a covalent side-chain staple using Huisgencycloaddition, and the other a linear analogue. Both peptides contain a redox active terminal ferrocene moiety, and were separately attached to a single walled carbon nanotube (SWCNT)/gold electrode array for electrochemical analysis. The effect of backbone rigidity imparted by the side-bridge constraint was revealed, which was shown to restrict the necessary torsional motions that lead to facile intramolecular electron transfer along the peptide backbone. High level calculations were used to support the electrochemical observations. Chapter Three: A series of peptides constrained into either a 310-helix or [beta]-strand conformation were synthesized, each containing a varied number of electron rich alkene side chains. The ability of the alkene(s) to facilitate electron transfer through the peptides by exploiting a hopping mechanism, and thus act as a "stepping stone" was investigated. Ring closing metathesis was used to further rigidify the backbones of a helical and a [beta]-strand peptide via side chain tethers. The ensuing saturated and unsaturated compounds were electrochemically interrogated in order to explore any possible interplay between the effects of the alkene side-chains and backbone rigidity. High level calculations were conducted to verify the observed electrochemical data. Chapter Four: Two [beta]-strand peptides were synthesized, one constrained via a covalent side-chain staple using Huisgen cycloaddition, and the other a linear analogue. Both peptides contain a redox active terminal ferrocene moiety, and were separately attached to a SWCNT/gold electrode array for electrochemical analysis. The charge transfer pathway was determined to be intramolecular by measuring the electron transfer rate at various concentrations of the constrained peptide bound to the electrode. This pathway is analogous to charge transfer through a molecular junction involving a single peptide. Theoretical conductance simulations were then undertaken using two peptide analogues in order to establish a link between the electrochemical observations and conductance measurements through a molecular junction. Chapter Five: Two macrocyclic peptides were synthesized, one constrained into a 310-helical conformation by linking its i to i+3 residues to form a lactam bridge, and the other constrained into a [beta]- strand geometry via a lactam-bridge tether, linking its i to i+2 residues. These peptides were chosen in order to define the role of the amide bond in a lactam bridge constraint. Direct linear analogues of each were used to establish the effect on electron transfer from a terminal amide bond located in an untethered side-chain. High level calculations were also conducted in order to elucidate the mechanism(s) responsible for electron transfer in each of the linear and macrocyclic helical peptides.
Book Synopsis Peptide Materials by : Carlos Aleman
Download or read book Peptide Materials written by Carlos Aleman and published by John Wiley & Sons. This book was released on 2013-03-29 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptides are the building blocks of the natural world; with varied sequences and structures, they enrich materials producing more complex shapes, scaffolds and chemical properties with tailorable functionality. Essentially based on self-assembly and self-organization and mimicking the strategies that occur in Nature, peptide materials have been developed to accomplish certain functions such as the creation of specific secondary structures (a- or 310-helices, b-turns, b-sheets, coiled coils) or biocompatible surfaces with predetermined properties. They also play a key role in the generation of hybrid materials e.g. as peptide-inorganic biomineralized systems and peptide/polymer conjugates, producing smart materials for imaging, bioelectronics, biosensing and molecular recognition applications. Organized into four sections, the book covers the fundamentals of peptide materials, peptide nanostructures, peptide conjugates and hybrid nanomaterials, and applications with chapters including: Properties of peptide scaffolds in solution and on solid substrates Nanostructures, peptide assembly, and peptide nanostructure design Soft spherical structures obtained from amphiphilic peptides and peptide-polymer hybrids Functionalization of carbon nanotubes with peptides Adsorption of peptides on metal and oxide surfaces Peptide applications including tissue engineering, molecular switches, peptide drugs and drug delivery Peptide Materials: From Nanostructures to Applications gives a truly interdisciplinary review, and should appeal to graduate students and researchers in the fields of materials science, nanotechnology, biomedicine and engineering as well as researchers in biomaterials and bio-inspired smart materials.
Download or read book Chemical Abstracts written by and published by . This book was released on 2002 with total page 2540 pages. Available in PDF, EPUB and Kindle. Book excerpt:
