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Effects Of Specific Conjugated Linoleic Acid Cla Isomers On Insulin Resistance And Skeletal Muscle Amp Activated Protein Kinase Alpha Ampk Alpha In Fa Fa And Lean Zucker Rats
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Book Synopsis Effects of Specific Conjugated Linoleic Acid (CLA) Isomers on Insulin Resistance, and Skeletal Muscle AMP-activated Protein Kinase-alpha (AMPK-[alpha]) in Fa/fa and Lean Zucker Rats by : Robert Peter Diakiw
Download or read book Effects of Specific Conjugated Linoleic Acid (CLA) Isomers on Insulin Resistance, and Skeletal Muscle AMP-activated Protein Kinase-alpha (AMPK-[alpha]) in Fa/fa and Lean Zucker Rats written by Robert Peter Diakiw and published by . This book was released on 2006 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Effects of Specific Conjugated Linoleic Acid (CLA) Isomers on Insulin Resistance, and Skeletal Muscle AMP-activated Protein Kinase-alpha (AMPK-α) in Fa/fa and Lean Zucker Rats by : Robert Peter Diakiw
Download or read book Effects of Specific Conjugated Linoleic Acid (CLA) Isomers on Insulin Resistance, and Skeletal Muscle AMP-activated Protein Kinase-alpha (AMPK-α) in Fa/fa and Lean Zucker Rats written by Robert Peter Diakiw and published by . This book was released on 2006 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Découverte des sources written by and published by . This book was released on 1882 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Conjugated Linoleic Acid (CLA) in Liver and Adipose Metabolism by : Amy Dianne Noto
Download or read book Conjugated Linoleic Acid (CLA) in Liver and Adipose Metabolism written by Amy Dianne Noto and published by . This book was released on 2005 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Advances in Conjugated Linoleic Acid Research by : Jean-Louis Sebedio
Download or read book Advances in Conjugated Linoleic Acid Research written by Jean-Louis Sebedio and published by CRC Press. This book was released on 2020-03-05 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Conjugated Linoleic Acid Research, Volume 2 is the second book in a series devoted entirely to conjugated linoleic acid. This book has updated information on the analysis, biochemistry and applications of conjugated fatty acids in an attempt to make Volume 2, in conjunction with Volume 1 (published in 1999), the most comprehensive, up-to-date sources of CLA-related information available today. Both scientific and commercial views are presented, with the same data sometimes interpreted differently.
Book Synopsis The Effect of Conjugated Linoleic Acid (CLA) Isomers on Hepatic Lipid Droplets and Lipid Droplet Proteins in Fa/fa Zucker Rats by : Nazanin Kazem Moosavi
Download or read book The Effect of Conjugated Linoleic Acid (CLA) Isomers on Hepatic Lipid Droplets and Lipid Droplet Proteins in Fa/fa Zucker Rats written by Nazanin Kazem Moosavi and published by . This book was released on 2010 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Martin P. Yurawecz Publisher :The American Oil Chemists Society ISBN 13 :9781893997875 Total Pages :284 pages Book Rating :4.9/5 (978 download)
Book Synopsis Advances in Conjugated Linoleic Acid Research, Volume 3 by : Martin P. Yurawecz
Download or read book Advances in Conjugated Linoleic Acid Research, Volume 3 written by Martin P. Yurawecz and published by The American Oil Chemists Society. This book was released on 2006-09-29 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in the chemistry, biological properties and healthful benefits of conjugated linoleic acid (CLA) continues to grow. The number of peer reviewed publications produced on CLA since the 2003 publication of Advances in Conjugated Linoleic Acid Research, Volume 2, has more than doubled. It is likely that CLA will be used in the future in many more studies related to diseases such as cancer, atherosclerosis, and diabetes. This text provides comprehensive coverage of this area of research. Sections include material on biosynthesis and metabolic processes, techniques of determination of individual isomers, diversity of CLA, and effects of CLA isomers in humans.
Book Synopsis Dietary Conjugated Linoleic Acid (CLA) Reduces Protein Level of Cytosolic Phopholipase A2 and Peroxisome Proliferator-activated Receptor Alpha and Ameliorates Early Renal Disease Progression in Obese Fa/fa Zucker Rats by : Lori Joanna Mildred Warford
Download or read book Dietary Conjugated Linoleic Acid (CLA) Reduces Protein Level of Cytosolic Phopholipase A2 and Peroxisome Proliferator-activated Receptor Alpha and Ameliorates Early Renal Disease Progression in Obese Fa/fa Zucker Rats written by Lori Joanna Mildred Warford and published by . This book was released on 2003 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mechanisms of Conjugated Linoleic Acid on Insulin Resistance, Hepatic Steatosis, and Adiposity by : Angela Ann Wendel
Download or read book Mechanisms of Conjugated Linoleic Acid on Insulin Resistance, Hepatic Steatosis, and Adiposity written by Angela Ann Wendel and published by . This book was released on 2007 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: The significant depletion of adipose in mice by CLA may contribute to the lipodystrophic-like effects that accompany. The final objective of this research was to determine mechanisms by which CLA reduces adipose mass. Six-week old, male ob/ob mice were fed either a control diet (CON) or a diet supplemented with 1.5% mixed isomer CLA (CLA) for 4 weeks. A third group of mice (LEPTIN) were fed the control diet and received daily, intraperitoneal injections of 1 mg/kg BW recombinant leptin as a positive control for adipose depletion in ob/ob mice. The depletion of adipose tissue by CLA was accompanied by the acquirement of brown adipose-like characteristics, such as increased CPT-1b, PGC-1alpha, and UCP-1, in the white adipose of CLA-fed mice. This alteration may facilitate the reduction of adipose mass by increasing mitochondrial oxidation and energy dissipation. However, it appears that CLA does not increase UCP-1 through beta3AR signaling.
Book Synopsis Effect of Omega-3 Fatty Acids on T10, C12-conjugated Linoleic Acid Induced Insulin Resistance, Non Alcoholic Fatty Liver Disease and Tissue Fatty Acid Composition by : Madhuri Vemuri
Download or read book Effect of Omega-3 Fatty Acids on T10, C12-conjugated Linoleic Acid Induced Insulin Resistance, Non Alcoholic Fatty Liver Disease and Tissue Fatty Acid Composition written by Madhuri Vemuri and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Conjugated linoleic acid (CLA) refers to all the positional and geometric isomers of linoleic acid. The two most studied isomers are cis9, trans11-CLA and trans10, cis12-CLA. CLA supplements, often a mixture of the two isomers, have been popularly used for weight loss and other claimed health benefits. However supplementing CLA isomers, especially trans10, cis12-CLA has been shown to cause non alcoholic fatty liver disease (NAFLD) and insulin resistance (IR) in several animal models. Here we have confirmed that supplementing 0.5% trans10, cis12-CLA to C57BL/6 mice for 8 weeks causes NAFLD and IR. When CLA diets were concomitantly supplemented with omega-3 fatty acids docosahexaenoic acid (DHA) or eicosapentaenoic acid (EPA) at 1.5% (w/w) for 8 weeks, DHA prevented CLA induced IR, while EPA was ineffective. Both EPA and DHA prevented CLA induced fatty liver. CLA also reduced the plasma leptin and adiponectin concentrations, and both EPA and DHA partially restored plasma leptin, but only DHA partially restored the plasma adiponectin. In another experiment, concomitant supplementation of CLA diets with 0.5% of flaxseed oil (rich in alpha linolenic acid) also prevented IR and decreased liver weights and lipids compared with those in CLA group. CLA supplementation also altered lipid profile in liver, decreasing n-6 and n-3 wt% and increasing n-6:n-3 ratio. Concomitant supplementation with flaxseed oil increased n-6 and n-3 polyunsaturated (PUFA) in liver lipids and decreased the n-6:n-3 ratio compared to that in CLA group. Supplementing 0.5% (w/w) of purified c9, t11- or trans10, cis12-CLA to mice for 8 weeks altered fatty acid profile of tissues differently. c9, t11-CLA diet reduced MUFA wt% in liver, adipose tissue, and spleen, and reduced the spleen n-3 PUFAs significantly while increasing the n-6 PUFA wt% in all tissues except heart. In contrast, trans10, cis12-CLA reduced both the n-6 and n-3 PUFA wt% in liver and heart however increased the wt% of n-3 PUFAs in spleen. Considering the adverse health effects of trans10, cis12-CLA and of mixtures of CLA isomers on NAFLD, IR and tissue fatty acids, human use of CLA supplements should not be recommended.
Book Synopsis Anti-Catabolic Effects of Conjugated Linoleic Acid and Omega-3 Polyunsaturated Fatty Acid Administration in Resting Or Loaded Skeletal Muscles of Middle Aged Mice During 20 Weeks of High Fat Diet by : Sang-Rok Lee
Download or read book Anti-Catabolic Effects of Conjugated Linoleic Acid and Omega-3 Polyunsaturated Fatty Acid Administration in Resting Or Loaded Skeletal Muscles of Middle Aged Mice During 20 Weeks of High Fat Diet written by Sang-Rok Lee and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: ABSTRACT: The age-related loss of muscle mass and strength (i.e. sarcopenia) is a fundamental cause of frailty, functional decline, and disability, leading to poor quality of life in aging populations. Sarcopenic obesity, a recent medical term, refers to a new trend in aged individuals who simultaneously demonstrate reductions and increases in lean mass and fat mass, respectively. It is currently thought that increases in fat mass with age start the actual sarcopenic process by increasing inflammatory factors. Chronic resistance exercise training (RET) is considered the most cost effective intervention to combat sarcopenia, improving muscle strength followed by improved quality of life. Conjugated linoleic acid (CLA) and omega-3 polyunsaturated fatty acid (n-3) attract great attention for their anti-inflammatory properties, possibly reducing risks of muscle wasting. However, the efficacy of CLA/n-3 on resting or loaded muscles during chronic high fat diet (HFD)-induced inflammation has not been fully elucidated. Therefore, the overarching aim of the present study was to investigate the impact of HFD-induced inflammation on sarcopenia and the effects of 20-wk CLA/n-3 administration on muscle at rest or with RET in the middle aged mice. Nine-month old C57BL/6 male mice were randomly assigned to five groups (n=10/group): 1) normal diet (C), 2) High fat diet (H), 3) HFD+RET (HE), 4) HFD+CLA/n-3 (HCN), and 5) HFD+RET+CLA/n-3 (HECN). Progressive RET (4 sets of 3 repetitions with 1-min inter-set rest) was conducted using a ladder climbing device 3x/wk for 20 wks. The combined supplement was comprised of 1% CLA (0.5% of c9, t11 and 0.5% of t10, c12) and 1% n-3. Body composition (dual X-ray absorptiometry, DXA), grip strength, and sensorimotor function were assessed pre- and post-experiment. Muscle isolation was performed to determine muscle wet weight and RT-PCR was used to analyze transcript levels of target factors involved in muscle cell growth and regeneration: pro-inflammatory regulators [tumor necrosis factor alpha (TNF-alpha) and Interleukin-1 beta (IL-1beta)], anti-inflammatory regulators (IL-6 and IL-15), protein kinase B (Akt), mammalian target of rapamycin (mTOR), atrogin-1, muscle ring finger 1 (MURF1), insulin-like growth factor-I Ea(IGF-IEa), MyoD, and myogenin. There were significant group x time interactions for lean body mass (LBM), fat mass (FM), grip strength, and sensorimotor function. FM increased in H (+74%) and HE (+142%), and HECN (+43%) but not in C and HCN. LBM decreased in C (-27%), H (-31%), and HE (-55%),) while no change was found in HECN. Strength significantly declined in H (-15%) and HCN (-17%),) but was maintained in C. Sensorimotor function markedly declined in H (-11%) with no change in C, HCN, and HE. Interestingly, CLA/n-3 administration appeared to facilitate greater RET-mediated improvements in strength (+22%) and sensorimotor coordination (+17%). There were significant group effects in muscle wet weight. Gastrocnemius wet weight significantly decreased in C (-27%), H (-39%) and HCN (-35%) from baseline but was maintained in HE and HECN. Soleus wet weight significantly decreased in H (-24%) while maintained in C, HE, and HCN. In contrast, soleus wet weight was greater in HECN compared to C, H, and HCN. FA was significantly decreased in HECN (-22%). While eigenvalue 2 decreased in HECN (-8%), HCN significantly increased eigenvalue 3 from baseline (+16%). Chronic CLA/n-3 administration improved the inflammatory state in HFD-fed middle aged animals. TNF-alpha mRNA expression was greater in H compared to C, HCN, HECN and HE in the gastrocnemius. Moreover, HE, HCN, and HECN demonstrated increased IL-6 mRNA expression from baseline in the gastrocnemius. HCN showed increased IL-15 mRNA expression from baseline and was greater than H in the gastrocnemius. Both H and HE had significantly lower IL-15 expression than C and HECN in the soleus. Based on our findings, chronic HFD negatively altered body composition, muscle wet weight, and functional capacity in middle aged mice. Daily CLA/n-3 administration attenuated these impairments while facilitating RET-induced improvement in functional capacity, possibly by improving the inflammatory state. Future research needs to apply for a human trial in the same condition to authenticate our findings.
Book Synopsis Functional Foods and Nutraceuticals by : Rotimi E. Aluko
Download or read book Functional Foods and Nutraceuticals written by Rotimi E. Aluko and published by Springer Science & Business Media. This book was released on 2012-06-05 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Functional food or medicinal food is any fresh or processed food claimed to have a health-promoting and/or disease-preventing property beyond the basic nutritional function of supplying nutrients, although there is no consensus on an exact definition of the term. This is an emerging field in food science, in which such foods are usually accompanied by health claims for marketing purposes, such as a company's ‘cereal is a significant source of fiber. Studies have shown that an increased amount of fiber in one's diet can decrease the risk of certain types of cancer in individuals.’ Functional foods are sometimes called nutraceuticals, a portmanteau of nutrition and pharmaceutical, and can include food that has been genetically modified. The general category includes processed food made from functional food ingredients, or fortified with health-promoting additives, like "vitamin-enriched" products, and also fresh foods (e.g., vegetables) that have specific claims attached. Fermented foods with live cultures are often also considered to be functional foods with probiotic benefits."
Book Synopsis Lipid Modification of Proteins by : N. M. Hooper
Download or read book Lipid Modification of Proteins written by N. M. Hooper and published by Oxford University Press, USA. This book was released on 1992 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipid Modification of Proteins: A Practical Approach is a unique guide to the latest methods is use, written by the acknowledged experts in the field. Detailed protocols are provided for all the key techniques, and the relevant background material is included. This book is an essential manual for a wide range of scientists studying the modification of protein by lipids, including membrane and protein biochemists, cell biologists, immunologists, bacteriologists, parasitologists, and virologists.
Book Synopsis Anti-diabetes and Anti-obesity Medicinal Plants and Phytochemicals by : Bashar Saad
Download or read book Anti-diabetes and Anti-obesity Medicinal Plants and Phytochemicals written by Bashar Saad and published by Springer. This book was released on 2017-05-11 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work presents a systematic review of traditional herbal medicine and their active compounds, as well as their mechanism of action in the prevention and treatment of diabetes and obesity. The side effects and safety of herbal-derived anti-diabetic and anti-obesity phytochemicals are detailed in depth, and the text has a strong focus on current and future trends in anti-diabetic medicinal plants. This unique and comprehensive text is the only current book on the market focusing exclusively on medicinal plants used to combat obesity and diabetes. An introductory chapter focuses on diabetes and obesity and introduces the major causes and main treatments of this increasing epidemic in modern society. Readers are then introduced to medicinal plants, including details on their therapeutic aspects, plus side effects and safety. Following chapters focus on anti-diabetic and anti-obesity medicinal plants, as well as phytogenic natural products in the treatment of each. The text closes by focusing on present and future trends and challenges in these medicinal plants. Anti-diabetes and Anti-obesity Medicinal Plants and Phytochemicals: Safety, Efficacy, and Action Mechanisms is a much-needed and truly original work, finally presenting in one place all the necessary information on medicinal plants used in conjunction with obesity and diabetes prevention.
Book Synopsis Probiotic Bacteria and Their Effect on Human Health and Well-Being by : A. Guarino
Download or read book Probiotic Bacteria and Their Effect on Human Health and Well-Being written by A. Guarino and published by Karger Medical and Scientific Publishers. This book was released on 2013-04-29 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our microflora is an individual personal feature, providing a distinct tag to individuals. However, our intestinal microbiome is strongly affected by genetic, nutritional, and other external factors, and evolves with age. An effect of different microbial patterns on health appears very likely as there seem to be specific changes of intestinal microflora associated with various diseases. Specific microbial tags may thus be used as biomarkers of disease: to diagnose it, to monitor its evolution, and eventually to predict its response to treatment. This scenario opens the opportunity for targeting intestinal microflora using probiotics, both for prevention and treatment of an increasing number of conditions. Probiotic therapy is applied either as an adjunct to other treatments or as primary therapy, and evidence of efficacy is accumulating in several conditions, affecting either the intestine or nonintestinal organs. This publication provides an update on probiotics directed at physicians, biologists, biotechnologists, and researchers working in the food industry and agriculture, as well as in the environmental and basic sciences.
Book Synopsis Natural Bio-active Compounds by : Mallappa Kumara Swamy
Download or read book Natural Bio-active Compounds written by Mallappa Kumara Swamy and published by Springer Nature. This book was released on 2019-09-19 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nature has consistently provided human beings with bioactive compounds that can be used directly as drugs or indirectly as drug leads. Some of the major classes of natural bioactive compounds include phenolics, alkaloids, tannins, saponins, lignin, glycosides, terpenoids, and many more. They possess a broad range of biological activities and are primarily useful in the treatment of various health issues. At the same time, the search for new and novel drugs is never-ending and, despite major advances in synthetic chemistry, nature remains an essential resource for drug discovery. Therefore, more and more researchers are interested in understanding the chemistry, clinical pharmacology, and beneficial effects of bioactive compounds in connection with solving human health problems. This book presents a wealth of information on natural metabolites that have been or are currently being used as drugs or leads for the discovery of new drugs. In addition, it highlights the importance of natural products against various human diseases, and their applications in the drug, nutraceuticals, cosmetics and herbal industries. Accordingly, the book offers a valuable resource for all students, educators, and healthcare experts involved in natural product research, phytochemistry, and pharmacological research.
Book Synopsis Methods of Analysis for Functional Foods and Nutraceuticals by : W. Jeffrey Hurst
Download or read book Methods of Analysis for Functional Foods and Nutraceuticals written by W. Jeffrey Hurst and published by CRC Press. This book was released on 2002-04-16 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by experts at the forefront of phytochemical analysis, this book covers the important classes of bioactive components of functional foods and nutraceuticals. It also includes some components for which no acceptable methods of analysis are yet available. Organized by compound class, Methods of Analysis for Functional Foods and Nutraceuticals
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