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Effects Of Dietary Trans Fatty Acids On Lipoprotein Metabolism And Cholesterol Homeostatic Mechanisms In Gerbils
Download Effects Of Dietary Trans Fatty Acids On Lipoprotein Metabolism And Cholesterol Homeostatic Mechanisms In Gerbils full books in PDF, epub, and Kindle. Read online Effects Of Dietary Trans Fatty Acids On Lipoprotein Metabolism And Cholesterol Homeostatic Mechanisms In Gerbils ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Effects of Dietary Trans Fatty Acids on Lipoprotein Metabolism and Cholesterol Homeostatic Mechanisms in Gerbils by : Jason B. Dictenberg
Download or read book Effects of Dietary Trans Fatty Acids on Lipoprotein Metabolism and Cholesterol Homeostatic Mechanisms in Gerbils written by Jason B. Dictenberg and published by . This book was released on 1993 with total page 70 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Diet and Health by : National Research Council
Download or read book Diet and Health written by National Research Council and published by National Academies Press. This book was released on 1989-01-01 with total page 765 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diet and Health examines the many complex issues concerning diet and its role in increasing or decreasing the risk of chronic disease. It proposes dietary recommendations for reducing the risk of the major diseases and causes of death today: atherosclerotic cardiovascular diseases (including heart attack and stroke), cancer, high blood pressure, obesity, osteoporosis, diabetes mellitus, liver disease, and dental caries.
Book Synopsis Fat Detection by : Jean-Pierre Montmayeur
Download or read book Fat Detection written by Jean-Pierre Montmayeur and published by CRC Press. This book was released on 2009-09-14 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents the State-of-the-Art in Fat Taste TransductionA bite of cheese, a few potato chips, a delectable piece of bacon - a small taste of high-fat foods often draws you back for more. But why are fatty foods so appealing? Why do we crave them? Fat Detection: Taste, Texture, and Post Ingestive Effects covers the many factors responsible for the se
Book Synopsis Effects of Dietary Lipids on Hepatic Cholesterol Homeostasis in F1B Hamsters by : Zhikai Zhang
Download or read book Effects of Dietary Lipids on Hepatic Cholesterol Homeostasis in F1B Hamsters written by Zhikai Zhang and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The regulation of cholesterol homeostatsis is of considerable interest because of the host of studies that show a clear positive relationship between plasma cholesterol levels and the risk of coronary heart disease. It has become apparent that plasma cholesterol levels are affected by a number of life style factors including the amount and type of fat in the diet. However, the mechanisms whereby dietary fat affects plasma cholesterol remain unclear. In this study we have investigated the effects of the levels and types of dietary fat on the cholesterol homeostasis. We used the FIB strain of hamster as a model as this strain has been shown to be sensitive to dietary fat induced atherosclerosis. We propose that this sensitivity reflects differences in the regulation of lipid metabolism between the F1B and the parent strain of hamsters. -- Cholesterol homeostasis in the liver is tightly regulated by several sterol-sensitive regulatory proteins and receptors, including LDL receptor, HMG-CoA reductase, ACAT, CYP7, and SREBPs. It is postulated that the ER cholesterol is the cholesterol regulatory pool plays a major role in the regulation of these enzymes of the whole cell. -- We examined the effect of different dietary fats on the activity or expression of these proteins and observed that the activities of these enzymes are not directly regulated by the fats and cholesterol in the diet; instead, they appear more responsive to changes in the lipid environment of the microsome in the F1B hamster liver. Both the HMG-CoA reductase and the ACAT activity are positively correlated with the level of n-3 fatty acids in the microsome, and ACAT activity also depend on the content of microsomal cholesterol. -- We suggested that the levels of n-3 fatty acids and cholesterol in the diets may change the lipid composition microsomal membranes. This might alter membrane fluidity or the distribution of the key enzymes and regulatory proteins in the membrane of the ER. We suggest that the formation of microdomains (rafts) may sequester much of the cholesterol into pools that are separate from the cholesterol regulatory pool in the ER. However, further studies on the lipid composition of these microdomains are needed for clarify our hypothesis.
Book Synopsis The Effect of Dietary Fatty Acids and Cholesterol on Lipoprotein Metabolism in Hamsters by : Victoria A. Sessions
Download or read book The Effect of Dietary Fatty Acids and Cholesterol on Lipoprotein Metabolism in Hamsters written by Victoria A. Sessions and published by . This book was released on 1994 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Effects of Dietary Trans Fatty Acids on Serum Lipid and Lipoprotein Levels in the Framingham Study by : Ronald Laurent Thibert
Download or read book The Effects of Dietary Trans Fatty Acids on Serum Lipid and Lipoprotein Levels in the Framingham Study written by Ronald Laurent Thibert and published by . This book was released on 1996 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Endothelium written by Michel Félétou and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Download or read book Research Awards Index written by and published by . This book was released on 1986 with total page 854 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Coronary Primary Prevention Trial by :
Download or read book Coronary Primary Prevention Trial written by and published by . This book was released on 1984 with total page 2 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Lipid Nutrition Guidelines by : Harumi Okuyama
Download or read book Lipid Nutrition Guidelines written by Harumi Okuyama and published by MDPI. This book was released on 2021-04-30 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ever since the publication of Ancel Keys’ watershed ‘Seven Countries Study’ in 1970, medical thinking has posited a causal link between the intake of animal fats and coronary heart disease. The research of Prof. Harumi Okuyama and his colleagues presented in this new publication suggests that this link is in fact tenuous. It goes beyond that to suggest that current medical wisdom regarding lipid nutrition may actually be counterproductive. This ground-breaking analysis is likely to be debated for many years to come. The ‘Seven Countries Study’, which identified the specifics of the Mediterranean Diet and awarded it a central position in combating coronary heart disease, triggered significant changes in Western diets. Most notably, it stimulated a widespread attempt to reduce animal fats and replace them with vegetable fats. The low-density lipoprotein (LDL) element of the cholesterol naturally present in animal-source foods was dubbed a killer, and a significant industry developed around the provision of plant-based oils and fats. The clinical consensus on cholesterol was further strengthened in 1987 by the introduction of statins, an innovative class of drugs that reduce LDL production in the liver and are designed to help guard against coronary heart disease. Thirteen Nobel Prizes have been awarded to scientists who devoted major parts of their careers to cholesterol research. It is therefore a brave research team that dares to challenge the link between animal fats and coronary heart disease. This, however, is precisely what Prof. Okuyama and his team set out to do in this book. They actually recommend increasing the intake of cholesterol and animal fats, to an extent that does not lead to obesity. This recommendation is based on the discovery by Prof. Okuyama and his team that common vegetable oils such as canola and hydrogenated vegetable fats have toxic effects. They demonstrate that hydrogenated vegetable fats and oils are important culprits in atherosclerosis and other lifestyle diseases, and suggest that high total or LDL-cholesterol is not the cause of atherosclerosis or cardiovascular disease. Further, they argue that current medical guidelines on lipid nutrition conflict with evidence-based research, and that persistently focusing on LDL-cholesterol as the cause of atherosclerotic cardiovascular disease (ASCVD) is counterproductive. Key findings Some types of vegetable fats and oils exhibit stroke-inducing and endocrine-disrupting activity. Their inhibition of the vitamin K2–osteocalcin link is the major cause of ASCVD and related diseases. In the current food environment, the balance of omega-6 and omega-3 fatty acids is too much in favour of omega-6, and therefore lowering the omega-6/omega-3 ratio is recommended for the prevention of allergic and inflammatory diseases including ASCVD and cancer. Atherogenesis can develop without elevated LDL-cholesterol levels and/or in association with decreasing LDL-cholesterol levels. Increased intake of vegetable fats and oils with stroke-inducing and endocrine-disrupting activities in countries with restricted intakes of animal fats and cholesterol has led to the critical situations surrounding physical and mental health currently seen in Japan, East Asia, and the Mediterranean countries. Medical care professionals continue to insist on actively reducing LDL-cholesterol levels. This approach will only heighten the extensive health problems that Japan and some countries are at present facing. Many aspects of current medical practice in Japan are indeed likely to be in conflict with that country’s Medical Care Act. This thought-provoking analysis of one of the major health syndromes of our day demands serious consideration by professionals interested in cardiovascular health in particular and in public health more widely. Its implications are far-reaching – for medical practitioners, medical insurers, nutritionists, food producers and pharmaceutical manufacturers alike, as well as for individual patients.
Book Synopsis Mechanisms of Insulin Action by : Alan R. Saltiel
Download or read book Mechanisms of Insulin Action written by Alan R. Saltiel and published by Springer Science & Business Media. This book was released on 2007-10-05 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. This book attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. It explores insulin action at the most basic levels, through complex systems.
Book Synopsis Nutrient Requirements of Laboratory Animals, by : National Research Council
Download or read book Nutrient Requirements of Laboratory Animals, written by National Research Council and published by National Academies Press. This book was released on 1995-02-01 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the years since the third edition of this indispensable reference was published, a great deal has been learned about the nutritional requirements of common laboratory species: rat, mouse, guinea pig, hamster, gerbil, and vole. The Fourth Revised Edition presents the current expert understanding of the lipid, carbohydrate, protein, mineral, vitamin, and other nutritional needs of these animals. The extensive use of tables provides easy access to a wealth of comprehensive data and resource information. The volume also provides an expanded background discussion of general dietary considerations. In addition to a more user-friendly organization, new features in this edition include: A significantly expanded section on dietary requirements for rats, reporting substantial new findings. A new section on nutrients that are not required but that may produce beneficial results. New information on growth and reproductive performance among the most commonly used strains of rats and mice and on several hamster species. An expanded discussion of diet formulation and preparationâ€"including sample diets of both purified and natural ingredients. New information on mineral deficiency and toxicity, including warning signs. This authoritative resource will be important to researchers, laboratory technicians, and manufacturers of laboratory animal feed.
Book Synopsis Subject Index of Current Research Grants and Contracts Administered by the National Heart, Lung and Blood Institute by : National Heart, Lung, and Blood Institute
Download or read book Subject Index of Current Research Grants and Contracts Administered by the National Heart, Lung and Blood Institute written by National Heart, Lung, and Blood Institute and published by . This book was released on 1979 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Swine in the Laboratory by : M. Michael Swindle
Download or read book Swine in the Laboratory written by M. Michael Swindle and published by CRC Press. This book was released on 2015-10-28 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: For two decades, Swine in the Laboratory: Surgery, Anesthesia, and Experimental Techniques has been the most respected practical technical guide for medical and veterinary researchers using swine as experimental animals. Extensively updated and expanded since the publication of the second edition in 2007 and now sponsored by the American College of
Book Synopsis Functional Foods and Cardiovascular Disease by : Mohammed H. Moghadasian
Download or read book Functional Foods and Cardiovascular Disease written by Mohammed H. Moghadasian and published by CRC Press. This book was released on 2012-02-10 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular disease remains the number one killer in North America and around the world. The staggering medical costs involved in treating patients suffering from this disease demand an alternative approach to prevent or minimize its development. In Functional Foods and Cardiovascular Disease, international researchers reveal essential up-to-date information on the role that functional foods and nutraceuticals play in preventing the development of heart disease. Highlighting the physiological benefits of a host of functional foods, the book examines: The pathogenesis of coronary artery disease Genetic methods for enhancing bioactives in foods and new techniques for extracting bioactive components for developing functional foods Clinical and experimental evidence of the cardiovascular benefits of fish oils and plant oils, particularly flaxseed oil The importance of folic acid in homocysteine metabolism and its impact on cardiovascular disease Clinical and experimental evidence for the cardiovascular benefits of plant sterols The beneficial effects of wine, garlic products, eggs, fiber, cocoa and chocolate, and coffee and tea on cardiovascular health While there have been great improvements in treating coronary heart disease through surgery and medications, prevention through diet and exercise should remain an essential priority in maintaining the health of the aging population. Nutritionists, food scientists, and those working in the health industry will find that this book enhances their understanding of the potential role of functional foods in combating cardiovascular disease before more aggressive treatment is needed.
Book Synopsis A Flexible System of Enzymatic Analysis by : Oliver Lowry
Download or read book A Flexible System of Enzymatic Analysis written by Oliver Lowry and published by Elsevier. This book was released on 2012-12-02 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Flexible System of Enzymatic Analysis is a multipurpose manual of laboratory methods that offers a systematic scheme for the analysis of biological materials from the level of the wholeorgan down to the single cell and beyond. It intends to guide the development of methods, the refinement of old ones, and the adaptation in general of methods to almost any scale of sensitivity. This manual is organized into three parts: a general section, one on quantitative histochemistry, and an appendix containing information that may be useful to have at the bench. The general section is comprised of nine chapters that focus on properties of the pyridine nucleotides, kinetics, and glassware, as well as on improvement, modification, adaptation, trouble shooting, and development of methods. This part also describes the preparation of tissues for analysis, the enzymatic cycling methods, and a compendium of 36 metabolite assays. The quantitative histochemistry section is comprised of four chapters that include information on the preparation of frozen-dried material and dissection of samples for analysis; the fishpole balance for weighing samples; and the generalities of analysis with emphasis on the ""oil well technique."" This book will be useful to novices as well as experts who are familiar with other analytical styles.
Book Synopsis Aging and Health by : Anatoli I. Yashin
Download or read book Aging and Health written by Anatoli I. Yashin and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging is a major risk factor for chronic diseases, which in turn can provide information about the aging of a biological system. This publication serves as an introduction to systems biology and its application to biological aging. Key pathways and processes that impinge on aging are reviewed, and how they contribute to health and disease during aging is discussed. The evolution of this situation is analyzed, and the consequences for the study of genetic effects on aging are presented. Epigenetic programming of aging, as a continuation of development, creates an interface between the genome and the environment. New research into the gut microbiome describes how this interface may operate in practice with marked consequences for a variety of disorders. This analysis is bolstered by a view of the aging organism as a whole, with conclusions about the mechanisms underlying resilience of the organism to change, and is expanded with a discussion of circadian rhythms in aging. Finally, the book presents an outlook for the development of interventions to delay or to reverse the features of aging. The publication is recommended to students, researchers as well as professionals dealing with public health and public policy related to an aging society.
