Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Download Effect Of Small Molecules On Dental Pulp Stem Cells Properties And Pulp Regeneration full books in PDF, epub, and Kindle. Read online Effect Of Small Molecules On Dental Pulp Stem Cells Properties And Pulp Regeneration ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author :
Publisher :
ISBN 13 :
Total Pages : 354 pages
Book Rating : 4.:/5 (927 download)
Download or read book Effect of Small Molecules on Dental Pulp Stem Cells Properties and Pulp Regeneration written by and published by . This book was released on 2015 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Barbara Zavan
Publisher : Humana Press
ISBN 13 : 3319332996
Total Pages : 288 pages
Book Rating : 4.3/5 (193 download)
Download or read book Dental Stem Cells: Regenerative Potential written by Barbara Zavan and published by Humana Press. This book was released on 2016-07-25 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the basic aspects of dental stem cells (DSCs) as well as their clinical applications in tissue engineering and regenerative medicine. It opens with a discussion of classification, protocols, and properties of DSCs and proceeds to explore DSCs within the contexts of cryopreservation; epigenetics; pulp, periodontal, tooth, bone, and corneal stroma regeneration; neuronal properties, mesenchymal stem cells and biomaterials; and as sources of hepatocytes for liver disease treatment. The fifteen expertly authored chapters comprehensively examine possible applications of DSCs and provide invaluable insights into mechanisms of growth and differentiation. Dental Stem Cells: Regenerative Potential draws from a wealth of international perspectives and is an essential addition to the developing literature on dental stem cells. This installment of Springer’s Stem Cell Biology and Regenerative Medicine series is indispensable for biomedical researchers interested in bioengineering, dentistry, tissue engineering, regenerative medicine, cell biology and oncology.
Author : Sibel Yildirim
Publisher : Springer Science & Business Media
ISBN 13 : 146145686X
Total Pages : 89 pages
Book Rating : 4.4/5 (614 download)
Download or read book Dental Pulp Stem Cells written by Sibel Yildirim and published by Springer Science & Business Media. This book was released on 2012-10-15 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cell technology is moving forward at a tremendous rate. Recent discoveries have surprised even the most expert researchers. While every piece of new data broadens the current knowledge and contributes to this moving forward, the new data also serve as paradigm shifters of fundamental knowledge of cell biology. While the question ‘What is a Stem Cell’ may now seem to basic to even discuss, there are still some discrepancies, however, between groups in terms of their functional roles. Teeth develop from the ectoderm of the first branchial arch and the ectomesenchyme of the neural crest. Deciduous teeth start to form between the sixth and eighth weeks, and permanent teeth begin to form in the twentieth weeks. Several studies have demonstrated that the pulp from both adult teeth and deciduous teeth contains dental pulp stem cells. Several factors have made them very attractive as a model system for many researchers; they are multipotent, ethically and non-controversially available in large numbers, immuno-compatible, developmentally primitive, easy to isolate and have high expansion potential in vitro. However, many controversies still exist in the field. There are several unanswered questions in the biology of dental pulp and odontoblasts. This new volume in the SpringerBriefs in Stem Cells series presents an evaluation of stem cells from human dental pulp as a reliable stem cell source for cell-based therapy to stimulate tissue regeneration.
Author : Muhammad Fawwaz Abdullah
Publisher : Penerbit USM
ISBN 13 : 9838619310
Total Pages : 72 pages
Book Rating : 4.8/5 (386 download)
Download or read book Dental Stem Cells Culturing for the Future (Penerbit USM) written by Muhammad Fawwaz Abdullah and published by Penerbit USM. This book was released on 2016 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt: The importance of stem cells for various treatment purposes came to be realized after the advent of its prolific research. Stem cells are being popularly harvested from many sources such as embryo and bone marrow. However, harvesting and reaping the beneficial effects of stem cells from dental pulp is still cradling in its infancy. Indeed, there is a dearth of information on the detailed procedure of harvesting the stem cells from the dental pulp. This book is a compendium which highlights on the procedures of harvesting the stem cells from dental pulp and its characterization, with the aim to trigger the interests of the readers who are keen to venture further in this field. Keywords: Universiti Sains Malaysia, Penerbit Universiti Sains Malayia, Penerbit USM
Author : Mona Marei
Publisher : Springer Nature
ISBN 13 : 3031025814
Total Pages : 164 pages
Book Rating : 4.0/5 (31 download)
Download or read book Regenerative Dentistry written by Mona Marei and published by Springer Nature. This book was released on 2022-06-01 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dental caries, periodontitis, tooth loss, and bone resorption are considered prevalent health problems that have direct affect on the quality of life. While, advances in stem cell biology and biotechnology have sparked hope for devastating maladies, such as diabetes, cardiovascular diseases, etc., it also provides a strategy of regenerative therapy for dental tissues. From the prospective of tissue engineering, it is of utmost importance to understand and emulate the complex cell interactions that make up a tissue or organ. Unlike other tissues in the body, dental tissues are unique in their development, function, and even in their maintenance throughout life. The harmonized stimulations of biology and mechanical regulators to promote cellular activities have matured our understanding of the value of regenerative therapy of dental tissue versus the reparative treatment. In this book, we review the current knowledge available to regenerate alveolar bone, periodontal structure, and pulp/dentin complex. The book provides researchers with detailed information about development and functional characteristics of the dental unit with detailed protocols covering a comprehensive range of various approaches to engineer dental tissues: to use isolated cells or cell substitutes as cellular replacement, to use acellular biomaterials capable of inducing tissue regeneration, and/or to use a combination of cells, biomaterial and growth factors. We are well aware, with the concept changes in the field toward in-vitro biomimetics of in-vivo tissue development. The theoretical frame work integrating these concepts of developmental biology and developmental engineering is yet to be emphasized and implemented. Until this happens, we consider this book of regenerative dentistry as a call for scientists to achieve, researchers to innovate, practitioners to apply, and students to learn the art and science of regenerative therapy in dentistry. Table of Contents: Introduction to Regenerative Dentistry / Tissue Engineering Alveolar Bone / Tissue Engineering of the Periodontal Tissues / Dynamics for Pulp-Dentin Tissue Engineering in Operative Dentistry
Author : Tatsuya Ishikawa
Publisher : Quintessence Publishing (IL)
ISBN 13 :
Total Pages : 206 pages
Book Rating : 4.3/5 (91 download)
Download or read book Dentin/Pulp Complex written by Tatsuya Ishikawa and published by Quintessence Publishing (IL). This book was released on 2002 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Waruna Lakmal Dissanayaka
Publisher : Open Dissertation Press
ISBN 13 : 9781361337462
Total Pages : pages
Book Rating : 4.3/5 (374 download)
Download or read book Synergistic Effects of Dental Pulp Stem Cells and Endothelial Cells in Pulp Regeneration written by Waruna Lakmal Dissanayaka and published by Open Dissertation Press. This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Synergistic Effects of Dental Pulp Stem Cells and Endothelial Cells in Pulp Regeneration" by Waruna Lakmal, Dissanayaka, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Regeneration of the tissues to replace diseased, missing and traumatized dentin/pulp requires combining the recent progress in stem cell and tissue engineering research. Dental pulp stem cells (DPSCs) are considered as a promising population of cells in regenerative dentistry and shown to be able to produce dentin/pulp-like tissues following implantation in-vivo. Securing a good blood supply is critical in pulp regeneration, however, this is a challenging task due to the unique structure of the tooth, the anatomy of which permits only a microcirculatory system via a very small apical opening (In this study, for the first time, synergistic effects of DPSCs and human umbilical vein endothelial cells (HUVECs) on osteo/odontogenic differentiation and angiogenesis were investigated using two-dimensional and three-dimensional direct co-culture systems. Furthermore, the potential of three-dimensional DPSC constructs prevascularized with HUVECs in dental pulp regeneration in-vivo was exmined. HUVECs promoted odonto/osteogenic differentiation of DPSCs in direct two-dimensional co-cultures in-vitro. Further, addition of DPSCs stabilized the pre-existing vessel-like structures formed by HUVECs and increased the longevity of these structures on matrigel in-vitro. Using two different systems, scaffold-free self-assembling microtissue spheroids and peptide hydrogel scaffold, the interactions of DPSCs and HUVECs in three-dimensional cultures were investigated. The results demonstrated that DPSCs can self assemble into three-dimensional microtissue spheroids when cultured alone or with HUVECs. DPSCs promoted survival and vascular structure formation by HUVECs both in scaffold-free microtissue spheroids and peptide hydrogel scaffold. In contrast, HUVECs, when cultured alone, neither formed vascular structures nor survived in either of the 3D systems. The latter phenomenon was attributable to vascular endothelial growth factor secreted by DPSCs, a major factor responsible for endothelial function. Co-cultures also showed enhanced odonto/osteogenic differentiation in both three-dimensional microtissue spheroid and peptide hydrogel scaffold systems. Following implantation of tooth-root fragments filled with three-dimensional DPSC constructs into the subcutaneous space of immunodefficient mice, vascularised pulp-like tissue was regenerated within the root canals. Compared to DPSC-only group, DPSC/HUVEC co-culture groups showed higher vascularisation, extracellular matrix formation and mineralization in regenerated tissue. More importantly, HUVEC-lined vascular lumens were observed in regenerated tissues suggesting the successful integration of in-vitro formed pre-vascular structures to the host vasculature. In summary, the findings suggest that DPSCs and HUVECs display significant synergy during odonto/osteogenic differentiation and ang
Author : Waruna Lakmal Dissanayaka
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (88 download)
Download or read book Synergistic Effects of Dental Pulp Stem Cells and Endothelial Cells in Pulp Regeneration written by Waruna Lakmal Dissanayaka and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Manasi Bhoj
Publisher : Open Dissertation Press
ISBN 13 : 9781361031803
Total Pages : 138 pages
Book Rating : 4.0/5 (318 download)
Download or read book LAB-CENTRED APPROACH FOR INITI written by Manasi Bhoj and published by Open Dissertation Press. This book was released on 2017-01-26 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "A Lab-centred Approach for Initiating Early Stage Regeneration of Dental Pulp Using Specialised Alginate Biomimetic Microenvironments" by Manasi, Bhoj, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: A living, self-supporting pulp tissue replacement for patients remains a considerable bioengineering challenge. As yet there is no method for engineering a self-sustaining living pulp tissue that can be successfully transplanted into the patient and have any beneficial clinical outcomes. The main reason for this failure is the inability to reconstitute a functional blood vessel tubular network within the engineered pulp tissue. In addition, it has yet not been possible to engineer the various anatomically distinct structures and architectures of the healthy pulp tissue. The idea is that a bio-engineered pulp-like structure prior to transplantation will accelerate integration and reduce the potential for complications. Recently new strides are being taken to make a functioning living pulp tissue using the latest step by step enhancements that are occurring in biomimetic molecular engineering. The use of this basic tissue engineering processes of living organic matter in fabrication is ensuring that prospective lab-made tissue products are biologically compatible. Systems built into biomaterials involving self-assembly, feedback mechanisms will lead to realistic tissue replicates. The new methods include, fabricating biomimetic tissue frameworks with an array of keystone biochemical cues and structural cues. Alternatively others are suggesting that it is feasible to stimulate natural repair using small molecules and temporary frameworks together or independently. A typical tissue engineering strategy that also promises to work is to combine mixed cell populations and growth factors in a scaffold microenvironment. The hypothesis is that recreating an early stage tissue microenvironment-one that resembles the postnatal constitution that will initiate the autonomous reconstruction of native pulp tissue in vitro. As a result, a coherent self-sustaining and self-supporting tissue construct is prepared for rapid integration and remodeling. Our purpose, in this study is to create the formative elements for pulp tissue that go on to develop and regenerate into a functional living pulp tissue. The objective were firstly, to combine dental mesenchymal stem cells and human umbilical vein endothelial cells with limited key growth factors within a space filling the aalginate hydrogel. Secondly, to test the capacity of these encapsulated stem cells for proliferationon, and lastly, measure the capture level for soluble bio-chemicals and test the capacity of the system to release growth factors in a slow, continuous fashion. These are critical performance issues for building pulp de novo. There are more to be tackled in later stages of developing this technology. An alginate-RGD conjugated gel was used to encapsulate adult dental pulp mesenchymal stem cells and human umbilical vein endothelial cells (HUVEC) in the ratio of 1:1. It also served as a means for the targeted delivery of two key growth factors 〖VEGF〗 DEGREES121 (Vascular endothelial growth factor) and FGF-2 (Fibroblastic growth factor) towards the population of cells. In the experiments we varied the combinations of these four components and results with SEM and confocal microscopy show uniform cell distribution and viable cells in all test and control groups. There were significant differences between the groups with no growth factors and groups in which growth factors were added. Interestingly, c
Author : Petros Papagerakis
Publisher : Humana Press
ISBN 13 : 9781493990115
Total Pages : 565 pages
Book Rating : 4.9/5 (91 download)
Download or read book Odontogenesis written by Petros Papagerakis and published by Humana Press. This book was released on 2019-04-22 with total page 565 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides methods and approaches to study genetic and environmental regulatory controls on odontogenesis. Chapters guide readers through protocols for isolation and characterization of both epithelial and mesenchymal dental cells, methods on isolation, phenotypic characterization, expansion, differentiation, immunofluorescence, in situ hybridization, immunohistochemistry, imaging protocols, rodent dental fluorosis model, 3D assessment of crown size, dental diseases models, next generation sequencing, genetic and epigenetic studies, genome-wide association studies as well as clinical protocols for measurement of early childhood caries and saliva, and supragingival fluids and biofilm collection and subsequent analyses. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Odontogenesis: Methods and Protocols aims to guide researchers towards elucidating the secrets and mysteries of a fascinating and unique organ, the tooth.
Author : Matthias Widbiller
Publisher : Mdpi AG
ISBN 13 : 9783036584768
Total Pages : 0 pages
Book Rating : 4.5/5 (847 download)
Download or read book Molecular Advances in Dental Pulp Tissue Engineering written by Matthias Widbiller and published by Mdpi AG. This book was released on 2023-09-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The dental pulp, surrounded by the barriers of enamel, dentin and cementum, has several functions. It senses thermal and mechanical stimuli, defends against invading microorganisms and supports root development in young patients. Loss of dental pulp due to caries or trauma requires root canal treatment with synthetic materials. Recent advances in regenerative medicine and tissue engineering aim to restore the dentin-pulp complex using stem cells, growth factors and tailored scaffolds to achieve biological regeneration within the root canal. This Special Issue highlights scientific advances in pulp regeneration, bridging the gap between research and clinical application.
Author : Tara Gross
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (137 download)
Download or read book Biomechanical Modulation of Dental Pulp Stem Cell (DPSC) Properties for Soft Tissue Engineering written by Tara Gross and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Dental pulp regeneration strategies frequently result in hard tissue formation and pulp obliteration. The aim of this study was to investigate whether dental pulp stem cells (DPSCs) can be directed toward soft tissue differentiation by extracellular elasticity. STRO-1-positive human dental pulp cells were magnetically enriched and cultured on substrates with elasticities of 1.5, 15, and 28 kPa. The morphology of DPSCs was assessed visually. Proteins relevant in mechanobiology ACTB, ITGB1, FAK, p-FAK, TALIN, VINCULIN, PAXILLIN, ERK 1/2, and p-ERK 1/2 were detected by immunofluorescence imaging. Transcription of the pulp marker genes BMP2, BMP4, MMP2, MMP3, MMP13, FN1, and IGF2 as well as the cytokines ANGPT1, VEGF, CCL2, TGFB1, IL2, ANG, and CSF1 was determined using qPCR. A low stiffness, i.e., 1.5 kPa, resulted in a soft tissue-like phenotype and gene expression, whereas DPSCs on 28 kPa substrates exhibited a differentiation signature resembling hard tissues with a low cytokine expression. Conversely, the highest cytokine expression was observed in cells cultured on intermediate elasticity, i.e., 15 kPa, substrates possibly allowing the cells to act as "trophic mediators". Our observations highlight the impact of biophysical cues for DPSC fate and enable the design of scaffold materials for clinical pulp regeneration that prevent hard tissue formation
Author : Fikrettin Şahin
Publisher : Springer
ISBN 13 : 3319289470
Total Pages : 322 pages
Book Rating : 4.3/5 (192 download)
Download or read book Dental Stem Cells written by Fikrettin Şahin and published by Springer. This book was released on 2016-06-08 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores Dental Stem Cell (DSC) biology, from a review of basic concepts for cell culture, to isolation, self-renewal, multipotency and differentiation, regulation by molecular medicine, and prospective research areas for regenerative medicine. The first seven chapters delve into basic DSC properties, vital signaling pathways involved in differentiation, pluripotency, iPS cell development from DSCs, and genetic engineering approaches of DSCs in accordance with the current literature. A comprehensive review of possible clinical applications and in vitro/in vivo studies follows, illustrating the future of DSC research for in the tissue engineering field. The text also discusses the political, ethical, social, and legal ramifications of the use of dental stem cells. Expertly authored and drawing from a multitude of international perspectives, Dental Stem Cells is an invaluable addition to Springer’s Stem Cell Biology and Regenerative Medicine series. It is essential reading for advanced graduate students, basic researchers, and clinical investigators in the fields of stem cell therapy, biological sciences of dentistry, and regenerative medicine.
Author : Michael Tuan Hoang
Publisher :
ISBN 13 :
Total Pages : 60 pages
Book Rating : 4.:/5 (15 download)
Download or read book Molecular Effect of Alcohol on the Osteogenic Potency of Dental Pulp Stem Cells written by Michael Tuan Hoang and published by . This book was released on 2018 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetic changes, such as alteration of DNA methylation patterns, have been proposed as a molecular mechanism underlying the effect of alcohol on the maintenance of adult stem cells. Epigenetic changes have been proposed as a molecular mechanism underlying the effect of alcohol on the osteogenic potency of adult stem cells. Through genome-wide gene expression microarray and DNA methylome analysis, we identified that lysine specific demethylase 6B (KDM6B), an epigenetic modifier known to be involved in the osteogenic and odontogenic potency in DPSCs, was significantly downregulated by EtOH. We hypothesize that EtOH downregulates the osteogenic potency of DPSCs through KDM6B and its upstream regulatory factors. In order to investigate the upstream and downstream effects of EtOH on the osteogenic potency of DPSCs through KDM6B, we performed a pathway-focused RT-PCR array, western blot, immunofluorescence, and ChIP analyses, and in-vivo experiments. EtOH treatment during osteogenic differentiation of DPSCs suppressed the induction of KDM6B with alterations in the expression of differentiation markers. Knockdown of KDM6B resulted in a marked decrease in mineralization from implanted DPSCs in vivo. Furthermore, an ectopic expression of KDM6B in EtOH-treated DPSCs restored the expression of differentiation-related genes. In addition, we investigated upstream regulators and identified a link between Orai1 and the SMAD1 pathway on KDM6B and osteogenic differentiation. We have identified that osteoinduction decreases Ca2+ influx with a concurrent upregulation in Orai1 and Stim1 expression levels, which are further increased in the presence of EtOH during osteogenic differentiation. We believe the changes observed in Orai1 are indicative of cellular compensation in the presence of osteogenic differentiation and EtOH in order to regulate KDM6B expression and ultimately osteogenic potency. Finally, we have observed that EtOH exposure decreases the osteogenic potential in nai ve DPSCs. Our study has demonstrated that EtOH-induced inhibition of KDM6B plays a role in the downregulation of osteogenic differentiation in DPSCs. This suggests a potential molecular mechanism for cellular insults of heavy alcohol consumption that can lead to decreased mineral deposition potentially associated with abnormalities in dental development and also osteopenia/osteoporosis, hallmark features of fetal alcohol spectrum disorders.
Author : Agnieszka Stokowski
Publisher :
ISBN 13 :
Total Pages : 466 pages
Book Rating : 4.:/5 (225 download)
Download or read book Guidance and Neuronal Properties of Dental Pulp Stem Cells written by Agnieszka Stokowski and published by . This book was released on 2006 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human adult dental pulp cells (DPSC) reside within the perivascular niche of dental pulp and are thought to originate from migrating cranial neural crest (CNC) cells. During development, CNC cells respond to the environmental cues to migrate and differentiate into the different cell types that contribute to the formation of craniofacial structures and the peripheral nervous system. The Eph family of receptor tyrosine kinases and their ligands, the ephrin molecules, play an essential role in the migration of neural crest cells during development and postnatal stem cell (SC) niche maintenance." "The present study demonstrated multiple Eph receptors expressed primarily on DPSC within the perivascular niche, while the surrounding pulp tissue expressed ephrin-B ligands. EphB/ephrin-B bi-directional signalling inhibited DPSC attachment and spreading, while DPSC migration was restricted through uni-directional ephrin-B1 activated EphB forward signalling in vitro. Furthermore, we observed that ephrin-B was down-regulated in diseased adult teeth compared to paired uninjured controls. Collectively, these studies suggest that EphB/ephrin-B molecules play a role in restricting DPSC attachment and migration in order to maintain DPSC within their SC niche under steady-state conditions." --p. xii.
Author : Chandra P. Sharma
Publisher : Academic Press
ISBN 13 : 0128231955
Total Pages : 371 pages
Book Rating : 4.1/5 (282 download)
Download or read book Regenerated Organs written by Chandra P. Sharma and published by Academic Press. This book was released on 2021-01-13 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regenerated Organs: Future Perspectives provides the translational-research aspects, currently lacking in existing literature, in this rapidly-moving field. The book is divided into six sections: Engineering Approaches, Cardiovascular System, Musculoskeletal Regeneration, Regenerative Neuroscience, Respiratory Research, a Future Outlook and Conclusions. Each chapter is multi-authored by international experts in each area. The book's primary audience is academic faculty and those in industry interested in translational research in regenerative medicine and tissue engineering. Additionally, this book is ideal for graduate students in the field. - Discusses recent advances in tissue and organ fabrication - Provides translational-research aspects that are often lacking in existing literature - Contains chapters that are multi-authored by international experts in the field
Author : F. Schwendicke
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 331806369X
Total Pages : 190 pages
Book Rating : 4.3/5 (18 download)
Download or read book Caries Excavation: Evolution of Treating Cavitated Carious Lesions written by F. Schwendicke and published by Karger Medical and Scientific Publishers. This book was released on 2018-09-13 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: Currently there is no reason, in most cases of cavitated caries lesions, to remove affected tissue. This book presents evidence-based research on the topic and provides assessments of diagnostic devices. It offers new insights into how a dentine carious cavity can be managed by either tissue removal or restoration. Methods for preserving dental tissue are presented and ample evidence highlights the need to seal with a quality restorative material. An update on how to conduct a randomized clinical trial is followed by a chapter on agreed upon terminology for supporting improved communication among oral health professionals around the world. This is a must-read for general practitioners, restorative specialists, dental students, and oral hygienists/therapists.
