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Author : Muralikrishnan Srikanth
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (16 download)
Download or read book Effect of Novel Agents in Myeloma written by Muralikrishnan Srikanth and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Morie A. Gertz
Publisher : Springer Science & Business Media
ISBN 13 : 1461485207
Total Pages : 311 pages
Book Rating : 4.4/5 (614 download)
Download or read book Multiple Myeloma written by Morie A. Gertz and published by Springer Science & Business Media. This book was released on 2013-10-01 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a comprehensive, state-of-the-art guide to the diagnosis, treatment, and biology of multiple myeloma and related plasma disorders. Edited and written by a multidisciplinary group of recognized authorities from the Mayo Clinic, it presents clear guidelines on diagnosis and therapy and covers all aspects of multiple myeloma, from molecular classification and diagnosis, to risk stratification and therapy. Closely related plasma cell disorders such as solitary plasmacytoma, Waldenstrom macroglobulinemia, and light chain amyloidosis are discussed in detail as well. The book addresses often overlooked topics, including the role of radiation therapy, vertebral augmentation, and supportive care. Our understanding of this group of disorders is developing at an unprecedented rate, and Multiple Myeloma meets the need among oncologists and hematologists for a clear, timely, and authoritative resource on their biology, diagnosis, and treatment.
Author : Heinz Ludwig
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (123 download)
Download or read book Prevention and Management of Adverse Events of Novel Agents in Multiple Myeloma: a Consensus of the European Myeloma Network written by Heinz Ludwig and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: During the last few years, several new drugs have been introduced for treatment of patients with multiple myeloma, which have significantly improved the treatment outcome. All of these novel substances differ at least in part in their mode of action from similar drugs of the same drug class, or are representatives of new drug classes, and as such present with very specific side effect profiles. In this review, we summarize these adverse events, provide information on their prevention, and give practical guidance for monitoring of patients and for management of adverse events
Author : Claudio Cerchione
Publisher : Frontiers Media SA
ISBN 13 : 2832548849
Total Pages : 180 pages
Book Rating : 4.8/5 (325 download)
Download or read book Novel Agents for Multiple Myeloma written by Claudio Cerchione and published by Frontiers Media SA. This book was released on 2024-05-07 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple myeloma (MM) is a malignant neoplasm of plasma cells that accumulate in bone marrow, leading to bone destruction and marrow failure. It accounts for approximately 1.8% of all hematologic and solid cancers and slightly > 15% of hematologic malignancies in the United States. MM is typically sensitive to different classes of cytotoxic drugs, both as frontline treatment and as treatment for relapsed disease. Unfortunately, even if responses are typically durable, nowadays MM is not considered curable with current approaches. However, MM survival rates have been brilliantly improved thanks to the introduction of novel agents: patients diagnosed after 2010 have had higher rates of novel therapy use and better survival outcomes compared with those of earlier years. Most relevant therapeutic advances over the past decades has been the introduction of novel therapies, such as immune-modifying agents (thalidomide and lenalidomide) and proteasome inhibitors (bortezomib), adopted with or without stem cell transplantation.
Author : Mohamad Mohty
Publisher : Springer
ISBN 13 : 3319182188
Total Pages : 109 pages
Book Rating : 4.3/5 (191 download)
Download or read book Handbook of Multiple Myeloma written by Mohamad Mohty and published by Springer. This book was released on 2015-07-14 with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook is an in-depth and comprehensive guide to the pathophysiology, diagnosis, staging, treatment and management of patients with multiple myeloma. The Handbook was commissioned to address an unmet need for a book of this kind in the myeloma field and to provide busy healthcare professionals with an informative and educational review of the current and emerging treatment recommendations for multiple myeloma. Myeloma is a type of bone marrow cancer arising from plasma cells and is the second most common form of bone marrow cancer, but represents just 1% of all cancers. The causes of myeloma are not fully understood but it is thought to be caused by an interaction of both genetic and environmental factors. This Handbook discusses these issues as well the latest developments in the field and will be an invaluable source of topical information for all healthcare professionals with an interest in multiple myeloma.
Author : Hillard M. Lazarus
Publisher : Springer Science & Business Media
ISBN 13 : 1597454788
Total Pages : 885 pages
Book Rating : 4.5/5 (974 download)
Download or read book Allogeneic Stem Cell Transplantation written by Hillard M. Lazarus and published by Springer Science & Business Media. This book was released on 2010-03-02 with total page 885 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.
Author : Khalid Ahmed Al-Anazi
Publisher :
ISBN 13 : 178985217X
Total Pages : 236 pages
Book Rating : 4.7/5 (898 download)
Download or read book Update on Multiple Myeloma written by Khalid Ahmed Al-Anazi and published by . This book was released on 2019-02 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive overview of the recent developments in the clinical and research fields of multiple myeloma. It is divided into three main sections that cover a wide range of topics, including: epidemiology and pathogenesis of the disease, genetic targets and pathways, resistance to novel therapies, angiogenesis and anti-angiogenesis, hematopoietic stem cell transplantation, role of radiology and radiotherapy in myeloma, infectious complications, and management of multiple myeloma in resource-poor countries.
Author : Sagar Lonial
Publisher : Springer Science & Business Media
ISBN 13 : 1597455644
Total Pages : 674 pages
Book Rating : 4.5/5 (974 download)
Download or read book Myeloma Therapy written by Sagar Lonial and published by Springer Science & Business Media. This book was released on 2009-01-01 with total page 674 pages. Available in PDF, EPUB and Kindle. Book excerpt: Therapeutic options for patients with myeloma have dramatically changed over the past 10 years. Beginning with the advances in therapy resulting from the use of high-dose therapy and autologous bone marrow or stem cell tra- plant, we have more than doubled the median survival for patients as a whole, and have now have a wealth of different biology -based treatment approaches for our patients in all disease stages. This book represents state-of-the-art information from many of the leaders in the plasma cell disorders world. Sections focusing on disease pathogenesis and biology, chemotherapy-based approaches, immune -based therapies, currently approved novel agents, developing targets, supportive care, and other plasma cell disorders provides a comprehensive collection and an excellent resource in this time of rapid change in clinical and preclinical disease knowledge. It is important to realize that these changes did not occur in a vacuum. Partnerships between academic institutions, the pharmaceutical industry, patient advocacy groups, the National Cancer Institute, community onco- gists, and ultimately our patients worked closely together to realize these advances, and to effect the radical changes in therapy we have witnessed over the past few years. This book would not have been possible without contri- tions from each of the gifted scientists and clinicians who worked tirelessly to prepare their individual chapters all the while maintaining commitment to the scientific and clinical mission of advancing care.
Author : Nikhil C. Munshi
Publisher : Springer Science & Business Media
ISBN 13 : 1461452600
Total Pages : 291 pages
Book Rating : 4.4/5 (614 download)
Download or read book Advances in Biology and Therapy of Multiple Myeloma written by Nikhil C. Munshi and published by Springer Science & Business Media. This book was released on 2012-12-09 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. Two major advances are making this goal possible. First, recent advances in genomics and proteomics in MM have allowed for increased understanding of disease pathogenesis, identified novel therapeutic targets, allowed for molecular classification, and provided the scientific rationale for combining targeted therapies to increase tumor cell cytotoxicity and abrogate drug resistance. Second, there is now an increased understanding of how adhesion of MM cells in bone marrow (BM) further impacts gene expression in MM cells, as well as in BM stromal cells (BMSCs). As a result of these advances in oncogenomics on the one hand and increased understanding of the role of the BM in the pathogenesis of MM on the other, a new treatment paradigm targeting the tumor cell and its BM microenvironment to overcome drug resistance and improve patient outcome has now been developed. Thalidomide, lenalidomide, and Bortezomib are three agents which target the tumor cell in its microenvironment in both laboratory and animal models and which have rapidly translated from the bench to the bedside. Ongoing efforts are using oncogenomics and cell signaling studies to identify next generation of therapies in MM on the one hand, and to inform the design of combination trials on the other. This new paradigm for overcoming drug resistance and improving patient outcome in MM has great promise not only to change the natural history of MM, but also to serve as a model for targeted therapeutics directed to improve outcome of patients with MM.
Author : G. David Roodman
Publisher : Springer Science & Business Media
ISBN 13 : 1607615541
Total Pages : 257 pages
Book Rating : 4.6/5 (76 download)
Download or read book Myeloma Bone Disease written by G. David Roodman and published by Springer Science & Business Media. This book was released on 2010-04-28 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the forefront in the science and clinical management of myeloma bone disease. Coverage begins with sections on clinical presentation, imaging, and biochemical markers and goes on to discuss radiation, surgical, and medical therapies.
Author :
Publisher :
ISBN 13 :
Total Pages : 28 pages
Book Rating : 4.:/5 (17 download)
Download or read book ˜Aœ Disease in Transition written by and published by . This book was released on 2008 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 63 pages
Book Rating : 4.:/5 (17 download)
Download or read book Managing the Side Effects of Novel Agents for Multiple Myeloma written by and published by . This book was released on 2008 with total page 63 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Antonio Palumbo
Publisher :
ISBN 13 :
Total Pages : 45 pages
Book Rating : 4.:/5 (17 download)
Download or read book Novel Agents and the Paradigm of Continuous Treatment in Multiple Myeloma written by Antonio Palumbo and published by . This book was released on 2012 with total page 45 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Roman Hajek
Publisher : BoD – Books on Demand
ISBN 13 : 9535110837
Total Pages : 338 pages
Book Rating : 4.5/5 (351 download)
Download or read book Multiple Myeloma written by Roman Hajek and published by BoD – Books on Demand. This book was released on 2013-04-10 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book does not provide a comprehensive overview of Multiple Myeloma but a collection of chapters with in-depth information of distinct hot topics in the diagnostic, research and therapeutic fields. The dynamics of testing new drugs for multiple myeloma treatment in clinical trials is breathtaking. Scientific discoveries have uncovered complicated pathogenesis of multiple myeloma; complicated reactions to treatment lead to the creation of super cocktails. Curability of multiple myeloma is a question that is being discussed by the entire professional myeloma world. Improvement of prognosis is a fact which is most important from a patient's perspective. We believe that this book could be of interest to medical professionals specializing in hematooncology, researchers, as well as many others.
Author : Ian McDowell
Publisher : Oxford University Press
ISBN 13 : 0199725306
Total Pages : 765 pages
Book Rating : 4.1/5 (997 download)
Download or read book Measuring Health written by Ian McDowell and published by Oxford University Press. This book was released on 2006-03-09 with total page 765 pages. Available in PDF, EPUB and Kindle. Book excerpt: Worldwide economic constraints on health care systems have highlighted the importance of evidence-based medicine and evidence-based health policy. The resulting clinical trials and health services research studies require instruments to monitor the outcomes of care and the output of the health system. However, the over-abundance of competing measurement scales can make choosing a measure difficult at best. Measuring Health provides in-depth reviews of over 100 of the leading health measurement tools and serves as a guide for choosing among them.LNow in its third edition, this book provides a critical overview of the field of health measurement, with a technical introduction and discussion of the history and future directions for the field. This latest edition updates the information on each of the measures previously reviewed, and includes a complete new chapter on anxiety measurement to accompany the one on depression. It has also added new instruments to those previously reviewed in each of the chapters in the book.LChapters cover measurements of physical disability, social health, psychological well-being, anxiety, depression, mental status testing, pain, general health status and quality of life. Each chapter presents a tabular comparison of the quality of the instruments reviewed, followed by a detailed description of each method, covering its purpose and conceptual basis, its reliability and validity and, where possible, shows a copy of the actual scale. To ensure accuracy of the information, each review has been approved by the original author of each instrument or by an acknowledged expert.
Author : Ferreira Flu00e1via
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (125 download)
Download or read book Real-World Analysis Of Characteristics And Main Outcomes Of Multiple Myeloma Patients written by Ferreira Flu00e1via and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: CONTEXT: Treatment of multiple myeloma (MM) has recently been improved with the introduction of novel agents. In low- and middle-income countries, the evaluation of clinical features and treatment outcomes is not often reported, and is necessary for tailoring successful local strategies.OBJECTIVE: To evaluate the impact of clinical characteristics in the outcomes of MM patients.DESIGN: Retrospective analysis of medical records.SETTING: Insurance-based hematology center in Su00e3o Paulo, Brazil.PATIENTS OR OTHER PARTICIPANTS: All patients treated for MM between January 2000 and January 2018. INTERVENTIONS: No intervention was intended.MAIN OUTCOMES MEASURES: Progression-free survival (PFS), Overall survival (OS).RESULTS: Of 193 patients included, 68% were female, 65% were Durie-Salmon IIIA-B, and median age at diagnosis was 70 (44-87). Treatment was started within one month of MM diagnosis in 77 patients (40%). Median follow-up time was 25 months. For first-line (FL) treatment, bortezomib-based regimens were received by 76% of patients. Median PFS was 24 months for FL treatment. Median PFS for patients receiving autologous stem-cell transplant (autoSCT) and/or maintenance therapy (MT) after FL was 30 months, and 24 months for those without auto-SCT or MT (p
Author : Robert F. Cornell
Publisher :
ISBN 13 :
Total Pages : 55 pages
Book Rating : 4.:/5 (95 download)
Download or read book Divergent Effects of Novel Immunomodulatory Agents and Cyclophosphamide on the Risk of Engraftment Syndrome After Autologous Peripheral Blood Stem Cell Transplantation for Multiple Myeloma written by Robert F. Cornell and published by . This book was released on 2014 with total page 55 pages. Available in PDF, EPUB and Kindle. Book excerpt:
