Drug Discovery and Evaluation

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Publisher : Springer Science & Business Media
ISBN 13 : 366203333X
Total Pages : 790 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis Drug Discovery and Evaluation by : Hans G. Vogel

Download or read book Drug Discovery and Evaluation written by Hans G. Vogel and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference book contains a comprehensive selection of the most frequently used assays for reliably detecting pharmacological effects of potential drugs, including tests for cardiovascular, analgesic, psychotropic, metabolic, endocrine, respiratory, renal, and immunomodulatory activities. Each of the over 700 assays comprises a detailed protocol with the purpose and rationale of the method, a description of the experimental procedure, a critical assessment of the results and their pharmacological and clinical relevance, and pertinent references. Identification of specific tests is facilitated by the enclosed CD-ROM which allows for a quick and full text research. An appendix with guidelines and legal regulations for animal experiments in various countries will help to plan these experiments properly in accordance with the welfare of laboratory animals.

Cardiac Cell Biology

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Publisher : Springer Science & Business Media
ISBN 13 : 9781402072963
Total Pages : 222 pages
Book Rating : 4.0/5 (729 download)

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Book Synopsis Cardiac Cell Biology by : Elissavet Kardami

Download or read book Cardiac Cell Biology written by Elissavet Kardami and published by Springer Science & Business Media. This book was released on 2003-02-28 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac cell biology has come of age. Recognition of activated or modified signaling molecules by specific antibodies, new selective inhibitors, and fluorescent fusion tags are but a few of the tools used to dissect signaling pathways and cross-talk mechanisms that may eventually allow rational drug design. Understanding the regulation of cardiac hypertrophy in all its complexity remains a fundamental goal of cardiac research. Since the advancement of adenovirally mediated gene transfer, transfection efficiency is no longer a limiting factor in the study of cardiomyocytes. A limiting factor in considering cell transplantion as a strategy to repair the damaged heart is cell availability at the right time. Cardiac gap junctions, intercellular communication channels that allow electrical and metabolic coupling and play an important role in arrhythmogenesis are now understood to be exquisite sensors of cardiac change. The reports in this volume incLude elegant studies that made use of cutting edge technological advances and many specialized reagents to address these issues.

Heart Failure

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Publisher : Springer
ISBN 13 : 1447142195
Total Pages : 843 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Heart Failure by : Howard Eisen

Download or read book Heart Failure written by Howard Eisen and published by Springer. This book was released on 2017-02-21 with total page 843 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensively covers everything from pathophysiology to the evaluation of patients presenting with heart failure to medical management, device therapy, heart transplantation and mechanical circulatory support, and include relevant cardiac imaging studies such as echocardiograms and magnetic resonance imaging studies which could be seen in their entirety as well as pathology slides, hemodynamic tracings and videos of cardiac surgery such as heart transplants and ventricular assist device implantation. Finally, the book would have videos of patients with heart failure, heart transplants or ventricular assist devices, describing their clinical presentation and experiences. It is structured so that it can be used as a guide by physicians studying for the general Cardiology or Advanced Heart Failure and Cardiac Transplantations Boards.

Cardiovascular Genomics

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Publisher : Methods in Molecular Biology
ISBN 13 :
Total Pages : 368 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Cardiovascular Genomics by : Keith DiPetrillo

Download or read book Cardiovascular Genomics written by Keith DiPetrillo and published by Methods in Molecular Biology. This book was released on 2009-09-25 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first section of this guide provides methods for cardiovascular phenotyping of rodent models; the second section covers bioinformatic integration of phenotypde data with genome-wide genotype and expression data. Chapters include step-by-step protocols.

Excitation-Contraction Coupling and Cardiac Contractile Force

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Publisher : Springer Science & Business Media
ISBN 13 : 9780792371571
Total Pages : 468 pages
Book Rating : 4.3/5 (715 download)

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Book Synopsis Excitation-Contraction Coupling and Cardiac Contractile Force by : D. M. Bers

Download or read book Excitation-Contraction Coupling and Cardiac Contractile Force written by D. M. Bers and published by Springer Science & Business Media. This book was released on 2001-08-31 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Then the characteristics of some key calcium transport systems (calcium channels, sodium/calcium exchange and SR calcium uptake and release) are discussed in detail. This is then built into a more integrated picture of calcium regulation in succeeding chapters by detailed discussions of excitation-calcium coupling mechanisms (in skeletal, cardiac, and smooth muscle), the interplay between calcium regulatory processes, and finally mechanisms of cardiac inotropy, calcium overload, and dysfunction (e.g., ischemia, hypertrophy, and heart failure).

Handbook of Models for Human Aging

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Publisher : Elsevier
ISBN 13 : 0080460062
Total Pages : 1103 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Handbook of Models for Human Aging by : P. Michael Conn

Download or read book Handbook of Models for Human Aging written by P. Michael Conn and published by Elsevier. This book was released on 2011-04-28 with total page 1103 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. - Utilizes a multidisciplinary approach - Shows tricks and approaches not available in primary publications - First volume of its kind to combine both methods of study for human aging and animal models - Over 200 illustrations

Hypertension in Postmenopausal Women

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Publisher : Springer Science & Business Media
ISBN 13 : 3642790771
Total Pages : 125 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Hypertension in Postmenopausal Women by : Michel E. Safar

Download or read book Hypertension in Postmenopausal Women written by Michel E. Safar and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: On the occasion of the symposium on Hypertension in Postmenopausal Women (Monte Carlo, January 19-22, 1994), international scientists and clinicians discussed the various aspects of high blood pressure in older women. This volume presents an overview of this important aspect of both cardiology and gynecology. Special emphasis is given to the different approaches to antihypertension treatment.

Cambridge International AS & A Level Further Mathematics Coursebook

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Publisher : Cambridge University Press
ISBN 13 : 9781108403375
Total Pages : 608 pages
Book Rating : 4.4/5 (33 download)

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Book Synopsis Cambridge International AS & A Level Further Mathematics Coursebook by : Lee Mckelvey

Download or read book Cambridge International AS & A Level Further Mathematics Coursebook written by Lee Mckelvey and published by Cambridge University Press. This book was released on 2018-08-31 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cambridge International AS & A Level Further Mathematics supports students following the 9231 syllabus. This single coursebook comprehensively covers all four modules of the syllabus and helps support students in their studies and develops their mathematical skills. Authored by experienced teachers of Further Mathematics, the coursebook provides detailed explanations and clear worked examples with practice exercises and exam-style questions. Answers are at the back of the book.