Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
E3 Ubiquitin Ligases From Structure To Physiology
Download E3 Ubiquitin Ligases From Structure To Physiology full books in PDF, epub, and Kindle. Read online E3 Ubiquitin Ligases From Structure To Physiology ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis E3 Ubiquitin Ligases: From Structure to Physiology by : Victor M. Bolanos-Garcia
Download or read book E3 Ubiquitin Ligases: From Structure to Physiology written by Victor M. Bolanos-Garcia and published by Frontiers Media SA. This book was released on 2020-07-22 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Macromolecular Protein Complexes III: Structure and Function by : J. Robin Harris
Download or read book Macromolecular Protein Complexes III: Structure and Function written by J. Robin Harris and published by Springer Nature. This book was released on 2020-11-30 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers important topics such as the dynamic structure and function of the 26S proteasome, the DNA replication machine: structure and dynamic function and the structural organization and protein–protein interactions in the human adenovirus capsid, to mention but a few. The 18 chapters included here, written by experts in their specific field, are at the forefront of scientific knowledge. The impressive integration of structural data from X-ray crystallography with that from cryo-electron microscopy is apparent throughout the book. In addition, functional aspects are also given a high priority. Chapter 1 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Book Synopsis Molecular Aspects of Plant Salinity Stress and Tolerance by : Jen-Tsung Chen
Download or read book Molecular Aspects of Plant Salinity Stress and Tolerance written by Jen-Tsung Chen and published by MDPI. This book was released on 2021-09-08 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the advances in plant salinity stress and tolerance, including mechanistic insights revealed using powerful molecular tools and multi-omics and gene functions studied by genetic engineering and advanced biotechnological methods. Additionally, the use of plant growth-promoting rhizobacteria in the improvement of plant salinity tolerance and the underlying mechanisms and progress in breeding for salinity-tolerant rice are comprehensively discussed. Clearly, the published data have contributed to the significant progress in expanding our knowledge in the field of plant salinity stress and the results are valuable in developing salinity-stress-tolerant crops; in benefiting their quality and productivity; and eventually, in supporting the sustainability of the world food supply.
Book Synopsis Plant Photomorphogenesis by : Ruohe Yin
Download or read book Plant Photomorphogenesis written by Ruohe Yin and published by Humana. This book was released on 2022-03-18 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides detailed protocols for research in plant photomorphogenesis. The collection includes a broad range of topics including assays for shade avoidance responses, assays for light-dependent protein-protein interactions, photobody detection with immunofluorescence and the super-resolution imaging method, protein complex isolation from plants, detection of homodimer and monomer of photoreceptor UVR8 with immunoblotting analysis, assays for seedling greening, procedures for studying skotomorphogenesis, phenotypic study of photomorphogenesis at the seedling stage, expression of Cryptochrome in insect cells, and more. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Plant Photomorphogenesis: Methods and Protocols serves as an ideal guide for researchers and students who are new to the field, as well as a stepping stone for experienced researchers to further their skills in this fast-developing field.
Book Synopsis Ubiquitin Proteasome System by : Matthew Summers
Download or read book Ubiquitin Proteasome System written by Matthew Summers and published by BoD – Books on Demand. This book was released on 2019-06-19 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human ubiquitin proteasome system (UPS) is comprised of nearly 1000 proteins. Although originally identified as a mechanism of protein destruction, the UPS has numerous additional functions and mediates central signaling events in myriad processes involved in both cellular and organismal health and homeostasis. Numerous pathways within the UPS are implicated in disease, ranging from cancer to neurodegenerative diseases such as Parkinson's. The goal of this book is to deliver a collection of synopses of current areas of UPS research that highlights the importance of understanding the biology of the UPS to identify disease-relevant pathways, and the need to elucidate the molecular machinations within the UPS to develop methods for therapeutic modulation of these pathways.
Book Synopsis Proteostasis and Disease by : Rosa Barrio
Download or read book Proteostasis and Disease written by Rosa Barrio and published by Springer Nature. This book was released on 2020-04-09 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.
Book Synopsis The Ubiquitin System by : Milton J. Schlesinger
Download or read book The Ubiquitin System written by Milton J. Schlesinger and published by Cold Spring Harbor Laboratory Press. This book was released on 1988 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Reversible Ubiquitylation in Plant Biology by : Hongyong Fu
Download or read book Reversible Ubiquitylation in Plant Biology written by Hongyong Fu and published by Frontiers Media SA. This book was released on 2015-03-26 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reversible ubiquitylation plays an important regulatory role in almost all aspects of cellular and organismal processes in plants. Its pervasive regulatory role in plant biology is primarily due to the involvement of a large set of ubiquitin system constituents (encoded by approximately 6% Arabidopsis genome), the huge number of important cellular proteins targeted as substrates, and various drastic effects on the modified proteins. The major components of the ubiquitin system include a large set of enzymes and proteins involved in ubiquitin conjugation (E1s, E2s, and E3s) and deconjugation (deubiquitinases of different classes) and post ubiquitin conjugation components such as ubiquitin receptors, endocytic machineries, and 26S proteasome. The established substrates include transcriptional activators and repressors, signaling components, key metabolic enzymes, and critical mechanistic components of major cellular processes and regulatory mechanisms. Post-translational modification of proteins by reversible ubiquitylation could drastically affects the modified proteins by proteolytic processing and turnover, altering catalytic activity, subcellular targeting, and protein-protein interaction. Continued efforts are being carried out to identify novel substrates critical for various cellular and organismal processes, to determine effects of reversible ubiquitylation on the modified substrates, to determine signaling determinants triggering reversible ubiquitylation of specific substrates, to illustrate individual components of the ubiquitin system for their in vivo functions and involved mechanistic roles, and to determine mechanistic roles of modification acting on critical components of major cellular processes and regulatory mechanisms. The aim of this special topic is to serve as a platform to report most recent advances on those above listed current research endeavors. We welcome article types including original research, review, mini review, method, and perspective/opinion/hypothesis.
Author :Crestina L. Beites Publisher :National Library of Canada = Bibliothèque nationale du Canada ISBN 13 :9780612915961 Total Pages :452 pages Book Rating :4.9/5 (159 download)
Book Synopsis The Septin CDCrel-1 [microform] : Protein Associations, Modifications and Effects on Exocytosis by : Crestina L. Beites
Download or read book The Septin CDCrel-1 [microform] : Protein Associations, Modifications and Effects on Exocytosis written by Crestina L. Beites and published by National Library of Canada = Bibliothèque nationale du Canada. This book was released on 2004 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: SNARE proteins mediate the docking and/or fusion of the vesicle with the plasma membrane. However, it is not clearly understood how this process is regulated. In a search for potential SNARE regulators, we have identified a novel snare interacting protein, the septin CDCrel-1. Septins were first identified as filamentous proteins required for cytokinesis in yeast. However, in mammals little is known about their functions. I show here that cdcrel-1 is predominantly expressed in the brain where it associates with membranes via binding to syntaxin 1A. Wildtype CDCrel-1 transfected into HIT-T15 cells inhibits secretion while mutated forms of CDCrel-1 potentiate secretion, suggesting that cdcrel-1 may be regulating vesicle targeting and/or fusion events. I further map the CDCrel-1 domains important for syntaxin binding and investigate the ability of CDCrel-1 to bind to syntaxin when in various SNARE complexes. CDCrel-1 can bind syntaxin in a SNARE complex, but its binding is occluded by alpha-SNAP. This suggests that CDCrel-1 may act as a novel filamentous element, regulating the delivery and/or fusion of vesicles to the presynaptic membrane through its interaction with syntaxin and the 7S complex. The regulation of filaments may be via post-translational modifications. Indeed we have discovered a novel interaction between SUMO E3 PIAS proteins and CDCrel-1. The conjugation of SUMO to substrates is dependent upon an E1 and E2, whereas specificity is mediated by an E3. Although several SUMO-1 substrates have been characterized, conjugation solely by SUMO-2/3 has not been described. Here I describe the colocalization of CDCrel-1 with SUMO-2 and 3 but not SUMO-1. Transfection of SUMO-2/3 but not SUMO-1 causes a reorganization of CDCrel-1 distribution in CHO cells. Furthermore, CDCrel-1 sequesters the nuclear pool of SUMO-2/3 and of the E2 Ubc9 but not SUMO1 into the cytoplasm. Sumoylation of CDCrel-l is shown in vivo and putative SUMO modification sites on CDCrel-1 are investigated by deletion of lysine residues. These experiments strongly suggest that CDCrel-1 is sumoylated specifically by SUMO-2/3. Sumoylation of CDCrel-1 may therefore play a regulatory role in secretion and septin filament formation. Future work will be aimed at determining the functional significance of SUMO modified CDCrel-1.
Book Synopsis Autophagy: Biology and Diseases by : Zheng-Hong Qin
Download or read book Autophagy: Biology and Diseases written by Zheng-Hong Qin and published by Springer Nature. This book was released on 2019-11-27 with total page 727 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy. Volume 1 focuses on the biology of autophagy, including the signaling pathways, regulating processes and biological functions. Autophagy is a fundamental physiological process in eukaryotic cells. It not only regulates normal cellular homeostasis, and organ development and function, but also plays an important role in the pathogenesis of a wide range of human diseases. Thanks to the rapid development of molecular biology and omic technologies, research on autophagy has boomed in recent decades, and more and more cellular and animal models and state-of the-art technologies are being used to shed light on the complexity of signaling networks involved in the autophagic process. Further, its involvement in biological functions and the pathogenesis of various diseases has attracted increased attention around the globe. Presenting cutting-edge knowledge, this book series is a useful reference resource for researchers and clinicians who are working on or interested in autophagy.
Book Synopsis Environmental Adaptations and Stress Tolerance of Plants in the Era of Climate Change by : Parvaiz Ahmad
Download or read book Environmental Adaptations and Stress Tolerance of Plants in the Era of Climate Change written by Parvaiz Ahmad and published by Springer Science & Business Media. This book was released on 2011-12-02 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: Climate change is a complex phenomenon with a wide range of impacts on the environment. Biotic and abiotic stress are a result of climate change. Abiotic stress is caused by primary and secondary stresses which are an impediment to plant productivity. Prolonged exposure to these stresses results in altered metabolism and damage to biomolecules. Plants evolve defense mechanisms to withstand these stresses, e.g. synthesis of osmolytes, osmoprotectants, and antioxidants. Stress responsive genes and gene products including expressed proteins are implicated in conferring tolerance to the plant. This volume will provide the reader with a wide spectrum of information, including vital references. It also provides information as to how phytoconstituents, hormones and plant associated microbes help the plants to tolerate the stress. This volume also highlights the use of plant resources for ameliorating soil contaminants such as heavy metals. Dr. Parvaiz is Assistant professor in Botany at A.S. College, Srinagar, Jammu and Kashmir, India. He has completed his post-graduation in Botany in 2000 from Jamia Hamdard New Delhi India. After his Ph.D from the Indian Institute of Technology (IIT) Delhi, India in 2007 he joined the International Centre for Genetic Engineering and Biotechnology, New Delhi. He has published more than 20 research papers in peer reviewed journals and 4 book chapters. He has also edited a volume which is in press with Studium Press Pvt. India Ltd., New Delhi, India. Dr. Parvaiz is actively engaged in studying the molecular and physio-biochemical responses of different plants (mulberry, pea, Indian mustard) under environmental stress. Prof. M.N.V. Prasad is a Professor in the Department of Plant Sciences at the University of Hyderabad, India. He received B.Sc. (1973) and M.Sc. (1975) degrees from Andhra University, India, and the Ph.D. degree (1979) in botany from the University of Lucknow, India. Prasad had published 216 articles in peer reviewed journals and 82 book chapters and conference proceedings in the broad area of environmental botany and heavy metal stress in plants. He is the author, co-author, editor, or co-editor for eight books. He is the recipient of Pitamber Pant national Environment Fellowship of 2007 awarded by the Ministry of Environment and Forests, Government of India.
Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Book Synopsis Ubiquitin Proteasome System by : Aldrin V. Gomes
Download or read book Ubiquitin Proteasome System written by Aldrin V. Gomes and published by Nova Medicine & Health. This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decade, major advancements in our understanding of the ubiquitin-proteasome system (UPS) have occurred. This book focuses on recent trends in the UPS. The UPS is possibly the most complex of all intracellular pathways as close to 7% of all genes in the human genome make up part of the UPS. This complex system serves as an essential role in intracellular protein degradation, and because of its critical function, improper functioning of the UPS is associated with nearly all know diseases, including cancer, cardiovascular disease, and neurological diseases. The proteolytic component of the UPS is the proteasome, a multicatalytic complex found in the nucleus and cytoplasm. Another form of the proteasome, the immunoproteasome, is less abundant than the constitutive proteasome, but is important in immune response and degradation of oxidized proteins, and recent research suggests that it may be important in longevity. The articles in this book discuss recent findings which indicate that mutations in proteins involved with the UPS are associated with genetic diseases such as familial dilated cardiomyopathy, Nakajo syndrome, and spinal muscular atrophy (X-linked). Some chapters also discuss recent results which suggest that the UPS is heavily regulated by post-translational modifications such as phosphorylation, acetylation, and methylation. The UPS is also heavily regulated by ubiquitination itself. This book contains a research article using PubMed bibliometric data to present current research trends in the UPS. Articles are written so that no one tissue is emphasized to allow readers from any discipline to benefit from this information.
Book Synopsis The TGF-[beta] Family by : Rik Derynck
Download or read book The TGF-[beta] Family written by Rik Derynck and published by CSHL Press. This book was released on 2008 with total page 1108 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transforming growth factor-[beta] (TGF-[beta]), identified nearly three decades ago, is a secreted polypeptide that functions in critical cell cycle processes, including cellular proliferation, differentiation, and development: It belongs to a large protein family that, in humans, contains 33 members, including activins, inhibins, bone morphogenetic proteins, growth and differentiation factors, and Mullerian inhibiting substance. This volume draws on the world's leading laboratories to comprehensively cover all aspects of the biology of TGF-[beta] and related factors. In addition to providing historical and background information, it describes the cell biology and signaling pathways of TGF-[beta] members in detail, including the roles of TGF-[beta] factors in the development and physiology of humans and model organisms. The last few chapters are devoted to the role of TGF-[beta] members in cancer and other diseases, as well as the possibilities for therapeutics based on knowledge of signaling pathways and macromolecular structures. It serves as a comprehensive reference work for both specialists and researchers less familiar with the field.
Download or read book Plant Meiosis written by Wojtek Pawlowski and published by Humana Press. This book was released on 2013-04-05 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Meiosis is one of the most critical processes in eukaryotes, required for continuation of species and generation of new variation. In plants, meiotic recombination is by far the most important source of genetic variation. In Plant Meiosis: Methods and Protocols, expert researchers in the field detail methods for molecular cytogenetics and chromosome analysis in plants. These state-of -the-art protocols allow studying the organization and behavior of the genetic material in a wide range of both model and crop species. Written in the highly successful Methods in Molecular BiologyTMseries format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Plant Meiosis: Methods and Protocols provides and extensive list of protocols developed and used in a number of laboratories at the cutting edge of meiosis and chromosome research.
Book Synopsis Insights in Structural Biology: 2021 by : Annalisa Pastore
Download or read book Insights in Structural Biology: 2021 written by Annalisa Pastore and published by Frontiers Media SA. This book was released on 2022-11-15 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Ubiquitin-dependent Protein Degradation by :
Download or read book Ubiquitin-dependent Protein Degradation written by and published by Academic Press. This book was released on 2019-03-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ubiquitination and Protein Stability - Part B, Volume 619, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this updated volume presenting interesting chapters written by an international board of authors. Topics of note include chapters on Assays of SUMO protease function in mammalian cells, In vitro analysis of proteasome-associated USP14 activity for substrate degradation and deubiquitylation, Methods to study proteasome regulatory particle assembly, Native mass spectrometry approaches to study the proteasome, Single-molecule methods to study the ubiquitin-proteasome system, Assays for the function of ubiquitin in the mammalian endocytic pathway, and much more.
![Download The Septin CDCrel-1 [microform] : Protein Associations, Modifications and Effects on Exocytosis PDF Online Free](https://books.google.com/books/content/images/frontcover/EP3PygAACAAJ?fife=w200-h370)
![Download The TGF-[beta] Family PDF Online Free](https://books.google.com/books/content/images/frontcover/QW5xq75p5gYC?fife=w200-h370)
