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Dysregulated Calcium Signaling In Cardiomyocytes From Diabetic Atrial Fibrillation To Chemotherapy Induced Cardiac Hypertrophy
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Book Synopsis Dysregulated Calcium Signaling in Cardiomyocytes from Diabetic Atrial Fibrillation to Chemotherapy-induced Cardiac Hypertrophy by : Xian Liu (Ph.D.)
Download or read book Dysregulated Calcium Signaling in Cardiomyocytes from Diabetic Atrial Fibrillation to Chemotherapy-induced Cardiac Hypertrophy written by Xian Liu (Ph.D.) and published by . This book was released on 2022 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ca2+ is a vital second messenger in cardiomyocytes and controls excitation contraction coupling. It also regulates cell cycle, apoptosis, hypertrophy and downstream gene transcription in the heart remodeling. Calcium homeostasis is a complicated network and the intracellular Ca2+ signaling is composed of different Ca2+ movements like Ca2+ spikes [1], waves and oscillations [2-4]. The spatially-temporally regulated Ca2+ signaling is orchestrated with the Ca2+ release through ryanodine receptor (RyR) or IP3 receptor (IP3R) from Ca2+ stores such assarcoplasmic/endoplasmic reticulum (SR/ER), recycling of Ca2+ from cell plasma back to the ER and Ca2+ influx through plasma membrane (PM) from extracellular space. There are many channels and transporters responsible for the intracellular Ca2+ homeostasis in cardiomyocytes. Firstly, the RyR mediates Ca2+ release from SR/ER [5]. Secondly, the ER/SR Ca2+-ATPase (SERCA) pumps Ca2+ from the cytosol back into the ER/SR. Plasma membrane Ca2+-ATPase (PMCA) drives Ca2+ from the cytosol to the extracellular space [6]. Thirdly, the Ca2+ channels or transporters located on the cell membrane allow Ca2+ influx across the plasma membrane (PM) from the extracellular space. These channels or transporters include voltage-gated Ca2+ channel (VGCC), transient receptor potential channel (TRP), store-operated calcium entry (SOCE) or Ca2+ release activated Ca2+ channel (CRAC), Na+/Ca2+ exchanger (NCX) and purinergic receptor. Fourthly, mitochondrial Ca2+ uniporter (MCU) regulates mitochondrial Ca2+ uptake. Besides, there are more channels or transporters on the cell membrane and the ER membrane involved in the regulation of intracellular Ca2+ homeostasis. The dysregulation of intracellular Ca2+ can lead to a wide spectrum of cardiovascular diseases, including but not limited to arrhythmias, cardiac hypertrophy, cardiomyopathy and heart failure (summarized in the following illustrative figure). The first chapter of this dissertation is devoted to a literature review on the intracellular Ca2+ in the cardiac system with particular emphasis on SOCE and its machinery components. In Chapter 2, the IP3-mediated disrupted calcium homeostasis in type 2 diabetes (T2DM)and atrial fibrillation (AF) is examined. In Chapter 3, the role of SOCE in chemotherapy drug epirubicin induced cardiotoxicity is investigated. Finally, in Chapter 4, conclusion will be stated and future directions will be discussed.
Book Synopsis Coronary Microvascular Dysfunction by : Filippo Crea
Download or read book Coronary Microvascular Dysfunction written by Filippo Crea and published by Springer Science & Business Media. This book was released on 2013-08-15 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past two decades a number of studies have shown that abnormalities in the function and structure of coronary microcirculation can be detected in several cardiovascular diseases. On the basis of the clinical setting in which it occurs, coronary microvascular dysfunction (CMD) can be classified into four types: CMD in the absence of any other cardiac disease; CMD in myocardial diseases; CMD in obstructive epicardial coronary artery disease; and iatrogenic CMD. In some instances CMD represents an epiphenomenon, whereas in others it represents an important marker of risk or may contribute to the pathogenesis of myocardial ischemia, thus becoming a possible therapeutic target. This book provides an update on coronary physiology and a systematic assessment of microvascular abnormalities in cardiovascular diseases, in the hope that it will assist clinicians in prevention, detection and management of CMD in their everyday activity.
Book Synopsis Calcium Signaling by : Md. Shahidul Islam
Download or read book Calcium Signaling written by Md. Shahidul Islam and published by Springer Nature. This book was released on 2019-10-23 with total page 1110 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains a unique selection of chapters covering a wealth of contemporary topics in this ubiquitous and diverse system of cell signaling. It offers much more than the accessibility and authority of a primary text book, exploring topics ranging from the fundamental aspects of calcium signaling to its varied clinical implications. It presents comprehensive discussion of cutting-edge research alongside detailed analysis of critical issues, at the same time as setting out testable hypotheses that point the way to future scientific endeavors. The contributions feature material on theoretical and methodological topics as well as related subjects including mathematical modeling and simulations. They examine calcium signaling in a host of contexts, from mammalian cells to bacteria, fruit fly and zebrafish. With much of interest to newcomers to the field as well as seasoned experts, this new publication is both wide-ranging and authoritative. The chapter “Calcium Signaling: From Basic to Bedside” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Book Synopsis Anticancer Treatments and Cardiotoxicity by : Patrizio Lancellotti
Download or read book Anticancer Treatments and Cardiotoxicity written by Patrizio Lancellotti and published by Academic Press. This book was released on 2016-11-11 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anticancer Treatments and Cardiotoxicity: Mechanisms, Diagnostic and Therapeutic Interventions presents cutting edge research on the adverse cardiac effects of both radiotherapy and chemotherapy, brought together by leaders in the field. Cancer treatment-related cardiotoxicity is the leading cause of treatment-associated mortality in cancer survivors and is one of the most common post-treatment issues among survivors of adult cancer. Early detection of the patients prone to developing cardiotoxicity, taking in to account the type of treatment, history and other risk factors, is essential in the fight to decrease cardiotoxic mortality. This illustrated reference describes the most effective diagnostic and imaging tools to evaluate and predict the development of cardiac dysfunction for those patients undergoing cancer treatment. In addition, new guidelines on imaging for the screening and monitoring of these patients are also presented. Anticancer Treatments and Cardiotoxicity is an essential reference for those involved in the research and treatment of cardiovascular toxicity. Provides algorithms essential for the use of imaging, and biomarkers for the screening and monitoring of patients Written by world-leading experts in the field of cardiotoxicity Includes high-quality images, case studies, and test questions Describes the most effective diagnostic and imaging tools to evaluate and predict the development of cardiac dysfunction for those patients undergoing cancer treatment
Book Synopsis The Diabetic Heart by : Makoto Nagano
Download or read book The Diabetic Heart written by Makoto Nagano and published by New York : Raven Press. This book was released on 1991 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Drug-Induced Mitochondrial Dysfunction by : James A. Dykens
Download or read book Drug-Induced Mitochondrial Dysfunction written by James A. Dykens and published by Wiley-Interscience. This book was released on 2008-09-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the definitive, one-stop resource on preclinical drug evaluation for potential mitochondrial toxicity, addressing the issue upfront in the drug development process. It discusses mitochondrial impairment to organs, skeletal muscle, and nervous systems and details methodologies used to assess mitochondria function. It covers both in vitro and in vivo methods for analysis and includes the latest models. This is the authoritative reference on drug-induced mitochondrial dysfunction for safety assessment professionals in the pharmaceutical industry and for pharmacologists and toxicologists in both drug and environmental health sciences.
Book Synopsis Oxidative Stress and Neurodegenerative Disorders by : G. Ali Qureshi
Download or read book Oxidative Stress and Neurodegenerative Disorders written by G. Ali Qureshi and published by Elsevier. This book was released on 2007-03-22 with total page 795 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders. * Contains the latest information on the subject of neurodegenerative disorders* Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems
Book Synopsis Congestive Heart Failure and Cardiac Transplantation by : Daniel J. Garry
Download or read book Congestive Heart Failure and Cardiac Transplantation written by Daniel J. Garry and published by Springer. This book was released on 2017-06-01 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive overview of heart failure and cardiac transplantation and integrates scientific and clinical information about the physiology, pathophysiology, diagnosis, and treatment of this disorder. Organized into five parts, it reviews the history and basic mechanisms of heart failure; etiology of heart failure; heart failure disease progression; advanced therapies for heart failure; and cardiac transplantation. The book presents basic concepts in the physiology, molecular biology, pathology, and epidemiology of the normal and failing heart; known causes of heart failure, such as right heart failure, valvular cardiomyopathy, molecular mechanisms of sarcomeric cardiomyopathies, and neuromuscular cardiomyopathy; cardiorenal syndrome; neurohormonal activation; cardiac resynchronization, ventricular assist devices; regenerative mechanisms; orthotopic heart transplantation; early and late management of the post-transplant patient; heart transplantation and antibody-mediated rejections; heart-lung transplantation; and cardiac xenotransplantation. Featuring contributions from leaders in the fields of heart failure, cardiac transplantation, cardiac pathology, and cardiovascular molecular research, Congestive Heart Failure and Cardiac Transplantation is a valuable compendium for cardiologists, cardiothoracic surgeons, researchers, trainees, and students.
Download or read book Fabry Disease written by Deborah Elstein and published by Springer Science & Business Media. This book was released on 2010-08-02 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fabry disease is an X-linked inborn error of metabolism wherein deficiency of a lysosomal enzyme results in systemic deposition of glycosphingolipids. Storage deposition, and hence pathological disease, occurs preferentially in renal glomerular and tubular epithelial cells, myocardial cells, heart valve fibrocytes, neurons of dorsal root ganglia, and in endothelial smooth muscle cells of blood vessels. Thus, Fabry disease is a multi-system disorder, albeit with considerable phenotypic heterogeneity in onset and in severity; however, it is progressive, exhibits extensive morbidity, and is life-threatening. Within the past two decades, there has been a radical change in the natural course Fabry disease by virtue of the availability of specific enzyme replacement therapy. Moreover, there has been a concerted effort to better understand the underlying pathology and equally to identify patients prior to the onset of irreversible end-organ damage. It is to be hoped that the future for patients with Fabry disease can be viewed with greater, albeit guarded, optimism. This state-of-the-art textbook attempts to bridge the span of pre-clinical studies, clinical finding, and management options in a readable but comprehensive manner for the medical practitioner as well as the interested non-medical reader.
Book Synopsis Pharmacological Control of Calcium and Potassium Homeostasis by : T. Godfraind
Download or read book Pharmacological Control of Calcium and Potassium Homeostasis written by T. Godfraind and published by Springer. This book was released on 1995-07-31 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: This up to date treatment of calcium and potassium channel pharmacology first presents both molecular and preclinical pharmacology data, followed by contributions on the clinical application of the drugs that modulate calcium and potassium channels. Cardiovascular data prevail, but other chapters also discuss possible roles and application to the nervous system. Further, some contributions deal with future prospects in the area. Audience: Researchers, both pharmacological and medical, working in cardiovascular medicine with strong interests in the treatment of myocardial infarction and hypertension.
Book Synopsis Advances in Geroscience by : Felipe Sierra
Download or read book Advances in Geroscience written by Felipe Sierra and published by Springer. This book was released on 2015-11-10 with total page 637 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the first comprehensive overview of a new scientific discipline termed Geroscience. Geroscience examines the molecular and cellular mechanisms that might explain why aging is the main risk factor for most chronic diseases affecting the elderly population. Over the past few decades, researchers have made impressive progress in understanding the genetics, biology and physiology of aging. This book presents vital research that can help readers to better understand how aging is a critical malleable risk factor in most chronic diseases, which, in turn, could lead to interventions that can help increase a healthy lifespan, or ‘healthspan.’ The book begins with an analysis of the Geroscience hypothesis, as well as the epidemiological underpinnings that define aging as a candidate main risk factor for most chronic diseases. Next, each chapter focuses on one particular disease, or group of diseases, with an emphasis on how basic molecular and cellular biology might explain why aging is a major risk factor for it. Coverage in the book includes: cancer, cardiovascular disease, dementias, stroke, Parkinson's and Alzheimer’s diseases, osteoporosis, arthritis, diabetes asthma, emphysema, kidney disease, vision impairment, and AIDS/HIV. It finishes with a chapter on pain in the elderly and an overview of future steps needed to bring the newly acquired knowledge into the clinic and the public at large.
Book Synopsis Peptidyl-prolyl Cis/trans Isomerases by : Andrzej Galat
Download or read book Peptidyl-prolyl Cis/trans Isomerases written by Andrzej Galat and published by Oxford University Press, USA. This book was released on 1998 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptidyl-prolyl cist/trans isomerases (PPIases) are a family of proteins that are present in a wide range of species. They display an interesting multi-domain structure, and because of their affinity for proline residues, they are involved in a diversity of biological processes. This volume presents the latest information on their sequences, structures, and functions, their distribution within the cell, their interactions with other proteins and ligands, and their involvement in signalling pathways.
Author :Constantinos Koumenis Publisher :Springer Science & Business Media ISBN 13 :146145915X Total Pages :293 pages Book Rating :4.4/5 (614 download)
Book Synopsis Tumor Microenvironment and Cellular Stress by : Constantinos Koumenis
Download or read book Tumor Microenvironment and Cellular Stress written by Constantinos Koumenis and published by Springer Science & Business Media. This book was released on 2013-11-23 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.
Author :Stefan I. McDonough Publisher :Springer Science & Business Media ISBN 13 :9780306478789 Total Pages :440 pages Book Rating :4.4/5 (787 download)
Book Synopsis Calcium Channel Pharmacology by : Stefan I. McDonough
Download or read book Calcium Channel Pharmacology written by Stefan I. McDonough and published by Springer Science & Business Media. This book was released on 2004 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume reviews the current ability, future prospects, and physiological and medical significance of being able to distinguish pharmacologically among different calcium channel subtypes. Chapters are organized around broad concepts addressing the state of the field that naturally cover the pharmacology of each different calcium channel. Mechanistic information on drug-channel interactions is also presented in several chapters, as a theoretical and practical guide to working with calcium channel blockers in general.
Book Synopsis Clinical Cardiovascular Physiology by : Herbert Jerome Levine
Download or read book Clinical Cardiovascular Physiology written by Herbert Jerome Levine and published by . This book was released on 1976 with total page 982 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Genes and Cardiovascular Function by : Bohuslav Ostadal
Download or read book Genes and Cardiovascular Function written by Bohuslav Ostadal and published by Springer Science & Business Media. This book was released on 2011-08-09 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rapid advances in molecular medicine have led to pronounced new developments in experimental and clinical cardiology. In the embrace of modern molecular biology and bridging the gap between the clinical and the genomic, cardiovascular medicine has seen major strides in the understanding of the molecular mechanisms that drive disease progression. The ability to rapidly identify candidate human genes for cardiovascular diseases lends itself to the development of diverse strategies for disease treatment and management. The wide variety of gene expressions proffers excellent targets for novel therapeutics. Gene therapy is steadily increasing in viability and represents a fascinating arena of research and clinical focus. This book is based on two international Mendel symposia on “Genes and the Heart,” joint meetings of the Japanese and European sections of the International Academy of Cardiovascular Sciences. Highlighting selected symposia contributions, this book explores the role of molecular biology and genetics in the basic knowledge, genesis, and clinical interventions of cardiovascular diseases.
Author :Theophile Theophanides Publisher :Springer Science & Business Media ISBN 13 :9780792348214 Total Pages :448 pages Book Rating :4.3/5 (482 download)
Book Synopsis Magnesium: Current Status and New Developments by : Theophile Theophanides
Download or read book Magnesium: Current Status and New Developments written by Theophile Theophanides and published by Springer Science & Business Media. This book was released on 1997-09-30 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the Proceedings of the 8th International Symposium on Magnesium. It presents research and applications in order to interface between medical doctors, clinicians and scientists responsible for magnesium involvement in the pathogenesis of diseases, its biological significance, metabolism and many other utilizations which are associated with membranes and cells. The topics which are discussed concern mechanisms of the mode of action of free magnesium cations, hydrated cations and magnesium-linked cations.
