Author : Ukamushu Ann Undieh
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)
Book Synopsis Dysfunction of the Gut-Microbiome Brain Axis in Neurodegenerative Disease: Role of Indole and Its Metabolites by : Ukamushu Ann Undieh
Download or read book Dysfunction of the Gut-Microbiome Brain Axis in Neurodegenerative Disease: Role of Indole and Its Metabolites written by Ukamushu Ann Undieh and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's Disease (AD) and Parkinson's Disease (PD) are the two most common age-related chronic neurodegenerative diseases with significant global health burden. In addition to motor and cognitive impairments, these patients experience gut dysbiosis and gastrointestinal effects that may have a role in exacerbation of the neurological symptoms via the gut microbiome-brain axis. It has also been theorized that certain gut microbial-derived metabolites, indole metabolites of L-tryptophan are associated with neurodegeneration. Increasing evidence suggests that the bacteria that produce them are dysregulated in PD and AD patients. In this study, we used LCMS and Unifi analysis to measure and quantify the levels of these metabolites in fecal samples of rodents with PD or AD disease phenotype. In addition, we evaluated the levels of indole and its metabolites in PD animals treated with long-term L-DOPA which causes dyskinesia (LID) and LID rats treated with an experimental drug called S-SK609. The results showed decreases in the levels of indole-3-carbaldehyde and indole-3-acrylate with an increase in indole in PD animals; decreases in indole-3-carbaldehyde, indole-3-lactate and tryptophan in AD animals; and decreases in tryptophan, tryptamine, indole-3-lactate and indole-3-carbaldehyde with an increase in indole in LID animals. Treatment with the experimental drug S-SK609 had no ameliorating effect on metabolite levels in rodents with either LID or AD but it notably did not worsen the dysbiosis. Our findings validate that there is significant gut dysbiosis in neurodegeneration and measuring the levels of indole and its metabolites can serve as early biomarkers for neurodegeneration.