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Dynamic Laser Speckle Imaging Of Cerebral Blood Flow
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Book Synopsis Dynamic Laser Speckle Imaging of Cerebral Blood Flow by :
Download or read book Dynamic Laser Speckle Imaging of Cerebral Blood Flow written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Laser speckle imaging (LSI) based on the speckle contrast analysis is a simple and robust technique for imaging of heterogeneous dynamics. LSI finds frequent application for dynamical mapping of cerebral blood flow, as it features high spatial and temporal resolution. However, the quantitative interpretation of the acquired data is not straightforward for the common case of a speckle field formed by both by moving and localized scatterers such as blood cells and bone or tissue. Here we present a novel processing scheme, we call dynamic laser speckle imaging (dLSI), that can be used to correctly extract the temporal correlation parameters from the speckle contrast measured in the presence of a static or slow-evolving background. The static light contribution is derived from the measurements by cross-correlating sequential speckle images. In-vivo speckle imaging experiments performed in the rodent brain demonstrate that dLSI leads to improved results. The cerebral hemodynamic response observed through the thinned and intact skull are more pronounced in the dLSI images as compared to the standard speckle contrast analysis. The proposed method also yields benefits with respect to the quality of the speckle images by suppressing contributions of non-uniformly distributed specular reflections.
Book Synopsis Dynamic Light Scattering Imaging by : Anton Sdobnov
Download or read book Dynamic Light Scattering Imaging written by Anton Sdobnov and published by CRC Press. This book was released on 2024-10-18 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines Dynamic Light Scattering (DLS) and its derivatives Laser Doppler Flowmetry (LDF), Diffusing Wave Spectroscopy (DWS), Laser Speckle Contrast Imaging (LSCI), and Doppler Optical Coherence Tomography (OCT) for characterizing particle motion in turbid mediums like suspensions and solutions. It focuses on non-invasive blood flow imaging in biological tissues, detailing technological advancements, practical applications, and inherent challenges. Essential for professionals in biomedical optics and medical fields, as well as physics and engineering students, the book highlights its use in brain, skin, and micro-circulation studies, providing key insights and practical guidance. Key Features: • Presents a deep dive into DLS and its derivative techniques. • Emphasizes practical applications, including brain blood flow monitoring, skin perfusion measurements, and micro-circulation characterization. • Delivers insights into the challenges and limitations associated with DLS-based blood flow imaging.
Book Synopsis Quantitative Cerebral Blood Flow Measurement with Multi Exposure Speckle Imaging by : Ashwin Bharadwaj Parthasarathy
Download or read book Quantitative Cerebral Blood Flow Measurement with Multi Exposure Speckle Imaging written by Ashwin Bharadwaj Parthasarathy and published by . This book was released on 2010 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cerebral blood flow (CBF) measures are central to the investigation of ischemic strokes, spreading depressions, functional and neuronal activation. Laser Speckle Contrast Imaging (LSCI) is an optical imaging technique that has been used to obtain CBF measures in vivo at high spatial and temporal resolutions, by quantifying the localized spatial blurring of backscattered coherent light induced by blood flow. Despite being widely used for biomedical applications, LSCI's critical limitations such as its tendency to underestimate large flow changes and its inability to accurately estimate CBF through a thinned skull have not been overcome. This dissertation presents a new Multi Exposure Speckle Imaging (MESI) technique that combines a new instrument and mathematical model to overcome these limitations. Additionally, in a pilot clinical study, an adapted neurosurgical microscope was used to obtain intra-operative LSCI images of CBF in humans. The MESI instrument accurately estimates experimental constants by imaging backscattered speckles over a wide range of the camera's exposure durations. The MESI mathematical model helps account for light that has scattered from both static and moving particles. In controlled flow experiments using tissue simulating phantoms, the MESI technique was found to estimate large changes in flow accurately and the estimates of flow changes were found to be unaffected by the presence of static particles in these phantoms. In an in vivo experiment in which the middle cerebral artery in mice was occluded to induce ~ 100% reduction in CBF, not only was the reduction in CBF accurately estimated by the MESI technique but these estimates of CBF changes were found to be unaffected by the presence of a thinned skull. The validity of statistical models used to derive the MESI mathematical model was confirmed using in vivo dynamic light scattering (DLS) measurements of CBF in mice. The MESI technique's potential to estimate absolute values of CBF in vivo was demonstrated by comparing CBF estimates obtained using the MESI technique to DLS measurements. The MESI technique's ability to measure CBF changes quantitatively through a thinned skull makes it particularly useful in chronic and long term studies leading to the development of better, more accurate stroke models.
Book Synopsis Dynamic Laser Speckle and Applications by : Hector J. Rabal
Download or read book Dynamic Laser Speckle and Applications written by Hector J. Rabal and published by CRC Press. This book was released on 2018-10-03 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Speckle study constitutes a multidisciplinary area with inherent complexities. In order to conquer challenges such as the variability of samples and sensitive measurements, researchers must develop a theoretical and statistical understanding of both biological and non-biological metrology using dynamic speckle laser. Dynamic Laser Speckle and Applications discusses the main methodologies used to analyze biospeckle phenomena with a strong focus on experimentation. After establishing a theoretical background in both speckle and biospeckle, the book presents the main methodologies for statistical and image analysis. It then deals with the concept of frequency decomposition before moving on to a discussion of fuzzy methods to treat dynamic speckle data. The book dedicates two sections to applications, including agricultural approaches. Additional features include photo images of experiments and software to aid in easy start-up of dynamic speckle usage. A systematic approach to new dynamic speckle laser phenomena, this book provides the physical theory and statistical background needed to analyze images formed by laser illumination in biological and non-biological samples.
Book Synopsis High-speed Laser Speckle Contrast Imaging of In-vivo Cerebral Blood Flow Time Varying Events by : 陳勁豪
Download or read book High-speed Laser Speckle Contrast Imaging of In-vivo Cerebral Blood Flow Time Varying Events written by 陳勁豪 and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Microscopic Laser Speckle Contrast Imaging of Cerebral Blood Flow During Brain Functional Activation by : Jian Yu
Download or read book Microscopic Laser Speckle Contrast Imaging of Cerebral Blood Flow During Brain Functional Activation written by Jian Yu and published by . This book was released on 2006 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis High Resolution Imaging in Microscopy and Ophthalmology by : Josef F. Bille
Download or read book High Resolution Imaging in Microscopy and Ophthalmology written by Josef F. Bille and published by Springer. This book was released on 2019-08-13 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.
Author :Alexander A. Kokhanovsky Publisher :Springer Science & Business Media ISBN 13 :354074276X Total Pages :516 pages Book Rating :4.5/5 (47 download)
Book Synopsis Light Scattering Reviews 4 by : Alexander A. Kokhanovsky
Download or read book Light Scattering Reviews 4 written by Alexander A. Kokhanovsky and published by Springer Science & Business Media. This book was released on 2009-07-25 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fourth volume of Light Scattering Reviews is composed of three parts. The ?rstpartisconcernedwiththeoreticalandexperimentalstudiesofsinglelightsc- tering by small nonspherical particles. Light scattering by small particles such as, for instance, droplets in the terrestrial clouds is a well understood area of physical optics. On the other hand, exact theoretical calculations of light scattering p- terns for most of nonspherical and irregularly shaped particles can be performed only for the restricted values of the size parameter, which is proportional to the ratio of the characteristic size of the particle to the wavelength?. For the large nonspherical particles, approximations are used (e. g. , ray optics). The exact th- retical techniques such as the T-matrix method cannot be used for extremely large particles, such as those in ice clouds, because then the size parameter in the v- iblex=2?a/???,wherea is the characteristic size (radius for spheres), and the associated numerical codes become unstable and produce wrong answers. Yet another problem is due to the fact that particles in many turbid media (e. g. , dust clouds) cannot be characterized by a single shape. Often, refractive indices also vary. Because of problems with theoretical calculations, experimental (i. e. , la- ratory) investigations are important for the characterization and understanding of the optical properties of such types of particles. The ?rst paper in this volume, written by B. Gustafson, is aimed at the descr- tionofscaledanalogueexperimentsinelectromagneticscattering.
Book Synopsis Laser Speckle Contrast Imaging for Intraoperative Monitoring of Cerebral Blood Flow by : Lisa Michelle Richards
Download or read book Laser Speckle Contrast Imaging for Intraoperative Monitoring of Cerebral Blood Flow written by Lisa Michelle Richards and published by . This book was released on 2015 with total page 598 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ensuring adequate blood flow during surgical procedures is crucial, as prolonged ischemia can result in tissue death and lead to poor clinical outcomes. This is especially important during neurosurgery, since the brain relies on a constant supply of cerebral blood flow (CBF) to maintain normal function. Intraoperative blood flow monitoring tools are essential to detect ischemia in a timely manner, and allow surgical correction before the onset of irreversible brain injury. Laser speckle contrast imaging (LSCI) is an optical imaging method that provides blood flow maps with high spatiotemporal resolution, and overcomes many of the limitations of current intraoperative monitoring technologies. The objective of this dissertation is to demonstrate that LSCI is an effective tool for blood flow monitoring during neurosurgery, and to optimize and improve LSCI technology for clinical use. This research has two primary elements: assessing the LSCI instrumentation components in a controlled laboratory setting, and evaluating the clinical performance of LSCI during neurosurgery. The laboratory study aims to determine the optimal specifications for the clinical instrument design, using controlled static and microfluidic flow experiments. Two of the main components of the LSCI instrument are the camera used for recording, and the laser used for coherent illumination of the tissue. Thus, a broad camera and laser comparison was performed spanning a wide array of available hardware options to determine which specifications are the most important for reliable and highly sensitive flow measurements. The two-phase clinical study aims to demonstrate the performance and utility of LSCI in a neurosurgical setting as a potential tool for real-time, continuous, and noninvasive image guidance. These studies demonstrate that LSCI can produce blood flow maps consistent with expected physiological trends, and show the impact of instrument design and image acquisition techniques on image quality and quantitative flow assessment. The results from both the laboratory and clinical studies can be used to design a more sensitive and robust LSCI system, which increases its value as an intraoperative tool for monitoring blood flow. LSCI has the potential to be the next generation of neurosurgical image guidance for blood flow visualization, and the work presented in this dissertation can accelerate its clinical adoption.
Book Synopsis Progress in Brain Research by : J. P. Schadé
Download or read book Progress in Brain Research written by J. P. Schadé and published by . This book was released on 1963 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Neurovascular Imaging by : Anna Devor
Download or read book Neurovascular Imaging written by Anna Devor and published by Frontiers E-books. This book was released on 2012-02-01 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent technological advances are significantly enhancing ones ability to image the interplay of neuronal activity, metabolism, and the associated vascular response with high spatial and temporal resolution. This Research Topic will cover these recent technological advances as well as the impact they have had on understanding the coupling of neuronal, metabolic, and vascular responses. We invite contributions to highlight new original research and to provide a forum for discussion of hot neurovascular topics. Potential contributions include, but are not limited by the following examples: - Development and application of novel optical technologies for imaging of neuronal, metabolic and vascular activity. Examples include 2-Photon Microscopy, Optical Coherence Tomography, and Second Harmonic Microscopy. - Intravital imaging of metabolites such as NADH and flavoproteins - Application of optical methods for manipulation of neuroglial circuits and vascular architectonics - Development of novel Magnetic Resonance contrasts for noninvasive imaging of blood flow, volume, and oxygen consumption. - Application of imaging tools for studying of neurovascular dysfunctions such as stroke, vascular dementia and Alzheimer’s Disease - Hypotheses, Perspectives, Commentaries and Opinions with regards to the body of recent publications that utilize imaging tools for investigation of neurogliovascular communication and the regulation of cerebral blood flow
Book Synopsis 5th Kuala Lumpur International Conference on Biomedical Engineering 2011 by : Hua-Nong Ting
Download or read book 5th Kuala Lumpur International Conference on Biomedical Engineering 2011 written by Hua-Nong Ting and published by Springer Science & Business Media. This book was released on 2011-06-17 with total page 892 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Biomed 2011 brought together academicians and practitioners in engineering and medicine in this ever progressing field. This volume presents the proceedings of this international conference which was hold in conjunction with the 8th Asian Pacific Conference on Medical and Biological Engineering (APCMBE 2011) on the 20th to the 23rd of June 2011 at Berjaya Times Square Hotel, Kuala Lumpur. The topics covered in the conference proceedings include: Artificial organs, bioengineering education, bionanotechnology, biosignal processing, bioinformatics, biomaterials, biomechanics, biomedical imaging, biomedical instrumentation, BioMEMS, clinical engineering, prosthetics.
Book Synopsis Cerebral Angiogenesis by : Richard Milner
Download or read book Cerebral Angiogenesis written by Richard Milner and published by Humana. This book was released on 2014-02-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a selection of the key techniques that are used in characterizing cerebral angiogenesis, Cerebral Angiogenesis: Methods and Protocols aims to define the cellular and molecular mechanisms underlying this important process. Divided into six parts, this detailed volume examines cerebral angiogenesis occurring in different scenarios, a variety of different models in which cerebral angiogenesis can be studied, methods to characterize and quantify angiogenic events as well as several different approaches to measure changes in cerebral blood flow, different approaches to investigate the role of specific candidate genes in cerebral angiogenesis, methods of therapeutically manipulating cerebral angiogenesis by gene delivery, and finally important approaches to examine cerebral angiogenic mechanisms in vitro. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their specific topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and decidedly practical, Cerebral Angiogenesis: Methods and Protocols should be a vital resource for all researchers, both those new to this field as well as those looking to use more specialized and sophisticated techniques to examine blood vessel growth in the brain.
Book Synopsis New Laser Speckle Methods for in Vivo Blood Flow Imaging and Monitoring by : Claudia Patricia Valdés Escobar
Download or read book New Laser Speckle Methods for in Vivo Blood Flow Imaging and Monitoring written by Claudia Patricia Valdés Escobar and published by . This book was released on 2014 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: Blood flow and its regulation are important for the health of tissues and its measurement has many applications in research and clinical environments. Optical techniques are often attractive for the non- or minimally-invasive, continuous and relatively inexpensive measurement of blood flow. This work contributes to the monitoring of blood flow in translational research with the construction of a multimodal device, based on laser speckle flowmetry and optical intrinsic signals, capable of measuring superficial microvascular cerebral blood flow, blood oxygenation and blood volume. This device was applied in animal models of ischemic stroke and is flexible to be modified and used for other purposes. In doing so, I have developed new experimental methods and image processing protocols that allowed us to perform longitudinal studies where the animal can be removed from the device several times. This device has also been used to elucidate the role of the Mannose-binding lectin protein in reperfusion injury after an ischemic stroke in animal models. This led to the main contribution of this work: the development of the speckle contrast optical spectroscopy and tomography, a new non-invasive, optical technique for deep blood flow measurement that paves the way for deeper and three dimensional imaging of blood flow. This new method was first developed from a theoretical perspective. Then it was validated in tissue simulating phantoms and demonstrated to be feasible in measurements on the human arm muscle. Overall, these contributions will allow the development of cost-effective, non-invasive tomographic methods for the measurement of blood flow even in humans.
Book Synopsis Imaging the Brain with Optical Methods by : Anna W. Roe
Download or read book Imaging the Brain with Optical Methods written by Anna W. Roe and published by Springer Science & Business Media. This book was released on 2009-11-11 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: Monitoring brain function with light in vivo has become a reality. The technology 33 of detecting and interpreting patterns of reflected light has reached a degree of 34 maturity that now permits high spatial and temporal resolution visualization at both 35 the systems and cellular levels. There now exist several optical imaging methodolo- 36 gies, based on either hemodynamic changes in nervous tissue or neurally induced 37 light scattering changes, that can be used to measure ongoing activity in the brain. 38 These include the techniques of intrinsic signal optical imaging, near-infrared optical 39 imaging, fast optical imaging based on scattered light, optical imaging with voltage 40 sensitive dyes, and two-photon imaging of hemodynamic signals. The purpose of 41 this volume is to capture some of the latest applications of these methodologies to 42 the study of cerebral cortical function. 43 This volume begins with an overview and history of optical imaging and its use 44 in the study of brain function. Several chapters are devoted to the method of intrin- 45 sic signal optical imaging, a method used to record the minute changes in optical 46 absorption due to hemodynamic changes that accompanies cortical activity. Since the 47 detected hemodynamic changes are highly localized, this method has excellent 48 spatial resolution (50–100 μm ), a resolution sufficient for visualization of fundamen- 49 tal modules of cerebral cortical function.
Book Synopsis Advanced Biophotonics by : Ruikang K. Wang
Download or read book Advanced Biophotonics written by Ruikang K. Wang and published by Taylor & Francis. This book was released on 2016-04-19 with total page 726 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite a number of books on biophotonics imaging for medical diagnostics and therapy, the field still lacks a comprehensive imaging book that describes state-of-the-art biophotonics imaging approaches intensively developed in recent years. Addressing this shortfall, Advanced Biophotonics: Tissue Optical Sectioning presents contemporary methods and
Book Synopsis Dynamic Laser Speckle and Applications by : Hector J. Rabal
Download or read book Dynamic Laser Speckle and Applications written by Hector J. Rabal and published by CRC Press. This book was released on 2018-10-03 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Speckle study constitutes a multidisciplinary area with inherent complexities. In order to conquer challenges such as the variability of samples and sensitive measurements, researchers must develop a theoretical and statistical understanding of both biological and non-biological metrology using dynamic speckle laser. Dynamic Laser Speckle and Applications discusses the main methodologies used to analyze biospeckle phenomena with a strong focus on experimentation. After establishing a theoretical background in both speckle and biospeckle, the book presents the main methodologies for statistical and image analysis. It then deals with the concept of frequency decomposition before moving on to a discussion of fuzzy methods to treat dynamic speckle data. The book dedicates two sections to applications, including agricultural approaches. Additional features include photo images of experiments and software to aid in easy start-up of dynamic speckle usage. A systematic approach to new dynamic speckle laser phenomena, this book provides the physical theory and statistical background needed to analyze images formed by laser illumination in biological and non-biological samples.
