Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Download Dynamic Fluorescence Guided Surgery full books in PDF, epub, and Kindle. Read online Dynamic Fluorescence Guided Surgery ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author : Maxime Slooter
Publisher :
ISBN 13 :
Total Pages : 244 pages
Book Rating : 4.:/5 (124 download)
Download or read book Dynamic Fluorescence-guided Surgery written by Maxime Slooter and published by . This book was released on 2021 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Robert Hoffman
Publisher : Academic Press
ISBN 13 : 0128126779
Total Pages : 296 pages
Book Rating : 4.1/5 (281 download)
Download or read book Strategies for Curative Fluorescence-Guided Surgery of Cancer written by Robert Hoffman and published by Academic Press. This book was released on 2020-05-27 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Strategies for Curative Fluorescence-Guided Surgery of Cancer is the first book to discuss how fluorescence-guided surgery can be successfully used during surgeries with several tumor types. FGS is one of the most exciting emerging modalities of surgery, especially cancer surgery, as it potentially allows the surgeon to visualize the actual margin of the tumor, thus greatly increasing the possibility of curative resection. The book discusses the applicability of FGS for several types of cancer, such as pancreatic cancer, liver metastasis, soft-tissue sarcoma, glioma, melanoma, and breast and lung cancer. This book is a valuable resource for cancer surgeons, cancer researchers and members of several other areas in the biomedical field who are interested in understanding this powerful technique. Presents an overview of fluorescence-guided surgery Explains general strategies for curative fluorescence-guided surgery and their applicability for each major tumor type Discusses the current and future achievements of FGS as a precise technique for cancer surgeries
Author : Sun Kuk Kwon
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (69 download)
Download or read book Dynamic Fluorescence Imaging with Molecular Agents for Cancer Detection written by Sun Kuk Kwon and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-invasive dynamic optical imaging of small animals requires the development of a novel fluorescence imaging modality. Herein, fluorescence imaging is demonstrated with sub-second camera integration times using agents specifically targeted to disease markers, enabling rapid detection of cancerous regions. The continuous-wave fluorescence imaging acquires data with an intensified or an electronmultiplying charge-coupled device. The work presented in this dissertation (i) assessed dose-dependent uptake using dynamic fluorescence imaging and pharmacokinetic (PK) models, (ii) evaluated disease marker availability in two different xenograft tumors, (iii) compared the impact of autofluorescence in fluorescence imaging of near-infrared (NIR) vs. red light excitable fluorescent contrast agents, (iv) demonstrated dual-wavelength fluorescence imaging of angiogenic vessels and lymphatics associated with a xenograft tumor model, and (v) examined dynamic multi-wavelength, whole-body fluorescence imaging with two different fluorescent contrast agents. PK analysis showed that the uptake of Cy5.5-c(KRGDf) in xenograft tumor regions linearly increased with doses of Cy5.5-c(KRGDf) up to 1.5 nmol/mouse. Above 1.5 nmol/mouse, the uptake did not increase with doses, suggesting receptor saturation. Target to background ratio (TBR) and PK analysis for two different tumor cell lines showed that while Kaposi's sarcoma (KS1767) exhibited early and rapid uptake of Cy5.5-c(KRGDf), human melanoma tumors (M21) had non-significant TBR differences and early uptake rates similar to the contralateral normal tissue regions. The differences may be due to different compartment location of the target. A comparison of fluorescence imaging with NIR vs. red light excitable fluorescent dyes demonstrates that NIR dyes are associated with less background signal, enabling rapid tumor detection. In contrast, animals injected with red light excitable fluorescent dyes showed high autofluorescence. Dual-wavelength fluorescence images were acquired using a targeted 111In- DTPA-K(IRDye800)-c(KRGDf) to selectively detect tumor angiogenesis and an untargeted Cy5.5 to image lymphatics. After acquiring the experimental data, fluorescence image-guided surgery was performed. Dynamic, multi-wavelength fluorescence imaging was accomplished using a liquid crystal tunable filter (LCTF). Excitation light was used for reflectance images with a LCTF transmitting a shorter wavelength than the peak in the excitation light spectrum. Therefore, images can be dynamically acquired alternating frame by frame between emission and excitation light, which should enable image-guided surgery.
Author : Steven Michael Blair
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (18 download)
Download or read book A Bio-inspired, Asynchronous, Time-domain, Multispectral Imaging System for High Dynamic Range Near-infrared Fluorescence Image-guided Surgery written by Steven Michael Blair and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Takeaki Ishizawa
Publisher : Springer Nature
ISBN 13 : 9811973725
Total Pages : 254 pages
Book Rating : 4.8/5 (119 download)
Download or read book Fluorescence-Guided Surgery written by Takeaki Ishizawa and published by Springer Nature. This book was released on 2023-12-05 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a practical guide of theranostics using intraoperative fluorescence imaging technology, as an all-out effort by the Japanese Society for Fluorescence Guided Surgery. It describes the various approaches the technique is being used such as vascular imaging, identification of lymphatic vessels by intratissue injection, lymph node imaging, and imaging for identification of anatomical structures. The book is organized into three major parts and the first one delivers the basics, introducing the use of the technology in clinical settings and initial setups. Next comes the description of clinical applications where chapters illustrate perfusion assessment, cancer localization, anatomy visualization, and lymph nodes/ducts mapping. Each chapter is devoted to the specific surgical field and disease areas, presenting images and videos of case studies. The last part presents some upcoming techniques for treatments. The Editor and the authors wish the ideas presented here will be hints to bridge the knowledge between surgeons and basic researchers for further innovation and practicality. It is important to stay up-to-date since intraoperative fluorescence imaging has been applied to clinical settings in various surgical fields and at the same time, novel techniques improving the efficacy of the technology have also been developed actively. Fluorescence-Guided Surgery – From Lab to Operation Room is recommended for surgeons, operating nurses, medical experts, basic researchers and, industry engineers worldwide beyond boundaries of specialties. Edited and written by experts of The Japanese Society for Fluorescence-Guided Surgery, those who are the founders of the technology, it describes the accurate development history and cutting-edge techniques based on the knowledge accumulated over the years.
Author : Nova Szoka
Publisher : Springer Nature
ISBN 13 : 3031406850
Total Pages : 515 pages
Book Rating : 4.0/5 (314 download)
Download or read book The SAGES Manual of Fluorescence-Guided Surgery written by Nova Szoka and published by Springer Nature. This book was released on 2023-11-27 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluorescence-guided surgery (FGS) is defined as a medical imaging technique that uses a fluorescent dye or a near-infrared emitting light source to identify anatomic structures during surgical procedures. In 2020 alone, over 1200 academic articles were published on the topic of fluorescence-guidance surgery, a sign that this modality is making significant inroads into surgical practice. The use of near-infrared imaging and FGS is a rapidly growing modality, allowing surgeons to see more intraoperatively, enhance surgical precision, and improve surgical decision-making and patient outcomes. This manual provides a comprehensive, state-of-the art review of this field and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in fluorescence-guided surgery, guiding patient management and stimulating investigative efforts. After initial chapters discussing the history of FGS and the current platforms and devices, it presents the most up-to-date data regarding the use of FGS in multiple surgical fields - colorectal, hepatic, endocrine, reconstructive, pediatric, among others - as well as in the treatment of specific conditions such as burns. Chapters are generously illustrated with full-color figures and intraoperative photographs, and selected chapters include video segments. Access to a comprehensive resource such as this is currently limited by the relatively new inroads that fluorescence-guided technology has made into surgery. The SAGES Manual of Fluorescence-Guided Surgery fills this gap in the literature.
Author : Mark Preul
Publisher : Frontiers Media SA
ISBN 13 : 2889668568
Total Pages : 368 pages
Book Rating : 4.8/5 (896 download)
Download or read book Applications of Fluorescence in Surgery and Interventional Diagnostics written by Mark Preul and published by Frontiers Media SA. This book was released on 2021-06-04 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Nan Cui
Publisher :
ISBN 13 :
Total Pages : 101 pages
Book Rating : 4.:/5 (15 download)
Download or read book Bio-inspired Multi-spectral Image Sensor and Augmented Reality Display for Near-infrared Fluorescence Image-guided Surgery written by Nan Cui and published by . This book was released on 2018 with total page 101 pages. Available in PDF, EPUB and Kindle. Book excerpt: Background: Cancer remains a major public health problem worldwide and poses a huge economic burden. Near-infrared (NIR) fluorescence image-guided surgery (IGS) utilizes molecular markers and imaging instruments to identify and locate tumors during surgical resection. Unfortunately, current state-of-the-art NIR fluorescence imaging systems are bulky, costly, and lack both fluorescence sensitivity under surgical illumination and co-registration accuracy between multimodal images. Additionally, the monitor-based display units are disruptive to the surgical workflow and are suboptimal at indicating the 3-dimensional position of labeled tumors. These major obstacles have prevented the wide acceptance of NIR fluorescence imaging as the standard of care for cancer surgery. The goal of this dissertation is to enhance cancer treatment by developing novel image sensors and presenting the information using holographic augmented reality (AR) display to the physician in intraoperative settings.Method: By mimicking the visual system of the Morpho butterfly, several single-chip, color-NIR fluorescence image sensors and systems were developed with CMOS technologies and pixelated interference filters. Using a holographic AR goggle platform, an NIR fluorescence IGS display system was developed. Optoelectronic evaluation was performed on the prototypes to evaluate the performance of each component, and small animal models and large animal models were used to verify the overall effectiveness of the integrated systems at cancer detection.Result: The single-chip bio-inspired multispectral logarithmic image sensor I developed has better main performance indicators than the state-of-the-art NIR fluorescence imaging instruments. The image sensors achieve up to 140 dB dynamic range. The sensitivity under surgical illumination achieves 6 x 108 [mu]V/(mW/cm2), which is up to 25 times higher. The signal-to-noise ratio is up to 56 dB, which is 11 dB greater. These enable high sensitivity fluorescence imaging under surgical illumination. The pixelated interference filters enable temperature-independent co-registration accuracy between multimodal images. Pre-clinical trials with small animal model demonstrate that the sensor can achieve up to 95% sensitivity and 94% specificity with tumor-targeted NIR molecular probes. The holographic AR goggle provides the physician with a non-disruptive 3-dimensional display in the clinical setup. This is the first display system that co-registers a virtual image with human eyes and allows video rate image transmission. The imaging system is tested in the veterinary science operating room on canine patients with naturally occurring cancers. In addition, a time domain pulse-width-modulation address-event-representation multispectral image sensor and a handheld multispectral camera prototype are developed.Conclusion: The major problems of current state-of-the-art NIR fluorescence imaging systems are successfully solved. Due to enhanced performance and user experience, the bio-inspired sensors and augmented reality display system will give medical care providers much needed technology to enable more accurate value-based healthcare.
Author : Fernando D. Dip
Publisher : Springer
ISBN 13 : 3319156780
Total Pages : 357 pages
Book Rating : 4.3/5 (191 download)
Download or read book Fluorescence Imaging for Surgeons written by Fernando D. Dip and published by Springer. This book was released on 2015-07-21 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text presents the experiences of leading researchers and surgeons with different fluorescence methods. Chapters range from basic science of fluorescence to current clinical applications and new horizons. The first few chapters describe the historical evolution and physical principles of fluorescence and provide the foundation for the reader to understand the current scope and limits of its use in surgery. The second section focuses on the clinical applications of intraoperative fluorescence imaging including subsections on fluorescence cholangiography, applications to hepatectomy, lymph node navigation, applications to GI tract and pelvic surgery and identification of cancer tissues. The third section focuses on new frontiers including fluorescence probes, imaging systems and applications to photodynamic therapy. Authored by leaders in the development of fluorescent methods worldwide, Fluorescence Imaging for Surgeons: Concepts and Applications will have an impact on numerous medical specialists including general surgeons, colorectal and minimally-invasive surgeons and surgical oncologists. Researchers will find the book to be an invaluable resource on the latest advances in the utilization of nanoparticles and fluorescent probes.
Author :
Publisher :
ISBN 13 : 9789064647666
Total Pages : 243 pages
Book Rating : 4.6/5 (476 download)
Download or read book Near-infrared Fluorescence-guided Surgery written by and published by . This book was released on 2014 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Davide Volpi
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (16 download)
Download or read book New Technologies for Fluorescence Image-guided Surgery written by Davide Volpi and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Hok Yan Cheng
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (17 download)
Download or read book Near Infrared Fluorescence Probes written by Hok Yan Cheng and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Raffaello Papadakis
Publisher : BoD – Books on Demand
ISBN 13 : 1803551836
Total Pages : 110 pages
Book Rating : 4.8/5 (35 download)
Download or read book Fluorescence Imaging - Recent Advances and Applications written by Raffaello Papadakis and published by BoD – Books on Demand. This book was released on 2023-11-22 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluorescence imaging is widely used in scientific fields ranging from biology to biomedicine and even materials science. The development of novel fluorescent labels and microscopy techniques has rendered fluorescence imaging profoundly useful. Particularly in bioscience, fluorescence imaging empowers the study of the intracellular distribution, dynamics, gene expression, protein–protein interactions, and protein localization and enables the identification and tracking of lysosomes. Fluorescence imaging is applicable in cells and tissues and is constantly gaining attention in medicine too, in the fields of fluorescence-guided surgery and robotic-assisted fluorescence surgery. Acknowledging all these important new trends, this book provides an overview of the recent advances and applications in fluorescence imaging.
Author : Caroline Filan
Publisher :
ISBN 13 :
Total Pages : 82 pages
Book Rating : 4.:/5 (14 download)
Download or read book Improving Tumor to Normal Tissue Contrast in Fluorescein-based Fluorescence Guided Surgery of Brain Tumors written by Caroline Filan and published by . This book was released on 2018 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Buhong Li
Publisher : John Wiley & Sons
ISBN 13 : 3527346562
Total Pages : 309 pages
Book Rating : 4.5/5 (273 download)
Download or read book Advances in Biomedical Photonics written by Buhong Li and published by John Wiley & Sons. This book was released on 2023-04-24 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: A state-of-the-art examination of biomedical photonic research, technologies, and applications In Biomedical Photonic Technologies, a team of distinguished researchers delivers a methodical inquiry and evaluation of the latest developments in the field of biomedical photonics, with a focus on novel technologies, including optical microscopy, optical coherence tomography, fluorescence imaging-guided surgery, photodynamic therapy dosimetry, and optical theranostic technologies. Each discussion of individual technologies includes examples of their contemporary application in areas like cancer therapy and drug delivery. Readers will discover the major research advancements in biomedical photonics from the last 20 years, ascertaining the basic principles of formation, development, and derivation of biomedical photonics phenomena at a variety of scales. Readers will also find: A thorough introduction to advanced wide-field fluorescent microscopy for biomedicine Comprehensive explorations of fluorescence resonance energy transfer and optical coherence tomography for structural and functional imaging Practical exploration of coherent Raman scattering microscopy and biomedical applications, as well as fluorescence image-guided surgery Complete analyses of enhanced photodynamic therapy, optogenetics, and optical theranostics employing gold nanoparticles Perfect for biophysicists and applied physicists, Biomedical Photonic Technologies will also benefit bioengineers and biotechnologists in academia and in industry.
Author : Suman Bikash Mondal
Publisher :
ISBN 13 :
Total Pages : 231 pages
Book Rating : 4.:/5 (954 download)
Download or read book Goggle Augmented Imaging and Navigation System for Fluorescence-guided Surgery written by Suman Bikash Mondal and published by . This book was released on 2016 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surgery remains the only curative option for most solid tumors. The standard-of-care usually involves tumor resection and sentinel lymph node biopsy for cancer staging. Surgeons rely on their vision and touch to distinguish healthy from cancer tissue during surgery, often leading to incomplete tumor resection that necessitates repeat surgery. Sentinel lymph node biopsy by conventional radioactive tracking exposes patients and caregivers to ionizing radiation, while blue dye tracking stains the tissue highlighting only superficial lymph nodes. Improper identification of sentinel lymph nodes may misdiagnose the stage of the cancer. Therefore there is a clinical need for accurate intraoperative tumor and sentinel lymph node visualization. Conventional imaging modalities such as x-ray computed tomography, positron emission tomography, magnetic resonance imaging, and ultrasound are excellent for preoperative cancer diagnosis and surgical planning. However, they are not suitable for intraoperative use, due to bulky complicated hardware, high cost, non-real-time imaging, severe restrictions to the surgical workflow and lack of sufficient resolution for tumor boundary assessment. This has propelled interest in fluorescence-guided surgery, due to availability of simple hardware that can achieve real-time, high resolution and sensitive imaging. Near-infrared fluorescence imaging is of particular interest due to low background absorbance by photoactive biomolecules, enabling thick tissue assessment. As a result several near-infrared fluorescence-guided surgery systems have been developed. However, they are limited by bulky hardware, disruptive information display and non-matched field of view to the user. To address these limitations we have developed a compact, light-weight and wearable goggle augmented imaging and navigation system (GAINS). It detects the near-infrared fluorescence from a tumor accumulated contrast agent, along with the normal color view and displays accurately aligned, color-fluorescence images via a head-mounted display worn by the surgeon, in real-time. GAINS is a platform technology and capable of very sensitive fluorescence detection. Image display options include both video see-through and optical see-through head-mounted displays for high-contrast image guidance as well as direct visual access to the surgical bed. Image capture options from large field of view camera as well high magnification handheld microscope, ensures macroscopic as well as microscopic assessment of the tumor bed. Aided by tumor targeted near-infrared contrast agents, GAINS guided complete tumor resection in subcutaneous, metastatic and spontaneous mouse models of cancer with high sensitivity and specificity, in real-time. Using a clinically-approved near-infrared contrast agent, GAINS provided real-time image guidance for accurate visualization of lymph nodes in a porcine model and sentinel lymph nodes in human breast cancer and melanoma patients with high sensitivity. This work has addressed issues that have limited clinical adoption of fluorescence-guided surgery and paved the way for research into developing this approach towards standard-of-care practice that can potentially improve surgical outcomes in cancer.
Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (14 download)
Download or read book Multicolor Fluorescence Guided Surgery for Head and Neck Cancer written by and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This project aims to take a novel, NIR nerve-specific fluorophore LGW05-754 and test its compatibility with a tumor-targeting affibody molecule, ABY-0296 that has been labeled with IRDye800CW. The overall goal is to show that these two molecules can be co-administered to show the nerves and tumor cells in real-time to better assist surgeons in a full resection while avoiding iatrogenic nerve damage.
