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Drug Resistance In Leukemia And Lymphoma
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Book Synopsis Drug Resistance in Leukemia and Lymphoma III by : G.J.L. Kaspers
Download or read book Drug Resistance in Leukemia and Lymphoma III written by G.J.L. Kaspers and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 613 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular drug resistance is a major limitation to the success of chemotherapy of leu kemia and lymphoma. The importance of this has now been recognized by both clinicians and scientists. It is of utmost importance to bridge the gap between laboratory and clinic in this field of research. This is the main purpose of the series of International Symposia on Drug Resistance in Leukemia and Lymphoma. These are held every three years in Am sterdam, The Netherlands, since 1992. This book contains the proceedings of the third of these meetings, organised in 1998. The book covers all important aspects of drug resistance in leukemia and lymphoma, both in the form of extensive reviews as in manuscripts describing original data. General mechanisms of resistance are discussed, including the drug resistance related proteins p glycoprotein, MRP (multi-drug resistance protein) and LRP (lung resistance protein), and the role of glutathione and glutathione-S-transferases. Moreover, more drug type-specific mechanisms of resistance are a topic, such as for glucocorticoids and antifolates. Much in formation is provided on apoptosis and its regulators, and on the results of cell culture drug resistance assays. Several papers focus on the modulation or circumvention of drug resistance.
Book Synopsis Drug Resistance in Leukemia & by : Gert-Jan L. Kaspers
Download or read book Drug Resistance in Leukemia & written by Gert-Jan L. Kaspers and published by CRC Press. This book was released on 1993-01-01 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last ten years have seen the publication of a vast amount of data regarding cellular resistance to drugs in cancer cells. Recent studies have demonstrated that drug resistance assays appear to be predictive of clinical response and suggest that clinicians should now be considering the potential applications of these assays in the treatment of patients with hematological neoplasms. This collection of papers from the International Symposium on the Clinical Value of Drug Resistance Assays in Leukemia and Lymphoma, Amsterdam, 1992, provides a state-of-the-art discussion on drug resistance assays and their role in the design and individualization of treatment protocols.
Book Synopsis Drug Resistance in Leukemia and Lymphoma by : G. J. Kaspers
Download or read book Drug Resistance in Leukemia and Lymphoma written by G. J. Kaspers and published by . This book was released on with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Drug Resistance in Leukemia and Lymphoma II by : R. Pieters
Download or read book Drug Resistance in Leukemia and Lymphoma II written by R. Pieters and published by Routledge. This book was released on 1997 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Resistance in Leukemia and Lymphoma contains material presented at the 2nd International Symposium in Drug Resistance in Leukemia and Lymphoma held at the Free University in Amsterdam in March 1995. In the last decade many studies have been performed in the field of drug resistance. This book reviews the current status and indicates future directions of such studies. Both laboratory scientists and clinicians have recognized the importance of drug resistance for the clinical outcome of patients with leukemia and lymphoma. New in vitro cell culture assays have been developed and the in vitro drug resistance measured with these assays has been shown to correlate with both short and long-term clinical response to chemotherapy. This book is, therefore, an essential guide for researchers and clinicians.
Book Synopsis Drug Resistance in Leukemia and Lymphoma by : G.J.L. Kaspers
Download or read book Drug Resistance in Leukemia and Lymphoma written by G.J.L. Kaspers and published by . This book was released on 1993-02-01 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis 4th International Symposium on Drug Resistance in Leukemia and Lymphoma Abstracts by :
Download or read book 4th International Symposium on Drug Resistance in Leukemia and Lymphoma Abstracts written by and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :International Symposium on Drug Resistance in Leukemia and Lymphoma Publisher : ISBN 13 : Total Pages :187 pages Book Rating :4.:/5 (488 download)
Book Synopsis Drug Resistance in Leukemia and Lymphoma by : International Symposium on Drug Resistance in Leukemia and Lymphoma
Download or read book Drug Resistance in Leukemia and Lymphoma written by International Symposium on Drug Resistance in Leukemia and Lymphoma and published by . This book was released on 1995 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Resistance to Targeted Therapies in Lymphomas by : Ana C. Xavier
Download or read book Resistance to Targeted Therapies in Lymphomas written by Ana C. Xavier and published by Springer Nature. This book was released on 2019-09-13 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past few decades, lymphoma patient outcomes have improved as a result of multidrug chemotherapy and radiation therapy, intensification of treatment, improvement in supportive care, and better imaging and staging systems. Even more recently, there has been tremendous progress in the understanding of cancer cell biology and its microenvironment which has resulted in the development of biologic agents, also called "target" therapies. These therapies are more specific in targeting cancer cells either directly or via enhancement of the immune system. Many clinical studies have focused on biological agents in combination with traditional chemotherapy with the goal of improved outcomes, or reduced acute long term complications that are associated with lymphoma therapy. This volume will review different classes of "target" drugs that have been developed, approved, or are under investigation in the field of lymphoma therapy. The discussion will not only be on the understanding of the mechanisms of action or clinical response of those agents, but will also help the reader to understand the nature of lymphoma biology in patients who relapse or are refractor after exposure to those drugs. Contributors will discuss what is currently known about mechanisms of tumor-related or host-related resistance, and how to overcome this resistance. This understanding is crucial given the dismal outcomes of patients with relapsed or refractory lymphomas. The book provides a unique opportunity to review and reflect on the recent successes and pitfalls of the modern lymphoma therapy era.
Book Synopsis Mechanisms of Drug Resistance in Cancer Therapy by : Mario Mandalà
Download or read book Mechanisms of Drug Resistance in Cancer Therapy written by Mario Mandalà and published by Springer. This book was released on 2019-01-10 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: A major objective of this book is to reveal unprecedented opportunities to understand and overcome drug resistance through the clinical assessment of rational therapeutic drug combinations and the use of predictive and prognostic biomarkers to enable patient stratification and tailor treatments. It offers to the readers an updated overview on the possible reasons of failure of new and promising therapeutic opportunities.
Book Synopsis Third International Symposium Drug Resistance in Leukemia and Lymphoma by :
Download or read book Third International Symposium Drug Resistance in Leukemia and Lymphoma written by and published by . This book was released on 1998 with total page 34 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis 2nd International Symposium Drug Resistance in Leukemia and Lymphoma, March 6-8, 1995, Amsterdam, The Netherlands by :
Download or read book 2nd International Symposium Drug Resistance in Leukemia and Lymphoma, March 6-8, 1995, Amsterdam, The Netherlands written by and published by . This book was released on 1995 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis 4th International Symposium on Drug Resistance in Leukemia and Lymphoma Abstracts, 7-10 March 2001, University Hospital, Amsterdam, the Netherlands by :
Download or read book 4th International Symposium on Drug Resistance in Leukemia and Lymphoma Abstracts, 7-10 March 2001, University Hospital, Amsterdam, the Netherlands written by and published by . This book was released on 2001 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Drug Resistance in the Treatment of Cancer by : Herbert M. Pinedo
Download or read book Drug Resistance in the Treatment of Cancer written by Herbert M. Pinedo and published by Cambridge University Press. This book was released on 1998-03-26 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: International authorities review the mechanisms and clinical implications of drug resistance in cancer.
Book Synopsis Drug Resistance As a Biochemical Target in Cancer Chemotherapy by : Makoto Ogawa
Download or read book Drug Resistance As a Biochemical Target in Cancer Chemotherapy written by Makoto Ogawa and published by Academic Press. This book was released on 1991-11-12 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Resistance as a Biochemical Target in Cancer Chemotherapy covers the proceedings of the 13th Bristol-Myers Squibb Symposium on Cancer Research, entitled ""Drug Resistance as a Biochemical Target in Cancer Chemotherapy"", hosted by the Japanese Foundation for Cancer Research in Tokyo. This book is divided into four parts encompassing 18 chapters that summarize the results of both preclinical and clinical research on circumvention of drug resistance. The first two parts discuss the genetic aspects of multidrug resistance and the proteins involved in drug resistance. These parts also examine the structure, function, and expression of P-glycoproteins, with an emphasis on the role of these proteins as targets for cancer chemotherapy. The third part describes the methods for detection of P-glycoprotein and its antagonists to counter clinical drug resistance. This topic is followed by a discussion on the interactions among steroid hormones, steroid hormone receptors, antiandrogens, biological-response modifiers, and cytotoxic drugs in human breast cancer. The concluding part explores the clinical applications of chemosensitizers in cancer therapy. This part also considers the alternative clinical approaches against drug failure, including non-crosss-resistant therapies, autologous bone marrow transplantation, dose-intensive therapy, and high-dose chemotherapy. Biomedical scientists and researchers and clinicians will find this book invaluable.
Download or read book Leukemia and Lymphoma written by and published by . This book was released on 2001 with total page 37 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Childhood Acute Lymphoblastic Leukemia by : Ajay Vora
Download or read book Childhood Acute Lymphoblastic Leukemia written by Ajay Vora and published by Springer. This book was released on 2017-04-21 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.
Book Synopsis Molecular and Clinical Advances in Anticancer Drug Resistance by : Robert F. Ozols
Download or read book Molecular and Clinical Advances in Anticancer Drug Resistance written by Robert F. Ozols and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: The importance of drug resistance in cancer chemotherapy cannot be over stated. The 500,000 patients who die every year from cancer in the United States have, in most cases, been treated with chemotherapy. Many of these patients responded initially to chemotherapy, but death resulted from the development of drug-resistant tumors. In the first volume in the series. Drug Resistance in Chemotherapy the results of comprehensive laboratory studies aimed at understanding the mechanisms for resistance to individual agents and to the development of broad cross-resistance were described. In the past 2 years there has been substantial progress in understanding the molecular biology associated with these mechanisms of drug resistance. For the first time we are starting to understand which mechanisms are playing an im portant role in human tumors, and even more importantly, clinical trials have recently been initiated in an effort to reverse specific forms of drug resistance. The purpose of this volume is to describe the new advances, both at the molecular level and in the clinic regarding mechanisms of drug resistance and potential ways this resistance can be circumvented. This volume is focused upon mechanisms of resistance associated with two major classes of anticancer drugs: alkylating agents (including cisplatin) and the natural products (e. g. , adriamycin and vinblastine). The first section of the book describes new insights into the genetic mechanisms associated with drug resistance.
