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Author : Gerald Gartlehner
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (847 download)
Download or read book Drug Class Review on Second Generation Antidepressants written by Gerald Gartlehner and published by . This book was released on 2006 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Gerald Gartlehner
Publisher :
ISBN 13 :
Total Pages : 534 pages
Book Rating : 4.:/5 (847 download)
Download or read book Drug Class Review on Second Generation Antidepressants written by Gerald Gartlehner and published by . This book was released on 2006 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Gerald Gartlehner
Publisher :
ISBN 13 :
Total Pages : 27 pages
Book Rating : 4.:/5 (811 download)
Download or read book Drug Class Review on Second-generation Antidepressants written by Gerald Gartlehner and published by . This book was released on 2004 with total page 27 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Gerald Gartlehner
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (847 download)
Download or read book Drug Class Review written by Gerald Gartlehner and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drug Class Review written by and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drug Class Review: Second Generation Antidepressants: Final Report Update 4 written by and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drug Class Review written by and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Axis I psychiatric disorders such as depressive disorder, anxiety disorder, adjustment disorder, and premenstrual disorders are serious disabling illnesses. Newer treatments for these disorders include selective serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors, and other second-generation drugs. The purpose of this review is to evaluate the comparative evidence on benefits and harms of these medications in people with depression to help policymakers and clinicians make informed choices about the use of selective serotonin reuptake inhibitors and newer antidepressants.
Author :
Publisher :
ISBN 13 :
Total Pages : 190 pages
Book Rating : 4.:/5 (752 download)
Download or read book Drug Class Review written by and published by . This book was released on 2011 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: PURPOSE: We compared the effectiveness and harms of second-generation antidepressants in the treatment of major depressive disorder (MDD), dysthymia, subsyndromal depression, seasonal affective disorder, generalized anxiety disorder, obsessive compulsive disorder, panic disorder, post-traumatic stress disorder, social anxiety disorder, and premenstrual dysphoric disorder. DATA SOURCES: We searched PubMed, Embase, PsycINFO, the Cochrane Library, and the International Pharmaceutical Abstracts until September 2010. For additional data we also hand searched reference lists, US Food and Drug Administration medical and statistical reviews and dossiers submitted by pharmaceutical companies. REVIEW METHODS: Study selection, data abstraction, validity assessment, grading the strength of the evidence, and data synthesis were all carried out according to standard Drug Effectiveness Review Project review methods. RESULTS AND CONCLUSIONS: Overall, we found no substantial differences in comparative efficacy and effectiveness of second-generation antidepressants for the treatment of depressive or anxiety disorders. Differences exist in the incidence of specific adverse events and the onset of action. Except for MDD, the evidence is limited to few direct comparisons for most indications. No head-to-head evidence is available for MDD in pediatric populations, dysthymia, subsyndromal depression, seasonal affective disorder, and premenstrual dysphoric disorder.
Download or read book Drug Class Review written by and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Axis I psychiatric disorders such as depressive disorder, anxiety disorder, adjustment disorder, and premenstrual disorders are serious disabling illnesses. Newer treatments for these disorders include selective serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors, and other second-generation drugs. The purpose of this review is to evaluate the comparative evidence on benefits and harms of these medications in people with depression to help policymakers and clinicians make informed choices about the use of selective serotonin reuptake inhibitors and newer antidepressants.
Author : Oregon Health Sciences University. Evidence-based Practice Center
Publisher :
ISBN 13 :
Total Pages : 3 pages
Book Rating : 4.:/5 (811 download)
Download or read book Second Generation Antidepressants written by Oregon Health Sciences University. Evidence-based Practice Center and published by . This book was released on 2005 with total page 3 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Canadian Agency for Drugs and Technology in Health
Publisher :
ISBN 13 :
Total Pages : 56 pages
Book Rating : 4.:/5 (921 download)
Download or read book Second Generation Antidepressants for Pediatric Patients with Major Depressive Disorder and Anxiety Disorder written by Canadian Agency for Drugs and Technology in Health and published by . This book was released on 2015 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Shalak S. Gunjal
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (14 download)
Download or read book Effects of Second-generation Antidepressants on Cognitive Functions written by Shalak S. Gunjal and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Objectives: Second-generation antidepressants are currently the first-line of treatment for depression and are widely used. The aim of this study was to determine the effects on cognition by second-generation antidepressants through a systematic review and meta-analysis of recent scientific literature. Methods: Electronic search in Medline, PubMed, PsycINFO, CINAHL, and Embase for English-language abstracts from 1980 through May 2014, supplemented with a manual search from reference lists of relevant review articles was carried out to identify eligible studies. Studies were included if they met the following selection criteria: Population: adults (age≥18) with diagnosis of depression; Intervention: second-generation antidepressants (SGAD) marketed in the United States based on the American Hospital Formulary Service (AHFS) 2014 drug classification; Comparator: placebo or second-generation antidepressants; Outcomes: attention, processing speed, executive function and memory; and Study Design: Randomized Controlled Trials (RCTs) and observational studies. Data management and screening procedures were carried out by using RefWorks (ProQuest) and Microsoft Excel workbook. Data extraction and synthesis was conducted by the primary author using a data extraction form specially designed for this study. Studies were sorted according to type of neurocognitive test used and a minimum of 3 studies per test per study design type was required in order to conduct further systematic review and meta-analysis. The methodological quality of the included studies was assessed by Cochrane risk of bias tool. A random effects model was used to estimate the pooled effects of antidepressant use on cognitive functioning. Heterogeneity was assessed by I2 testing. Egger's regression test and Trim and Fill method were used to examine for the presence of potential publication bias along with analysis of funnel plots. All analyses were performed using Comprehensive Meta-Analysis, v2.2 (Biostat, Englewood, NJ) Results: A total of 4,274 abstracts were screened; 342 were retrieved for a full-text review. Of the reviewed full text articles, 17 (13 RCTs and 4 Observational) studies involving a total of 2,437 depressed patients) met the inclusion criteria. Studies were of optimum quality as assessed by the Risk of bias tool. Out of the 43 unique neurocognitive test; Mini-Mental State Exam (MMSE), Stroop Color Word test (SCWT), Choice Reaction Time Task (CRT) and Digit Symbol Substitution Test (DSST) were the most common tests used across the studies which fulfilled the selection criteria (minimum of 3 studies per test per study design type) for further systematic review and meta-analysis. Six studies were found eligible for inclusion into the meta-analysis for MMSE and the results were not significant with (SMD=0.126; 95%CI -0.046, 0.298; p > 0.05). There was no heterogeneity (I2=0%, p= 0.975) and publication bias (Egger’s regression intercept (B0= 0.29359; 95%CI -1.04627, 1.63344; p > 0.05). Insufficient and inconsistent reporting of results involving SCWT, CRT and DSST prevented meta-analysis of study findings; hence, a systematic review was performed. Four studies were found eligible for SCWT out of which two studies with positive findings which had a combined sample size of almost 13 times that of the non-significant study, which suggests improvement in executive function with second-generation antidepressants compared to placebo. The systematic review conducted on four studies which had used CRT suggests positive results with one study with sample size 30 times that of the non-significant study showing improvements in attention and processing speed in depressed patients treated with low dose second-generation antidepressants. The systematic review conducted on three studies which had used Digit Symbol Substitution Test suggested mixed evidence with two studies showing significant improvement in attention and processing speed with SMs compared to placebo while one study suggesting otherwise with SNRIs. Conclusions: Meta-analysis of studies using MMSE suggests that SGADs do not affect global cognition but might affect other specific domains. Systematic reviews on studies involving SCWT, CRT and DSST suggest variable evidence regarding the effects of second-generation antidepressants on specific domains of cognition. However, there were indications of possible improvements in executive function, attention and processing speed with SGADs compared with placebo. Further studies involving reliable and widely used neurocognitive tests reporting necessary statistical detail for computing effect sizes are needed to estimate and quantify the effects of second-generation antidepressants on cognition.
Author : Graziano Pinna
Publisher :
ISBN 13 : 9781634820769
Total Pages : 412 pages
Book Rating : 4.8/5 (27 download)
Download or read book Fluoxetine written by Graziano Pinna and published by . This book was released on 2015-04-01 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluoxetine, best known by the trade name Prozac®, unlike other psychotropic drugs whose effects were serendipitously stumbled upon, was the first developed for a precise mechanism of action, that is, the ability to selectively inhibit serotonin reuptake, based upon the theory that increasing the availability of serotonin would treat major depression. Once approved by the FDA in 1987, fluoxetine quickly became the most prescribed psychotropic drug worldwide and its success in improving mood disorders has triggered the development of a large number of congener molecules, commonly known as SSRIs after their purported mechanism of action. However, a quarter of a century after its development, the idea that fluoxetine asserts its positive behavioral effect through inhibition of serotonergic reuptake is not firmly established. This book reviews several preclinical and clinical reports suggesting that the pharmacological effects of fluoxetine may be mediated by means other than the regulation of serotonin, including the regulation of gene expression, modifying epigenetic mechanisms as well as modifying microRNAs. One of the most prominent mechanisms for the therapeutic relevance of fluoxetine relates to influencing neuroplasticity by enhancing neurotropic factors, including BDNF signaling and altering adult neurogenesis. The ability of fluoxetine to rapidly increase neurosteroid levels accounts for the fast anxiolytic effects of this drug. Fluoxetine action at sigma-1 receptor or modulating glutamatergic neurotransmission as well as the combination of fluoxetine with other psychotropic drugs is discussed in relation to its therapeutic effects. While fluoxetine was primarily prescribed as an antidepressant, this drug currently represents a treatment of choice for a broad spectrum of psychiatric disorders, including post-traumatic stress disorder and a range of anxiety disorders. This drug even possesses analgesic actions and is a valuable therapy for stroke. This book also highlights emerging evidence on the gender-specific effects of fluoxetine, its potential adverse features, including its addiction liability in combination with psychostimulants, and the impact of perinatal fluoxetine exposure.
Author : Peter Riederer
Publisher : Springer Nature
ISBN 13 : 303062059X
Total Pages : 4652 pages
Book Rating : 4.0/5 (36 download)
Download or read book NeuroPsychopharmacotherapy written by Peter Riederer and published by Springer Nature. This book was released on 2022-11-04 with total page 4652 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a reference guide describing the current status of medication in all major psychiatric and neurological indications, together with comparisons of pharmacological treatment strategies in clinical settings in Europe, USA, Japan and China. In addition, it highlights herbal medicine as used in China and Japan, as well as complementary medicine and nutritional aspects. This novel approach offers international readers a global approach in a single dedicated publication and is also a valuable resource for anyone interested in comparing treatments for psychiatric disorders in three different cultural areas. There are three volumes devoted to Basic Principles and General Aspects, offering a general overview of psychopharmacotherapy (Vol. 1); Classes, Drugs and Special Aspects covering the role of psychotropic drugs in the field of psychiatry and neurology (Vol. 2) and Applied Psychopharmacotherapy focusing on applied psychopharmacotherapy (Vol. 3). These books are invaluable to psychiatrists, neurologists, neuroscientists, medical practitioners and clinical psychologists.
Author : Bernhard Baune
Publisher : Academic Press
ISBN 13 : 0128131772
Total Pages : 604 pages
Book Rating : 4.1/5 (281 download)
Download or read book Personalized Psychiatry written by Bernhard Baune and published by Academic Press. This book was released on 2019-10-16 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt: Personalized Psychiatry presents the first book to explore this novel field of biological psychiatry that covers both basic science research and its translational applications. The book conceptualizes personalized psychiatry and provides state-of-the-art knowledge on biological and neuroscience methodologies, all while integrating clinical phenomenology relevant to personalized psychiatry and discussing important principles and potential models. It is essential reading for advanced students and neuroscience and psychiatry researchers who are investigating the prevention and treatment of mental disorders. Combines neurobiology with basic science methodologies in genomics, epigenomics and transcriptomics Demonstrates how the statistical modeling of interacting biological and clinical information could transform the future of psychiatry Addresses fundamental questions and requirements for personalized psychiatry from a basic research and translational perspective
Author : Somnath Mookherjee
Publisher : Springer Nature
ISBN 13 : 3030348148
Total Pages : 347 pages
Book Rating : 4.0/5 (33 download)
Download or read book Chalk Talks in Internal Medicine written by Somnath Mookherjee and published by Springer Nature. This book was released on 2020-09-30 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides teaching scripts for medical educators in internal medicine and coaches them in creating their own teaching scripts. Every year, thousands of attending internists are asked to train the next generation of physicians to master a growing body of knowledge. Formal teaching time has become increasingly limited due to rising clinical workload, medical documentation requirements, duty hour restrictions, and other time pressures. In addition, today’s physicians-in-training expect teaching sessions that deliver focused, evidence-based content that is integrated into clinical workflow. In keeping with both time pressures and trainee expectations, academic internists must be prepared to effectively and efficiently teach important diagnostic and management concepts. A teaching script is a methodical and structured plan that aids in effective teaching. The teaching scripts in this book anticipate learners’ misconceptions, highlight a limited number of teaching points, provide evidence to support the teaching points, use strategies to engage the learners, and provide a cognitive scaffold for teaching the topic that the teacher can refine over time. All divisions of internal medicine (e.g. cardiology, rheumatology, and gastroenterology) are covered and a section on undifferentiated symptom-based presentations (e.g. fatigue, fever, and unintentional weight loss) is included. This book provides well-constructed teaching scripts for commonly encountered clinical scenarios, is authored by experienced academic internists and allows the reader to either implement them directly or modify them for their own use. Each teaching script is designed to be taught in 10-15 minutes, but can be easily adjusted by the reader for longer or shorter talks. Teaching Scripts in Internal Medicine is an ideal tool for internal medicine attending physicians and trainees, as well as physician’s assistants, nurse practitioners, and all others who teach and learn internal medicine.
Author : Teri J. Barkoukis
Publisher : Elsevier Health Sciences
ISBN 13 : 1455723304
Total Pages : 817 pages
Book Rating : 4.4/5 (557 download)
Download or read book Therapy in Sleep Medicine E-Book written by Teri J. Barkoukis and published by Elsevier Health Sciences. This book was released on 2011-10-31 with total page 817 pages. Available in PDF, EPUB and Kindle. Book excerpt: Therapy in Sleep Medicine, by Drs. Teri J. Barkoukis, Jean K. Matheson, Richard Ferber, and Karl Doghrami, provides the clinically focused coverage you need for rapid diagnosis and effective treatment of sleep disorders. A multidisciplinary team of leading authorities presents the latest on sleep breathing disorders (including obstructive sleep apnea), neuropharmacology, parasomnias, neurologic disorders affecting sleep, sleep therapy for women, sleep therapy in geriatric patients, controversies, and future trends in therapy in a highly illustrated, easy-to-follow format. Diagnose and treat patients effectively with complete coverage of the full range of sleep disorders. Find diagnostic and treatment information quickly and easily thanks to a highly illustrated, easy-to-read format that highlights key details. Stay current on discussions of hot topics, including sleep breathing disorders (including obstructive sleep apnea), neuropharmacology, parasomnias, neurologic disorders affecting sleep, sleep therapy for women, sleep therapy in geriatric patients, controversies, and future trends in therapy. Tap into the expertise of a multidisciplinary team of leading authorities for well-rounded, trusted guidance.
