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Author : Andrew Lambert DeMond
Publisher :
ISBN 13 :
Total Pages : 134 pages
Book Rating : 4.:/5 (34 download)
Download or read book Driving Forces in the Immunological Synapse written by Andrew Lambert DeMond and published by . This book was released on 2007 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Pedro Roda-Navarro
Publisher : Frontiers Media SA
ISBN 13 : 288945133X
Total Pages : 122 pages
Book Rating : 4.8/5 (894 download)
Download or read book Molecular Dynamics at the Immunological Synapse written by Pedro Roda-Navarro and published by Frontiers Media SA. This book was released on 2017-03-21 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: The immunological synapse (IS) is a specialised cell-cell adhesion that mediates antigen acquisition and regulates the activation of lymphocytes. Initial studies of the IS showed a structure composed of stable supra-molecular activation clusters (SMAC) organised during the interaction of helper T lymphocytes with B lymphocytes, working as antigen presenting cells. A central SMAC of coalesced T cell receptors (TCRs) and a peripheral SMAC for cell-cell adhesion were observed. IS with similar structure was later described during antigen acquisition by B cells and during the interaction of NK cells with target and healthy cells. More recent research developed with microscopy systems that improve the spatial and temporal resolution has showed the complex molecular dynamics at the IS that governs lymphocyte activation. Currently, the IS is seen as a three-dimensional structure where signalling networks for lymphocyte activation and endosomal and cytoskeleton machinery are polarised. A view has emerged in which dynamic microclusters of signalling complexes are composed of molecular components attached to the plasma membrane and other components conveyed on sub-synaptic vesicles transported to the membrane by cytoskeletal fibers and motor proteins. Much information is nonetheless missing about how the dynamics of the endosomal compartment, the cytoskeleton, and signalling complexes are reciprocally regulated to achieve the function of lymphocytes. Experimental evidence also suggests that the environment surrounding lymphocytes exposed to different antigenic challenge regulates IS assembly and functional output, making an even more complex scenario still far from being completely understood. Also, although some signalling molecular components for lymphocyte activation have been identified and thoroughly studied, the function of other molecules has not been yet uncovered or deeply characterised. This research topic aims to provide the reader with the latest information about the molecular dynamics governing lymphocyte activation. These molecular dynamics dictate cell decisions. Thus, we expect that understanding them will provide new avenues for cell manipulation in therapies to treat different immune-related pathologies.
Author : Cosima T. Baldari
Publisher : Humana
ISBN 13 : 9781071631379
Total Pages : 0 pages
Book Rating : 4.6/5 (313 download)
Download or read book The Immune Synapse written by Cosima T. Baldari and published by Humana. This book was released on 2024-04-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new collection features the most up-to-date essential protocols that are currently being used to study the immune synapse. Beginning with methods for making biophysical measurements, the volume continues by covering the cell biology of synapses, methods for advanced substrate engineering, mechanobiology topics, new technologies to describe and manipulate synaptic components, as well as methods related to sites of action and immunotherapy. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and fully updated, The Immune Synapse: Methods and Protocols, Second Edition serves as an ideal practical guide for researchers working in this dynamic field. Chapters 5, 11,18, 27, 30, and 32 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Author : Martin Flajnik
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1975142527
Total Pages : 3597 pages
Book Rating : 4.9/5 (751 download)
Download or read book Paul's Fundamental Immunology written by Martin Flajnik and published by Lippincott Williams & Wilkins. This book was released on 2022-07-19 with total page 3597 pages. Available in PDF, EPUB and Kindle. Book excerpt: Selected as a Doody's Core Title for 2022! Defining the field of immunology for 40 years, Paul’s Fundamental Immunology continues to provide detailed, authoritative, up-to-date information that uniquely bridges the gap between basic immunology and the disease process. The fully revised 8th edition maintains the excellence established by Dr. William E. Paul, who passed away in 2015, and is now under new editorial leadership of Drs. Martin F. Flajnik, Nevil J. Singh, and Steven M. Holland. It’s an ideal reference and gold standard text for graduate students, post-doctoral fellows, basic and clinical immunologists, microbiologists and infectious disease physicians, and any physician treating diseases in which immunologic mechanisms play a role.
Author : Sung-Joo Eugene Lee
Publisher :
ISBN 13 :
Total Pages : 184 pages
Book Rating : 4.:/5 (34 download)
Download or read book The Immunological Synapse written by Sung-Joo Eugene Lee and published by . This book was released on 2003 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ann Arvin
Publisher : Cambridge University Press
ISBN 13 : 1139461648
Total Pages : 1325 pages
Book Rating : 4.1/5 (394 download)
Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Author : Marita Bosticardo
Publisher : Frontiers Media SA
ISBN 13 : 2889714497
Total Pages : 177 pages
Book Rating : 4.8/5 (897 download)
Download or read book Thymic Epithelial Cells: New Insights into the Essential Driving Force of T-Cell Differentiation written by Marita Bosticardo and published by Frontiers Media SA. This book was released on 2021-09-30 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Klaus Ebnet
Publisher : Springer
ISBN 13 : 3319144634
Total Pages : 396 pages
Book Rating : 4.3/5 (191 download)
Download or read book Cell Polarity 1 written by Klaus Ebnet and published by Springer. This book was released on 2015-03-04 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work provides a state-of-the art overview on the most relevant aspects of cell polarity. Volume 1 addresses cell polarity and cell migration (front-rear polarity), cell polarity and barrier formation (apico-basal polarity) and neuronal polarity. It particularly focuses on cell polarity at the molecular level and the underlying molecular mechanisms. It also elaborates the common principles and mechanisms that regulate cellular polarization in different cell types and contexts. Both volumes are intended for professors, group leaders and researchers in cell biology as well as medical professionals in the fields of anatomy, cell biology, physiology, pathology and tumor biology.
Author : Jonathan Soboloff
Publisher : CRC Press
ISBN 13 : 149870509X
Total Pages : 258 pages
Book Rating : 4.4/5 (987 download)
Download or read book Signaling Mechanisms Regulating T Cell Diversity and Function written by Jonathan Soboloff and published by CRC Press. This book was released on 2017-03-27 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.
Author : Chaim Putterman
Publisher : Academic Press
ISBN 13 : 0128033703
Total Pages : 192 pages
Book Rating : 4.1/5 (28 download)
Download or read book Structural Biology in Immunology written by Chaim Putterman and published by Academic Press. This book was released on 2018-05-14 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Structural Biology in Immunology, Structure/Function of Novel Molecules of Immunologic Importance delivers important information on the structure and functional relationships in novel molecules of immunologic interest. Due to an increasingly sophisticated understanding of the immune system, the approach to the treatment of many immune-mediated diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease has been dramatically altered. Furthermore, there is an increasing awareness of the critical role of the immune system in cancer biology. The improved central structure function relationships presented in this book will further enhance our ability to understand what defects in normal individuals can lead to disease. - Describes novel/recently discovered immunomodulatory proteins, including antibodies and co-stimulatory or co-inhibitory molecules - Emphasizes new biologic and small molecule drug design through the exploration of structure-function relationship - Features a collaborative editorial effort, involving clinical immunologists and structural biologists - Provides useful and practical insights on developing the necessary links between basic science and clinical therapy in immunology - Gives interested parties a bridge to learn about computer modeling and structure based design principles
Author : Barbara A. Veskler
Publisher : Nova Publishers
ISBN 13 : 9781594543807
Total Pages : 274 pages
Book Rating : 4.5/5 (438 download)
Download or read book Progress in Immunology Research written by Barbara A. Veskler and published by Nova Publishers. This book was released on 2005 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunology is the study of the body's protection from foreign macromolecules or invading organisms and the responses to them. These invaders include viruses, bacteria, protozoa or even larger parasites. In addition, immune responses are developed against our own proteins (and other molecules) in autoimmunity and against our own aberrant cells in tumour immunity. The first line of defence against foreign organisms are barrier tissues such as the skin that stop the entry of organism into our bodies. A second line of defence is the specific or adaptive immune system which may take days to respond to a primary invasion (that is infection by an organism that has not hitherto been seen). This new book brings together new research from around the globe dealing with this extremely important subject.
Author : Mark C. Leake
Publisher : Springer
ISBN 13 : 3319321897
Total Pages : 364 pages
Book Rating : 4.3/5 (193 download)
Download or read book Biophysics of Infection written by Mark C. Leake and published by Springer. This book was released on 2016-05-18 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes modern biophysical techniques that enable us to understand and examine dynamic processes of infection at the molecular level. Cutting-edge research articles, laboratory protocols, case studies and up-to-date reviews cover topics such as single-molecule observation of DNA replication repair pathways in E. coli; evolution of drug resistance in bacteria; restriction enzymes as barriers to horizontal gene transfer in Staphylococcus aureus; infectious and bacterial pathogen biofilms; killing infectious pathogens through DNA damage; bacterial surfaces in host-pathogen interactions; bacterial gene regulation by riboswitches; transcription regulation in enterobacterial pathogens; the bacterial flagellar motor; initial surface colonization by bacteria; Salmonella Typhi host restrictions; as well as monitoring proton motive force in bacteria; microbial pathogens using digital holography; mathematical modelling of microbial pathogen motility; neutron reflectivity in studying bacterial membranes; force spectroscopy in studying infection and 4D multi-photon imaging to investigate immune responses. The focus is on the development and application of complex techniques and protocols at the interface of life sciences and physics, which increase the physiological relevance of biophysical investigations.
Author : Luis Graca
Publisher : Springer Science & Business Media
ISBN 13 : 3764382961
Total Pages : 201 pages
Book Rating : 4.7/5 (643 download)
Download or read book The Immune Synapse as a Novel Target for Therapy written by Luis Graca and published by Springer Science & Business Media. This book was released on 2007-12-18 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume gives an overview on the progress in immune synapse research, from basic science to clinical trials, and the major mechanisms involved. It discusses how interfering with T cell activation may lead to immune tolerance, immune modulation, and the recruitment of regulatory T cells; the role of monoclonal antibodies in tolerance induction; and mechanisms maintaining dominant tolerance.
Author :
Publisher :
ISBN 13 :
Total Pages : 850 pages
Book Rating : 4.F/5 ( download)
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2008 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Boryana Nikolaeva Manz
Publisher :
ISBN 13 :
Total Pages : 198 pages
Book Rating : 4.:/5 (35 download)
Download or read book Spatial Organization in the Immune Synapse written by Boryana Nikolaeva Manz and published by . This book was released on 2009 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Takeshi Watanabe
Publisher : Springer
ISBN 13 : 4431560270
Total Pages : 210 pages
Book Rating : 4.4/5 (315 download)
Download or read book Synthetic Immunology written by Takeshi Watanabe and published by Springer. This book was released on 2016-06-09 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the emerging studies of synthetic immunology, including the development and regeneration of immune cells, immune organ development and artificial regeneration, and the synthetic approach towards understanding human immune system. Immunology has developed rapidly over the last 50 years through the incorporation of new methods and concepts in cell and molecular biology, genetics, genomics and proteomics. This progress is the result of works by many excellent researchers all over the world. Currently, immunological research has accumulated detailed knowledge on basic mechanisms of immunity and is in the process to change medical practices. Yet, due to the enormous complexity of the immune system, many aspects on the regulation and function of this system remain unknown. Synthetic biology uses gain-of-function rather than loss-of-function approaches. The goals of synthetic biology can be described in a simple phrase “rebuild, alter, and understand,” namely, to rebuild minimal functional systems using well-defined parts from nature and then to perturb the system to understand its working principles. Given the richness of accumulated knowledge in molecular and cellular mechanisms of the immune system, we now begin adapting the concepts of synthetic biology to immunology. An immune response is a spatiotemporal phenomenon occurring at a given time and at a specialized place in the body. One goal of synthetic immunology is to reconstruct artificial microenvironments for better understanding of an immune response. We hope this yet-to-be-experimental approach of synthetic immunology and the compilation of this book will aid our further understanding of the immune system and future devising the tools to manipulate the immune system for therapy and prevention of the diseases.
