Down Syndrome From Understanding The Neurobiology To Therapy

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Down Syndrome: From Understanding the Neurobiology to Therapy

Author : Mara Dierssen
Publisher : Elsevier
ISBN 13 : 044454299X
Total Pages : 273 pages
Book Rating : 4.4/5 (445 download)

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Book Synopsis Down Syndrome: From Understanding the Neurobiology to Therapy by : Mara Dierssen

Download or read book Down Syndrome: From Understanding the Neurobiology to Therapy written by Mara Dierssen and published by Elsevier. This book was released on 2012-06-19 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Down syndrome (DS) is the most common example of neurogenetic aneuploid disorder leading to mental retardation. In most cases, DS results from an extra copy of chromosome 21 (HSA21) producing deregulated gene expression in brain that gives raise to subnormal intellectual functioning. The topic of this volume is of broad interest for the neuroscience community, because it tackles the concept of neurogenomics, that is, how the genome as a whole contributes to a neurodevelopmental cognitive disorders, such as DS, and thus to the development, structure and function of the nervous system. This volume of Progress in Brain Research discusses comparative genomics, gene expression atlases of the brain, network genetics, engineered mouse models and applications to human and mouse behavioral and cognitive phenotypes. It brings together scientists of diverse backgrounds, by facilitating the integration of research directed at different levels of biological organization, and by highlighting translational research and the application of the existing scientific knowledge to develop improved DS treatments and cures. Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Genetics and Neurobiology of Down Syndrome

Author : Bani Bandana Ganguly
Publisher : Academic Press
ISBN 13 : 0323904572
Total Pages : 500 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Genetics and Neurobiology of Down Syndrome by : Bani Bandana Ganguly

Download or read book Genetics and Neurobiology of Down Syndrome written by Bani Bandana Ganguly and published by Academic Press. This book was released on 2022-08-21 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics and Neurobiology of Down Syndrome provides a thorough review of the genetic etiology and mechanisms of trisomy 21. The author discusses the history of the syndrome, along with the clinical features and health consequences, including physical features, cognitive, and neurologic symptoms. Genetic counseling on pros and cons of prenatal screening and testing and associated ethical issues are explored. This unique book also covers the societal and demographic aspects as well as the future direction of therapeutic development. Reviews genetic etiology and mechanisms of trisomy 21 Discusses prenatal screening and genetic counseling, including ethical aspects Explores link between Down Syndrome and susceptibility to Alzheimer’s and early brain aging Covers cognitive and neurological symptoms and other health consequences Identifies future therapeutic developments

Down Syndrome: From Understanding the Neurobiology to Therapy

Author :
Publisher : Elsevier
ISBN 13 : 0444543007
Total Pages : 273 pages
Book Rating : 4.4/5 (445 download)

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Book Synopsis Down Syndrome: From Understanding the Neurobiology to Therapy by :

Download or read book Down Syndrome: From Understanding the Neurobiology to Therapy written by and published by Elsevier. This book was released on 2012-10-16 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Down syndrome (DS) is the most common example of neurogenetic aneuploid disorder leading to mental retardation. In most cases, DS results from an extra copy of chromosome 21 (HSA21) producing deregulated gene expression in brain that gives raise to subnormal intellectual functioning. The topic of this volume is of broad interest for the neuroscience community, because it tackles the concept of neurogenomics, that is, how the genome as a whole contributes to a neurodevelopmental cognitive disorders, such as DS, and thus to the development, structure and function of the nervous system. This volume of Progress in Brain Research discusses comparative genomics, gene expression atlases of the brain, network genetics, engineered mouse models and applications to human and mouse behavioral and cognitive phenotypes. It brings together scientists of diverse backgrounds, by facilitating the integration of research directed at different levels of biological organization, and by highlighting translational research and the application of the existing scientific knowledge to develop improved DS treatments and cures. Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

The Neurobiology of Down Syndrome

Author : Charles J. Epstein
Publisher :
ISBN 13 : 9780608005799
Total Pages : 272 pages
Book Rating : 4.0/5 (57 download)

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Book Synopsis The Neurobiology of Down Syndrome by : Charles J. Epstein

Download or read book The Neurobiology of Down Syndrome written by Charles J. Epstein and published by . This book was released on 1986 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Intellectual Disabilities in Down Syndrome from Birth and throughout Life: Assessment and Treatment

Author : Marie-Claude Potier
Publisher : Frontiers Media SA
ISBN 13 : 2889450457
Total Pages : 183 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Intellectual Disabilities in Down Syndrome from Birth and throughout Life: Assessment and Treatment by : Marie-Claude Potier

Download or read book Intellectual Disabilities in Down Syndrome from Birth and throughout Life: Assessment and Treatment written by Marie-Claude Potier and published by Frontiers Media SA. This book was released on 2017-02-24 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on the multiple aspects of cognitive impairment in Down syndrome (DS), from genes to behavior to treatment, has made tremendous progress in the last decade. The study of congenital intellectual disabilities such as DS is challenging since they originate from the earliest stages of development and both the acquisition of cognitive skills and neurodegenerative pathologies are cumulative. Comorbidities such as cardiac malformations, sleep apnea, diabetes and dementia are frequent in the DS population, as well, and their increased risk provides a means of assessing early stages of these pathologies that is relevant to the general population. Notably, persons with DS will develop the histopathology of Alzheimer’s disease (formation of neuritic plaques and tangles) and are at high risk for dementia, something that cannot be predicted in the population at large. Identification of the gene encoding the amyloid precursor protein, its localization to chromosome 21 in the 90’s and realization that all persons with DS develop pathology identified this as an important piece of the amyloid cascade hypothesis in Alzheimer’s disease. Awareness of the potential role of people with DS in understanding progression and treatment as well as identification of genetic risk factors and also protective factors for AD is reawakening. For the first time since DS was recognized, major pharmaceutical companies have entered the search for ameliorative treatments, and phase II clinical trials to improve learning and memory are in progress. Enriched environment, brain stimulation and alternative therapies are being tested while clinical assessment is improving, thus increasing the chances of success for therapeutic interventions. Researchers and clinicians are actively pursuing the possibility of prenatal treatments for many conditions, an area with a huge potential impact for developmental disorders such as DS. Our goal here is to present an overview of recent advances with an emphasis on behavioral and cognitive deficits and how these issues change through life in DS. The relevance of comorbidities to the end phenotypes described and relevance of pharmacological targets and possible treatments will be considerations throughout.

Down Syndrome

Author : Siegfried M. Pueschel
Publisher :
ISBN 13 :
Total Pages : 552 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Down Syndrome by : Siegfried M. Pueschel

Download or read book Down Syndrome written by Siegfried M. Pueschel and published by . This book was released on 1982 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ce document propose un éventail des différentes recherches et découvertes touchant le syndrome de Down, tout particulièrement dans les domaines de la biologie médicale et des sciiences du comportement, En plus de l'historique de ce syndrome, l'étiologie, l'épidémiologie, de la cytogénétique (reproduction cellulaire) et différents aspects bio-médicaux de ce syndrome, il est également abordé le counseling aux parents, l'intervention précoce, le développement cognitif de la personne ainsi que son avenir et son autonomie.

State of the Art of Research on Down Syndrome

Author :
Publisher : Academic Press
ISBN 13 : 0128184558
Total Pages : 306 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis State of the Art of Research on Down Syndrome by :

Download or read book State of the Art of Research on Down Syndrome written by and published by Academic Press. This book was released on 2019-09-06 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: State of the Art of Research on Down Syndrome, Volume 56, the latest release in the International Review of Research in Developmental Disabilities series, highlights new advances in the field, with this new volume presenting interesting chapters on the Genetics and Genomics of Down Syndrome, Motor Development and Down Syndrome, Cognitive Profiles in Individuals with Down syndrome, Working Memory and Down syndrome, Environment Learning in Individuals with Down syndrome, Reading for Comprehension: The Contribution of Decoding, Linguistic and Cognitive Skills, Number Sense in Down syndrome, Early Starting States in Infants with Down Syndrome: Implications for Research and Practice, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the International Review of Research in Developmental Disabilities series Updated release includes the latest information on the State of the Art of Research on Down Syndrome

Fasten Your Seatbelt

Author : Brian Skotko
Publisher : Special Needs Collection
ISBN 13 : 9781890627867
Total Pages : 0 pages
Book Rating : 4.6/5 (278 download)

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Book Synopsis Fasten Your Seatbelt by : Brian Skotko

Download or read book Fasten Your Seatbelt written by Brian Skotko and published by Special Needs Collection. This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Even the closest brothers and sisters don't always get along or understand each other. Add a disability like Down syndrome to the mix, and that sibling relationship gets even more complicated, especially for teenagers. Fasten Your Seatbelt is the first book written exclusively for teens with a brother or sister with Down syndrome. In an easy-to-read, question & answer format, it tackles a broad range of their most common issues and concerns. Nearly 100 questions--all posed by teen siblings--are grouped into the following categories: Facts and stats about Down syndrome How people with Down syndrome learn Handling parent and family conflicts Dealing with your sibling's frustrating behaviors Managing uncomfortable situations Sorting out your feelings Becoming an advocate What the future holds for you and your sibling Finding local and national resources Thoughtful, knowledgeable answers are provided by Brian Skotko, the brother of a young woman with Down syndrome, and Sue Levine, a social worker focused on sibling issues for the past 30 years. Fasten Your Seatbelt gives teens the green light to explore their own feelings and questions about their sibling with Down syndrome and how their relationship may change in the future. Wondering whats on their minds? Here are a few sample questions from the book: Why does my brother always have temper tantrums? How can one extra chromosome make someone so different? Can my sister with Down syndrome marry someday? Will my brother be able to live on his own as an adult?

Neurobiology of Epilepsy

Author :
Publisher : Academic Press
ISBN 13 : 0444636455
Total Pages : 250 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Neurobiology of Epilepsy by :

Download or read book Neurobiology of Epilepsy written by and published by Academic Press. This book was released on 2016-06-20 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurobiology of Epilepsy: From Genes to Networks is the latest volume in the Progress in Brain Research series that focuses on new trends and developments. This established international series examines major areas of basic and clinical research within the neurosciences, as well as popular and emerging subfields. Explores new trends and developments in the neurobiology of Epilepsy Enhances the literature of neuroscience by further expanding the established, ongoing international series Progress in Brain Research Examines major areas of basic and clinical research within the field

International Review Research in Developmental Disabilities

Author :
Publisher : Academic Press
ISBN 13 : 0323990975
Total Pages : 284 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis International Review Research in Developmental Disabilities by :

Download or read book International Review Research in Developmental Disabilities written by and published by Academic Press. This book was released on 2022-11-08 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Review of Research in Developmental Disabilities, Volume 63 highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors, including updates on Theoretical Issues in Adult Siblings, Effects of Challenging Behavior on Others, Transition among Latino Families, Career and Technical Education for adults with IDD, and Emotion Regulation and Social Anxiety in Autism Spectrum Disorders. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the International Review of Research in Developmental Disabilities series

Preclinical Research in Down Syndrome: Insights for Pathophysiology and Treatments

Author :
Publisher : Elsevier
ISBN 13 : 9780444642561
Total Pages : 0 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Preclinical Research in Down Syndrome: Insights for Pathophysiology and Treatments by :

Download or read book Preclinical Research in Down Syndrome: Insights for Pathophysiology and Treatments written by and published by Elsevier. This book was released on 2020-02-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preclinical Research in Down Syndrome: From Bench to Bedside, Volume 251, the latest release in the Progress in Brain Research series, highlights new advances in the field. Chapters in this updated release include Exploring genetic and epigenetic mechanisms underlying cognitive deficits in Dow syndrome, The trisomy paradox: gene expression dysregulation domains, the Influence of allelic differences in mouse models of Down syndrome, Modelling Down syndrome in cells: From stem cells to organoids, Modelling Down syndrome in animals from the early stage to the new generation of models, Mapping behavioral landscapes in Down syndrome animal models, and more.

Chromosomal Abnormalities

Author : Marcelo Larramendy
Publisher : BoD – Books on Demand
ISBN 13 : 9535134736
Total Pages : 206 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Chromosomal Abnormalities by : Marcelo Larramendy

Download or read book Chromosomal Abnormalities written by Marcelo Larramendy and published by BoD – Books on Demand. This book was released on 2017-08-30 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited book, Chromosomal Abnormalities - A Hallmark Manifestation of Genomic Instability, contains a series of chapters highlighting several aspects related to the generation of chromosomal abnormalities in genetic material. We are extremely grateful to the authors who had contributed with valuable information about the role of genomic instability in pathological disorders as well as in the evolution process.

Therapies and Rehabilitation in Down Syndrome

Author : Jean-Adolphe Rondal, PhD
Publisher : Wiley
ISBN 13 : 0470319976
Total Pages : 228 pages
Book Rating : 4.4/5 (73 download)

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Book Synopsis Therapies and Rehabilitation in Down Syndrome by : Jean-Adolphe Rondal, PhD

Download or read book Therapies and Rehabilitation in Down Syndrome written by Jean-Adolphe Rondal, PhD and published by Wiley. This book was released on 2007-04-04 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Therapies and Rehabilitation in Down Syndrome covers the entire lifespan of a DS patient, from infancy to 60 years and beyond, focusing not simply on identifying problems, but providing a detailed look at major therapeutic approaches. Discussion includes future genetic therapy, questions of quality of life, hormone and other therapies for medical problems, prevention and treatment of normal and pathological aging, as well as psychomotoric rehabilitation. This is an important book not only for scientists concerned with various facets of DS, but practitioners looking for guidelines for therapies and clinical application of research findings.

Neurologic Interventions for Physical Therapy

Author : Suzanne "Tink" Martin, PT, PhD
Publisher : Elsevier Health Sciences
ISBN 13 : 1455740209
Total Pages : 520 pages
Book Rating : 4.4/5 (557 download)

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Book Synopsis Neurologic Interventions for Physical Therapy by : Suzanne "Tink" Martin, PT, PhD

Download or read book Neurologic Interventions for Physical Therapy written by Suzanne "Tink" Martin, PT, PhD and published by Elsevier Health Sciences. This book was released on 2015-06-24 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Master the role of the physical therapist or physical therapist assistant in neurologic rehabilitation! Neurologic Interventions for Physical Therapy, 3rd Edition helps you develop skills in the treatment interventions needed to improve the function of patients with neurologic deficits. It provides a solid foundation in neuroanatomy, motor control, and motor development, and offers clear, how-to guidelines to rehabilitation procedures. Case studies help you follow best practices for the treatment of children and adults with neuromuscular impairments caused by events such as spinal cord injuries, cerebral palsy, and traumatic brain injuries. Written by physical therapy experts Suzanne 'Tink' Martin and Mary Kessler, this market-leading text will help you prepare for the neurological portion of the PTA certification exam and begin a successful career in physical therapy practice. Comprehensive coverage of neurologic rehabilitation explores concepts in neuroanatomy, motor control and motor learning, motor development, and evidence-based treatment of adults and children with neuromuscular impairments. Over 700 photos and drawings clarify concepts, show anatomy, physiology, evaluation, and pathology, and depict the most current rehabilitation procedures and technology. Case studies demonstrate the patient examination and treatment process, and show how to achieve consistency in documentation. Proprioceptive Neuromuscular Facilitation chapter describes how PNF can be used to improve a patient's performance of functional tasks by increasing strength, flexibility, and range of motion - key to the treatment of individuals post stroke. Review questions are included at the end of each chapter, with answers at the back of the book. Illustrated step-by-step intervention boxes, tables, and charts highlight important information, and make it easy to find instructions quickly. Use of language of the APTA Guide to Physical Therapist Practice ensures that you understand and comply with best practices recommended by the APTA. NEW photographs of interventions and equipment reflect the most current rehabilitation procedures and technology. UPDATED study resources on the Evolve companion website include an intervention collection, study tips, and additional review questions and interactive case studies.

Literature, Neurology, and Neuroscience: Neurological and Psychiatric Disorders

Author :
Publisher : Elsevier
ISBN 13 : 0444633871
Total Pages : 252 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Literature, Neurology, and Neuroscience: Neurological and Psychiatric Disorders by :

Download or read book Literature, Neurology, and Neuroscience: Neurological and Psychiatric Disorders written by and published by Elsevier. This book was released on 2013-12-11 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume on the neurosciences, neurology, and literature vividly shows how science and the humanities can come together --- and have come together in the past. Its sections provide a new, broad look at these interactions, which have received surprisingly little attention in the past. Experts in the field cover literature as a window to neurological and scientific zeitgeists, theories of brain and mind in literature, famous authors and their suspected neurological disorders, and how neurological disorders and treatments have been described in literature. In addition, a myriad of other topics are covered, including some on famous authors whose important connections to the neurosciences have been overlooked (e.g., Roget, of Thesaurus fame), famous neuroscientists who should also be associated with literature, and some overlooked scientific and medical men who helped others produce great literary works (e,g., Bram Stoker's Dracula). There has not been a volume with this coverage in the past, and the connections it provides should prove fascinating to individuals in science, medicine, history, literature, and various other disciplines. This book looks at literature, medicine, and the brain sciences both historically and in the light of the newest scholarly discoveries and insights

Literature, Neurology, and Neuroscience: Historical and Literary Connections

Author :
Publisher : Elsevier
ISBN 13 : 0444632751
Total Pages : 368 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Literature, Neurology, and Neuroscience: Historical and Literary Connections by :

Download or read book Literature, Neurology, and Neuroscience: Historical and Literary Connections written by and published by Elsevier. This book was released on 2013-11-25 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume on the neurosciences, neurology, and literature vividly shows how science and the humanities can come together --- and have come together in the past. Its sections provide a new, broad look at these interactions, which have received surprisingly little attention in the past. Experts in the field cover literature as a window to neurological and scientific zeitgeists, theories of brain and mind in literature, famous authors and their suspected neurological disorders, and how neurological disorders and treatments have been described in literature. In addition, a myriad of other topics are covered, including some on famous authors whose important connections to the neurosciences have been overlooked (e.g., Roget, of Thesaurus fame), famous neuroscientists who should also be associated with literature, and some overlooked scientific and medical men who helped others produce great literary works (e,g., Bram Stoker's Dracula). There has not been a volume with this coverage in the past, and the connections it provides should prove fascinating to individuals in science, medicine, history, literature, and various other disciplines. This book looks at literature, medicine, and the brain sciences both historically and in the light of the newest scholarly discoveries and insights

Music, Neurology, and Neuroscience: Historical Connections and Perspectives

Author :
Publisher : Elsevier
ISBN 13 : 044463410X
Total Pages : 440 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Music, Neurology, and Neuroscience: Historical Connections and Perspectives by :

Download or read book Music, Neurology, and Neuroscience: Historical Connections and Perspectives written by and published by Elsevier. This book was released on 2015-02-12 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Music, Neurology, and Neuroscience: Historical Connections and Perspectives provides a broad and comprehensive discussion of history and new discoveries regarding music and the brain, presenting a multidisciplinary overview on music processing, its effects on brain plasticity, and the healing power of music in neurological and psychiatric disorders. In this context, the disorders that plagued famous musicians and how they affected both performance and composition are critically discussed, as is music as medicine and its potential health hazard. Additional topics, including the way music fits into early conceptions of localization of function in the brain, its cultural roots in evolution, and its important roles in societies and educational systems are also explored. Examines music and the brain both historically and in the light of the latest research findings The largest and most comprehensive volume on "music and neurology" ever written Written by a unique group of real world experts representing a variety of fields, ranging from history of science and medicine, to neurology and musicology Includes a discussion of the way music has cultural roots in evolution and its important role in societies