Dna Vaccination Genetic Vaccination

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DNA Vaccination/Genetic Vaccination

Author : Hilary Koprowski
Publisher : Springer Science & Business Media
ISBN 13 : 3642804756
Total Pages : 215 pages
Book Rating : 4.6/5 (428 download)

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Book Synopsis DNA Vaccination/Genetic Vaccination by : Hilary Koprowski

Download or read book DNA Vaccination/Genetic Vaccination written by Hilary Koprowski and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic / DNA immunization represents a novel approach to vaccine and immune therapeutic development. The direct injec tion of nucleic acid expression cassettes into a living host results in a limited number of its cells becoming factories for production of the introduced gene products. This host-inappropriate gene expression has important immunological consequences, resulting in the specific immune activation of the host against the gene delivered antigen. The recent demonstration by a number of laboratories that the induced immune responses are functional in experimental models against both specific infectious diseases and cancers is likely to have dramatic consequences for the develop ment of a new generation of experimental vaccines and immune therapies. This technology has the potential to enable the pro duction of vaccines and immune-based therapies that are not only effective immunologically but are accessible to the entire world (rather than just to the most developed nations). Vaccine Development Vaccination against pathogenic microorganisms represents one of the most important advances in the history of medicine. Vaccines, including those against polio, measles, mumps, rubella, hepatitis A, hepatitis B, pertussis and other diseases, have dramatically improved and protected more human lives than any other avenue of modern medicine. The vaccine against smallpox, for example, has been so successful that it is now widely believed that this malicious killer, responsible for more deaths in the twentieth century than World Wars I and II combined, has been removed from the face of the earth.

Vaccine Development and Manufacturing

Author : Emily P. Wen
Publisher : John Wiley & Sons
ISBN 13 : 1118870905
Total Pages : 452 pages
Book Rating : 4.1/5 (188 download)

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Book Synopsis Vaccine Development and Manufacturing by : Emily P. Wen

Download or read book Vaccine Development and Manufacturing written by Emily P. Wen and published by John Wiley & Sons. This book was released on 2014-10-06 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccine Manufacturing and Production is an invaluable reference on how to produce a vaccine - from beginning to end - addressing all classes of vaccines from a processing, production, and regulatory viewpoint. It will provide comprehensive information on the various fields involved in the production of vaccines, from fermentation, purification, formulation, to regulatory filing and facility designs. In recent years, there have been tremendous advances in all aspects of vaccine manufacturing. Improved technology and growth media have been developed for the production of cell culture with high cell density or fermentation. Vaccine Manufacturing and Production will serve as a reference on all aspects of vaccine production by providing an in-depth description of the available technologies for making different types of vaccines and the current thinking in facility designs and supply issues. This book will provide insight to the issues scientists face when producing a vaccine, the steps that are involved, and will serve as a reference tool regarding state-of-the-art vaccine manufacturing technologies and facility set-up. Highlights include: Comprehensive coverage of vaccine production : from a process point of view- fermentation to purification to formulation developments; from a production point of view - from facility design to manufacturing; and from a regulatory point of view - requirements from government agencies Authors from different major pharmaceutical and biotechnology companies Describes the challenges and issues involved in vaccine production and manufacturing of the different classes of vaccines, an area not covered by other books currently on the market

DNA Vaccines

Author : Ângela Sousa
Publisher : Humana
ISBN 13 : 9781071608746
Total Pages : 335 pages
Book Rating : 4.6/5 (87 download)

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Book Synopsis DNA Vaccines by : Ângela Sousa

Download or read book DNA Vaccines written by Ângela Sousa and published by Humana. This book was released on 2021-09-05 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details practical procedures on the latest DNA vaccine technology. Chapters guide readers through methods and protocols on DNA vaccine design, the adjuvant influence, production and purification methodologies, delivery systems, and approaches of the influence of DNA vaccines in the immunological response performance and in the cancer immunotherapy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, DNA Vaccines: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Toll-Like Receptors (TLRs) and Innate Immunity

Author : Stefan Bauer
Publisher : Springer Science & Business Media
ISBN 13 : 3540721673
Total Pages : 243 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Toll-Like Receptors (TLRs) and Innate Immunity by : Stefan Bauer

Download or read book Toll-Like Receptors (TLRs) and Innate Immunity written by Stefan Bauer and published by Springer Science & Business Media. This book was released on 2007-12-11 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Overall recent research on TLRs has led to tremendous increase in our understanding of early steps in pathogen recognition and will presumably lead to potent TLR targeting therapeutics in the future. This book reviews and highlights our recent understanding on the function and ligands of TLRs as well as their role in autoimmunity, dendritic cell activation and target structures for therapeutic intervention.

DNA Vaccines

Author : Douglas B. Lowrie
Publisher : Springer Science & Business Media
ISBN 13 : 1592596886
Total Pages : 530 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis DNA Vaccines by : Douglas B. Lowrie

Download or read book DNA Vaccines written by Douglas B. Lowrie and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of DNA vaccines has undergone explosive growth in the last few years. As usual, some historical precursors of this approach can be d- cerned in the scientific literature of the last decades. However, the present state of affairs appears to date from observations made discreetly in 1988 by Wolff, Malone, Felgner, and colleagues, which were described in a 1989 patent and published in 1990. Quite surprisingly, they showed that genes carried by pure plasmid DNA and injected in a saline solution, hence the epithet “naked DNA,” could be taken up and expressed by skeletal muscle cells with a low but reproducible frequency. Such a simple methodology was sure to spawn many applications. In a separate and important line of experimentation, Tang, De Vit, and Johnston announced in 1992 that it was indeed possible to obtain humoral immune responses against proteins encoded by DNA delivered to the skin by a biolistic device, which has colloquially become known as the “gene gun. ” The year 1993 saw the publication of further improvements in the me- ods of naked DNA delivery and, above all, the first demonstrations by several groups of the induction of humoral and cytotoxic immune responses to viral antigens expressed from injected plasmid DNA. In some cases, protection against challenge with the pathogen was obtained. The latter result was - questionably the touchstone of a method of vaccination worthy of the name.

DNA Vaccines

Author : Mark W. Saltzman
Publisher : Springer Science & Business Media
ISBN 13 : 1597451681
Total Pages : 382 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis DNA Vaccines by : Mark W. Saltzman

Download or read book DNA Vaccines written by Mark W. Saltzman and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the early 1990s, almost 200 yr after Edward Jenner demonstrated the effectiveness of the smallpox vaccine, a new paradigm for vaccination emerged. The conventional method of vaccination required delivery of whole pathogens or structural subunits, but in this new approach, DNA or genetic information was administered to elicit an immunological response. Once it was observed that plasmid DNA delivered in vivo led to production of an encoded transgene (1), two ground-breaking studies demonstrated that immunological responses could be generated against antigenic transgenes via plasmid DNA delivered by DNA vaccination (as this approach is called) (2,3). The appe- ance of this new vaccination strategy coincided with advances in molecular biology, which provided new tools to study and manipulate the basic elements of an organism’s genome and also could also be applied to the design and production of DNA vaccines. DNA Vaccines is a major updated and enhancement of the first edition. It reviews state-of-the-art methods in DNA vaccine technology, with chapters describing DNA vaccine design, delivery systems, adjuvants, current appli- tions, methods of production, and quality control. Consistent with the approach of the Methods in Molecular Medicine series, these chapters contain detailed practical procedures on the latest DNA vaccine technology. The enthusiasm for DNA vaccine technology is made clear by the number of research studies published on this topic since the mid-1990s.

Gene Vaccination: Theory and Practice

Author : Eyal Raz
Publisher : Springer Science & Business Media
ISBN 13 : 3642468675
Total Pages : 182 pages
Book Rating : 4.6/5 (424 download)

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Book Synopsis Gene Vaccination: Theory and Practice by : Eyal Raz

Download or read book Gene Vaccination: Theory and Practice written by Eyal Raz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccination has been established as an efficient procedure to prevent infections. Over the past few years, a new method of subunit vaccination has attracted the attention of immunologists. Despite its popularity, it is only recently that the basic mechanisms that drive the immune response to the encoded antigen have begun to unfold. The multidisciplinary approach of this book outlines the basic characteristics of gene (DNA) vaccination, the role of APCs or bone marrow derived cells in the induction of the immune response. It points out the potential applications for various infectious and allergic diseases and describes the multifaceted properties of DNA in initiating and determining the subsequent immune responses to the encoded antigen.

Opportunities in Biotechnology for Future Army Applications

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309075556
Total Pages : 118 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Opportunities in Biotechnology for Future Army Applications by : National Research Council

Download or read book Opportunities in Biotechnology for Future Army Applications written by National Research Council and published by National Academies Press. This book was released on 2001-07-11 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report surveys opportunities for future Army applications in biotechnology, including sensors, electronics and computers, materials, logistics, and medical therapeutics, by matching commercial trends and developments with enduring Army requirements. Several biotechnology areas are identified as important for the Army to exploit, either by direct funding of research or by indirect influence of commercial sources, to achieve significant gains in combat effectiveness before 2025.

DNA Vaccines

Author : Arthur M. Dixon
Publisher : Nova Science Publishers
ISBN 13 : 9781613244449
Total Pages : 0 pages
Book Rating : 4.2/5 (444 download)

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Book Synopsis DNA Vaccines by : Arthur M. Dixon

Download or read book DNA Vaccines written by Arthur M. Dixon and published by Nova Science Publishers. This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA vaccination is one of the most promising techniques for immunisation against diseases caused by viruses, protozoa, bacteria, and even for tumours and illnesses with genetic origins. These vaccines can be administered by direct inoculation of plasmid by several routes. In this book, the authors present topical research in the study of the types, advantages and limitations of DNA vaccines. Topics discussed include the role of novel carrier constructs in effective and safe DNA vaccine delivery; improving the immunogenicity of DNA vaccines; the role of DNA-IL-12 vaccination in cosinphilic inflammation; genetic immunisation enabling re-direction of the host immune system resulting in the development of effective immune responses; and DNA vaccination against herpesvirus.

Genetic Immunization

Author : Adrian Bot
Publisher : Springer Science & Business Media
ISBN 13 : 1475731639
Total Pages : 185 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Genetic Immunization by : Adrian Bot

Download or read book Genetic Immunization written by Adrian Bot and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Wolf's discovery demonstrating that a reporter gene is expressed in myocytes subsequent to injection of naked DNA, was exploited by immunologists and vaccinologists to develop a new generation of vaccines. This observation galvanized the research and in a short lapse of time, an oceanic volume of knowledge has been accumulated. The research carried out in a variety of animal models showed the efficacy of genetic immunization against viruses, bacteria, and some parasites by the ability to induce a strong priming effect resulting from long-lasting persistence of plasmid as episomes. Furthermore, it was demonstrated that newborn or infant immune unresponsiveness to classical vaccines can be corrected by genetic immunization. The applications of genetic immunization for prophylaxis of infections was extended to immunotherapy, namely, cancerous, auto immune, and allergic diseases. Immunologists have provided pertinent information on the cellular basis of the immune responses elicited by genetic immunization, and molecular biologists have established the molecular basis of intrinsic adjuvant properties of plasmids.

DNA Vaccines

Author : Hildegund C. J. Ertl
Publisher : Springer Science & Business Media
ISBN 13 : 9780306474446
Total Pages : 374 pages
Book Rating : 4.4/5 (744 download)

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Book Synopsis DNA Vaccines by : Hildegund C. J. Ertl

Download or read book DNA Vaccines written by Hildegund C. J. Ertl and published by Springer Science & Business Media. This book was released on 2003 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Vaccines: An Introduction; M.R. Hilleman. Architecture of a DNA vaccine; G. Pavlakis. DNA vaccine delivery; S. Kaufmann. Adjuvanticity of DNA vaccines; A. Krieg. Immune responses to DNA vaccines: Antigen presentation; R. Steinman. Immune responses to DNA vaccines: Antigen processing; J. Yewdell. Immune responses to DNA vaccines: Induction of B cells; G. Kelsoe. Immune responses to DNA vaccines: Induction of CD4+ T cells; E. Shevach. Immune responses to DNA vaccines: Induction of CD8+ T cells; L. Whitton. Immune responses to DNA vaccines: Cytokines as immune mediators as part of the immune response and their potential as genetic adjuvants to DNA vaccines; H. Ertl. Immune responses to DNA vaccines: Chemokines as immune mediators as part of the immune response and their potential as genetic adjuvants to DNA vaccines; P. Murphy. DNA Vaccines to infectious agents: RNA viruses; J. Ulmer. DNA Vaccines to infectious agents: HIV/SIV; B. Wahren. DNA Vaccines to infectious agents: DNA viruses; B. Rouse. DNA Vaccines to infectious agents: Tumor-associated viruses (excluding HBV); R. Kennedy. DNA Vaccines to infectious agents: Bacteria; D. Lowrie. DNA Vaccines to infectious agents: Parasites; S. Hoffman. Use of DNA vaccines for neonatal/early childhood immunization; C.-A. Siegrist. The potential of DNA vaccines for developing countries; H. Wilde. DNA vaccines and their potential to counterbalance biological warfare/bioterrorism; A. Schmaljohn. DNA vaccines to cancer associated/specific antigens; DNA vaccines to autoimmune diseases; H. Wigzell. DNA vaccines to allergic diseases; Yan Chuah, P. Holt. DNA vaccines for gene therapy; K. High. Safety concerns for DNA; D. Klinman. DNA vaccines: Summary.

Gene Vaccines

Author : Josef Thalhamer
Publisher : Springer Science & Business Media
ISBN 13 : 3709104394
Total Pages : 332 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Gene Vaccines by : Josef Thalhamer

Download or read book Gene Vaccines written by Josef Thalhamer and published by Springer Science & Business Media. This book was released on 2011-08-31 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: The induction of antigen-specific immune responses after in vivo transfection with expression plasmids has triggered a revolution of vaccine research. After a first hype, evoked by the fascinating options of this method, clinical studies did not reach the ambitious aims and a phase of disillusion ensued. It became obvious that Gene vaccines displayed a weaker immunogenicity in humans than had been observed in the mouse models. Meanwhile these hurdles have been overcome and gene vaccines undergo a renaissance. The present book gives an update of the “world of naked gene vaccines”, namely DNA and RNA vaccines. Its content ranges from general mechanisms, inherent immunostimulatory properties and the vast potential to modulate immune responses, to recent successful clinical studies and approved veterinary gene vaccines. Beyond the state-of-the-art of genetic immunization, the reader will be stimulated with a chapter addressing “burning questions”.

Advances in DNA Vaccines

Author : Maria Isaguliants
Publisher :
ISBN 13 : 9783036503011
Total Pages : 210 pages
Book Rating : 4.5/5 (3 download)

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Book Synopsis Advances in DNA Vaccines by : Maria Isaguliants

Download or read book Advances in DNA Vaccines written by Maria Isaguliants and published by . This book was released on 2021 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA is a rapidly developing vaccine platform for cancer and infectious and non-infectious diseases. Plasmids are used as immunogens to encode proteins to be further synthesized in vaccine recipients. DNA is mainly synthetic, ensuring enhanced expression in the cells of vaccine recipients (mostly mammalians). Their introduction into the host induces antibody and cellular responses. The latter are often more pronounced, and mimic the events occurring in infection, especially viral. There are a few distinct ways in which the vaccine antigen can be processed and presented, which determine the resulting immune response and which can be manipulated. Routinely, the antigen synthesized within the host cell is processed by proteasome, loaded onto, and presented in a complex with MHC I molecules. Processing can be re-routed to the lysosome, or immunogen can be secreted for further presentation in a complex with MHC II. Apart from expression, vaccination efficacy depends on DNA delivery. DNA immunogens are generally administered by intramuscular or intradermal injections, usually followed by electroporation, which enhances delivery 1000-fold. Other techniques are also used, such as noninvasive introduction by biojectors, skin applications with plasters and microneedles/chips, sonication, magnetofection, and even tattooing. An intense debate regarding the pros and cons of different routes of delivery is ongoing. A number of studies have compared the effect of delivery methods at the level of immunogen expression, and the magnitude and specificity of the resulting immune response. According to some, the delivery route determines immunogenic performance; according to others, it can modulate the level of response, but not its specificity or polarity. The progress of research aiming at the optimization of DNA vaccine design, delivery, and immunogenic performance has led to a marked increase in their efficacy in large species and humans. New DNA vaccines for use in the treatment of infectious diseases, cancer, allergies, and autoimmunity are forthcoming. This Special Issue covers various aspects of DNA vaccine development.

Plasmids for Therapy and Vaccination

Author : Martin Schleef
Publisher : John Wiley & Sons
ISBN 13 : 352761284X
Total Pages : 307 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Plasmids for Therapy and Vaccination by : Martin Schleef

Download or read book Plasmids for Therapy and Vaccination written by Martin Schleef and published by John Wiley & Sons. This book was released on 2008-07-11 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book specializing in plasmids and their biomedical use, including all relevant aspects of production, applications, quality, and regulations. Readers will discover clinical applications for the wide range of preventive and therapeutic applications using plasmid DNA. The book describes modified vector systems based on plasmids, as well as the potency of genomic research and vector design by informatics. Using the example of fish vaccination, the application of DNA vaccination in veterinary health care is reviewed, followed by a detailed overview of plasmid production technology on an industrial scale. Finally, the book considers regulatory and quality assurance aspects of such new drugs plus thire market potential.

The Flaviviruses: Detection, Diagnosis and Vaccine Development

Author :
Publisher : Elsevier
ISBN 13 : 0080493831
Total Pages : 607 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis The Flaviviruses: Detection, Diagnosis and Vaccine Development by :

Download or read book The Flaviviruses: Detection, Diagnosis and Vaccine Development written by and published by Elsevier. This book was released on 2003-12-18 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat. Detection, Diagnosis and Vaccine Development, the third volume of The Flaviviruses details the current status of technologies for detection and differentiation of these viruses, their use in surveillance and outbreak investigation, and also reviews the latest clinical research. Comprehensive approach to the scientific disciplines needed to unravle the complexities of virus-host interactions Descibes the technologies that have contributed to our current knowledge about the Flaviviruses Identifies the major problems faced in understanding the virus-host interactins that result in disease An exhaustive compendium of current and past knowledge on the Flavivirus family

Concepts in Viral Pathogenesis

Author : A. L. Notkins
Publisher : Springer Science & Business Media
ISBN 13 : 1461252504
Total Pages : 418 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Concepts in Viral Pathogenesis by : A. L. Notkins

Download or read book Concepts in Viral Pathogenesis written by A. L. Notkins and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: The current proliferation of scientific information makes it difficult for even the most diligent reader to keep up with the latest developments in his/her own field, let alone other areas of interest. Review articles are one solution, but they too have become so voluminous and detailed that they often defeat the purpose for which they were intended. We have attempted to ease this problem by using a different format. In this volume on Concepts in Viral Pathogenesis, we have assembled a series of mini-reviews/editorials, 1,000 to 2,000 words in length. Each is a pithy distil lation of the state-of-the-art with emphasis on current thinking and unifying concepts rather than a compendium of the literature. The 53 articles, all written by active workers in their respective fields, are organized systemati cally so that the book will provide busy investigators, teachers and students of up-to-date information in a very brief and easily read a conceptual core able form. In addition, the authors have attempted to identify unresolved problems and point to future directions.

DNA Vaccine

Author : Fouad Sabry
Publisher : One Billion Knowledgeable
ISBN 13 :
Total Pages : 375 pages
Book Rating : 4.:/5 (661 download)

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Book Synopsis DNA Vaccine by : Fouad Sabry

Download or read book DNA Vaccine written by Fouad Sabry and published by One Billion Knowledgeable. This book was released on 2022-10-05 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: What Is DNA Vaccine A particular antigen-coding DNA sequence is transfected into the cells of an organism via a method known as transfection in order to stimulate an immune response. This sort of vaccination is known as a DNA vaccine. How You Will Benefit (I) Insights, and validations about the following topics: Chapter 1: DNA vaccine Chapter 2: Antigen Chapter 3: T helper cell Chapter 4: Epitope Chapter 5: Adaptive immune system Chapter 6: Immunogen Chapter 7: Original antigenic sin Chapter 8: Immunogenicity Chapter 9: Antigenic variation Chapter 10: Murine respirovirus Chapter 11: Interleukin 15 Chapter 12: Toll-like receptor 9 Chapter 13: Subunit vaccine Chapter 14: Active immunotherapy Chapter 15: Peptide vaccine Chapter 16: Immunomics Chapter 17: Reverse genetics Chapter 18: Intrastructural help Chapter 19: Transient expression Chapter 20: Edible vaccines Chapter 21: Genetic vaccine (II) Answering the public top questions about dna vaccine. (III) Real world examples for the usage of dna vaccine in many fields. (IV) 17 appendices to explain, briefly, 266 emerging technologies in each industry to have 360-degree full understanding of dna vaccine' technologies. Who This Book Is For Professionals, undergraduate and graduate students, enthusiasts, hobbyists, and those who want to go beyond basic knowledge or information for any kind of dna vaccine.