DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells

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Publisher : Springer Science & Business Media
ISBN 13 : 1468413279
Total Pages : 654 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells by : M. Lambert

Download or read book DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells written by M. Lambert and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains edited contributions from the speakers at the NATO Advanced Research Workshop on "DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells" held October 1-6, 1988, at the Abbaye Royale de Fontevraud, Fontevraud France. The meeting was dedicated to Paul Howard-Flanders (Yale University, New Haven, CT. , 1919-1988), whose seminal con tributions to the DNA repair field include the cO-discovery of the excision repair pathway, the elucidation of post-repli cation repair in E. coli, the isolation of the lexA and recC mutants, and his extensive work on the enzymology of RecA. A plethora of recent developments in DNA repair mechan isms and related processes in mammalian cells have advanced our understanding of this field in a number of different areas and have given new emphasis to the ways these systems both resemble DNA repair processes in other groups of organisms in some respects yet are strikingly different from them in others. Within the past decade there have been a number of international conferences on DNA damage and repair mechanisms but none has been focused on these processes in mammalian cells.

DNA Repair Mechanisms

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Publisher : Elsevier
ISBN 13 : 032314232X
Total Pages : 832 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis DNA Repair Mechanisms by : Philip Hanawalt

Download or read book DNA Repair Mechanisms written by Philip Hanawalt and published by Elsevier. This book was released on 2012-12-02 with total page 832 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Repair Mechanisms is an account of the proceedings at a major international conference on DNA Repair Mechanisms held at Keystone, Colorado on February 1978. The conference discusses through plenary sessions the overall standpoint of DNA repair. The papers presented and other important documents, such as short summaries by the workshop session conveners, comprise this book. The compilation describes the opposing views, those that agree and dispute about certain topic areas. This book, divided into 15 parts, is arranged according to the proceedings in the conference. The plenary sessions are grouped with the related workshop and poster manuscripts. The first two parts generally tackle repair in terms of its identification and quantification, as well as the models, systems, and perspectives it utilizes. The following parts discuss the various types of repair including base excision, nucleotide excision repair in bacteria, excision repair in mammalian cells, inducible/error-prone repair in prokaryotes, and strand break repair in mammalian cells among others. This reference material looks into the replicative bypass mechanisms in mammalian cells, viral probes, and hereditary repair defects. It explains repair deficiency and human disease, as well as mutagenesis and carcinogenesis. The last part of this book deals with the consequences and effects of DNA repair. This volume is a helpful source of reference for students, teachers, scientists, and researchers in the different fields of genetics, radiology, biochemistry, and environmental biology.

Molecular Biology of The Cell

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Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of The Cell by : Bruce Alberts

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

DNA Damage and Repair

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Publisher : Springer Science & Business Media
ISBN 13 : 1592594557
Total Pages : 1050 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis DNA Damage and Repair by : Jac A. Nickoloff

Download or read book DNA Damage and Repair written by Jac A. Nickoloff and published by Springer Science & Business Media. This book was released on 1998-08-12 with total page 1050 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cutting edge reviews by leading researchers illuminate key aspects of DNA repair in mammalian systems and its relationship to human genetic disease and cancer. Major topics include UV and X-Ray repair, repair of chemical damage, recombinational repair, mismatch repair, transcription-repair coupling, and the role of DNA repair in disease prevention. Extensive up-to-date references and rigorous peer-review of each chapter make this volume definitive and bring it to the active frontiers of research.

DNA Repair Mechanisms

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Publisher : Springer
ISBN 13 :
Total Pages : 418 pages
Book Rating : 4.:/5 (89 download)

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Book Synopsis DNA Repair Mechanisms by : Jean-Michel H. Vos

Download or read book DNA Repair Mechanisms written by Jean-Michel H. Vos and published by Springer. This book was released on 1995 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mechanisms of DNA Damage Recognition in Mammalian Cells

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Publisher : Springer Science & Business Media
ISBN 13 : 146846468X
Total Pages : 215 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Mechanisms of DNA Damage Recognition in Mammalian Cells by : Hanspeter Naegeli

Download or read book Mechanisms of DNA Damage Recognition in Mammalian Cells written by Hanspeter Naegeli and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt:

DNA Replication, Recombination, and Repair

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Publisher : Springer
ISBN 13 : 443155873X
Total Pages : 555 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis DNA Replication, Recombination, and Repair by : Fumio Hanaoka

Download or read book DNA Replication, Recombination, and Repair written by Fumio Hanaoka and published by Springer. This book was released on 2016-01-22 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive review of the detailed molecular mechanisms of and functional crosstalk among the replication, recombination, and repair of DNA (collectively called the "3Rs") and the related processes, with special consciousness of their biological and clinical consequences. The 3Rs are fundamental molecular mechanisms for organisms to maintain and sometimes intentionally alter genetic information. DNA replication, recombination, and repair, individually, have been important subjects of molecular biology since its emergence, but we have recently become aware that the 3Rs are actually much more intimately related to one another than we used to realize. Furthermore, the 3R research fields have been growing even more interdisciplinary, with better understanding of molecular mechanisms underlying other important processes, such as chromosome structures and functions, cell cycle and checkpoints, transcriptional and epigenetic regulation, and so on. This book comprises 7 parts and 21 chapters: Part 1 (Chapters 1–3), DNA Replication; Part 2 (Chapters 4–6), DNA Recombination; Part 3 (Chapters 7–9), DNA Repair; Part 4 (Chapters 10–13), Genome Instability and Mutagenesis; Part 5 (Chapters 14–15), Chromosome Dynamics and Functions; Part 6 (Chapters 16–18), Cell Cycle and Checkpoints; Part 7 (Chapters 19–21), Interplay with Transcription and Epigenetic Regulation. This volume should attract the great interest of graduate students, postdoctoral fellows, and senior scientists in broad research fields of basic molecular biology, not only the core 3Rs, but also the various related fields (chromosome, cell cycle, transcription, epigenetics, and similar areas). Additionally, researchers in neurological sciences, developmental biology, immunology, evolutionary biology, and many other fields will find this book valuable.

Mechanisms of DNA Damage and Repair

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Publisher : Springer Science & Business Media
ISBN 13 : 1461594626
Total Pages : 567 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Mechanisms of DNA Damage and Repair by : Michael G. Simic

Download or read book Mechanisms of DNA Damage and Repair written by Michael G. Simic and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 567 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is based on the papers presented at the conference on "Mecha nisms of DNA Damage and Repair: Implications for Carcinogenesis and Risk Assessment," held at the National Bureau of Standards on June 2-7, 1985, This volume deals with mechanisms of DNA damage and repair at the molecular level; consequences of unrepaired or misrepaired damage, with major emphasis on carcinogenesis; drugs which bind selectively to altered and potentially damaging DNA sequences; and potential utilization of DNA damage as an endpoint for assessing risks of UV light, ionizing radiations, chemicals, drugs, and hazardous agents in foods. Because the induction of mutations by radiation and genotoxic chemicals has been observed to follow one-hit kinetics in some instances, it is generally assumed that any level of exposure to a DNA-damaging agent may increase the risk of genetic disease or cancer in an exposed population. At the same time, however, there is evidence that although the DNA of living cells is continually damaged by natural background radiation, free radicals, and other naturally occurring processes, most of the damage is normally repaired.

DNA Repair, Genetic Instability, and Cancer

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Publisher :
ISBN 13 : 9814477117
Total Pages : pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis DNA Repair, Genetic Instability, and Cancer by :

Download or read book DNA Repair, Genetic Instability, and Cancer written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

DNA Repair, Genetic Instability, and Cancer

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Publisher : World Scientific
ISBN 13 : 9812700145
Total Pages : 374 pages
Book Rating : 4.8/5 (127 download)

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Book Synopsis DNA Repair, Genetic Instability, and Cancer by : Qingyi Wei

Download or read book DNA Repair, Genetic Instability, and Cancer written by Qingyi Wei and published by World Scientific. This book was released on 2007 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes the elaborate surveillance systems and various DNA repair mechanisms that ensure accurate passage of genetic information onto daughter cells. In particular, it narrates how the cell cycle checkpoint and DNA repair machineries detect and restore DNA damages that are embedded in millions to billions of normal base pairs. The scope of the book ranges from biochemical analyses and structural details of DNA repair proteins, to integrative genomics and population-based studies. It provides a snapshot of current understanding about some of the major DNA repair pathways, including base-excision repair, nucleotide excision repair, mismatch repair, homologous recombination, and non-homologous end-joining as well as cell cycle checkpoints and translesion DNA synthesis. One of the particular emphases of the book is the link between inherited DNA repair deficiencies and susceptibility to cancer in the general population. For the first time, the book brings together a collection of review articles written by a group of active and laboratory-based investigators who have a clear understanding of the recent advances in the fields of DNA damage repair and genomic stability and their implications in carcinogenesis, new approaches in cancer therapy, and cancer prevention.

Ubiquitination Governing DNA Repair

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Publisher : BoD – Books on Demand
ISBN 13 : 1789235847
Total Pages : 221 pages
Book Rating : 4.7/5 (892 download)

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Book Synopsis Ubiquitination Governing DNA Repair by : Effrossyni Boutou

Download or read book Ubiquitination Governing DNA Repair written by Effrossyni Boutou and published by BoD – Books on Demand. This book was released on 2018-08-01 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA damage response (DDR) and lesion repair are vital processes ensuring genome integrity through various pathways depending mainly on the nature of DNA injury and cell cycle stage. DDR is finely regulated at many levels in co-ordination with other ongoing processes as is genome replication and cell cycle progression. Posttranslational modifications (PTMs), affecting both protein-protein and protein-DNA interactions, play a crucial role in finely tuning all processes involved in the restoration of genome lesions. Regarding damaged chromatin, PTMs serve in many cases as recruitment platforms for DNA repair mechanisms by facilitating binding sites or regulating interactions between involved proteins. Ubiquitination, the addition of ubiquitin moieties on a target protein, apart from controlling protein availability through degradation, is also involved, together with partner small ubiquitin-like modifier (SUMO), in controlling many pathways involved in DDR by modifying the structure-function relationship and thus interacting with partner molecules. The aim of this book is to cover a broad spectrum of current topics in ubiquitination and to a lesser extent SUMOylation involvement in regulation of DDR and repair in health and disease. This book is intended for pre- and postgraduate students and young scientists in this field. Members of both academic and research institutions, actively involved in the field, have described their current understanding of major mechanisms involved, highlighted key events, described ongoing applications in both developmental diseases and cancer and provided hints for future potential applications.

DNA Repair and Replication

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Publisher : Garland Science
ISBN 13 : 0429876548
Total Pages : 368 pages
Book Rating : 4.4/5 (298 download)

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Book Synopsis DNA Repair and Replication by : Roger J. A. Grand

Download or read book DNA Repair and Replication written by Roger J. A. Grand and published by Garland Science. This book was released on 2018-09-03 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Repair and Replication brings together contributions from active researchers. The first part of this book covers most aspects of the DNA damage response, emphasizing the relationship to replication stress. The second part concentrates on the relevance of this to human disease, with particular focus on both the causes and treatments which make use of DNA Damage Repair (DDR) pathways. Key Selling Features: Chapters written by leading researchers Includes description of replication processes, causes of damage, and methods of repair

DNA

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Publisher : BoD – Books on Demand
ISBN 13 : 1838810935
Total Pages : 235 pages
Book Rating : 4.8/5 (388 download)

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Book Synopsis DNA by : Payam Behzadi

Download or read book DNA written by Payam Behzadi and published by BoD – Books on Demand. This book was released on 2021-05-19 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA is the most important biomolecule ever discovered. Indeed, this molecule bears genetic information from one generation to another. In this regard, DNA bases have a key role in transferring genetic information and data safely. However, there are cellular, genetic, and environmental factors that may damage the different parts of DNA molecules. These damages may result in mutations and cell death. As such, several DNA repair mechanisms have evolved. Over three sections, this book examines many of these mechanisms.

DNA Repair

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Publisher : BoD – Books on Demand
ISBN 13 : 9533076976
Total Pages : 652 pages
Book Rating : 4.5/5 (33 download)

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Book Synopsis DNA Repair by : Inna Kruman

Download or read book DNA Repair written by Inna Kruman and published by BoD – Books on Demand. This book was released on 2011-11-07 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book consists of 31 chapters, divided into six parts. Each chapter is written by one or several experts in the corresponding area. The scope of the book varies from the DNA damage response and DNA repair mechanisms to evolutionary aspects of DNA repair, providing a snapshot of current understanding of the DNA repair processes. A collection of articles presented by active and laboratory-based investigators provides a clear understanding of the recent advances in the field of DNA repair.

DNA Repair Mechanisms

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Publisher :
ISBN 13 :
Total Pages : 813 pages
Book Rating : 4.:/5 (251 download)

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Book Synopsis DNA Repair Mechanisms by : Philip C. Hanawalt

Download or read book DNA Repair Mechanisms written by Philip C. Hanawalt and published by . This book was released on 1978 with total page 813 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Intra-and Intermolecular Interactions, Radiation Effects in DNA Cells, and Repair Mechanisms

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Author :
Publisher : Elsevier
ISBN 13 : 0323159516
Total Pages : 236 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Intra-and Intermolecular Interactions, Radiation Effects in DNA Cells, and Repair Mechanisms by : J Duchesne

Download or read book Intra-and Intermolecular Interactions, Radiation Effects in DNA Cells, and Repair Mechanisms written by J Duchesne and published by Elsevier. This book was released on 2012-12-02 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physico-chemical Properties of Nucleic Acids, Volume III revolves around three major concepts, which are intra- and intermolecular interactions, radiation effects in DNA cells, and repair mechanisms. This volume also presents the stage of specific biological functions and how repair mechanisms relate to the problem of evolution. Comprised of six chapters, this volume begins with the concept of renaturation of polynucleotides. Interactions in nucleic acids and nucleotides are discussed in several chapters. Other topics covered in this volume include polymer and salt-induced condensation of DNA and strand-breaks in the DNA of mammalian cells. The last chapter explores the stability and evolution of DNA in terms of molecular radiobiology. This chapter also presents and reviews some evolutionary problems, specifically the prebiotic evolution. The elements of stabilization and variability of genetic information are also discussed in the last chapter. As with the other volumes, this volume is a valuable reference for students and researchers in the fields of chemistry, biology, molecular biology, microbiology, and biophysics.

Molecular Mechanisms for Repair of DNA

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Publisher : Springer
ISBN 13 :
Total Pages : 456 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Molecular Mechanisms for Repair of DNA by : Philip Hanawalt

Download or read book Molecular Mechanisms for Repair of DNA written by Philip Hanawalt and published by Springer. This book was released on 1975-10 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: