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Disorders Of Protein Synthesis
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Book Synopsis Disorders of Protein Synthesis by : Rossen Donev
Download or read book Disorders of Protein Synthesis written by Rossen Donev and published by Academic Press. This book was released on 2022-09-08 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disorders of Protein Synthesis, Volume 132 in the Advances in Protein Chemistry and Structural Biology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Protein Chemistry and Structural Biology series Includes the latest information on disorders of protein synthesis
Book Synopsis Molecular Biology of The Cell by : Bruce Alberts
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Alcohol and Abnormal Protein Biosynthesis by : Marcus A. Rothschild
Download or read book Alcohol and Abnormal Protein Biosynthesis written by Marcus A. Rothschild and published by Elsevier. This book was released on 2014-05-17 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alcohol and Abnormal Protein Biosynthesis: Biochemical and Clinical focuses on the methods for measuring protein metabolism and the effects of alcohol and altered protein intake as they affect the heart, liver, skeletal muscle, and the brain. Organized into six sections, this book begins with an overview on malnutrition and alcoholism, as well as available techniques for the study of protein synthesis. Subsequent section details the adaptation of protein synthesis and transport to alcohol and malnutrition. Section three discusses the skeletal and cardiac muscle protein metabolism. The last three sections describe the reaction of hepatic protein synthesis to malnutrition and alcohol; effects of alcohol on brain RNA metabolism; and alcohol associated cardiac and hepatic disease.
Book Synopsis Essentials of Glycobiology by : Ajit Varki
Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Book Synopsis PET Studies on Amino Acid Metabolism and Protein Synthesis by : B.M. Mazoyer
Download or read book PET Studies on Amino Acid Metabolism and Protein Synthesis written by B.M. Mazoyer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parameters such as membrane transport, metabolism and protein incorporation govern the fate of amino acids in living tissue. Is it possible to use positron tomography to measure some of them, and what is their meaning in normal and pathological situations? These questions have been addressed for a long time and no satisfactory answer has yet been given. This book, which derives from an EEC workshop organized in the frame of the Concerted Action on `PET Investigation of Cellular Regeneration and Degeneration', held in Lyon in February 1992, gives the present state of knowledge in this field based on the most recent studies. Contributions from 24 leading European and American scientists are presented and discussed in the following four parts: biochemistry and animal studies; amino acids labelling with positron emittors, quality control and metabolites measurement; kinetic modelling of amino acids transport, metabolism, and protein incorporation; clinical use of amino acids. This book will aid and interest biochemists, radiochemists, pharmacologists, neurologists, oncologists and medical imaging scientists.
Book Synopsis Plasma Protein Metabolism by : Marcus Rothschild
Download or read book Plasma Protein Metabolism written by Marcus Rothschild and published by Elsevier. This book was released on 2012-12-02 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plasma Protein Metabolism: Regulation of Synthesis, Distribution, and Degradation covers the concepts concerning the physiological and pathophysiological factors regulating the distribution, degradation, and synthesis of plasma proteins. This book is organized into nine parts encompassing 32 chapters. The first parts present the assumptions and methodology involved in the various in vivo and in vitro techniques that provide insights to protein metabolism. The next parts describe the techniques of protein isolation, characterization, labeling, and mathematical analysis of the data, as well as the methods for directly quantitating protein synthetic rates in nonsteady state conditions. Other parts are devoted to the factors involved in regulating the serum levels of albumin, acute phase reactants, immunoglobulins, clotting factors, complement and hormone-binding proteins. The controlling factors include such general and specific physiological regulators of protein synthesis and catabolism as levels of specific serum proteins, hormonal regulators, variations of temperature and oncotic pressure, antigenic stimulation, and nutritional factors. The remaining parts analyze the pathophysiological factors including disorders of protein synthesis, distribution, exogenous catabolism, and external loss and stress that produce abnormal levels of serum proteins. This book is intended primarily intended to protein chemists and researchers.
Book Synopsis The Role of Protein and Amino Acids in Sustaining and Enhancing Performance by : Institute of Medicine
Download or read book The Role of Protein and Amino Acids in Sustaining and Enhancing Performance written by Institute of Medicine and published by National Academies Press. This book was released on 1999-09-15 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is a commonly held belief that athletes, particularly body builders, have greater requirements for dietary protein than sedentary individuals. However, the evidence in support of this contention is controversial. This book is the latest in a series of publications designed to inform both civilian and military scientists and personnel about issues related to nutrition and military service. Among the many other stressors they experience, soldiers face unique nutritional demands during combat. Of particular concern is the role that dietary protein might play in controlling muscle mass and strength, response to injury and infection, and cognitive performance. The first part of the book contains the committee's summary of the workshop, responses to the Army's questions, conclusions, and recommendations. The remainder of the book contains papers contributed by speakers at the workshop on such topics as, the effects of aging and hormones on regulation of muscle mass and function, alterations in protein metabolism due to the stress of injury or infection, the role of individual amino acids, the components of proteins, as neurotransmitters, hormones, and modulators of various physiological processes, and the efficacy and safety considerations associated with dietary supplements aimed at enhancing performance.
Book Synopsis Brain Neurotrauma by : Firas H. Kobeissy
Download or read book Brain Neurotrauma written by Firas H. Kobeissy and published by CRC Press. This book was released on 2015-02-25 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries.
Book Synopsis Protein Degradation in Health and Disease by : David Evered
Download or read book Protein Degradation in Health and Disease written by David Evered and published by John Wiley & Sons. This book was released on 2009-09-14 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
Book Synopsis Pathophysiology of Plasma Protein Metabolism by : Giulian Mariant
Download or read book Pathophysiology of Plasma Protein Metabolism written by Giulian Mariant and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents a factual account of the proceedings of an international symposium on the pathophysiology of plasma protein metabolism, which was organised in October 1982 by the Plasmaprotein and Immunology Division of the C.N.R. Institute of Clinical Physiology at the University of Pisa (Italy). Several of the contributors are former members of the International Study Group on Plasma Protein Metabolism, the last meeting of which was held in Turin (Italy) in 1974, under the auspices of the scientific organisation of the same institute. The symposium took the form of a series of lectures, with the main objective of providing a positive contribution to the state of the art of several topics related to the kinetic and pathophysiological factors regulating the synthesis, distribution and degradation of plasma proteins. The first four chapters form a group, each one considering a special aspect of the kinetics of turnover and distribution of plasma proteins in general; particular attention is paid to the recent advances in the field of kinetic modelling, the choice of the best models and the optimisation of the experimental designs. The next seven chapters consider the regulation of synthesis, distribution and catab olism of various classes of plasma proteins including albumin, immunoglobulins, complement fractions and acute-phase proteins. The remaining chapters deal with metabolic studies of various plasma proteins (including tumour markers, coagUlation proteins and lipoproteins) in different disease states, such as malig nancies, coagulative disorders, malnutrition and the extensive group of athero sclerotic cardiovascular diseases.
Book Synopsis Protein Synthesis in Disease by : M. Norman
Download or read book Protein Synthesis in Disease written by M. Norman and published by . This book was released on 1977 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Anatomy and Physiology by : J. Gordon Betts
Download or read book Anatomy and Physiology written by J. Gordon Betts and published by . This book was released on 2013-04-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Metabolic Diseases by : E. Gilbert-Barness
Download or read book Metabolic Diseases written by E. Gilbert-Barness and published by IOS Press. This book was released on 2017-01-06 with total page 960 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 2nd Edition of Metabolic Diseases provides readers with a completely updated description of the Foundations of Clinical Management, Genetics, and Pathology. A distinguished group of 31 expert authors has contributed 25 chapters as a tribute to Enid Gilbert-Barness and the late Lewis Barness--- both pioneers in this topic. Enid’s unique perspectives on the pathology of genetic disorders and Lew’s unsurpassed knowledge of metabolism integrated with nutrition have inspired the contributors to write interdisciplinary descriptions of generally rare, and always challenging, hereditary metabolic disorders. Discussions of these interesting genetic disorders are organized in the perspective of molecular abnormalities leading to morphologic disturbances with distinct pathology and clinical manifestations. The book emphasizes recent advances such as development of improved diagnostic methods and discovery of new, more effective therapies for many of the diseases. It includes optimal strategies for diagnosis and information on access to specialized laboratories for specific testing. The target audience is a wide variety of clinicians, including pediatricians, neonatologists, obstetricians, maternal-fetal specialists, internists, pathologists, geneticists, and laboratorians engaged in prenatal and/or neonatal screening. In addition, all scientists and health science professionals interested in metabolic diseases will find the comprehensive, integrated chapters informative on the latest discoveries. It is our hope that the 2nd Edition will open new avenues and vistas for our readers and that they will share with us the interest, excitement and passion of the research into all these challenging disorders.
Book Synopsis Protein Synthesis in Health and Disease by : Chris G. Proud
Download or read book Protein Synthesis in Health and Disease written by Chris G. Proud and published by . This book was released on 2005 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biology for AP ® Courses by : Julianne Zedalis
Download or read book Biology for AP ® Courses written by Julianne Zedalis and published by . This book was released on 2017-10-16 with total page 1923 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biology for AP® courses covers the scope and sequence requirements of a typical two-semester Advanced Placement® biology course. The text provides comprehensive coverage of foundational research and core biology concepts through an evolutionary lens. Biology for AP® Courses was designed to meet and exceed the requirements of the College Board’s AP® Biology framework while allowing significant flexibility for instructors. Each section of the book includes an introduction based on the AP® curriculum and includes rich features that engage students in scientific practice and AP® test preparation; it also highlights careers and research opportunities in biological sciences.
Book Synopsis Protein Synthesis and Translational Control by : John W. B. Hershey
Download or read book Protein Synthesis and Translational Control written by John W. B. Hershey and published by Cold Spring Harbor Perspective. This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The synthesis of proteins by ribosomes is a fundamental cellular process. Cells must tightly control protein synthesis to maintain homeostasis and regulate proliferation, growth, differentiation, and development. Indeed, aberrant translational control is associated with cancer, several neurologic syndromes, and genetic disorders including "ribosomopathies." Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers our current understanding of protein synthesis and its control, from the genomic level to single- molecule analysis and single-cell imaging. The contributors describe the fundamental steps in protein synthesis (initiation, elongation, and termination), the factors involved, and high- resolution structures of the translational machinery. They review the targets of translational control (e.g., initiation factors and mRNAs) and how signaling pathways modulate this machinery. The roles of the endoplasmic reticulum, the unfolded protein response, processing bodies (P-bodies), stress granules, and small RNAs (including microRNAs) are also covered. This volume includes discussion of translational deregulation in cancer and the development of therapeutic agents that target translation initiation. Thus, it is an essential reference for cell and molecular biologists, as well as developmental and neurobiologists, oncologists, virologists, and all those investigating human diseases associated with translation dysfunction.
Book Synopsis Investigating the Mechanisms Linking Mutations in the Protein Synthesis Apparatus to Neurological Disease by : Patrick Mullen
Download or read book Investigating the Mechanisms Linking Mutations in the Protein Synthesis Apparatus to Neurological Disease written by Patrick Mullen and published by . This book was released on 2022 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aminoacyl-tRNA synthetases (ARS) are a large family of enzymes that catalyze the aminoacylation reaction, in which an amino acid is attached to cognate tRNAs. This reaction is essential for the process of protein synthesis, as it allows tRNAs to carry amino acids to the ribosome during translation. In recent years, genome sequencing has revealed an association between ARS and inherited diseases of the nervous system. Dominant ARS mutations are linked to the inherited peripheral neuropathy Charcot-Marie-Tooth disease (CMT), while recessive ARS mutations cause multisystem disorders that often include severe neurodevelopmental defects. Additionally, bi-allelic mutations in 2 of the 3 aminoacyl-tRNA synthetase multifunctional interacting proteins (AIMPs) are associated with developmental encephalopathies that overlap phenotypically with recessive ARS disorders. A key outstanding question regarding inherited ARS disorders is whether loss of enzyme function and subsequent protein synthesis defects underlie disease pathogenesis. Additionally, the effects of ARS mutations on cellular and organismal physiology remain unclear. A better understanding of the processes linking ARS mutations to neurological diseases may ultimately lead to novel therapeutic strategies for these currently untreatable disorders. In this work, I investigated histidyl-tRNA synthetase (HARS) mutations that are associated with CMT. Previous work in the lab determined that CMT-HARS variants compromise enzyme activity, but the effects on neuronal function had not been explored. In studies using rat pheochromocytoma (PC12) cells, I found that expression of CMT-HARS impaired neurite outgrowth in response to nerve growth factor. Consistent with these in vitro findings, transgenic zebrafish injected with mRNAs encoding V155G and Y330C mutant HARS displayed axonal abnormalities and concomitant disruption of touch responsiveness and swimming behavior. Effects on neurite outgrowth were recapitulated by inhibiting HARS or global protein translation, suggesting that dysregulation of protein synthesis is a key component of the observed phenotypes. In support of this hypothesis, I found that PC12 cells expressing mutant HARS proteins displayed attenuated protein synthesis and increased phosphorylation of eIF2[alpha], which is a signaling event that reduces protein translation in response to cellular stress. Owing to the fact that CMT-HARS variants confer loss-of-function effects, it is possible that mutant proteins decrease protein translation through a dominant negative inhibition of aminoacylation. In support of this hypothesis, I found that mutant proteins dimerize with wild-type subunits. In sum, these data demonstrate that inhibition of protein synthesis is a common effect of ARS-CMT variants and provide support for the involvement of a dominant negative mechanism. I also investigated the effects of novel bi-allelic mutations in the aminoacyl-tRNA synthetase multifunctional interacting protein 2 (AIMP2). These mutations were identified in patients with developmental encephalopathy, and lead to a profound reduction in AIMP2 protein expression. At the cellular level, the consequences of loss of AIMP2 included decreased protein synthesis and delayed progression through the G1-S checkpoint of the cell cycle. Loss of AIMP2 caused a reduction in the levels of an interacting protein, methionyl-tRNA synthetase (MARS), which is known to regulate protein synthesis initiation and cell cycle progression. These results indicated that dysregulation of protein synthesis and impaired progression through the cell cycle are key pathogenic processes in AIMP2-linked developmental encephalopathies. Notably, decreased AIMP2 expression caused by mutations encoding premature stop codons was rescued by anticodon-engineered tRNAs, which may represent a viable therapeutic strategy for a select group of patients. Together, these data suggest that dominant HARS mutations and bi-allelic AIMP2 mutations cause neurological disease through dysregulation of proteostasis, with differential downstream consequences on neurite outgrowth and cell-cycle progression, respectively.
