Disordered Pharmaceutical Materials

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Disordered Pharmaceutical Materials

Author : Marc Descamps
Publisher : John Wiley & Sons
ISBN 13 : 352765271X
Total Pages : 544 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Disordered Pharmaceutical Materials by : Marc Descamps

Download or read book Disordered Pharmaceutical Materials written by Marc Descamps and published by John Wiley & Sons. This book was released on 2016-03-28 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: A one-stop resource for researchers, developers, and post graduate students in pharmaceutical science. This handbook and ready reference provides detailed, but not overloaded information -- presenting the topic without unnecessarily complex formalism. As such, it gives a systematic and coherent overview of disordered materials for pharmaceutical applications, covering fundamental aspects, as well as preparation and characterization techniques for the target-oriented development of drug delivery systems based on disordered crystals and amorphous solids. Special attention is paid to examine the different facets and levels of disorder in their structural and dynamic aspects as well as the effect of disorder on dissolution and stability. Chapters on processing induced disorder and on patenting issues round off the book. As a result the book helps overcoming the challenges of using these materials in the pharmaceutical industry. For pharmaceutical and medicinal chemists, materials scientists, clinical physicists, and pharmaceutical laboratories looking to make better and more potent pharmaceuticals.

Investigating the Degree of Induced Disorder in Mechanicaly Combined Pharmaceutical Materials

Author : Brendon Woodhead
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (18 download)

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Book Synopsis Investigating the Degree of Induced Disorder in Mechanicaly Combined Pharmaceutical Materials by : Brendon Woodhead

Download or read book Investigating the Degree of Induced Disorder in Mechanicaly Combined Pharmaceutical Materials written by Brendon Woodhead and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Disordered Materials

Author : Paolo M. Ossi
Publisher : Springer Science & Business Media
ISBN 13 : 9783540413288
Total Pages : 306 pages
Book Rating : 4.4/5 (132 download)

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Book Synopsis Disordered Materials by : Paolo M. Ossi

Download or read book Disordered Materials written by Paolo M. Ossi and published by Springer Science & Business Media. This book was released on 2003 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This self-contained textbook aims to introduce the physics of structurally disordered condensed systems at the level of advanced undergraduate and graduate students. The topics discussed include the geometry and symmetries of the building blocks commonly used to obtain atomic structures, the various kinds of disorder, the phenomenology and the main theories of the glass transition, investigation of the structure of amorphous systems, the dependence of system structure on its dimensions (clusters), and the case of positional order in the absence of translational order (quasicrystals).

Amorphous Food and Pharmaceutical Systems

Author : Harry Levine
Publisher : Royal Society of Chemistry
ISBN 13 : 1847550118
Total Pages : 397 pages
Book Rating : 4.8/5 (475 download)

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Book Synopsis Amorphous Food and Pharmaceutical Systems by : Harry Levine

Download or read book Amorphous Food and Pharmaceutical Systems written by Harry Levine and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decade, the importance of amorphous water-soluble substances has been increasingly recognised within the food and pharmaceutical industries. In response, Amorphous Food and Pharmaceutical Systems brings together current leading experts to contribute to this unique cross-disciplinary account of the subject. Coverage includes: water-compatible amorphous solids (physical, chemical behaviour), low water content systems (water as plasticizer); applications in food and pharmaceutical sciences and industries (processing and stability) along with state-of-the-art technology in food and pharmaceutical systems. This timely publication will be welcomed by academic and industrial researchers and professionals in the pharmaceuticals, food, materials and polymer sciences.

Solid-State Properties of Pharmaceutical Materials

Author : Stephen R. Byrn
Publisher : John Wiley & Sons
ISBN 13 : 1119264448
Total Pages : 432 pages
Book Rating : 4.1/5 (192 download)

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Book Synopsis Solid-State Properties of Pharmaceutical Materials by : Stephen R. Byrn

Download or read book Solid-State Properties of Pharmaceutical Materials written by Stephen R. Byrn and published by John Wiley & Sons. This book was released on 2017-07-12 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents a detailed discussion of important solid-state properties, methods, and applications of solid-state analysis Illustrates the various phases or forms that solids can assume and discussesvarious issues related to the relative stability of solid forms and tendencies to undergo transformation Covers key methods of solid state analysis including X-ray powder diffraction, thermal analysis, microscopy, spectroscopy, and solid state NMR Reviews critical physical attributes of pharmaceutical materials, mainly related to drug substances, including particle size/surface area, hygroscopicity, mechanical properties, solubility, and physical and chemical stability Showcases the application of solid state material science in rational selection of drug solid forms, analysis of various solid forms within drug substance and the drug product, and pharmaceutical product development Introduces appropriate manufacturing and control procedures using Quality by Design, and other strategies that lead to safe and effective products with a minimum of resources and time

Polymorphism in the Pharmaceutical Industry

Author : Rolf Hilfiker
Publisher : John Wiley & Sons
ISBN 13 : 3527340408
Total Pages : 512 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Polymorphism in the Pharmaceutical Industry by : Rolf Hilfiker

Download or read book Polymorphism in the Pharmaceutical Industry written by Rolf Hilfiker and published by John Wiley & Sons. This book was released on 2019-04-29 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Polymorphism in the Pharmaceutical Industry - Solid Form and Drug Development" highlights the relevance of polymorphism in modern pharmaceutical chemistry, with a focus on quality by design (QbD) concepts. It covers all important issues by way of case studies, ranging from properties and crystallization, via thermodynamics, analytics and theoretical modelling right up to patent issues. As such, the book underscores the importance of solid-state chemistry within chemical and pharmaceutical development. It emphasizes why solid-state issues are important, the approaches needed to avoid problems and the opportunities offered by solid-state properties. The authors include true polymorphs as well as solvates and hydrates, while providing information on physicochemical properties, crystallization thermodynamics, quantum-mechanical modelling, and up-scaling. Important analytical tools to characterize solid-state forms and to quantify mixtures are summarized, and case studies on solid-state development processes in industry are also provided. Written by acknowledged experts in the field, this is a high-quality reference for researchers, project managers and quality assurance managers in pharmaceutical, agrochemical and fine chemical companies as well as for academics and newcomers to organic solid-state chemistry.

NMR in Pharmaceutical Science

Author : Jeremy R. Everett
Publisher : John Wiley & Sons
ISBN 13 : 1118660242
Total Pages : 504 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis NMR in Pharmaceutical Science by : Jeremy R. Everett

Download or read book NMR in Pharmaceutical Science written by Jeremy R. Everett and published by John Wiley & Sons. This book was released on 2015-08-20 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: NMR in Pharmaceutical Sciences is intended to be a comprehensive source of information for the many individuals that utilize MR in studies of relevance to the pharmaceutical sector. The book is intended to educate and inform those who develop and apply MR approaches within the wider pharmaceutical environment, emphasizing the toolbox that is available to spectroscopists and radiologists. This book is structured on the key processes in drug discovery, development and manufacture, but underpinned by an understanding of fundamental NMR principles and the unique contribution that NMR (including MRI) can provide. After an introductory chapter, which constitutes an overview, the content is organised into five sections. The first section is on the basics of NMR theory and relevant experimental methods. The rest follow a sequence based on the chronology of drug discovery and development, firstly 'Idea to Lead' then 'Lead to Drug Candidate', followed by 'Clinical Development', and finally 'Drug Manufacture'. The thirty one chapters cover a vast range of topics from analytical chemistry, including aspects involved in regulatory matters and in the prevention of fraud, to clinical imaging studies. Whilst this comprehensive volume will be essential reading for many scientists based in pharmaceutical and related industries, it should also be of considerable value to a much wider range of academic scientists whose research is related to the various aspects of pharmaceutical R&D; for them it will supply vital understanding of pharmaceutical industrial concerns and the basis of key decision making processes. About eMagRes Handbooks eMagRes (formerly the Encyclopedia of Magnetic Resonance) publishes a wide range of online articles on all aspects of magnetic resonance in physics, chemistry, biology and medicine. The existence of this large number of articles, written by experts in various fields, is enabling the publication of a series of eMagRes Handbooks on specific areas of NMR and MRI. The chapters of each of these handbooks will comprise a carefully chosen selection of eMagRes articles. In consultation with the eMagRes Editorial Board, the eMagRes handbooks are coherently planned in advance by specially-selected Editors, and new articles are written to give appropriate complete coverage. The handbooks are intended to be of value and interest to research students, postdoctoral fellows and other researchers learning about the scientific area in question and undertaking relevant experiments, whether in academia or industry. Have the content of this handbook and the complete content of eMagRes at your fingertips! Visit: www.wileyonlinelibrary.com/ref/eMagRes

Amorphous Drugs

Author : Marzena Rams-Baron
Publisher : Springer
ISBN 13 : 3319720023
Total Pages : 234 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Amorphous Drugs by : Marzena Rams-Baron

Download or read book Amorphous Drugs written by Marzena Rams-Baron and published by Springer. This book was released on 2018-02-09 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains theoretical and technological aspects of amorphous drug formulations. It is intended for all those wishing to increase their knowledge in the field of amorphous pharmaceuticals. Conversion of crystalline material into the amorphous state, as described in this book, is a way to overcome limited water solubility of drug formulations, in this way enhancing the chemical activity and bioavailability inside the body. Written by experts from various fields and backgrounds, the book introduces to fundamental physical aspects (explaining differences between the ordered and the disordered solid states, the enhancement of solubility resulting from drugs amorphization, physical instability and how it can be overcome) as well as preparation and formulation procedures to produce and stabilize amorphous pharmaceuticals. Readers will thus gain a well-funded understanding and find a multi-faceted discussion of the properties and advantages of amorphous drugs and of the challenges in producing and stabilizing them. The book is an ideal source of information for researchers and students as well as professionals engaged in research and development of amorphous pharmaceutical products.

Solid State Characterization of Pharmaceuticals

Author : Richard A. Storey
Publisher : John Wiley & Sons
ISBN 13 : 1119970172
Total Pages : 557 pages
Book Rating : 4.1/5 (199 download)

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Book Synopsis Solid State Characterization of Pharmaceuticals by : Richard A. Storey

Download or read book Solid State Characterization of Pharmaceuticals written by Richard A. Storey and published by John Wiley & Sons. This book was released on 2011-03-31 with total page 557 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of solid state characterization is central to the pharmaceutical industry, as drug products are, in an overwhelming number of cases, produced as solid materials. Selection of the optimum solid form is a critical aspect of the development of pharmaceutical compounds, due to their ability to exist in more than one form or crystal structure (polymorphism). These polymorphs exhibit different physical properties which can affect their biopharmaceutical properties. This book provides an up-to-date review of the current techniques used to characterize pharmaceutical solids. Ensuring balanced, practical coverage with industrial relevance, it covers a range of key applications in the field. The following topics are included: Physical properties and processes Thermodynamics Intellectual guidance X-ray diffraction Spectroscopy Microscopy Particle sizing Mechanical properties Vapour sorption Thermal analysis & Calorimetry Polymorph prediction Form selection

Pharmaceutical Crystals

Author : Tong Li
Publisher : John Wiley & Sons
ISBN 13 : 1119046297
Total Pages : 432 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Pharmaceutical Crystals by : Tong Li

Download or read book Pharmaceutical Crystals written by Tong Li and published by John Wiley & Sons. This book was released on 2018-10-16 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: An important resource that puts the focus on understanding and handling of organic crystals in drug development Since a majority of pharmaceutical solid-state materials are organic crystals, their handling and processing are critical aspects of drug development. Pharmaceutical Crystals: Science and Engineering offers an introduction to and thorough coverage of organic crystals, and explores the essential role they play in drug development and manufacturing. Written contributions from leading researchers and practitioners in the field, this vital resource provides the fundamental knowledge and explains the connection between pharmaceutically relevant properties and the structure of a crystal. Comprehensive in scope, the text covers a range of topics including: crystallization, molecular interactions, polymorphism, analytical methods, processing, and chemical stability. The authors clearly show how to find solutions for pharmaceutical form selection and crystallization processes. Designed to be an accessible guide, this book represents a valuable resource for improving the drug development process of small drug molecules. This important text: Includes the most important aspects of solid-state organic chemistry and its role in drug development Offers solutions for pharmaceutical form selection and crystallization processes Contains a balance between the scientific fundamental and pharmaceutical applications Presents coverage of crystallography, molecular interactions, polymorphism, analytical methods, processing, and chemical stability Written for both practicing pharmaceutical scientists, engineers, and senior undergraduate and graduate students studying pharmaceutical solid-state materials, Pharmaceutical Crystals: Science and Engineering is a reference and textbook for understanding, producing, analyzing, and designing organic crystals which is an imperative skill to master for anyone working in the field.

Impedance Spectroscopy

Author : Evgenij Barsoukov
Publisher : John Wiley & Sons
ISBN 13 : 1119333172
Total Pages : 550 pages
Book Rating : 4.1/5 (193 download)

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Book Synopsis Impedance Spectroscopy by : Evgenij Barsoukov

Download or read book Impedance Spectroscopy written by Evgenij Barsoukov and published by John Wiley & Sons. This book was released on 2018-03-19 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Essential Reference for the Field, Featuring Protocols, Analysis, Fundamentals, and the Latest Advances Impedance Spectroscopy: Theory, Experiment, and Applications provides a comprehensive reference for graduate students, researchers, and engineers working in electrochemistry, physical chemistry, and physics. Covering both fundamentals concepts and practical applications, this unique reference provides a level of understanding that allows immediate use of impedance spectroscopy methods. Step-by-step experiment protocols with analysis guidance lend immediate relevance to general principles, while extensive figures and equations aid in the understanding of complex concepts. Detailed discussion includes the best measurement methods and identifying sources of error, and theoretical considerations for modeling, equivalent circuits, and equations in the complex domain are provided for most subjects under investigation. Written by a team of expert contributors, this book provides a clear understanding of impedance spectroscopy in general as well as the essential skills needed to use it in specific applications. Extensively updated to reflect the field’s latest advances, this new Third Edition: Incorporates the latest research, and provides coverage of new areas in which impedance spectroscopy is gaining importance Discusses the application of impedance spectroscopy to viscoelastic rubbery materials and biological systems Explores impedance spectroscopy applications in electrochemistry, semiconductors, solid electrolytes, corrosion, solid state devices, and electrochemical power sources Examines both the theoretical and practical aspects, and discusses when impedance spectroscopy is and is not the appropriate solution to an analysis problem Researchers and engineers will find value in the immediate practicality, while students will appreciate the hands-on approach to impedance spectroscopy methods. Retaining the reputation it has gained over years as a primary reference, Impedance Spectroscopy: Theory, Experiment, and Applications once again present a comprehensive reference reflecting the current state of the field.

Discovering and Developing Molecules with Optimal Drug-Like Properties

Author : Allen C Templeton
Publisher : Springer
ISBN 13 : 1493913999
Total Pages : 510 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Discovering and Developing Molecules with Optimal Drug-Like Properties by : Allen C Templeton

Download or read book Discovering and Developing Molecules with Optimal Drug-Like Properties written by Allen C Templeton and published by Springer. This book was released on 2014-10-31 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative volume provides a contemporary view on the latest research in molecules with optimal drug-like properties. It is a valuable source to access current best practices as well as new research techniques and strategies. Written by leading scientists in their fields, the text consists of fourteen chapters with an underlying theme of early collaborative opportunities between pharmaceutical and discovery sciences. The book explores the practical realities of performing physical pharmaceutical and biopharmaceutical research in the context of drug discovery with short timelines and low compound availability. Chapters cover strategies and tactics to enable discovery as well as predictive approaches to establish, understand and communicate risks in early development. It also examines the detection, characterization, and assessment of risks on the solid state properties of advanced discovery and early development candidates, highlighting the link between solid state properties and critical development parameters such as solubility and stability. Final chapters center on techniques to improve molecular solubilization and prevent precipitation, with particularly emphasis on linking physiochemical properties of molecules to formulation selection in preclinical and clinical settings.

Frontiers in Chemistry: Editor's Pick 2022

Author : Frontiers in Chemistry Editorial Office
Publisher : Frontiers Media SA
ISBN 13 : 288976480X
Total Pages : 377 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Frontiers in Chemistry: Editor's Pick 2022 by : Frontiers in Chemistry Editorial Office

Download or read book Frontiers in Chemistry: Editor's Pick 2022 written by Frontiers in Chemistry Editorial Office and published by Frontiers Media SA. This book was released on 2022-09-06 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: We are pleased to introduce the 2022 Frontiers in Chemistry: Editor’s Pick collection, showcasing articles stimulating interest in the field, carefully selected in collaboration with our Field Chief Editor, Prof. Steven Suib, of University of Connecticut. With this ebook we aim to highlight and disseminate important findings across the domains of chemistry research, capturing the multidisciplinary and inclusive approach our journal takes towards advancing the field of chemistry and supporting new technological breakthroughs that help humanity live healthier lives on a healthy planet. 2021 was a year which saw our highest journal impact factor yet, international community growth, and a record-breaking number of articles to choose from. We wish to elevate the contributions made by authors, encourage readership and innovation through our open-access philosophies, and thank our Editorial Board for their continued hard work and collaboration.

Formulating Poorly Water Soluble Drugs

Author : Robert O. Williams III
Publisher : Springer
ISBN 13 : 3319426095
Total Pages : 781 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Formulating Poorly Water Soluble Drugs by : Robert O. Williams III

Download or read book Formulating Poorly Water Soluble Drugs written by Robert O. Williams III and published by Springer. This book was released on 2016-12-16 with total page 781 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this volume is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at minimum a working knowledge of each of the abovementioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop

Pain Management and the Opioid Epidemic

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309459575
Total Pages : 483 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Pain Management and the Opioid Epidemic by : National Academies of Sciences, Engineering, and Medicine

Download or read book Pain Management and the Opioid Epidemic written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-09-28 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.

Engineering of Biomaterials for Drug Delivery Systems

Author : Anilkumar Parambath
Publisher : Woodhead Publishing
ISBN 13 : 0081017510
Total Pages : 405 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Engineering of Biomaterials for Drug Delivery Systems by : Anilkumar Parambath

Download or read book Engineering of Biomaterials for Drug Delivery Systems written by Anilkumar Parambath and published by Woodhead Publishing. This book was released on 2018-02-01 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Engineering of Biomaterials for Drug Delivery Systems: Beyond Polyethylene Glycol examines the combined issues of PEGylation and viable biomaterials as alternatives. With a strong focus on polymeric biomaterials, the book first reviews the major issues associated with PEGylation and its use in vivo. Chapters then focus on alternative polymer systems for drug delivery systems. Finally, nanoparticles and future perspectives are examined. This book is a valuable resource for scientists and researchers in biomaterials, pharmaceuticals and nanotechnology, and all those who wish to broaden their knowledge in this field. Provides a self-contained work for the field of biomaterials for drug delivery Summarizes the current knowledge on PEGylation and strategies for bypassing it Presents research on an important, though under-represented issue in biomaterials Written by a world-class team of research scientists, engineers and clinicians

Enhancing the Pharmaceutical Behavior of Poorly Soluble Drugs Through the Formation of Cocrystals and Mesophases

Author : Barbara Rodriguez Spong
Publisher :
ISBN 13 :
Total Pages : 488 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Enhancing the Pharmaceutical Behavior of Poorly Soluble Drugs Through the Formation of Cocrystals and Mesophases by : Barbara Rodriguez Spong

Download or read book Enhancing the Pharmaceutical Behavior of Poorly Soluble Drugs Through the Formation of Cocrystals and Mesophases written by Barbara Rodriguez Spong and published by . This book was released on 2005 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: