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Discovery Of Novel Pain Genes Using Systems Genetics
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Book Synopsis Chasing Men on Fire by : Stephen G. Waxman
Download or read book Chasing Men on Fire written by Stephen G. Waxman and published by MIT Press. This book was released on 2018-03-09 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: A thirty-year quest, from genes to pain-signaling neurons to people with a rare genetic disorder that makes them feel they are on fire. Two soldiers, both with wounds injuring the same nerve, show very different responses: one is disabled by neuropathic pain, unable to touch the injured limb because even the lightest contact triggers excruciating discomfort; the other notices numbness but no pain at all. Could the difference lie in their genes? In this book, described in the foreword by Nobel Laureate James Rothman as “so well written that it reads like a detective novel,” Stephen Waxman recounts the search for a gene that controls pain—a search spanning more than thirty years and three continents. The story moves from genes to pain-signaling neurons that scream when they should be silent to people with a rare genetic disorder who feel they are on fire. Waxman explains that if pain-signaling neurons are injured by trauma or disease, they can become hyperactive and send pain signals to the brain even without external stimulus. Studying the hyperactive mutant pain gene in man on fire syndrome has pointed the way to molecules that produce pain more broadly within the general population, in the rest of us. Waxman's account of the many steps that led to discovery of the pain gene tells the story behind the science, of how science happens.
Book Synopsis The Genetics of Pain by : Jeffrey Steven Mogil
Download or read book The Genetics of Pain written by Jeffrey Steven Mogil and published by Progress in Pain Research and. This book was released on 2004 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics more than any other biological approach can explain why some people experience more pain than others and receive less benefit from existing analgesics. Sixteen scholarly articles from international contributors describe the application of genetic techniques to the problem of pain and consider the knowledge that has so far resulted. Three themed sections review the techniques that are allowing the study of pain mechanisms at the genetic level; describe the progress being made in lab animals and humans in identifying the genes responsible for individual differences; and explore the practical and ethical issues that face pain researchers. The editor is associated with the Centre for Research on Pain, McGill U., Montreal. Annotation : 2004 Book News, Inc., Portland, OR (booknews.com).
Book Synopsis TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades by : Wolfgang B. Liedtke, MD, PH.D.
Download or read book TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades written by Wolfgang B. Liedtke, MD, PH.D. and published by CRC Press. This book was released on 2006-09-29 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of st
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309459575 Total Pages :483 pages Book Rating :4.3/5 (94 download)
Book Synopsis Pain Management and the Opioid Epidemic by : National Academies of Sciences, Engineering, and Medicine
Download or read book Pain Management and the Opioid Epidemic written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-09-28 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.
Book Synopsis Genes, Brain Function, and Behavior by : Douglas Wahlsten
Download or read book Genes, Brain Function, and Behavior written by Douglas Wahlsten and published by Academic Press. This book was released on 2019-03-19 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genes, Brain Function, and Behavior offers a concise description of the nervous system that processes sensory input and initiates motor movements. It reviews how behaviors are defined and measured, and how experts decide when a behavior is perturbed and in need of treatment. Behavioral disorders that are clearly related to a defect in a specific gene are reviewed, and the challenges of understanding complex traits such as intelligence, autism and schizophrenia that involve numerous genes and environmental factors are explored. New methods of altering genes offer hope for treating or even preventing difficulties that arise in our genes. This book explains what genes are, what they do in the nervous system, and how this impacts both brain function and behavior.
Book Synopsis The Genetics of African Populations in Health and Disease by : Muntaser E. Ibrahim
Download or read book The Genetics of African Populations in Health and Disease written by Muntaser E. Ibrahim and published by Cambridge University Press. This book was released on 2019-12-19 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: A pioneering work that focuses on the unique diversity of African genetics, offering insights into human biology and genetic approaches.
Book Synopsis Pain Care Essentials and Innovations E-Book by : Sanjog Pangarkar
Download or read book Pain Care Essentials and Innovations E-Book written by Sanjog Pangarkar and published by Elsevier Health Sciences. This book was released on 2020-06-30 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering the newest trends and treatments in pain care, as well as the pain treatment strategies that have been successfully employed in the past, Pain Care Essentials and Innovations brings you fully up to date with effective treatments for acute and chronic pain. It offers expert guidance on both interventional and non-interventional strategies, provided by respected academic physiatrists who practice evidence-based medicine at UCLA and an ACGME-accredited rehabilitation and pain program. - Covers cannabinoids in pain care, novel therapeutics in pain medicine, and integrative care in pain management. - Discusses relevant basic science, psychological aspects of pain care, opioids and practice guidelines, geriatric pain management, and future research in the field. - Consolidates today's available information and guidance into a single, convenient resource.
Book Synopsis The Selfish Gene by : Richard Dawkins
Download or read book The Selfish Gene written by Richard Dawkins and published by Oxford University Press, USA. This book was released on 1989 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Science need not be dull and bogged down by jargon, as Richard Dawkins proves in this entertaining look at evolution. The themes he takes up are the concepts of altruistic and selfish behaviour; the genetical definition of selfish interest; the evolution of aggressive behaviour; kinshiptheory; sex ratio theory; reciprocal altruism; deceit; and the natural selection of sex differences. 'Should be read, can be read by almost anyone. It describes with great skill a new face of the theory of evolution.' W.D. Hamilton, Science
Book Synopsis Temporomandibular Disorders and Related Pain Conditions by : Barry J. Sessle
Download or read book Temporomandibular Disorders and Related Pain Conditions written by Barry J. Sessle and published by Progress in Pain Research and. This book was released on 1995 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neuroimaging of Pain written by Luca Saba and published by Springer. This book was released on 2017-06-08 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authored by world renowned scientists, this book expertly reviews all the imaging techniques and exciting new methods for the analysis of the pain, including novel tracers, biomarker, metabolomic and gene-array profiling, together with cellular, genetic, and molecular approaches. Recent advances in human brain imaging techniques have allowed a better understand of the functional connectivity in pain pathways, as well as the functional and anatomical alterations that occur in chronic pain patients. Modern imaging techniques have permitted rapid progress in the understanding of networks in the brain related to pain processing and those related to different types of pain modulation. Neuroimaging of Pain is designed to be a valuable resource for radiologists, neuroradiologists, neurologists and neuroscientists, working in hospitals and universities from junior trainees to consultants.
Download or read book Pain written by and published by . This book was released on 2001 with total page 58 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Translational Pain Research by : Lawrence Kruger
Download or read book Translational Pain Research written by Lawrence Kruger and published by CRC Press. This book was released on 2009-11-24 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practical
Book Synopsis Principles of Asynchronous Circuit Design by : Jens Sparsø
Download or read book Principles of Asynchronous Circuit Design written by Jens Sparsø and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Asynchronous Circuit Design - A Systems Perspective addresses the need for an introductory text on asynchronous circuit design. Part I is an 8-chapter tutorial which addresses the most important issues for the beginner, including how to think about asynchronous systems. Part II is a 4-chapter introduction to Balsa, a freely-available synthesis system for asynchronous circuits which will enable the reader to get hands-on experience of designing high-level asynchronous systems. Part III offers a number of examples of state-of-the-art asynchronous systems to illustrate what can be built using asynchronous techniques. The examples range from a complete commercial smart card chip to complex microprocessors. The objective in writing this book has been to enable industrial designers with a background in conventional (clocked) design to be able to understand asynchronous design sufficiently to assess what it has to offer and whether it might be advantageous in their next design task.
Book Synopsis Neuromorphic Olfaction by : Krishna C. Persaud
Download or read book Neuromorphic Olfaction written by Krishna C. Persaud and published by CRC Press. This book was released on 2016-04-19 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many advances have been made in the last decade in the understanding of the computational principles underlying olfactory system functioning. Neuromorphic Olfaction is a collaboration among European researchers who, through NEUROCHEM (Fp7-Grant Agreement Number 216916)-a challenging and innovative European-funded project-introduce novel computing p
Book Synopsis Bone Dysplasias by : Jürgen W. Spranger
Download or read book Bone Dysplasias written by Jürgen W. Spranger and published by Oxford University Press, USA. This book was released on 2018 with total page 929 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive guide to genetic bone disorders, now revised and expanded with glossy photographs and radiographs "Brilliantly written and produced and deserves to be on the shelves of all pediatric radiologists. It should also be available to geneticists, counselors, and pediatricians." --Radiology This updated and expanded fourth edition of Bone Dysplasias presents age-related radiographs, photographs and clinical guidelines for more than 250 rare constitutional skeletal diseases. Focusing on diagnostically essential imaging and clinical features, each chapter is supplemented with prognostic and therapeutic information, a guide to differential diagnoses, and a short list of the most relevant publications. Organized in accordance with the most recent International Nosology and Classification of Genetic Skeletal Disorders, this new Bone Dysplasias distills the insights of a small, world-class author team on diagnosis and clinical approaches to this most difficult class of disorders.
Book Synopsis Pharmacology of Pain by : Pierre Beaulieu
Download or read book Pharmacology of Pain written by Pierre Beaulieu and published by Lippincott Williams & Wilkins. This book was released on 2015-06-01 with total page 978 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacology of Pain provides a complete review of the pharmacology of pain, including mechanisms of drug actions, clinical aspects of drug usage, and new developments. This authoritative book describes the different systems involved in the perception, transmission, and modulation of pain and discusses the available options for pharmacological treatment of pain. Who should buy this book? Pharmacology of Pain is a particularly useful resource for: Basic researchers and clinicians, including physicians, dentists, pharmacists, nurses, and physical therapists Other professionals in the field of pain research and treatment Students and trainees
Book Synopsis Genomics of Pain and Co-Morbid Symptoms by : Susan G. Dorsey
Download or read book Genomics of Pain and Co-Morbid Symptoms written by Susan G. Dorsey and published by Springer Nature. This book was released on 2020-06-15 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of the field of pain genomics and the genomics of related, or co-occuring, symptoms, the current state-of-the-science, and challenges that remain. It brings differing views in the field together and provides examples of translational science from using cellular and rodent models to human clinical trials. This book's structure leads the reader through the physiology of pain and genomics into how pain is studied, mechanisms of acute and chronic pain, various protocols that are used throughout the field along with the pros/cons of the current methods used, and project into the future of pain genomics. This work is intended for classroom teaching, for nurses, for novice researchers in symptom science and pain research as well as students and postdoctoral fellows.
