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Author : Federica Di Sano
Publisher : Frontiers Media SA
ISBN 13 : 2889713393
Total Pages : 131 pages
Book Rating : 4.8/5 (897 download)
Download or read book Autophagy in Mammalian Development and Differentiation written by Federica Di Sano and published by Frontiers Media SA. This book was released on 2021-09-23 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Guohua Yuan
Publisher : Frontiers Media SA
ISBN 13 : 2889766462
Total Pages : 124 pages
Book Rating : 4.8/5 (897 download)
Download or read book Advances in Tooth Development and Regeneration: the Importance of Cytodifferentiation and Mineralization Processes written by Guohua Yuan and published by Frontiers Media SA. This book was released on 2023-01-05 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : B Sivapathasundharam
Publisher : Jaypee Brothers Medical Publishers
ISBN 13 : 935270567X
Total Pages : 371 pages
Book Rating : 4.3/5 (527 download)
Download or read book Textbook of Oral Embryology & Histology written by B Sivapathasundharam and published by Jaypee Brothers Medical Publishers. This book was released on 2018-10-23 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Antonio Nanci
Publisher : Elsevier Health Sciences
ISBN 13 : 032304557X
Total Pages : 432 pages
Book Rating : 4.3/5 (23 download)
Download or read book Ten Cate's Oral Histology written by Antonio Nanci and published by Elsevier Health Sciences. This book was released on 2008-01-01 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accompanying CD-ROM contains ... "150 color images with legends, 472 book figures with legends, 438 multiple choice test questions, and 119 interactive drag-and-drop exercises." -- from CD-ROM Welcome screen.
Author : Louis H. Berman
Publisher : Elsevier Health Sciences
ISBN 13 : 032367304X
Total Pages : 1092 pages
Book Rating : 4.3/5 (236 download)
Download or read book Cohen's Pathways of the Pulp - E-Book written by Louis H. Berman and published by Elsevier Health Sciences. This book was released on 2020-09-08 with total page 1092 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stay up on the latest research and techniques in endodontics with Cohen’s Pathways of the Pulp, 12th Edition. Written by a team of internationally renowned experts and trusted for more than 40 years, this definitive guide covers the science, theory, and practice of endodontics. Full color illustrations and detailed radiographs guide readers through each step of endodontic care — from diagnosis and treatment planning to proven techniques for managing pulpal and periapical diseases. This new twelfth edition also boasts the very latest evidence-based research and techniques, reorganized and condensed chapters, plus other features designed to help you locate important information quickly and easily. Complete with access to Expert Consult, it’s everything you need to stay ahead in the field of endodontics. Extensive illustration collection includes over 2,000 full-color photos, line art, and radiographs to clearly demonstrate core concepts and reinforce the essential principles and techniques of endodontics. Video clips and case studies demonstrate key procedures such as palpation of the masseter muscle, introsseous anesthesia with the X-tip system, dentin hypersensitivity, and more. Diverse and respected contributor pool includes experts from many national- and international-based dental education programs. NEW! Updated content and new images incorporate the most recent developments in research and clinical endodontic techniques. NEW! Additional topics cover pulp biology, pathobiology, diagnosis, treatment planning, pain control, isolation, access, cleaning and shaping, obturation, restoration, assessment of outcomes, emergencies and surgery. Each online topic comes with assigned reading lists, a PowerPoint lecture, written lesson objectives, and example exam questions. NEW! Compliance with the Commission on Dental Accreditation Curriculum ensures that the needs of all dental programs are met. NEW! Reorganized sections now divide chapters by those covering clinical endodontics, those covering the biological basis of endodontics, and chapters which detail endodontics in private practice to make content easier for both clinicians and students to navigate. NEW! Condensed chapters remove unnecessary duplication of content across the text and make the physical text lighter and easier to use.
Author : Sesha Hanson-Drury
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (14 download)
Download or read book Towards Regenerative Dentistry written by Sesha Hanson-Drury and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinicians, scientists, and the general public share the desire to regenerate missing tooth structure. The majority of mineralized tooth structure is composed of dentin, a material produced and mineralized by ectomesenchyme derived cells, odontoblasts. Though odontoblast development has been characterized in mouse models, mice constantly replenish their missing tooth structure though several stem cell niches not present in human teeth, posing translational challenges between the species. Human odontoblast differentiation and maturation remains largely unknown due to the rarity of tissue samples. To bioengineer missing dentin, increased understanding of human tooth development is required. Thus, our lab performed single cell combinatorial indexing RNA sequencing (sci-RNA-seq) followed by RNA Fluorescence in situ Hybridization (RNAScope) of the developing human oral cavity with the hypothesis that: the dental ectomesenchyme is composed of a heterogeneous cell population that each possess a unique transcriptional signature; changes in expression of these specific transcriptional signatures indicate transitions between cell types; and the molecular mechanisms that drive odontoblast developmental transitions occur at specific spatio-temporal intervals. We found that during early tooth development, the dental ectomesenchyme is divided into two transcriptionally unique components of the tooth germ tissue: the dental pulp composed of dental ectomesenchyme and dental papilla surrounded by the dental follicle. Strikingly, multiple computational assays indicate subodontoblasts (SOB) as a novel odontoblast progenitor source during human tooth development. SOB arise from the dental follicle and transition through a preodontoblast state before giving rise to odontoblasts. Further, we revealed the presence of SOB directly beneath the odontoblasts and intermingled with preodontoblasts at the pulpal periphery. SOB are a source of odontoblast renewal in adult mice following injury, but their presence and role in human odontoblast development has eluded researchers. Thus, our finding identifies this regenerative population in developing humans for the first time and holds incredible promise for SOB as a novel odontoblast progenitor not only during injury repair, but during normal human tooth development allowing us to manipulate and better utilize this naturally regenerating population in human dentistry. In order to further study odontoblast development, perform disease modeling, and test therapeutic agents, our lab developed an optimized in vitro human induced pluripotent stem cell to odontoblast differentiation protocol guided by sci-RNA-seq (iOB). Computational analysis identified fibroblast growth factor (FGF), bone morphogenic protein (BMP), and hedgehog (HH) signaling to play critical roles in human odontoblast development, with the majority of signaling ligands secreted by neighboring dental epithelium tissues. We found that activating these signaling pathways in induced neural crest cells by treatment with novel AI-designed FGFR superagonist minibinder, BMP ligand BMP4, and HH pathway agonist SAG signaling ligands produces more mature odontoblasts with increased expression of odontoblast markers and enhanced mineralization capacity. This finding implies great potential for AI-designed minibinders as therapeutic agents to induce odontoblast differentiation in clinical cases of pulp exposure or deep caries, as well as generation of mature iOB to be used for tooth organoid generation. Finally, the congenital disorder Tricho-Dento-Osseous syndrome produces debilitating dental defects associated with mutations in the gene DLX3. While transcription factor DLX3 is known to directly regulate Dspp activity and odontoblast development in mice, its role during human odontoblast differentiation is poorly understood. We generated a DLX3 knockout mutant line from HiPSC and tested their capacity to differentiate to mature odontoblasts. Importantly, we identified that DLX3 mutants are able to successfully differentiate towards a neural crest fate, however, odontoblast differentiation is arrested. This indicates DLX3 plays a critical role in early odontoblast development. The overall significance of this study is threefold: 1) providing unprecedented insight at the single cell level into cell types of the developing tooth dental ectomesenchyme; 2) applying the revealed molecular signaling that controls human odontoblast cell lineage commitment during differentiation to generate a HiPSC-derived odontoblast differentiation method (iOB); 3) utilizing the iOB tool to study the molecular mechanism of human odontoblast differentiation in states of health and disease in order to design appropriate therapies.
Author : Alexander Birbrair
Publisher : Academic Press
ISBN 13 : 0323900607
Total Pages : 438 pages
Book Rating : 4.3/5 (239 download)
Download or read book Molecular Players in iPSC Technology written by Alexander Birbrair and published by Academic Press. This book was released on 2021-08-29 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology.Molecular Players in iPSC Technology, Volume 12 addresses the molecular players underlying induced pluripotent stem cell (iPSC) generation, maintenance, expansion, and differentiation. The discovery of iPSCs revolutionized biomedical research. iPSC technology involves multiple molecular mechanisms. This volume covers exosomal microRNAs, auxiliary pluripotency-associated genes, inducible caspase-9 suicide gene, cell cycle proteins, ion channels, Notch signaling, kinase signaling, SOCS3/JAK2/STAT3 pathway, NANOG, Krüppel-like factors, H1FOO, and much more in iPSCs. The volume is written for researchers and scientists in stem cell therapy, cellular and molecular biology, and regenerative medicine and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of iPSC technology, regenerative medicine, and therapeutics Covers the different key molecular players involved in iPSC formation, maintenance, expansion, and differentiation Is contributed by world-renowned experts in the field
Author : Henry F. Duncan
Publisher : Springer
ISBN 13 : 3319968483
Total Pages : 197 pages
Book Rating : 4.3/5 (199 download)
Download or read book Clinical Approaches in Endodontic Regeneration written by Henry F. Duncan and published by Springer. This book was released on 2018-11-01 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: This richly illustrated book combines explanation of the scientific base underpinning vital pulp treatment with description of current and emerging trends in clinical practice. It guides the reader through modern views on pulp diagnostics, deep caries, and pulp exposure management, leading to an analysis of the biological aspects of regenerative techniques such as angiogenesis, neurogenesis, inflammation, and epigenetics. In the later chapters, practical considerations relating to bioengineering, biomaterial choice, revitalization, and stem cell-based procedures are discussed and their likely therapeutic impact considered. Aimed at dental students, postgraduates, and research-minded dental practitioners, this translational book summarizes state-of-the-art scientific knowledge on dentin–pulp interactions and regenerative endodontics, while highlighting the opportunities to incorporate recent developments into everyday practice. Readers will also find extensive discussion of potential future developments and research avenues relating to each aspect of this exciting and rapidly developing field.
Author : G. S. Kumar
Publisher : Elsevier Health Sciences
ISBN 13 : 8131238016
Total Pages : 448 pages
Book Rating : 4.1/5 (312 download)
Download or read book Orban's Oral Histology & Embryology written by G. S. Kumar and published by Elsevier Health Sciences. This book was released on 2014-02-10 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: • Incorporates all relevant changes especially in the field of molecular biology • Discusses molecular biological aspects of oral tissues • Emphasizes clinical relevance of oral histological aspects • contains more line diagrams and illustrations for easier understanding
Author : Michel Goldberg
Publisher : Bentham Science Publishers
ISBN 13 : 1608051714
Total Pages : 245 pages
Book Rating : 4.6/5 (8 download)
Download or read book Amelogenins: Multifaceted Proteins for Dental and Bone Formation and Repair written by Michel Goldberg and published by Bentham Science Publishers. This book was released on 2010 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This volume is the 1st in a series of Ebooks that bridges the gap between advances in science and clinical practice in odontology. Recent advances in biology, materials science and tissue engineering are increasingly viewed as being of enormous clinical p"
Author : Benedetta Artegiani
Publisher : Frontiers Media SA
ISBN 13 : 2832501192
Total Pages : 383 pages
Book Rating : 4.8/5 (325 download)
Download or read book Mechanisms of Cellular Differentiation, Organ Development, and Novel Model Systems written by Benedetta Artegiani and published by Frontiers Media SA. This book was released on 2022-09-29 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Mark F. Teaford
Publisher : Cambridge University Press
ISBN 13 : 1139429221
Total Pages : 328 pages
Book Rating : 4.1/5 (394 download)
Download or read book Development, Function and Evolution of Teeth written by Mark F. Teaford and published by Cambridge University Press. This book was released on 2007-02-01 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this field there has been an explosion of information generated by scientific research. One of the beneficiaries of this has been the study of morphology, where new techniques and analyses have led to insights into a wide range of topics. Advances in genetics, histology, microstructure, biomechanics and morphometrics have allowed researchers to view teeth from alternative perspectives. However, there has been little communication between researchers in the different fields of dental research. This book brings together overviews on a wide range of dental topics linking genes, molecules and developmental mechanisms within an evolutionary framework. Written by the leading experts in the field, this book will stimulate co-operative research in fields as diverse as paleontology, molecular biology, developmental biology and functional morphology.
Author : Mona Marei
Publisher : Springer Nature
ISBN 13 : 3031025814
Total Pages : 164 pages
Book Rating : 4.0/5 (31 download)
Download or read book Regenerative Dentistry written by Mona Marei and published by Springer Nature. This book was released on 2022-06-01 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dental caries, periodontitis, tooth loss, and bone resorption are considered prevalent health problems that have direct affect on the quality of life. While, advances in stem cell biology and biotechnology have sparked hope for devastating maladies, such as diabetes, cardiovascular diseases, etc., it also provides a strategy of regenerative therapy for dental tissues. From the prospective of tissue engineering, it is of utmost importance to understand and emulate the complex cell interactions that make up a tissue or organ. Unlike other tissues in the body, dental tissues are unique in their development, function, and even in their maintenance throughout life. The harmonized stimulations of biology and mechanical regulators to promote cellular activities have matured our understanding of the value of regenerative therapy of dental tissue versus the reparative treatment. In this book, we review the current knowledge available to regenerate alveolar bone, periodontal structure, and pulp/dentin complex. The book provides researchers with detailed information about development and functional characteristics of the dental unit with detailed protocols covering a comprehensive range of various approaches to engineer dental tissues: to use isolated cells or cell substitutes as cellular replacement, to use acellular biomaterials capable of inducing tissue regeneration, and/or to use a combination of cells, biomaterial and growth factors. We are well aware, with the concept changes in the field toward in-vitro biomimetics of in-vivo tissue development. The theoretical frame work integrating these concepts of developmental biology and developmental engineering is yet to be emphasized and implemented. Until this happens, we consider this book of regenerative dentistry as a call for scientists to achieve, researchers to innovate, practitioners to apply, and students to learn the art and science of regenerative therapy in dentistry. Table of Contents: Introduction to Regenerative Dentistry / Tissue Engineering Alveolar Bone / Tissue Engineering of the Periodontal Tissues / Dynamics for Pulp-Dentin Tissue Engineering in Operative Dentistry
Author : Ajaykumar Vishwakarma
Publisher : Academic Press
ISBN 13 : 0123977789
Total Pages : 933 pages
Book Rating : 4.1/5 (239 download)
Download or read book Stem Cell Biology and Tissue Engineering in Dental Sciences written by Ajaykumar Vishwakarma and published by Academic Press. This book was released on 2014-11-05 with total page 933 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem Cell Biology and Tissue Engineering in Dental Sciences bridges the gap left by many tissue engineering and stem cell biology titles to highlight the significance of translational research in this field in the medical sciences. It compiles basic developmental biology with keen focus on cell and matrix biology, stem cells with relevance to tissue engineering biomaterials including nanotechnology and current applications in various disciplines of dental sciences; viz., periodontology, endodontics, oral & craniofacial surgery, dental implantology, orthodontics & dentofacial orthopedics, organ engineering and transplant medicine. In addition, it covers research ethics, laws and industrial pitfalls that are of particular importance for the future production of tissue constructs. Tissue Engineering is an interdisciplinary field of biomedical research, which combines life, engineering and materials sciences, to progress the maintenance, repair and replacement of diseased and damaged tissues. This ever-emerging area of research applies an understanding of normal tissue physiology to develop novel biomaterial, acellular and cell-based technologies for clinical and non-clinical applications. As evident in numerous medical disciplines, tissue engineering strategies are now being increasingly developed and evaluated as potential routine therapies for oral and craniofacial tissue repair and regeneration. Diligently covers all the aspects related to stem cell biology and tissue engineering in dental sciences: basic science, research, clinical application and commercialization Provides detailed descriptions of new, modern technologies, fabrication techniques employed in the fields of stem cells, biomaterials and tissue engineering research including details of latest advances in nanotechnology Includes a description of stem cell biology with details focused on oral and craniofacial stem cells and their potential research application throughout medicine Print book is available and black and white, and the ebook is in full color
Author : Louis H. Berman, DDS, FACD
Publisher : Elsevier Health Sciences
ISBN 13 : 0323096352
Total Pages : 1143 pages
Book Rating : 4.3/5 (23 download)
Download or read book Cohen's Pathways of the Pulp Expert Consult written by Louis H. Berman, DDS, FACD and published by Elsevier Health Sciences. This book was released on 2015-10-02 with total page 1143 pages. Available in PDF, EPUB and Kindle. Book excerpt: Find the latest evidence-based research and clinical treatments! Cohen's Pathways of the Pulp, 11th Edition covers the science, theory, and practice of endondontics with chapters written by internationally renowned experts. Full-color illustrations and detailed radiographs guide you through each step of endodontic care - from diagnosis and treatment planning to proven techniques for managing pulpal and periapical diseases. New to the print edition are seven new chapters, and the eBook version adds three more. As an Expert Consult title, Cohen's Pathways of the Pulp lets you search the entire contents of the book on your desktop or mobile device, and includes videos, case studies, and more. Edited by noted specialists Kenneth Hargreaves and Louis Berman, this book is the definitive resource in endodontics! Print version of the text includes 27 comprehensive chapters and meets the CODA requirements for endodontic dental education. EBook version of the text consists of 30 searchable chapters, including the 27 chapters in the print version, and features videos, PowerPoint® slides, review questions, case studies, and more; this expanded version makes it easy to find clinical answers quickly, and meets the needs of students, clinicians, and residents in endodontics. Videos and animations demonstrate key procedures such as palpation of the masseter muscle, introsseous anesthesia with the X-tipT system, dentin hypersensitivity, indirect ultrasound, palpation of the temporomandibular joint, and ultrasonic settling. Over 2,000 illustrations include full-color photos and line art, along with a wide range of radiographs, clearly demonstrating core concepts and reinforcing the essential principles and techniques of endodontics. NEW co-editor Dr. Louis H. Berman joins lead editor Dr. Kenneth M. Hargreaves for this edition, and a respected team of contributors includes experts from many U.S.-based dental education programs, as well as programs in Canada, the U.K., Norway, Sweden, France, Germany, Italy, and Switzerland. NEW chapter organization reflects the chronology of endodontic treatment with three comprehensive sections: Clinical Endodontics, focusing on core clinical concepts, and Biological Basis of Endodontics and Endodontics in Clinical Practice, both with information that advanced students, endodontic residents, and clinicians need to know. NEW! Three chapters are available in the eBook: Understanding and Managing the Anxious Patient, Endodontic Records and Legal Responsibilities, and Endodontic Practice Management. NEW Radiographic Interpretation chapter clarifies the diagnostic process with coverage of imaging modalities, diagnostic tasks, three-dimensional imaging, cone beam computed tomography, intra- or post-operative assessment of endodontic treatment complications, and more. NEW Pain Control chapter addresses the management of acute endodontic pain with coverage of local anesthesia for restorative dentistry and endodontics, along with nonnarcotic analgesics and therapeutic recommendations. NEW Evaluation of Outcomes chapter helps you achieve optimal treatment outcomes with information on topics such as the reasons for evaluating outcomes, outcome measurements for endodontic treatment, and the outcomes of vital pulp therapy procedures, non-surgical root canal treatment, non-surgical retreatment, and surgical retreatment. NEW Root Resorption chapter covers the early detection, diagnosis, and histological features of root resorption, as well as external inflammatory resorption, external cervical resorption, and internal resorption. NEW Iatrogenic Endodontics chapter addresses failed treatment scenarios with key information on the event itself, the etiology, soft and hard tissue implications and symptoms, and treatment options and prognosis; the events include cervico-facial subcutaneous emphysema, sodium hypochlorite accidents, perforations (non-surgical), inferior alveolar nerve injury, surgical, sinus perforation, instrument separation, apical extrusion of obturation materials, and ledge formation. NEW Vital Pulp Therapy chapter provides an overview of new treatment concepts for the preservation of the pulpally involved permanent tooth, covering topics such as the living pulp, pulpal response to caries, procedures for generating reparative dentin, indications and materials for vital pulp therapy, MTA applications, and treatment recommendations. NEW Bleaching chapter addresses procedures that can be utilized during and following endodontic treatment to eliminate or reduce any discoloration issues, reviewing internal and external bleaching procedures and their impact on pulpal health/endodontic treatment - with presentations of cases and clinical protocols.
Author : Bharath Dr Rao K
Publisher : Elsevier Health Sciences
ISBN 13 : 8131254143
Total Pages : 474 pages
Book Rating : 4.1/5 (312 download)
Download or read book Fundamentals of Oral Anatomy, Physiology and Histology E -Book written by Bharath Dr Rao K and published by Elsevier Health Sciences. This book was released on 2018-09-27 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Master the basics of Dental Histology, Anatomy, Embryology and Physiology. Fundamentals of Oral Anatomy, Physiology and Histology comprises of four units: Oral Histology, Oral Anatomy, General Embryology and Oral Physiology sections elaborating essential concepts in altogether 38 chapters. Oral Histology emphasizes on the morphology and variation of teeth as a part of dental anatomy. The dental histology section describes the development of teeth and associated tissues including enamel, dentin, pulp, cementum and periodontal ligament. Salivary glands, oral mucosa, maxillary sinus, temporomandibular joint and tissue preparation comprise the rest of the second unit, Oral Anatomy. The third unit of Embryology explains the development of the oral and paraoral structures with details of general embryology from fertilization onwards. Physiology is the fourth unit which constitutes important topics related to year one of dentistry that include mastication, chewing cycle, saliva and calcium phosphorous metabolism. - Conforms to the syllabi prescribed by DCI - Offers an easy-to-follow format for each chapter with numerous tables, flowcharts, photos, and simple neatly labelled line diagrams and histomicrographs - Summarizes important take away points under Synopsis in each chapter - Provided Review Questions in each chapter for self-appraisal - Hand drawn histology diagrams
Author : Wolfgang Knabe
Publisher : Frontiers Media SA
ISBN 13 : 2889743888
Total Pages : 285 pages
Book Rating : 4.8/5 (897 download)
Download or read book Apoptosis and Senescence in Vertebrate Development written by Wolfgang Knabe and published by Frontiers Media SA. This book was released on 2022-02-14 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt:
