Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride

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Author :
Publisher : National Academies Press
ISBN 13 : 0309064031
Total Pages : 449 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride by : Institute of Medicine

Download or read book Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride written by Institute of Medicine and published by National Academies Press. This book was released on 1999-10-17 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since 1941, Recommended Dietary Allowances (RDAs) has been recognized as the most authoritative source of information on nutrient levels for healthy people. Since publication of the 10th edition in 1989, there has been rising awareness of the impact of nutrition on chronic disease. In light of new research findings and a growing public focus on nutrition and health, the expert panel responsible for formulation RDAs reviewed and expanded its approachâ€"the result: Dietary Reference Intakes. This new series of references greatly extends the scope and application of previous nutrient guidelines. For each nutrient the book presents what is known about how the nutrient functions in the human body, what the best method is to determine its requirements, which factors (caffeine or exercise, for example) may affect how it works, and how the nutrient may be related to chronic disease. The first volume of Dietary Reference Intakes includes calcium, phosphorus, magnesium, vitamin D, and fluoride. The second book in the series presents information about thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. Based on analysis of nutrient metabolism in humans and data on intakes in the U.S. population, the committee recommends intakes for each age groupâ€"from the first days of life through childhood, sexual maturity, midlife, and the later years. Recommendations for pregnancy and lactation also are made, and the book identifies when intake of a nutrient may be too much. Representing a new paradigm for the nutrition community, Dietary Reference Intakes encompasses: Estimated Average Requirements (EARs). These are used to set Recommended Dietary Allowances. Recommended Dietary Allowances (RDAs). Intakes that meet the RDA are likely to meet the nutrient requirement of nearly all individuals in a life-stage and gender group. Adequate Intakes (AIs). These are used instead of RDAs when an EAR cannot be calculated. Both the RDA and the AI may be used as goals for individual intake. Tolerable Upper Intake Levels (ULs). Intakes below the UL are unlikely to pose risks of adverse health effects in healthy people. This new framework encompasses both essential nutrients and other food components thought to pay a role in health, such as dietary fiber. It incorporates functional endpoints and examines the relationship between dose and response in determining adequacy and the hazards of excess intake for each nutrient.

Dietary Phosphorus

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Author :
Publisher : CRC Press
ISBN 13 : 1498706975
Total Pages : 388 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Dietary Phosphorus by : Jaime Uribarri

Download or read book Dietary Phosphorus written by Jaime Uribarri and published by CRC Press. This book was released on 2017-09-27 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phosphorus is an essential nutrient that occurs in almost all foods and is important for many normal physiological functions. In a typical Western diet, it is not harmful, but does adversely affect tissues in the body when consumed in excess or deficiency. This book provides a comprehensive review of various aspects of phosphorus in relation to human nutritional needs. Sections cover phosphorus nutrition and dietary issues; health risks associated with excess phosphorus intake that exceeds requirements; phosphorus intake in populations at risk; regulatory challenges and policy approaches; and environmental impacts of phosphates in the modern food supply. This book challenges the long held ideas that high dietary phosphorus intake beyond nutritional requirements is safe and the natural supply of phosphorus critical to agricultural and human food production is endless. Controversy surrounds the claim that largely unrestricted use of phosphorus in all aspects of food production from farm to fork increases dietary phosphorus intake and irretrievable environmental loss, both of which harm human and environmental health. The book editors have joined together experts in basic, medical, environmental, nutritional, and food science to explore the validity of these claims of harm from high intakes and the unchecked use of phosphorus in the global food supply. Despite the essential need for adequate phosphorus over all stages of plant, animal and human life, the growing evidence points to a worldwide increase in dietary phosphorus intake far beyond nutrient requirements, significant association with chronic disease risk even when renal function is not compromised, and the increase in environmental loss with crop run-off, animal husbandry, and unretrieved phosphorus from human waste. This current evidence alludes to a depleted, unsustainable natural supply of phosphorus, hazardous environmental pollution of lakes and waterways, and significant increases in the risk of kidney, skeletal, and other serious illnesses in humans in the future if action is not taken now.

Phosphate Metabolism

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Publisher : Springer Science & Business Media
ISBN 13 : 1461342171
Total Pages : 611 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Phosphate Metabolism by : Shaul Massry

Download or read book Phosphate Metabolism written by Shaul Massry and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: We present to our readers the proceedings of the Second International Workshop on Phosphate. A short account of the history of the effort led to the Phosphate Workshops is appro priate and can be of interest to the reader. The idea for Phosphate Workshops was born in the early days of November, 1974. One of us (S. G. M. ) suggested the thought to a group of scientists gathered for a luncheon in one of the attrac tive small restaurants in Weisbaden, Germany. The purpose of the workshop was to bring together interested scientists to discuss the newer developments and the recent advances in the field of phosphate metabolism and the other related minerals. An Organizing Committee made of Shaul G. Massry (USA), Louis V. Avioli (USA), Philippe Bordier (France), Herbert Fleisch (Switzerland), and Eduardo Slatopolsky (USA) was formed. The First Workshop was held in Paris during June 5-6, 1975 and was hosted by Dr. Philippe Bordier. Its proceeding was already published. The Second Workshop took place in Heidelberg during June 28-30, 1976 and was hosted by Dr. Eberhard Ritz. Both of these workshops were extremely successful scientific endeavors, and the need for them was demonstrated by the great interest they generated among the scientific community. The Or ganizing Committee, therefore, decided to continue with the tradi tion to hold additional Workshops annually or every other year.

Clinical Aspects of Natural and Added Phosphorus in Foods

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Author :
Publisher : Springer
ISBN 13 : 1493965662
Total Pages : 266 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Clinical Aspects of Natural and Added Phosphorus in Foods by : Orlando M. Gutiérrez

Download or read book Clinical Aspects of Natural and Added Phosphorus in Foods written by Orlando M. Gutiérrez and published by Springer. This book was released on 2017-05-16 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference covers the impact of dietary phosphorus in phosphorus physiology, public health and the pathogenesis of disease. Divided into three parts, the first section is an overview of the history of phosphorus and the regulation of phosphorus homeostasis. The second section focuses on specific matters related to phosphorus in the food supply. Clinical applications of the material presented in the preceding sections are pulled together in the third section - including the importance of both phosphorus excess and phosphorus deficiency for the pathogenesis of a wide variety of disease including kidney, cardiovascular, bone and oncologic diseases. Clinical Aspects of Natural and Added Phosphorus in Foods is an indispensable resource for understanding the growing importance of dietary phosphorus content in health and disease, enhancing patient care and moving forward the field of phosphorus science.

Present Knowledge in Nutrition

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Publisher : John Wiley & Sons
ISBN 13 : 0470963107
Total Pages : 2062 pages
Book Rating : 4.4/5 (79 download)

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Book Synopsis Present Knowledge in Nutrition by : John W. Erdman, Jr.

Download or read book Present Knowledge in Nutrition written by John W. Erdman, Jr. and published by John Wiley & Sons. This book was released on 2012-05-30 with total page 2062 pages. Available in PDF, EPUB and Kindle. Book excerpt: Present Knowledge in Nutrition, 10th Edition provides comprehensive coverage of all aspects of human nutrition, including micronutrients, systems biology, immunity, public health, international nutrition, and diet and disease prevention. This definitive reference captures the current state of this vital and dynamic science from an international perspective, featuring nearly 140 expert authors from 14 countries around the world. Now condensed to a single volume, this 10th edition contains new chapters on topics such as epigenetics, metabolomics, and sports nutrition.The remaining chapters have been thoroughly updated to reflect recent developments. Suggested reading lists are now provided for readers wishing to delve further into specific subject areas. An accompanying website provides book owners with access to an image bank of tables and figures as well as any updates the authors may post to their chapters between editions. Now available in both print and electronic formats, the 10th edition will serve as a valuable reference for researchers, health professionals, and policy experts as well as educators and advanced nutrition students.

Diet and Health

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Publisher : National Academies Press
ISBN 13 : 0309039940
Total Pages : 765 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Diet and Health by : National Research Council

Download or read book Diet and Health written by National Research Council and published by National Academies Press. This book was released on 1989-01-01 with total page 765 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diet and Health examines the many complex issues concerning diet and its role in increasing or decreasing the risk of chronic disease. It proposes dietary recommendations for reducing the risk of the major diseases and causes of death today: atherosclerotic cardiovascular diseases (including heart attack and stroke), cancer, high blood pressure, obesity, osteoporosis, diabetes mellitus, liver disease, and dental caries.

Nutrition and Bone Health

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Author :
Publisher : Springer
ISBN 13 : 1493920014
Total Pages : 737 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Nutrition and Bone Health by : Michael F. Holick

Download or read book Nutrition and Bone Health written by Michael F. Holick and published by Springer. This book was released on 2014-12-13 with total page 737 pages. Available in PDF, EPUB and Kindle. Book excerpt: This newly revised edition contains updated versions of all of the topics that were in the first edition and has been substantially expanded with an additional 5 chapters. Each chapter includes information from the most up-to-date research on how nutritional factors can affect bone health, written with an evidence-based focus and complete with comprehensive references for each subject. Nutrition and Bone Health, second edition covers all aspects of nutrition and the skeleton, from the history and fundamentals, to the effects of macronutrients, minerals, vitamins, and supplements, and even covers the effects of lifestyle, the different life stages, and nutrition-related disorders and secondary osteoporosis. New chapters include HIV & AIDs and the skeleton, celiac disease and bone health, and nutrition and bone health in space. Nutrition and Bone Health, second edition is a necessary resource for health care professionals, medical students, graduate students, dietitians, and nutritionists who are interested in how nutrition affects bone health during all stages of life.

Brenner & Rector's the Kidney

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Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (122 download)

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Book Synopsis Brenner & Rector's the Kidney by : Alan S. L. Yu

Download or read book Brenner & Rector's the Kidney written by Alan S. L. Yu and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Phosphorus, the Best Brain Food

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Author :
Publisher : Createspace Independent Publishing Platform
ISBN 13 : 9781492836469
Total Pages : 68 pages
Book Rating : 4.8/5 (364 download)

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Book Synopsis Phosphorus, the Best Brain Food by : Rudy Silva

Download or read book Phosphorus, the Best Brain Food written by Rudy Silva and published by Createspace Independent Publishing Platform. This book was released on 2013-09-29 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt: 2018 UpdateTHIS IS A LARGE PRINT BOOK:Do You Want To Be Smarter? If you want to have maximum brain power, you won't over look eating phosphorus foods. This mineral is neglected by calcium and magnesium lovers. Now, is your time to investigate and apply the information in this book, if you want to be smarter.Are Short On Phosphorus or Do You Have An Excess?Phosphorus is the second most abundant mineral in your body. Do you want to be short on this mineral? It is used in thousands of chemical reactions in your body every day. If you are short on this mineral you can't get your A's in school. If you are short on this mineral, you will get osteoporosis.Does Your Thinking Get Fuzzy At Times?Does your mind tend to wander and start thinking about what psychic can tell you about your future? What about at work. Do you keep focused on your work or does your mind wander and keep you on negative attitudes? Are you restless or do you frequently get depressed? Or, are you an over active person? This all relates to your phosphorus levels in your body.What You Will Discover In This e-BookIn this e-book, you will discover why you need to be concerned about your phosphorus levels. You will get some idea about whether you a low or high in phosphorus. But regardless of where you stand with phosphorus, you will find out what you can do about correcting your issue with phosphorus. Discover when you should take phosphorus supplements and when you should not.Take Action NowIf you are low in phosphorus, not only is your thinking affected but your bone structure is also. Many minerals are decreased when you lack phosphorus and this will affect your overall health. Check out this e-book so that you can come up-to-date on how to eliminate your concern with low or high phosphorus body levels.Click now on the buy button and start using this phosphorus information to avert phosphorus diseases. Don't be caught short on this mineral.

Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate

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Author :
Publisher : National Academies Press
ISBN 13 : 0309091586
Total Pages : 639 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate by : Institute of Medicine

Download or read book Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate written by Institute of Medicine and published by National Academies Press. This book was released on 2005-06-18 with total page 639 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate The Dietary Reference Intakes (DRIs) are quantitative estimates of nutrient intakes to be used for planning and assessing diets for healthy people. This new report, the sixth in a series of reports presenting dietary reference values for the intakes of nutrients by Americans and Canadians, establishes nutrient recommendations on water, potassium, and salt for health maintenance and the reduction of chronic disease risk. Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate discusses in detail the role of water, potassium, salt, chloride, and sulfate in human physiology and health. The major findings in this book include the establishment of Adequate Intakes for total water (drinking water, beverages, and food), potassium, sodium, and chloride and the establishment of Tolerable Upper Intake levels for sodium and chloride. The book makes research recommendations for information needed to advance the understanding of human requirements for water and electrolytes, as well as adverse effects associated with the intake of excessive amounts of water, sodium, chloride, potassium, and sulfate. This book will be an invaluable reference for nutritionists, nutrition researchers, and food manufacturers.

Dietary Phosphorus Excess and Health

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Publisher : Wiley-Blackwell
ISBN 13 : 9781573318365
Total Pages : 0 pages
Book Rating : 4.3/5 (183 download)

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Book Synopsis Dietary Phosphorus Excess and Health by : Jaime Uribarri

Download or read book Dietary Phosphorus Excess and Health written by Jaime Uribarri and published by Wiley-Blackwell. This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: " ... A one-day symposium entitled "Current Dietary Phosphorus Intake: Are There Potential Implications for Public Health?", held February 26, 2013 and sponsored by the Sackler Institute for Nutrition Science at the New York Academy of Sciences."--Introduction.

Probiotics and Prebiotics in Human Nutrition and Health

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Publisher : BoD – Books on Demand
ISBN 13 : 9535124757
Total Pages : 396 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Probiotics and Prebiotics in Human Nutrition and Health by : Venketeshwer Rao

Download or read book Probiotics and Prebiotics in Human Nutrition and Health written by Venketeshwer Rao and published by BoD – Books on Demand. This book was released on 2016-07-13 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Probiotic microorganisms are recognised as being beneficial for human health. Prebiotics are substrates that are used preferentially by the probiotic bacteria for their growth. A great deal of interest has been generated in recent years in identifying probiotic bacteria and prebiotics, their characterization, mechanisms of action and their role in the prevention and management of human health disorders. Together they are referred to as synbiotic. This book is in response to the need for more current and global scope of probiotics and prebiotics. It contains chapters written by internationally recognized authors. The book has been planned to meet the needs of the researchers, health professionals, government regulatory agencies and industries. This book will serve as a standard reference book in this important and fast-growing area of probiotics and prebiotics in human nutrition and health.

Nephrology and Public Health Worldwide

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Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 331806937X
Total Pages : 369 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Nephrology and Public Health Worldwide by : G.B. Silva Junior

Download or read book Nephrology and Public Health Worldwide written by G.B. Silva Junior and published by Karger Medical and Scientific Publishers. This book was released on 2021-11-02 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nephrology is one of the fastest growing specialties in medicine. Nevertheless, kidney disease is one of the most serious unmet health needs in many countries. To provide healthcare access with the desirable equity worldwide, the nephrology community needs to discuss this public health issue and take part in decisions for elaboration of public health policies with more justice and equity. This book brings together key current public health problems that affect kidney function and illuminates them in contributions by an international group of nephrologists and general practitioners. The chapters review current knowledge and provide guidelines to manage these conditions and decrease the disease burden. At the end, developments in the digital era and their application to kidney disease treatment are synthesized, and a broader outlook on the future of nephrology is given. Ultimately, the publication aims to gather nephrology and public health expertise from researchers from all over the world, providing a broad vision of issues that must be discussed and overcome to guarantee a better treatment for patients with kidney diseases in the world today.

Clinical Pediatric Nephrology

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Publisher : CRC Press
ISBN 13 : 1482214636
Total Pages : 1110 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Clinical Pediatric Nephrology by : Kanwal Kher

Download or read book Clinical Pediatric Nephrology written by Kanwal Kher and published by CRC Press. This book was released on 2016-11-25 with total page 1110 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third edition of a bestseller, this book provides insight from a wide array of international contributors in the field of pediatric nephrology. Copiously illustrated with photomicrographs and clinical diagrams, the third edition reflects current advances in the field. Each chapter contains a set of questions, directed at helping fellows succeed at the American Pediatric Nephrology Board examination. New information for this edition includes changes in treatment options for hyponatremia, and updates on hyperparathyroidism and transplantation. Text boxes highlight important "take home points" throughout the chapters. Clinical Pediatric Nephrology, Third Edition will be a valuable reference for clinicians in nephrology, pediatrics and urology, and any professional involved in the care of children with renal diseases seeking a reliable contemporary text.

Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride

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Author :
Publisher : National Academies Press
ISBN 13 : 0309063507
Total Pages : 449 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride by : Institute of Medicine

Download or read book Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride written by Institute of Medicine and published by National Academies Press. This book was released on 1999-10-17 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since 1941, Recommended Dietary Allowances (RDAs) has been recognized as the most authoritative source of information on nutrient levels for healthy people. Since publication of the 10th edition in 1989, there has been rising awareness of the impact of nutrition on chronic disease. In light of new research findings and a growing public focus on nutrition and health, the expert panel responsible for formulation RDAs reviewed and expanded its approachâ€"the result: Dietary Reference Intakes. This new series of references greatly extends the scope and application of previous nutrient guidelines. For each nutrient the book presents what is known about how the nutrient functions in the human body, what the best method is to determine its requirements, which factors (caffeine or exercise, for example) may affect how it works, and how the nutrient may be related to chronic disease. The first volume of Dietary Reference Intakes includes calcium, phosphorus, magnesium, vitamin D, and fluoride. The second book in the series presents information about thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. Based on analysis of nutrient metabolism in humans and data on intakes in the U.S. population, the committee recommends intakes for each age groupâ€"from the first days of life through childhood, sexual maturity, midlife, and the later years. Recommendations for pregnancy and lactation also are made, and the book identifies when intake of a nutrient may be too much. Representing a new paradigm for the nutrition community, Dietary Reference Intakes encompasses: Estimated Average Requirements (EARs). These are used to set Recommended Dietary Allowances. Recommended Dietary Allowances (RDAs). Intakes that meet the RDA are likely to meet the nutrient requirement of nearly all individuals in a life-stage and gender group. Adequate Intakes (AIs). These are used instead of RDAs when an EAR cannot be calculated. Both the RDA and the AI may be used as goals for individual intake. Tolerable Upper Intake Levels (ULs). Intakes below the UL are unlikely to pose risks of adverse health effects in healthy people. This new framework encompasses both essential nutrients and other food components thought to pay a role in health, such as dietary fiber. It incorporates functional endpoints and examines the relationship between dose and response in determining adequacy and the hazards of excess intake for each nutrient.

Nutrition and Osteoporosis

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1475790929
Total Pages : 325 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Nutrition and Osteoporosis by : Harold H. Draper

Download or read book Nutrition and Osteoporosis written by Harold H. Draper and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nutrition and Osteoporosis: Seeing Through a Glass, Darkly (1 Cor. 13:12) This volume of Advances in Nutritional Research deals with the present state of knowledge relative to the role of nutrition in the etiology of osteoporosis, one of the most serious degenerative diseases in the aging population. As a back drop for subsequent chapters on specific nutrients, Chapter 1 provides a com prehensive account of the gain and loss of bone throughout the life cycle, with emphasis on the architectural changes in later life that predispose to osteoporotic bone fractures. Chapter 2 documents the occurrence of aging bone loss through out human archeological history and Chapter 3 extends this documentation to all non-human vertebrate species so far examined, including primates living in the wild. It is apparent that a progressive loss of bone tissue is a normal accompaniment of aging among higher vertebrates. Whether it is a cause of bone fractures in animals, as it is in humans, is still unknown. It has also been established that there are significant differences in the frequency of osteoporotic fractures among human families, ethnic groups, national populations and diet cultures. Numerous studies have been carried out in an effort to explain these differences, and many of these deal with the possible effect of nutrition. Protracted controversies over the role of nutrition in the etiology of osteoporosis are reflected in the contents of several of the ensuing chapters.

Guiding Principles for Developing Dietary Reference Intakes Based on Chronic Disease

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Author :
Publisher : National Academies Press
ISBN 13 : 0309462592
Total Pages : 335 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Guiding Principles for Developing Dietary Reference Intakes Based on Chronic Disease by : National Academies of Sciences, Engineering, and Medicine

Download or read book Guiding Principles for Developing Dietary Reference Intakes Based on Chronic Disease written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-11-21 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since 1938 and 1941, nutrient intake recommendations have been issued to the public in Canada and the United States, respectively. Currently defined as the Dietary Reference Intakes (DRIs), these values are a set of standards established by consensus committees under the National Academies of Sciences, Engineering, and Medicine and used for planning and assessing diets of apparently healthy individuals and groups. In 2015, a multidisciplinary working group sponsored by the Canadian and U.S. government DRI steering committees convened to identify key scientific challenges encountered in the use of chronic disease endpoints to establish DRI values. Their report, Options for Basing Dietary Reference Intakes (DRIs) on Chronic Disease: Report from a Joint US-/Canadian-Sponsored Working Group, outlined and proposed ways to address conceptual and methodological challenges related to the work of future DRI Committees. This report assesses the options presented in the previous report and determines guiding principles for including chronic disease endpoints for food substances that will be used by future National Academies committees in establishing DRIs.