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Developpement Et Validation Dune Methode Analytique Par Lc Ms Pour La Quantification Du Saquinavir Dans Le Plasma Humain
Download Developpement Et Validation Dune Methode Analytique Par Lc Ms Pour La Quantification Du Saquinavir Dans Le Plasma Humain full books in PDF, epub, and Kindle. Read online Developpement Et Validation Dune Methode Analytique Par Lc Ms Pour La Quantification Du Saquinavir Dans Le Plasma Humain ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Trissel's Stability of Compounded Formulations by : Lawrence A. Trissel
Download or read book Trissel's Stability of Compounded Formulations written by Lawrence A. Trissel and published by American Pharmacists Association (APhA). This book was released on 2000 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Helps readers determine whether formulated compounds will be stable for the anticipated duration of use; properly store and repackage compounded formulations; formulate in accordance with documented standards; and, counsel patients on the use and storate of comounded medications." -- Back cover.
Book Synopsis Malaria: Drugs, Disease and Post-genomic Biology by : David Sullivan
Download or read book Malaria: Drugs, Disease and Post-genomic Biology written by David Sullivan and published by Springer Science & Business Media. This book was released on 2006-01-09 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite rapid increases in knowledge, malaria continues to kill more than a million people each year and causes symptomatic disease in a further 300 million individuals. This volume brings some of the world's best investigators to describe recent advances in both the scientific and clinical aspects of malaria, and bridges between the two.
Book Synopsis Antimalarial Chemotherapy by : Philip J. Rosenthal
Download or read book Antimalarial Chemotherapy written by Philip J. Rosenthal and published by Springer Science & Business Media. This book was released on 2001-04-01 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: Philip Rosenthal, MD, and a panel of leading malaria experts drawn from academia, the military, and international health organizations survey the latest scientific understanding of antimalarial chemotherapy, emphasizing the molecular mechanisms of resistance and the description of important new targets. Their survey covers the current status of malarial and antimalarial chemotherapy, the relevant biology and biochemistry of malaria parasites, the antimalarial drugs currently available, new chemical approaches to chemotherapy, and possible new targets for chemotherapy. Comprehensive and cutting-edge, Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery clearly delineates all the basic and clinical research now addressing one of the world's major unresolved disease problems, work that is now powerfully driving the rapid pace of antimalarial drug discovery today.
Book Synopsis Handbook of LC-MS Bioanalysis by : Wenkui Li
Download or read book Handbook of LC-MS Bioanalysis written by Wenkui Li and published by John Wiley & Sons. This book was released on 2013-09-03 with total page 709 pages. Available in PDF, EPUB and Kindle. Book excerpt: Consolidates the information LC-MS bioanalytical scientists need to analyze small molecules and macromolecules The field of bioanalysis has advanced rapidly, propelled by new approaches for developing bioanalytical methods, new liquid chromatographic (LC) techniques, and new mass spectrometric (MS) instruments. Moreover, there are a host of guidelines and regulations designed to ensure the quality of bioanalytical results. Presenting the best practices, experimental protocols, and the latest understanding of regulations, this book offers a comprehensive review of LC-MS bioanalysis of small molecules and macromolecules. It not only addresses the needs of bioanalytical scientists working on routine projects, but also explores advanced and emerging technologies such as high-resolution mass spectrometry and dried blood spot microsampling. Handbook of LC-MS Bioanalysis features contributions from an international team of leading bioanalytical scientists. Their contributions reflect a review of the latest findings, practices, and regulations as well as their own firsthand analytical laboratory experience. The book thoroughly examines: Fundamentals of LC-MS bioanalysis in drug discovery, drug development, and therapeutic drug monitoring The current understanding of regulations governing LC-MS bioanalysis Best practices and detailed technical instructions for LC-MS bioanalysis method development, validation, and stability assessment of analyte(s) of interest Experimental guidelines and protocols for quantitative LC-MS bioanalysis of challenging molecules, including pro-drugs, acyl glucuronides, N-oxides, reactive compounds, and photosensitive and autooxidative compounds With its focus on current bioanalytical practice, Handbook of LC-MS Bioanalysis enables bioanalytical scientists to develop and validate robust LC-MS assay methods, all in compliance with current regulations and standards.
Book Synopsis Applications of LC-MS in Toxicology by : Aldo Polettini
Download or read book Applications of LC-MS in Toxicology written by Aldo Polettini and published by Pharmaceutical Press. This book was released on 2006 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analytical toxicologists are involved in the analysis of drugs and poisons in biological samples in different environments. Many scientists in the field of analytical toxicology have adopted LC-MS in their daily work, and this is illustrated by the increasing numbers of research papers published and presented at relevant conferences.
Book Synopsis Dipeptidyl Aminopeptidases by : Uwe Lendeckel
Download or read book Dipeptidyl Aminopeptidases written by Uwe Lendeckel and published by Springer. This book was released on 2014-11-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first comprehensive volume on Dipeptidyl Aminopeptidases that can be marketed to a wide variety of disciplines, as well as to a variety of clinicians. Leading experts in the field contribute to this state-of-the-art view on these enzymes. This book comes at a time when our understanding of their function is growing ever more rapidly and therapeutic options have become imminent.
Book Synopsis Sample Preparation in LC-MS Bioanalysis by : Wenkui Li
Download or read book Sample Preparation in LC-MS Bioanalysis written by Wenkui Li and published by John Wiley & Sons. This book was released on 2019-03-12 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Revised and Expanded Handbook Provides Comprehensive Introduction and Complete Instruction for Sample Preparation in Vital Category of Bioanalysis Following in the footsteps of the previously published Handbook of LC-MS Bioanalysis, this book is a thorough and timely guide to all important sample preparation techniques used for quantitative Liquid Chromatography–Mass Spectrometry (LC-MS) bioanalysis of small and large molecules. LC-MS bioanalysis is a key element of pharmaceutical research and development, post-approval therapeutic drug monitoring, and many other studies used in human healthcare. While advances are continually being made in key aspects of LC-MS bioanalysis such as sensitivity and throughput, the value of research/study mentioned above is still heavily dependent on the availability of high-quality data, for which sample preparation plays the critical role. Thus, this text provides researchers in industry, academia, and regulatory agencies with detailed sample preparation techniques and step-by-step protocols on proper extraction of various analyte(s) of interest from biological samples for LC-MS quantification, in accordance with current health authority regulations and industry best practices. The three sections of the book with a total of 26 chapters cover topics that include: Current basic sample preparation techniques (e.g., protein precipitation, liquid-liquid extraction, solid-phase extraction, salting-out assisted liquid-liquid extraction, ultracentrifugation and ultrafiltration, microsampling, sample extraction via electromembranes) Sample preparation techniques for uncommon biological matrices (e.g., tissues, hair, skin, nails, bones, mononuclear cells, cerebrospinal fluid, aqueous humor) Crucial aspects of LC-MS bioanalytical method development (e.g., pre-analytical considerations, derivation strategies, stability, non-specific binding) in addition to sample preparation techniques for challenging molecules (e.g., lipids, peptides, proteins, oligonucleotides, antibody-drug conjugates) Sample Preparation in LC-MS Bioanalysis will prove a practical and highly valuable addition to the reference shelves of scientists and related professionals in a variety of fields, including pharmaceutical and biomedical research, mass spectrometry, and analytical chemistry, as well as practitioners in clinical pharmacology, toxicology, and therapeutic drug monitoring.
Book Synopsis Horizons in Biochemistry and Biophysics by :
Download or read book Horizons in Biochemistry and Biophysics written by and published by . This book was released on 1974 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mise au point d'une méthode de dosage quantitative de la carnitine et des acylcarnitines plasmatiques en HPLC couplée à la spectrométrie de masse en tandem dans le diagnostic des anomalies de la bêta oxydation des acides gras by : Harmony Benatre
Download or read book Mise au point d'une méthode de dosage quantitative de la carnitine et des acylcarnitines plasmatiques en HPLC couplée à la spectrométrie de masse en tandem dans le diagnostic des anomalies de la bêta oxydation des acides gras written by Harmony Benatre and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Les Maladies Héréditaires du Métabolisme et notamment les anomalies de la bêta oxydation des acides gras sont des maladies rares mais très diverses qui peuvent se manifester plus ou moins tôt dans la vie des personnes atteintes. Ces maladies sont dues à des mutations codant pour des protéines impliquées dans ces voies métaboliques. Alors que leur prévalence individuelle est faible, on estime leur prévalence collective entre 1/5000 et 1/10000 naissances. L'outil diagnostic principal de ces anomalies est l'analyse de la carnitine et des acylcarnitines dans les liquides biologiques. Actuellement, ce sont des analyses semi-quantitatives qui prédominent, en FIA-MS/MS, sur matrice de sang total. Elles font partie des programmes de dépistage néonatal dans de nombreux pays. Nous avons voulu proposer, au-delà du cadre du dépistage néonatal, une analyse quantitative de la carnitine et des acylcarnitines plasmatiques. Nous avons donc développé une méthode chromatographique couplée à la spectrométrie de masse en tandem. Nous avons procédé à la validation de cette méthode et nous avons effectué une estimation intra-laboratoire des valeurs de référence biologiques pour différentes tranches d'âge. Des améliorations restent à apporter à cette méthode mais nous espérons qu'elle aura un impact clinique positif sur le diagnostic de ces pathologies.
