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Development Of The Enantioselective Oxidation Of Secondary Alcohols And Natural Products Total Synthesis
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Book Synopsis Development of the Enantioselective Oxidation of Secondary Alcohols and Natural Products Total Synthesis by : Jeffrey Thomas Bagdanoff
Download or read book Development of the Enantioselective Oxidation of Secondary Alcohols and Natural Products Total Synthesis written by Jeffrey Thomas Bagdanoff and published by . This book was released on 2006 with total page 758 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Total Synthesis of Natural Products by : Jie Jack Li
Download or read book Total Synthesis of Natural Products written by Jie Jack Li and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced undergraduate students, as well as organic chemists in academia and industry.
Book Synopsis Enantioselective Chemical Synthesis by : Elias J. Corey
Download or read book Enantioselective Chemical Synthesis written by Elias J. Corey and published by Elsevier. This book was released on 2013-10-23 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by world-renowned and best-selling experts, Nobel Laureate E. J. Corey and Laszlo Kurti, Enantioselective Chemical Synthesis offers an authoritative and comprehensive overview of the field's progress; the processes and tools for key formations; future development for complex, stereocontrolled (enantiomeric or diastereoisomeric) molecules; and valuable examples of multi-step syntheses. Utilizing a color-coded scheme to illustrate chemical transformations, Enantioselective Chemical Synthesis provides clear explanation and guidance through vital asymmetrical syntheses and insight into the next steps for the field. Researchers, professionals, and academics will benefit from this valuable, thorough, and unique resource. - In Part I, the authors present clearly, comprehensively and concisely the most useful enantioselective processes available to synthetic chemists. - Part II provides an extensive discussion of the most logical ways to apply these new enantioselective methods to the planning of syntheses of stereochemically complex molecules. This hitherto neglected area is essential for the advancement of enantioselective synthesis to a more rational and powerful level. - Part III describes in detail many reaction sequences which have been used successfully for the construction of a wide variety of complex target molecules - Clearly explains stereochemical synthesis in theory and practice - Provides a handy tool box for scientists wishing to understand and apply chiral chemical synthesis - Describes almost 50 real life examples of asymmetric synthesis in practice and examines how the chiral centers were introduced at key synthetic stages
Book Synopsis Enantioselective Synthesis of Natural Products Containing Tertiary Alcohols and Contributions to a Total Synthesis of Phorbasin B by :
Download or read book Enantioselective Synthesis of Natural Products Containing Tertiary Alcohols and Contributions to a Total Synthesis of Phorbasin B written by and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Modern Sustainable Techniques In Total Synthesis Of Bioactive Natural Products by : Sasadhar Majhi
Download or read book Modern Sustainable Techniques In Total Synthesis Of Bioactive Natural Products written by Sasadhar Majhi and published by World Scientific. This book was released on 2023-04-25 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern Sustainable Techniques in Total Synthesis of Bioactive Natural Products comprises five parts for green tools, such as ultrasonic waves, microwave heating, visible-light photochemistry, organic electrochemistry, and flow chemistry, along with 72 chapters for each bioactive molecule of natural origin. Each chapter explores the natural source, structure, systematic name, structural features, compound class, biological activity, conventional approaches for their chemical synthesis, and demerit(s) of conventional approaches (where applicable). Finally, critical features of total synthesis using modern sustainable techniques, including reaction types, synthetic strategy, and synthetic route utilizing modern sustainable tools for each bioactive natural product and secondary metabolites, are discussed brilliantly. The spectrum of application of total synthesis of bioactive natural products using modern sustainable techniques may promote the development of more eco-friendly synthetic processes so that the next generations can live on this planet with a minimum energy requirement for chemical reactions with the least pollution.
Book Synopsis Enantioselective Synthesis by : Tse-Lok Ho
Download or read book Enantioselective Synthesis written by Tse-Lok Ho and published by Wiley-Interscience. This book was released on 1992-02-18 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years the intense activities of enantioselective synthesis have been reflected in the burgeoning and ingenious applications of such natural substances as carbohydrates, -amino acids and terpenes. A comprehensive summary of terpene-based synthesis is offered, focusing on synthetic efforts using transformed chiral synthons. The author provides analysis of synthetic strategies and discusses the intricacies of reaction courses. Along with the number and variety of natural products derived from chiral terpenes, numerous flow-charts aid in clearly delineating synthetic pathways.
Book Synopsis Strategies and Tactics in Organic Synthesis by : Jenny B. Werness
Download or read book Strategies and Tactics in Organic Synthesis written by Jenny B. Werness and published by Elsevier Inc. Chapters. This book was released on 2013-07-29 with total page 25 pages. Available in PDF, EPUB and Kindle. Book excerpt: Addition of halogen and nucleophiles to conjugated 1,3-enynes in a 1,4-fashion produces a chiral allene and a stereogenic center. The diastereo- and enantioselectivity of this process are discussed in detail. The 1,4-bromoetherification of 1,3-enynes can be applied to the synthesis of various bromoallene-containing natural products. Our diastereo- and enantioselective total synthesis of kumausallene is described in this chapter. The synthesis features a cascade reaction involving palladium-catalyzed desymmetrization and a DMF-mediated diastereoselective 1,4-bromoetherification reaction.
Book Synopsis The Enantioselective Synthesis of Complex Natural Products by : Ryan E. Stites
Download or read book The Enantioselective Synthesis of Complex Natural Products written by Ryan E. Stites and published by . This book was released on 2005 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Enantioselective Total Synthesis Of Diverse, Bioactive Natural Products by :
Download or read book Enantioselective Total Synthesis Of Diverse, Bioactive Natural Products written by and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural product synthesis is one of the most creative branch of chemistry in terms of its boundless scope for innovation and has stimulated several generations of synthetic organic chemists. With advancement in the technology, particularly in the isolation and purification techniques, high-field NMR and X-ray crystallography, it has become fairly routine to isolate and assign the structures, high-field NMR and X-ray crystallography, it has become fairly routine to isolate and assign the structures, even to those complex molecules, which are available only in microscopic quantities from natural sources. Concurrently, one has witnessed tremendous advances in the availability of new synthetic methodologies with high region-, stereo-, and enantiocontrol for one or multiple C-C bond formations and rapid generation of molecular complexity. These developments have rekindled interest with total synthesis of natural products as platforms for testing and validating new reactions and strategies. Many natural products exhibit wide range of biological activities and thus provide good leads in drug discovery but quite often such bioactive compounds are obtained only in minute quantities from Nature. Hence, there is need to synthesize them to obtain requisite quantities and build diversity around their scaffold to further explore their therapeutic potential. Thus, natural product synthesis combines both intellectual challenge and possible application for human wellbeing. Our research group is actively engaged in the synthesis of structurally complex, bioactive natural products and as a part of this endeavour, total syntheses of several bioactive compounds have been accomplished in our laboratory in recent past. The present thesis has also evolved around the ongoing theme directed towards natural product synthesis and is organized under three chapters. Chapter I: Total synthesis of (+)-1S-Minwanenone Chapter II: Enantioselective total synthesis of the bioactive natural product (+)-
Book Synopsis Enantioselective Organocatalyzed Reactions I by : Rainer Mahrwald
Download or read book Enantioselective Organocatalyzed Reactions I written by Rainer Mahrwald and published by Springer Science & Business Media. This book was released on 2011-08-03 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organocatalyzed Reactions I and II presents a timely summary of organocatalysed reactions including: a) Enantioselective C-C bond formation processes e.g. Michael-addition, Mannich-reaction, Hydrocyanation (Strecker-reaction), aldol reaction, allylation, cycloadditions, aza-Diels-Alder reactions, benzoin condensation, Stetter reaction, conjugative Umpolung, asymmetric Friedel-Crafts reactions; b) Asymmetric enantioselective reduction processes e.g. Reductive amination of aldehydes or ketones, asymmetric transfer hydrogenation; c) Asymmetric enantioselective oxidation processes; d) Asymmetric epoxidation, Bayer-Villiger oxidation; e) Enantioselective a-functionalization; f) A-alkylation of ketones, a-halogenation and a-oxidation of carbonyl compounds.
Book Synopsis Enantioselective Total Synthesis Of Bioactive Epoxyquinoid Natural Products by :
Download or read book Enantioselective Total Synthesis Of Bioactive Epoxyquinoid Natural Products written by and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Total synthesis of natural products with diverse architecture and varying degree of complexity is an area that has not only inspired and attracted several generations of organic chemists but also continues to enrich and refresh the foundations of organic chemistry itself, by offering new ideas and directions. Synthetic organic chemistry is perhaps the most formative and expressive enterprise of science in terms of its creative power and unlimited scope. Its impact on present day life and prosperity gets manifested when we see this science as the bedrock behind the production of pharmaceuticals, pesticides, fertilizers, nutritional products, high tech materials, polymers, cosmetics, plastics and clothing. Science of synthesis is also going to play an important role in the evolution of future societies based on the principles of the sustainable development. Being a precise science and a fine art, the endeavor of total synthesis is in a constant state of effervescence. Most significantly, the discipline is being continually challenged by new structures unraveled from the Nature bosom. The practice of total synthesis is being enriched constantly by new tools such as new reagents and catalysts as well as by analytical techniques. In fact, there has been a dramatic advancement in the recent past in the development of new synthetic protocols with high regio-, streo-, and enantiocontrol, which makes it possible to target natural product of any complexity. The demand for enantiomerically pure drugs, agrochemicals and food additives is growing, since pure enantiomers are often more target-specific and have fewer side effects than the recemic mixtures. As a result, synthesis of natural products in an enantioselective manner has been receiving increasing attention from synthetic chemists in recent years. Nature synthesizes a vast array of novel molecular structures in enantioselective fashion through several well-established biosynthetic pathways utilizing a few key building.
Book Synopsis Total Synthesis of (±)-Maoecrystal V by : Jianxian Gong
Download or read book Total Synthesis of (±)-Maoecrystal V written by Jianxian Gong and published by Springer. This book was released on 2014-07-08 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this thesis, the author describes the total synthesis of natural product Maoecrystal V in detail. In the first part of the thesis, the author introduces the research background and reviews the research progress in total synthesis of Maoecrystal V. In the second part, the author develops a novel and concise approach for the stereo selective construction of the tetracyclic model system of Maoecrystal V. The model system is accomplished in 8 steps with 20% yield. In the third part, the author describes the first successful total synthesis of Maoecrystal V and investigates four strategies for constructing the key tetrahydrofuran oxa-bridge skeleton. The total synthesis starts from a known compound and is accomplished in 17 steps with 1.2% yield. The successful total synthesis of Maoecrystal V will contribute to the development of efficient synthetic strategies for natural products and other compounds with complex structures.
Book Synopsis Classics in Total Synthesis by : K. C. Nicolaou
Download or read book Classics in Total Synthesis written by K. C. Nicolaou and published by John Wiley & Sons. This book was released on 1996-04-11 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt: K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry This book is a must for every synthetic chemist. With didactic skill and clarity, K. C. Nicolaou and E. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists. To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. The authors then carefully explain each synthetic step and give hints on alternative methods and potential pitfalls. Numerous references to useful reviews and the original literature make this book an indispensable source of further information. Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text. For easy reference, key intermediates are also shown in the margins. Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work. Every synthetic organic chemist will want to have a copy on his or her desk.
Book Synopsis Enantioselective Formal Total Synthesis of (+)-aspergillide C ; Iodine-mediated Oxidation of Nitrogen Heterocycles Directed Towards Natural Product Synthesis by : Joseph David Panarese
Download or read book Enantioselective Formal Total Synthesis of (+)-aspergillide C ; Iodine-mediated Oxidation of Nitrogen Heterocycles Directed Towards Natural Product Synthesis written by Joseph David Panarese and published by . This book was released on 2012 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt: A facile aromatization of tetrahydro-[Greek bata]-carbolines with both phenyl and aliphatic substituents at C-I has been accomplished. This oxidation, mediated by 2-iodoxybenzoic acid, occurs at room temperchure in two hours. A library of aromatic [Greek beta]-carbolines has been produced, and this methodology has been utilized in a total synthesis of the marine bis-indole alkaloid eudistomin U.
Book Synopsis Investigation of the Scope and Mechanism of the Palladium-catalyzed Synthesis of Enantioenriched Allylic Esters from Prochiral (Z)-allylic Alcohols and Progress Toward the Total Synthesis of ( -- )-massadine by : Jeffrey Scott Cannon
Download or read book Investigation of the Scope and Mechanism of the Palladium-catalyzed Synthesis of Enantioenriched Allylic Esters from Prochiral (Z)-allylic Alcohols and Progress Toward the Total Synthesis of ( -- )-massadine written by Jeffrey Scott Cannon and published by . This book was released on 2012 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Chapter 1, a review of the development and applications of enantioselective palladium(II) catalysts for the reactions of allylic imidates is provided. Planar chiral catalysts containing a metallocene unit were found to be the optimal catalysts for palladium(II)-catalyzed reactions. Cobalt oxazoline palladacycles (COP) are the most effective catalysts known for the enantioselective rearrangement of allylic imidates as well as a number of allylic displacement reactions. In Chapter 2, the scope and mechanism of the COP-catalyzed reaction of prochiral (Z)-allylic trichloroacetimidates to form enantioenriched 3-carboxy-1-alkenes is investigated. The scope of this reaction was determined to be broad, tolerating a wide variety of organic functionality. Experimental and computational mechanistic analysis established that anti oxypalladation is the rate- and enantiodetermining step. DFT computational studies further established a model for enantioselectivity. In Chapter 3, a review of recent synthetic approaches to the oxidized dimeric pyrrole imidazole alkaloids is provided. The first total syntheses of massadine, axinellamines, and palau'amine are described. Reports of progress toward the total synthesis of these natural products are also summarized. In Chapter 4, progress toward the total synthesis of ( - )-massadine is reported. The synthetic route features two key steps. The first is an Ireland-Claisen rearrangement of a trianionic allylic acetate that occurs with high stereospecificity. The second is an unprecedented intramolecular nitrone dipolar cycloaddition which stereoselectively constructs a fully substituted cyclopentane. Elaboration of cyclopentane intermediates to incorporate the bisguanidine functionality is described.
Book Synopsis Catalytic Aerobic Oxidations by : Esteban Mejía
Download or read book Catalytic Aerobic Oxidations written by Esteban Mejía and published by Royal Society of Chemistry. This book was released on 2020-07-14 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidation reactions are an important chemical transformation in both academia and industry. Among the major advances in the field has been the development of catalytic processes, which are not only selective and efficient, but also allow the replacement of common stoichiometric oxidants with molecular oxygen, ideally from air at atmospheric pressure. This results in processes with higher atom efficiency, where water is the only side product in line with the principles of green chemistry. Focusing on the use of molecular oxygen as the terminal oxidant, this book covers recent advances in both heterogeneous and homogeneous systems, with and without metals and on the “taming” of the highly reactive oxygen gas by use of micro-flow reactors and membranes. A useful reference for industrial and academic chemists working on oxidation processes, as well as green chemists.
Book Synopsis Comprehensive Enantioselective Organocatalysis by : Peter I. Dalko
Download or read book Comprehensive Enantioselective Organocatalysis written by Peter I. Dalko and published by Wiley-VCH. This book was released on 2013-08-14 with total page 1638 pages. Available in PDF, EPUB and Kindle. Book excerpt: Structured in three parts this manual recollects efficient organocatalytic transformations around clear principles that meet actual standard in asymmetric synthesis. Chapters were written by acknowledged leaders of the organocatalysis field, and are presented in a concise way. Volume 1: Privileged Catalysts gives insight to readers to the continuously increasing variety of catalysts, and the relatively complex interactions that make organocatalytic reactions selective. An appendix recollects catalyst structures with the adequate cross-references. Volume 2: Activations covers the fundamental activation types (non-covalent and covalent activations) and helps understanding the importance of physical parameters, and in particular, the role of water, that influences reactivity and selectivity. Volume 3: Reactions and Applications highlights transformations by reaction types. The final part of this volume is dedicated to application in multistep synthesis and industrial applications. Considering the ever increasing interest in the organocatalysis field, the book aims addressing to a large audience: to academic, and, industrial researchers, students and teachers who are interested in synthetic organic chemistry at advanced level. This book provides non-specialists with an introduction to the topic as well as serving as a valuable source for newcomers and researchers searching for an up-to-date and comprehensive overview of this promising area of synthetic organic chemistry.
