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Development Of Polymeric Coatings With Combined Antifouling Antibacterial Properties For Titanium Dental Implants
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Book Synopsis Development of Polymeric Coatings with Combined Antifouling/antibacterial Properties for Titanium Dental Implants by : Judit Buxadera Palomero
Download or read book Development of Polymeric Coatings with Combined Antifouling/antibacterial Properties for Titanium Dental Implants written by Judit Buxadera Palomero and published by . This book was released on 2017 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: Titanium dental implants are a commonly used solution for the replacement of lost teeth. Even though the success rate is high, the number of infections related to the placement of the implant is still remarkable and may impair the proper function of the device, leading to health and economic costs. The infections related to medical devices start with a bacterial adhesion and proliferation on the material surface, leading to the formation of a complex biofilm able to protect the bacteria from the host immune response and the treatment with antibiotic. Due to the difficulty of treatment of the implant site one the biofilm is settled, one of the strategies to avoid the infection is to deal with the initial bacterial adhesion. This PhD thesis deals with the development of polymeric antibacterial coatings on titanium for dental implants, focusing on the achievement of fast and cost-effective procedure. With this aim, different coating strategies have been developed, tested and compared. A pre-treatment of the titanium surface was optimized in the first part of the thesis in order to achieve a clean surface and to enhance the chemical reactivity of the titanium oxide. With this aim, low pressure plasma activation was the selected method. The use of plasma activation allows for the removal of organic contaminants while increasing the surface energy of the treated surfaces. For the preparation of the polymeric antibacterial coatings, two different antifouling polymers have been used, namely, polyethylene glycol (PEG) and poly-2-hydroxyethylmetacrylate (PHEMA). PEG coatings were prepared by three different techniques, a wet chemical technique (silanization), a plasma enhanced chemical vapor deposition and an electrochemical process (electrodeposition). The three methods rendered an ultra-thin coating able to resist the bacterial adhesion. On the other hand, PHEMA-like coatings were prepared in a novel set-up by treating the liquid monomer by a plasma jet. Moreover, the different coatings were biofunctionalized in order to achieve multifunctionality and enhance the performance of the coating. For instance, the combination of PEG with a cell adhesion peptide (RGD) reported a better human fibroblast adhesion while maintaining the antifouling properties of the coating. PEG was also used as a platform for the immobilization of antimicrobial peptides (AMP). The bonding of the polymer with the AMP was optimized, achieving a surface able to reduce the bacterial adhesion and to kill the bacteria still able to adhere to the surface. Finally, the combination of two different plasma polymerized coatings with antibiotics (either Doxycycline or Vancomycin) was used as a drug delivery system.
Book Synopsis Advancing Applications of Polymer Coating Technology by : Prem Kumar Karmakar
Download or read book Advancing Applications of Polymer Coating Technology written by Prem Kumar Karmakar and published by GRIN Verlag. This book was released on 2024-07-03 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific Study from the year 2024 in the subject Engineering - Mechanical Engineering, , course: B.Tech Mechanical, language: English, abstract: Research conducted over the past few decades has brought us closer to the development of functional polymer coatings that are easy to use, self-cleaning, antibacterial, and antifouling. The use of polymer coatings has little or no impact on other properties, and they do not compromise the safety or mechanical strength of the materials being coated. Coatings are highly durable, resistant, and are primarily used for protection against environmental factors such as water, corrosion, and other elements. These coatings must meet stringent performance requirements to ensure maximum effectiveness. In this work, we try to bring forward the recent research and advancements that are taking place in the field of Polymer Coating Technology, and have a better understanding of this technology getting implemented in our day-to-day life.
Book Synopsis Coatings for Biomedical Applications by : Mike Driver
Download or read book Coatings for Biomedical Applications written by Mike Driver and published by Elsevier. This book was released on 2012-02-22 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: The biomaterials sector is rapidly expanding and significant advances have been made in the technology of biomedical coatings and materials, which provide a means to improve the wear of joints, change the biological interaction between implant and host and combine the properties of various materials to improve device performance. Coatings for biomedical applications provides an extensive review of coating types and surface modifications for biomedical applications. The first part of the book explores a range of coating types and their biomedical applications. Chapters look at hydrophilic, mineral and pyrolytic carbon coatings in and ex vivo orthopaedic applications and finally at surface modification and preparation techniques. Part two presents case studies of orthopaedic and ophthalmic coatings, and biomedical applications including vascular stents, cardiopulomonary by-pass equipment and ventricular assist devices. With its clear structure and comprehensive review of research, Coatings for biomedical applications is a valuable resource to researchers, scientists and engineers in the biomedical industry. It will also benefit anyone studying or working within the biomedical sector, particularly those specialising in biomedical coatings. Provides an extensive review of coating types and surface modifications for biomedical applications Chapters look at hydrophilic coatings for biomedical applications in and ex vivo, mineral coatings for orthopaedic applications, pyrolytic carbon coating and other commonly-used biomedical coatings Presents case studies of orthopaedic and ophthalmic coatings, and biomedical applications including vascular stents, cardiopulomonary by-pass equipment and ventricular assist devices
Book Synopsis Advanced Manufacturing Techniques for Engineering and Engineered Materials by : Thanigaivelan, R.
Download or read book Advanced Manufacturing Techniques for Engineering and Engineered Materials written by Thanigaivelan, R. and published by IGI Global. This book was released on 2022-03-11 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: As technology advances, it is imperative to stay current in the newest developments made within the engineering industry and within material sciences. Trends in manufacturing such as 3D printing, casting, welding, surface modification, computer numerical control (CNC), non-traditional, Industry 4.0 ergonomics, and hybrid machining methods must be closely examined to utilize these important resources for the betterment of society. Advanced Manufacturing Techniques for Engineering and Engineered Materials provides a unified and complete overview about the recent and emerging trends, developments, and associated technology with scope for the commercialization of techniques specific to manufacturing materials. This book also reviews the various machining methods for difficult-to-cut materials and novel materials including matrix composites. Covering topics such as agro-waste, conventional machining, and material performance, this book is an essential resource for researchers, engineers, technologists, students and professors of higher education, industry workers, entrepreneurs, researchers, and academicians.
Book Synopsis Bioactive bone regenerative materials and bionic prosthesis interfaces by : He Liu
Download or read book Bioactive bone regenerative materials and bionic prosthesis interfaces written by He Liu and published by Frontiers Media SA. This book was released on 2023-01-18 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Bioinspired Surface Modification for Antifouling and Antibacterial Applications by : Anika Benozir Asha
Download or read book Bioinspired Surface Modification for Antifouling and Antibacterial Applications written by Anika Benozir Asha and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biofouling is a serious problem in the medical, marine, and several other industrial fields as it poses significant health risks and financial losses. Therefore, there is a great need to endow surfaces with antifouling and antimicrobial properties to mitigate biofouling. For long-term biofouling resistance, a unifunctional antimicrobial or non-adhesive surface is insufficient for preventing biofilm formation. To overcome this limitation, non-adhesive and antimicrobial dual-functional surfaces are highly desirable. Zwitterionic polymers have been used extensively as one of the best antifouling materials for surface modification. Being a super hydrophilic polymer, zwitterionic polymers need a strong binding agent to maintain attachment to the surface for long-term applications. In this thesis work, new strategies have been explored for surface modification to covalently graft zwitterionic polymers using mussel-inspired dopamine chemistry and prebiotic chemistry for long-term antifouling and antimicrobial applications. In the first project, a facile surface modification technique using dopamine chemistry was developed to prepare a super hydrophilic coating with both antifouling and antimicrobial properties. Catechol containing adhesive monomer dopamine methacrylamide (DMA) was copolymerized with bioinspired zwitterionic 2-methacryloyloxyethyl phosphorylcholine (MPC) monomer, and the synthesized copolymers were covalently grafted onto the amino (−NH2) rich polyethylenimine (PEI)/polydopamine (PDA) codeposited surface to obtain a stable antifouling surface. The resulting surface was used for in situ deposition of antimicrobial silver nanoparticles (AgNPs), facilitated by the presence of catechol groups of the coating. This dual functional coating significantly reduced the adhesion of both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus bacteria and showed excellent resistance to bovine serum albumin adsorption. This bioinspired and efficient surface modification strategy with dual functional coating promises its potential application in implantable biomedical devices. In the second project, a smart surface was developed which can not only kill the attached microbials but also can release the dead cells and foulants from the surface under a particular incitement on demand. In this project, sugar responsive self-cleaning coating was developed by forming covalent boronic ester bonds between catechol groups from polydopamine and benzoxaborole pendant from zwitterionic and cationic polymers. To incorporate antifouling property and enhance biocompatibility of the coating, zwitterionic compound MPC was chosen and benzoxaborole pendant containing zwitterionic polymer poly (MPC-st-MAABO) (MAABO: 5-Methacrylamido-1,2-benzoxaborole) was synthesized. Additionally, to impart antibacterial properties to the surface, quaternary ammonium containing cationic polymer poly (2-(methacryloyloxy)ethyl trimethylammonium (META)-st-MAABO)) was synthesized. These synthesized polymers were covalently grafted to PDA coated surface by forming a strong cyclic boronic ester complex with catechol group of PDA layer endowing the surface with bacteria contact-killing property and capturing specific protein. After the addition of cis-diol containing competitive molecules i.e. sugars, this boronic ester complex with catechol group of PDA was replaced and attached polymer layer cleaved from the surface resulting in the release of both absorbed protein and live/killed bacteria electrostatically attached to the polymer layer. This dynamic self-cleaning surface can be a promising material for biomedical applications avoiding the gathering of dead cells and debris which is typically encountered on traditional biocidal surfaces. In practice macro or micro scratches or damages can happen to the coating which can act as an active site for microbial deposition and destroy the antifouling or antibacterial functionality of the coating. In the third project, an excellent biocompatible and multifunctional coating with antifouling, antibacterial and self-healing property was developed. Prebiotic chemistry inspired self-polymerization of AMN was used as a primary coating layer which act as a primer to graft vitamin B5 analogous methacrylamide polymer poly(B5AMA) and zwitterionic compound MPC containing polymer poly (MPC-st-B5AMA) by forming strong hydrogen bond. B5AMA having multiple polar groups into the structure acted as an intrinsic self-healing material and showed excellent antifouling property against protein and bacteria maintaining a good hydration layer. To impart the antibacterial property into the coating AgNps has also been incorporated which showed more that 90% killing efficiency against both gram-positive and gram-negative bacteria with significant reduction of their adhesion on the surface. Incorporation of self-healing property into the fouling repelling and antibacterial coating can significantly extend the durability of the multifunctional coating making it promising for biomedical applications. Three different surface modification techniques explored in this thesis, not only demonstrates excellent antifouling and antibacterial property but also provides fundamental insights into the facile development of multifunctional coating in various biomedical applications.
Book Synopsis Advanced Oral Disease Therapy: Approaches, Biotechnology, and Bioactive Materials, Volume II by : Xing Wang
Download or read book Advanced Oral Disease Therapy: Approaches, Biotechnology, and Bioactive Materials, Volume II written by Xing Wang and published by Frontiers Media SA. This book was released on 2024-03-12 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Encyclopedia of Plasma Technology - Two Volume Set by : J. Leon Shohet
Download or read book Encyclopedia of Plasma Technology - Two Volume Set written by J. Leon Shohet and published by CRC Press. This book was released on 2016-12-12 with total page 1654 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technical plasmas have a wide range of industrial applications. The Encyclopedia of Plasma Technology covers all aspects of plasma technology from the fundamentals to a range of applications across a large number of industries and disciplines. Topics covered include nanotechnology, solar cell technology, biomedical and clinical applications, electronic materials, sustainability, and clean technologies. The book bridges materials science, industrial chemistry, physics, and engineering, making it a must have for researchers in industry and academia, as well as those working on application-oriented plasma technologies. Also Available Online This Taylor & Francis encyclopedia is also available through online subscription, offering a variety of extra benefits for researchers, students, and librarians, including: Citation tracking and alerts Active reference linking Saved searches and marked lists HTML and PDF format options Contact Taylor and Francis for more information or to inquire about subscription options and print/online combination packages. US: (Tel) 1.888.318.2367; (E-mail) [email protected] International: (Tel) +44 (0) 20 7017 6062; (E-mail) [email protected]
Book Synopsis Functional and Smart Biomaterials: Development and Application in Regenerative Medicine by : Guicai Li
Download or read book Functional and Smart Biomaterials: Development and Application in Regenerative Medicine written by Guicai Li and published by Frontiers Media SA. This book was released on 2022-06-02 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Innovations and Implementations of Computer Aided Drug Discovery Strategies in Rational Drug Design by : Sanjeev Kumar Singh
Download or read book Innovations and Implementations of Computer Aided Drug Discovery Strategies in Rational Drug Design written by Sanjeev Kumar Singh and published by Springer Nature. This book was released on 2021-02-02 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents various computer-aided drug discovery methods for the design and development of ligand and structure-based drug molecules. A wide variety of computational approaches are now being used in various stages of drug discovery and development, as well as in clinical studies. Yet, despite the rapid advances in computer software and hardware, combined with the exponential growth in the available biological information, there are many challenges that still need to be addressed, as this book shows. In turn, it shares valuable insights into receptor-ligand interactions in connection with various biological functions and human diseases. The book discusses a wide range of phylogenetic methods and highlights the applications of Molecular Dynamics Simulation in the drug discovery process. It also explores the application of quantum mechanics in order to provide better accuracy when calculating protein-ligand binding interactions and predicting binding affinities. In closing, the book provides illustrative descriptions of major challenges associated with computer-aided drug discovery for the development of therapeutic drugs. Given its scope, it offers a valuable asset for life sciences researchers, medicinal chemists and bioinformaticians looking for the latest information on computer-aided methodologies for drug development, together with their applications in drug discovery.
Book Synopsis Nanostructured Thin Films and Surfaces by :
Download or read book Nanostructured Thin Films and Surfaces written by and published by John Wiley & Sons. This book was released on 2010-03-08 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book series Nanomaterials for the Life Sciences, provides an in-depth overview of all nanomaterial types and their uses in the life sciences. Each volume is dedicated to a specific material class and covers fundamentals, synthesis and characterization strategies, structure-property relationships and biomedical applications. The series brings nanomaterials to the Life Scientists and life science to the Materials Scientists so that synergies are seen and developed to the fullest. Written by international experts of various facets of this exciting field of research, the series is aimed at scientists of the following disciplines: biology, chemistry, materials science, physics, bioengineering, and medicine, together with cell biology, biomedical engineering, pharmaceutical chemistry, and toxicology, both in academia and fundamental research as well as in pharmaceutical companies. VOLUME 5 - Nanostructured Thin Films and Surfaces
Book Synopsis Smart Coatings for Orthopedic Implants by : Dr Suja Mathai
Download or read book Smart Coatings for Orthopedic Implants written by Dr Suja Mathai and published by . This book was released on 2023-12-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Replacement of joints is a significant subspecialty of bone replacement surgery that calls for mechanically robust and biologically compatible, or biocompatible, implants. Stainless steels (SS), cobalt chromium alloys, or titanium (Ti) and its alloys is typically used to make orthopaedic implants. In this study, incorporating tellurium dioxide with niobium pentoxide is an effective method to impart the coatings with antibacterial properties by a thermal deposition method on titanium substrate. The developed coatings were treated for alkaline treatment and was subjected for in vitro study in 1.5 Kukubo's simulated body fluid to enhance biogrowth and adhesion strength. The physico-chemical and surface characterization revealed the presence of nanocomposite coatings with the deposition apatite on the surface of titanium metal strip was confirmed by XRD, FTIR, EIS, CV and SEM analysis studies. The electrochemical experiments revealed that the developed coatings had high adhesion strength and high biomimetic growth characteristics. The antibacterial test was used to evaluate the antibacterial properties of tellurium dioxide-niobium pentoxide coatings respectively. Antibacterial assays determined that treatment with nanocomposite coating induced a decay in the growth of both Gram-negative and Gram-positive bacteria. The highest zone of inhibition was observed for Staphylococcus aureus and Escherichia coli respectively. Incorporating tellurium dioxide (TeO2) and selenium dioxide (SeO2) with HAp coatings is also an effective method to impart coatings with anti-infective and anti-inflammatory properties. In this study, the thermal decomposition method for the formation of TeO2-SeO2-HAp nanocomposite coatings on titanium substrate to fabricate its biological and osseointegration behavior of implants was employed. The resultant coatings were chosen for in vitro study in Kukubo's 1.5 simulated body fluid after alkaline treatment and subjected to physio-chemical characterization, electrochemical evaluation, surface and topographical analyses.
Book Synopsis Applications of Polymeric Materials for Implant Fixed Dental Reconstructions by : Karl Ekstrand
Download or read book Applications of Polymeric Materials for Implant Fixed Dental Reconstructions written by Karl Ekstrand and published by . This book was released on 1988 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Stress and Structure Development in Polymeric Coatings by : Vaessen Diane Melissa
Download or read book Stress and Structure Development in Polymeric Coatings written by Vaessen Diane Melissa and published by . This book was released on 2002 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Silver Coordination Compounds as Light-stable, Nano-structured and Anti-bacterial Coatings for Dental Implant and Restorative Materials by :
Download or read book Silver Coordination Compounds as Light-stable, Nano-structured and Anti-bacterial Coatings for Dental Implant and Restorative Materials written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Silver coordination polymer chains were deposited on Au(111) as a model surface, as well as on gold alloy and titanium as dental implant and restorative materials. The topography of the surface was analysed on the model substrate and it was found to be a nano-structured crystalline material. In vitro investigations in a flow chamber imitating the oral environment prove the anti-bacterial properties of the silver compound.
Book Synopsis Materials Development and Processing for Biomedical Applications by : Savaş Kaya
Download or read book Materials Development and Processing for Biomedical Applications written by Savaş Kaya and published by CRC Press. This book was released on 2022-04-05 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Materials Development and Processing for Biomedical Applications focuses on various methods of manufacturing, surface modifications, and advancements in biomedical applications. This book examines in detail about five different aspects including, materials properties, development, processing, surface coatings, future perspectives and fabrication of advanced biomedical devices. Fundamental aspects are discussed to better understand the processing of various biomedical materials such as metals, ceramics, polymers, composites, etc. A wide range of surface treatments are covered in this book that will be helpful for the readers to understand the importance of surface treatments and their future perspectives. Additional Features Include: Examines various properties of biomedical materials at the beginning in several chapters which will enrich the fundamental knowledge of the readers. Discusses advancements in various fields of biomedical applications. Provides a glimpse of characterization techniques for the evaluation of material properties. Addresses biocompatibility, biocorrosion, and tribocorrosion. This book explores new and novel strategies for the development of materials and their biomedical applications. It will serve as a comprehensive resource for both students and scientists working in materials and biomedical sciences.
Book Synopsis Functional Polymer Coatings by : Limin Wu
Download or read book Functional Polymer Coatings written by Limin Wu and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
