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Development Of Novel Interfaces For Combining Liquid Chromatography With Matrix Assisted Laser Desorption Ionization Mass Spectrometry
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Book Synopsis Development of Novel Interfaces for Combining Liquid Chromatography with Matrix-assisted Laser Desorption Ionization Mass Spectrometry by : Jason Bryce Young
Download or read book Development of Novel Interfaces for Combining Liquid Chromatography with Matrix-assisted Laser Desorption Ionization Mass Spectrometry written by Jason Bryce Young and published by . This book was released on 2009 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Development of Matrix-assisted Laser Desorption/ionization and Liquid Chromatography - Electrospray Ionization Based Mass Spectrometric Techniques for Characterizing and Quantifying Endogenous and Therapeutic Biomolecules by : Bingming Chen
Download or read book Development of Matrix-assisted Laser Desorption/ionization and Liquid Chromatography - Electrospray Ionization Based Mass Spectrometric Techniques for Characterizing and Quantifying Endogenous and Therapeutic Biomolecules written by Bingming Chen and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endogenous biomolecules, such as neuropeptide, protein and carbohydrates, play important roles in biological and physiological processes. Over the last two decades, therapeutic biomolecules, including therapeutic peptides, proteins and monoclonal antibodies, have become large and fast-growing segments of the pharmaceutical industry. However, analyzing biomolecules is challenging due to their large size, complex structure and various modifications. In situ analysis of biomolecules is even more challenging due to the large dynamic range and complex microenvironments on tissue surface. In this dissertation, matrix-assisted laser desorption/ionization (MALDI) and liquid chromatography (LC) -- electrospray ionization (ESI) based mass spectrometric techniques were developed to characterize and quantify endogenous and therapeutic biomolecules. Specifically, this work developed novel ionization techniques and mass spectrometry imaging workflows to study the sequence and in situ distribution of biomolecules on high resolution accurate mass instrument platforms. Moreover, absolute or relative quantifications of biomolecules, such as therapeutic peptide or N-glycans, were measured by cutting-edge quantification workflows. In summary, this work not only improves current analytical methodology for characterizing biomolecules, but also demonstrates its potential applications in pharmaceutical industry and clinical settings.
Book Synopsis Liquid Chromatography Coupled with Electrospray-ionization Mass Spectrometry and Matrix-assisted Laser Desorption/ionization Time-of-flight Mass Spectrometry Method Development and Applications for the Analysis of Food and Medicinal Herbs by : Kim Chung Lee
Download or read book Liquid Chromatography Coupled with Electrospray-ionization Mass Spectrometry and Matrix-assisted Laser Desorption/ionization Time-of-flight Mass Spectrometry Method Development and Applications for the Analysis of Food and Medicinal Herbs written by Kim Chung Lee and published by . This book was released on 2009 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis LC/MS Applications in Drug Development by : Mike S. Lee
Download or read book LC/MS Applications in Drug Development written by Mike S. Lee and published by John Wiley & Sons. This book was released on 2002-03-07 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breakthroughs in combinatorial chemistry and molecular biology, as well as an overall industry trend toward accelerated development, mean the rate of sample generation now far exceeds the rate of sample analysis in the pursuit of producing new and better pharmaceuticals. LC/MS is an analytical tool that helps the researcher identify the most promising sample early in the selection process, effectively creating a shortcut to finding new drugs. This book is the first to describe LC/MS applications within the context of drug development, including the discovery, preclinical, clinical, and manufacturing phases. In addition to the thorough technical analysis of this tool, LC/MS Applications in Drug Development provides perspective on the significant changes in strategies for pharmaceutical analysis. A process overview of drug development from an analytical point of view is provided along with essential data required to successfully bring a drug to market. The incorporation of LC/MS is illustrated from target to product. Chapters pertaining to the discovery process itself include: Proteomics Glycoprotein Mapping Natural Products Dereplication Lead Identification Screening Open-Access LC/MS In Vitro Drug Screening Written for both the analytical chemist who uses LC/MS applications and the pharmaceutical scientist who works with the drugs they produce, LC/MS Applications in Drug Development is the premier reference on the subject.
Book Synopsis Liquid Chromatography Continuous-flow Matrix-assisted Laser Desorption Ionization Time-of-flight Mass Spectrometry for the Detection of Bioactive Peptides and Proteins by :
Download or read book Liquid Chromatography Continuous-flow Matrix-assisted Laser Desorption Ionization Time-of-flight Mass Spectrometry for the Detection of Bioactive Peptides and Proteins written by and published by . This book was released on 1997 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt: Describes the general approach of combining liquid chromatography with matrix-assisted laser desorption ionization mass spectrometry for on-line detection of peptides and proteins, based on the use of a continuous flow probe. Recent advances in time-of-flight mass spectrometric instrumentation for this approach are reported. Finally, the results of time-lag focusing matrix-assisted laser desorption ionization analysis of 15 peptides and proteins using solid matrices are presented. Mass measurement error is discussed along with the limitations of, and potential improvements to, the analytical system proposed.
Book Synopsis HPLC Method Development for Pharmaceuticals by : Satinder Ahuja
Download or read book HPLC Method Development for Pharmaceuticals written by Satinder Ahuja and published by Elsevier. This book was released on 2011-09-21 with total page 533 pages. Available in PDF, EPUB and Kindle. Book excerpt: High pressure, or high performance, liquid chromatography (HPLC) is the method of choice for checking purity of new drug candidates, monitoring changes during scale up or revision of synthetic procedures, evaluating new formulations, and running control/assurance of the final drug product. HPLC Method Development for Pharmaceuticals provides an extensive overview of modern HPLC method development that addresses these unique concerns. Includes a review and update of the current state of the art and science of HPLC, including theory, modes of HPLC, column chemistry, retention mechanisms, chiral separations, modern instrumentation (including ultrahigh-pressure systems), and sample preparation. Emphasis has been placed on implementation in a pharmaceutical setting and on providing a practical perspective. HPLC Method Development for Pharmaceuticals is intended to be particularly useful for both novice and experienced HPLC method development chemists in the pharmaceutical industry and for managers who are seeking to update their knowledge. Covers the requirements for HPLC in a pharmaceutical setting including strategies for software and hardware validation to allow for use in a regulated laboratory Provides an overview of the pharmaceutical development process (clinical phases, chemical and pharmaceutical development activities) Discusses how HPLC is used in each phase of pharmaceutical development and how methods are developed to support activities in each phase
Book Synopsis Subcellular Proteomics by : Eric Bertrand
Download or read book Subcellular Proteomics written by Eric Bertrand and published by Springer Science & Business Media. This book was released on 2007-08-29 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume summarizes the new developments that made subcellular proteomics a rapidly expanding area. It examines the different levels of subcellular organization and their specific methodologies. In addition, the book includes coverage of systems biology that deals with the integration of the data derived from these different levels to produce a synthetic description of the cell as a system.
Book Synopsis Development and Application of Novel Matrices Under Matrix-assisted Laser Desorption/ionization Time-of-flight (MALDI-TOF) Mass Spectrometry Conditions by : Bharat R. Mankani
Download or read book Development and Application of Novel Matrices Under Matrix-assisted Laser Desorption/ionization Time-of-flight (MALDI-TOF) Mass Spectrometry Conditions written by Bharat R. Mankani and published by . This book was released on 2010 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Liquid Chromatography - Mass Spectrometry by : Robert E. Ardrey
Download or read book Liquid Chromatography - Mass Spectrometry written by Robert E. Ardrey and published by John Wiley & Sons. This book was released on 2003-04-02 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Erklärt die Grundprinzipien der LC-MS-Kopplung speziell Beschäftigten im Labor, die diese Technik einsetzen, aber kein umfangreiches chemisches Vorwissen erworben haben. - LC-MS ist ein unentbehrliches Hilfsmittel zur Problemlösung in sämtlichen Gebieten der Analytik, besonders aber zur Trennung und Identifizierung komplexer Gemische organischer oder biologischer Verbindungen - Prinzipien von Flüssigchromatographie (LC) und Massenspektrometrie (MS) werden zunächst einzeln erklärt, Leser muss deshalb nicht auf spezielle Literatur zurückgreifen - Beschreibungen der instrumentellen Ausrüstung sind so anschaulich, dass auch Studenten ohne Zugang zum Labor davon profitieren - moderne Anwendungen der LC-MS und deren Vorteile werden ausführlich besprochen
Download or read book Biomarker written by Tapan Khan and published by BoD – Books on Demand. This book was released on 2012-04-27 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinicians, scientists, and health care professionals use biomarkers or biological markers as a measure of a person’s present health condition or response to interventions. An ideal -biomarker should have the following criteria: (I) ability to detect fundamental features of the disease, (II) ability to differentiate from other closely related diseases, (III) ability to detect early stages and stages of progression, (IV) the method should be highly reliable, easy to perform and inexpensive, and (V) sample sources should be easily accessible from body. Most of the chapters in this book follow the basic principle of biomarkers.
Book Synopsis Interpretation of MS-MS Mass Spectra of Drugs and Pesticides by : Wilfried M. A. Niessen
Download or read book Interpretation of MS-MS Mass Spectra of Drugs and Pesticides written by Wilfried M. A. Niessen and published by John Wiley & Sons. This book was released on 2017-01-30 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides comprehensive coverage of the interpretation of LC–MS–MS mass spectra of 1300 drugs and pesticides Provides a general discussion on the fragmentation of even-electron ions (protonated and deprotonated molecules) in both positive-ion and negative-ion modes This is the reference book for the interpretation of MS–MS mass spectra of small organic molecules Covers related therapeutic classes of compounds such as drugs for cardiovascular diseases, psychotropic compounds, drugs of abuse and designer drugs, antimicrobials, among many others Covers general fragmentation rule as well as specific fragmentation pathways for many chemical functional groups Gives an introduction to MS technology, mass spectral terminology, information contained in mass spectra, and to the identification strategies used for different types of unknowns
Book Synopsis Methodological Advances of MALDI Mass Spectrometry-Based Techniques in Organic and Biomedical Analysis by : Cheng Guo
Download or read book Methodological Advances of MALDI Mass Spectrometry-Based Techniques in Organic and Biomedical Analysis written by Cheng Guo and published by Frontiers Media SA. This book was released on 2022-07-13 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Novel Anticancer Agents by : Alex A. Adjei
Download or read book Novel Anticancer Agents written by Alex A. Adjei and published by Elsevier. This book was released on 2011-04-28 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: Novel Anticancer Agents offers pertinent basic science information on strategies used for the rational design and discovery of novel anticancer agents, and, in addition, translational studies involving clinical trial design and execution with these novel, mostly cytostatic agents. This book covers basic science strategies that are being used in drug discovery and preclinical evaluation focused on novel molecular targets, as well as clinical trial methodology including clinical pharmacokinetics and imaging to address issues of efficacy evaluation of the new, relatively non-cytotoxic anticancer agents. At present, there is no book that provides such an integration of basic and clinical studies of novel anticancer agents, covering both drug discovery and translational research extensively. Addresses the critical issues involved in the development of novel agents for cancer therapy by experts in the field Presents drug discovery strategies Discusses regulatory issues surrounding drug development
Book Synopsis Development and Evaluation of a Disposable Moving Ribbon Liquid Chromatography-laser Desorption Mass Spectrometry Interface by : William DeMaio
Download or read book Development and Evaluation of a Disposable Moving Ribbon Liquid Chromatography-laser Desorption Mass Spectrometry Interface written by William DeMaio and published by . This book was released on 1987 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Matrix-assisted Laser Desorption Ionization Mass Spectrometry by : Jonathon Kevin Gooden
Download or read book Matrix-assisted Laser Desorption Ionization Mass Spectrometry written by Jonathon Kevin Gooden and published by . This book was released on 2005 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Development of a Novel Matrix Assisted Laser Desorption by : Kandalama KD Priyasantha
Download or read book Development of a Novel Matrix Assisted Laser Desorption written by Kandalama KD Priyasantha and published by . This book was released on 2015 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Matrix Assisted Laser Desorption / Ionization (MALDI) Mass Spectrometry (MS) has emerged as an important tool in the field of proteomics mainly because it is simple, quick and efficient. The identification and quantitation of biomarkers, protein targets for drugs, and metabolites are some of the important fields in proteomics research. Although MALDI MS is an important tool in proteomics research there are drawbacks of the technique that need further development in order for the approach to be used in clinical laboratories. One major limitation of MALDI MS is the generally poor reproducibility of ion signal intensities, which negatively impacts the quantitation of peptides and protein by MALDI MS. A considerable amount of research has been performed in an effort to improve the ion signal reproducibility in MALDI MS. However, many of the approaches developed have introduced specific drawbacks with respect to the traditional dried-droplet sample preparation technique, negating many of the advantages of the MALDI MS approach. This project has focused on the development of a novel approach to quantify peptides by MALDI MS while preserving traditional known advantages of the technique. The studies performed show that an approach in which the ion signal base widths are manipulated to match that of a reference ion signal, through adjustments in desorption laser intensity, leads to much higher reproducibility in the integrated ion signal intensities. A standard curve acquired using the constant ion signal base width approach showed lower average RSDs ( 10.00% vs. 39.00%) and improved R 2 values (> 0.9600 vs.
Book Synopsis Proceedings of the ... ASMS Conference on Mass Spectrometry and Allied Topics by :
Download or read book Proceedings of the ... ASMS Conference on Mass Spectrometry and Allied Topics written by and published by . This book was released on 1992 with total page 2284 pages. Available in PDF, EPUB and Kindle. Book excerpt:
