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Development Of Covid 19 Therapies Lessons Learnt And Ongoing Efforts
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Book Synopsis Development of COVID-19 Therapies: Lessons Learnt and Ongoing Efforts by : Bruno Villoutreix
Download or read book Development of COVID-19 Therapies: Lessons Learnt and Ongoing Efforts written by Bruno Villoutreix and published by Frontiers Media SA. This book was released on 2023-10-24 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: Massive experimental, computational, and clinical studies have been performed worldwide, and are still ongoing, to understand and characterize Covid-19 molecular basis and transmission mechanisms, to develop diagnostics and vaccines, and to search for small chemical drug candidates and therapeutic proteins and peptides. Impressive results have been obtained for transmission control and vaccines so far, but what is the status of the other therapeutic options? The crisis has exposed different types of weaknesses in biomedical research in many countries. What can we learn from this crisis in the field of drug discovery and development so as to emerge stronger? The Covid-19 crisis has revealed the strengths of modern drug discovery and vaccine development but also exposed different types of weaknesses that would need to be addressed to be better prepared for a possible next global health crisis. These challenges/weaknesses/obstacles are of very different nature and as such hard to tackle. For instance, in addition to the inherent challenging nature of the scientific discovery, some scientists have mentioned insufficient local/national coordination and observed a fragmented drug discovery research, others have underlined a lack of coordination between the academic system and the private sector, an inadequate international global coordination and cooperation, others highlighted insufficient infrastructures, inappropriate financial supports, limited discussions between the scientific community performing the research and the public health authorities, decision makers and the society, while some remarked insufficient education/training about drug discovery and development leading to confusion… The crisis also raised important scientific questions about the technologies that would need to be used during an emergency situation, combined, integrated, or developed so as to accelerate the identification of small molecule drug candidates and of therapeutic peptides/proteins.
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :030968224X Total Pages :273 pages Book Rating :4.3/5 (96 download)
Book Synopsis Framework for Equitable Allocation of COVID-19 Vaccine by : National Academies of Sciences, Engineering, and Medicine
Download or read book Framework for Equitable Allocation of COVID-19 Vaccine written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-11-30 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: In response to the coronavirus disease 2019 (COVID-19) pandemic and the societal disruption it has brought, national governments and the international community have invested billions of dollars and immense amounts of human resources to develop a safe and effective vaccine in an unprecedented time frame. Vaccination against this novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), offers the possibility of significantly reducing severe morbidity and mortality and transmission when deployed alongside other public health strategies and improved therapies. Health equity is intertwined with the impact of COVID-19 and there are certain populations that are at increased risk of severe illness or death from COVID-19. In the United States and worldwide, the pandemic is having a disproportionate impact on people who are already disadvantaged by virtue of their race and ethnicity, age, health status, residence, occupation, socioeconomic condition, or other contributing factors. Framework for Equitable Allocation of COVID-19 Vaccine offers an overarching framework for vaccine allocation to assist policy makers in the domestic and global health communities. Built on widely accepted foundational principles and recognizing the distinctive characteristics of COVID-19, this report's recommendations address the commitments needed to implement equitable allocation policies for COVID-19 vaccine.
Book Synopsis Improving Pandemic Preparedness by : Thomas Bollyky
Download or read book Improving Pandemic Preparedness written by Thomas Bollyky and published by Council on Foreign Relations Press. This book was released on 2020-10-08 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: The United States and the world were unprepared for the COVID-19 pandemic, despite decades of warnings highlighting the inevitability of global pandemics and the need for international coordination. The failure to prioritize and adequately fund preparedness and effectively implement response plans has exacted a heavy human and economic price, and the crisis is not yet over. Emerging and reemerging infectious diseases are a threat to global and national security that neither the United States nor the world can afford to ignore. This Task Force proposes a comprehensive strategy that includes institutional reforms and policy innovations to help the United States and the multilateral system perform better in this crisis and when the next one emerges. Without increased U.S. leadership on and adequate investment in pandemic preparedness and response, the United States and the world will remain unnecessarily vulnerable to epidemic threats. The Council on Foreign Relations sponsors Independent Task Forces to assess issues of current and critical importance to U.S. foreign policy and provide policymakers with concrete judgments and recommendations. Diverse in backgrounds and perspectives, Task Force members aim to reach a meaningful consensus on policy through private deliberations. Once launched, Task Forces are independent of CFR and are solely responsible for the content of their reports. Task Force members are asked to join a consensus signifying that they endorse the general policy thrust and judgments reached by the group, though not necessarily every finding and recommendation. Each Task Force member also has the option of putting forward an additional or a dissenting view.
Book Synopsis National Strategy for the COVID-19 Response and Pandemic Preparedness by : Joseph R. Biden, Jr.
Download or read book National Strategy for the COVID-19 Response and Pandemic Preparedness written by Joseph R. Biden, Jr. and published by Simon and Schuster. This book was released on 2021-05-04 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ultimate guide for anyone wondering how President Joe Biden will respond to the COVID-19 pandemic—all his plans, goals, and executive orders in response to the coronavirus crisis. Shortly after being inaugurated as the 46th President of the United States, Joe Biden and his administration released this 200 page guide detailing his plans to respond to the coronavirus pandemic. The National Strategy for the COVID-19 Response and Pandemic Preparedness breaks down seven crucial goals of President Joe Biden's administration with regards to the coronavirus pandemic: 1. Restore trust with the American people. 2. Mount a safe, effective, and comprehensive vaccination campaign. 3. Mitigate spread through expanding masking, testing, data, treatments, health care workforce, and clear public health standards. 4. Immediately expand emergency relief and exercise the Defense Production Act. 5. Safely reopen schools, businesses, and travel while protecting workers. 6. Protect those most at risk and advance equity, including across racial, ethnic and rural/urban lines. 7. Restore U.S. leadership globally and build better preparedness for future threats. Each of these goals are explained and detailed in the book, with evidence about the current circumstances and how we got here, as well as plans and concrete steps to achieve each goal. Also included is the full text of the many Executive Orders that will be issued by President Biden to achieve each of these goals. The National Strategy for the COVID-19 Response and Pandemic Preparedness is required reading for anyone interested in or concerned about the COVID-19 pandemic and its effects on American society.
Book Synopsis AACR Report on the Impact of COVID-19 on Cancer Research and Patient Care by : American Association for Cancer Research
Download or read book AACR Report on the Impact of COVID-19 on Cancer Research and Patient Care written by American Association for Cancer Research and published by . This book was released on 2022-02-09 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Hydroxychloroquine and Chloroquine Retinopathy by : David J. Browning
Download or read book Hydroxychloroquine and Chloroquine Retinopathy written by David J. Browning and published by Springer. This book was released on 2014-05-09 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malpractice settlements are large for undetected hydroxychloroquine and chloroquine toxicity which, if untreated, can lead to permanent loss of central vision. Knowledge of the ocular toxicity of these drugs has increased during the past fifty years as their use has expanded. Hydroxychloroquine and Chloroquine Retinopathy is the first single-source book on the subject and is essential for the practicing ophthalmologists, rheumatologists, dermatologists, and internists who prescribe these drugs. It covers clinical topics such as signs and symptoms of toxicity, toxicity screening, ancillary testing, to whom and why the drugs are prescribed and dosing considerations. Additionally, the book addresses practice management considerations, including coding, reimbursement and equipment costs, and the medico-legal responsibilities of the rheumatologist and of the ophthalmologist. Guidelines for the management of hydroxychloroquine and chloroquine vary around the world and differences between the guidelines of the United Kingdom, the United States, and other countries are identified. The book concludes with a collection of case examples illustrating common clinical scenarios and their management. This book is a “must-have” resource for physicians who use these drugs.
Author :National Academies of Sciences Engineering and Medicine Publisher : ISBN 13 :9780309707848 Total Pages :0 pages Book Rating :4.7/5 (78 download)
Book Synopsis Applying Lessons Learned from Covid-19 Research and Development to Future Epidemics by : National Academies of Sciences Engineering and Medicine
Download or read book Applying Lessons Learned from Covid-19 Research and Development to Future Epidemics written by National Academies of Sciences Engineering and Medicine and published by . This book was released on 2024-05-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The COVID-19 pandemic catalyzed unparalleled speed and cross-sector collaboration in the innovation of tools and technologies to address an emerging infectious disease outbreak. Continued innovation and collaboration in rapid development and implementation of new vaccines, therapeutics, and diagnostics is central to future outbreak preparedness. The National Academies Forum on Microbial Threats; Forum on Drug Discovery, Development, and Translation; and the Forum on Medical and Public Health Preparedness for Emergencies and Disasters held a workshop in December 2022 to explore how innovative approaches in research can enhance health systems preparedness and responses to emerging infectious diseases and dangerous pathogens. Workshop participants reflected on critical scientific infrastructure for stakeholder coordination and innovations that can facilitate rapid and effective preparedness and response to emerging infectious disease threats. This Proceedings of a Workshop summarizes the discussions held during the workshop.
Download or read book SARS written by and published by . This book was released on 2004-01-01 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: SARS is a newly identified human infection caused by a corona virus unlike any other known human or animal virus in its family. The analysis of epidemiological information obtained from the sites of the outbreaks of SARS is still underway but the overall case fatality ratio is known to approach 11% although the rate among the elderly is much higher. Currently the major challenges for the treatment of SARS are: the source of the SARS virus and mode of transmission are still not well understood; there are problems with diagnostic tools; there is no effective treatment; and there is no vaccine for SARS. The above-mentioned difficulties and challenges have motivated national authorities health workers and scientists to explore the potential of complementary treatment. The results of research on integrated treatment with TCM and Western medicine showed that it is safe and that it also has some potential clinical benefits. Therefore the experts suggested that records of such experience could serve as reference material for treatment of SARS in the future. This publication is intended to share experience in the complementary treatment of SARS patients; share the experience of clinical studies in the field of traditional medicine for treatment of SARS between the physicians and researchers; and to further encourage and promote the quality of research in the filed of traditional medicine.
Book Synopsis Environmental and Health Management of Novel Coronavirus Disease (COVID-19) by : Mohammad Hadi Dehghani
Download or read book Environmental and Health Management of Novel Coronavirus Disease (COVID-19) written by Mohammad Hadi Dehghani and published by Academic Press. This book was released on 2021-06-26 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental and Health Management of Novel Coronavirus Disease (COVID-19) examines mitigation measures that can be adopted at the time of a novel coronavirus outbreak to lessen environmental contamination and impacts on human health. The book discusses origin, structure and pathogenesis, epidemiology, environmental transmission and the potential spread routes of COVID-19 via surfaces, air, water, wastewater, medical waste and food products. It also covers guidelines and protocols for setting safety conditions to provide adequate health care and reduce the risk of infection in health and non-healthcare settings, along with preventative measures and disinfection technologies. In addition, the book discusses challenges, opportunities and future perspectives, the global crisis, and global consequences on the environment and health. With contributions from experts, this book presents a multidisciplinary reference resource for virologists, microbiologists, public health professionals, environmental health managers and others engaged in the study and mitigation of the environmental and health impacts of the virus. Covers the environmental transmission and spread of COVID-19 Includes environmental disinfection technologies for prevention of COVID-19 Provides guidelines, standards and protocols related to COVID-19
Book Synopsis Guidance for Establishing Crisis Standards of Care for Use in Disaster Situations by : Institute of Medicine
Download or read book Guidance for Establishing Crisis Standards of Care for Use in Disaster Situations written by Institute of Medicine and published by National Academies Press. This book was released on 2009-09-23 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: The influenza pandemic caused by the 2009 H1N1 virus underscores the immediate and critical need to prepare for a public health emergency in which thousands, tens of thousands, or even hundreds of thousands of people suddenly seek and require medical care in communities across the United States. Guidance for Establishing Crisis Standards of Care for Use in Disaster Situations draws from a broad spectrum of expertise-including state and local public health, emergency medicine and response, primary care, nursing, palliative care, ethics, the law, behavioral health, and risk communication-to offer guidance toward establishing standards of care that should apply to disaster situations, both naturally occurring and man-made, under conditions in which resources are scarce. This book explores two case studies that illustrate the application of the guidance and principles laid out in the report. One scenario focuses on a gradual-onset pandemic flu. The other scenario focuses on an earthquake and the particular issues that would arise during a no-notice event. Outlining current concepts and offering guidance, this book will prove an asset to state and local public health officials, health care facilities, and professionals in the development of systematic and comprehensive policies and protocols for standards of care in disasters when resources are scarce. In addition, the extensive operations section of the book provides guidance to clinicians, health care institutions, and state and local public health officials for how crisis standards of care should be implemented in a disaster situation.
Book Synopsis Assessing Global Progress in the Governance of Critical Risks by : OECD
Download or read book Assessing Global Progress in the Governance of Critical Risks written by OECD and published by Org. for Economic Cooperation & Development. This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The successful governance of critical risks is a strategic investment in preserving economic competitiveness and sustainable growth and in ensuring safer and better lives for the future. Citizens and businesses expect governments to be prepared for a wide range of possible crises and global shocks. However, the increasing frequency of events previously believed impossible, and their significant economic impact, has often revealed significant governance gaps. This OECD report provides an overview of countries' progess in implementing the Recommendation of the Council on the Governance of Critical Risks, which were designed to better govern and manage complex national risks. Based on an OECD wide survey, the report evaluates the progress made by countries, seeking to evaluate the key challenges in institutional, policy, administrative and regulatory mechanisms, used to manage critical risks from a whole of government perspective. The ultimate goal is to guide governments in minimising the effects of critical risks on economies and on citizens' daily lives to preserve national security.
Book Synopsis Operational Framework for Building Climate Resilient Health Systems by : World Health Organization
Download or read book Operational Framework for Building Climate Resilient Health Systems written by World Health Organization and published by . This book was released on 2016-02-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This document presents the World Health Organization (WHO) operational framework for building climate resilient health systems. The framework responds to the demand from Member States and partners for guidance on how the health sector and its operational basis and health systems can systematically and effectively address the challenges increasingly presented by climate variability and change. This framework has been designed in light of the increasing evidence of climate change and its associated health risks; global, regional and national policy mandates to protect population health; and a rapidly emerging body of practical experience in building health resilience to climate change. Primarily intended for public health professionals and health managers, this framework would also help guide decision-makers in other health-determining sectors, such as nutrition, water and sanitation, and emergency management. International development agencies could use this framework to focus investments and country support for public health, health system strengthening and climate change adaptation. The objective of this framework is to provide guidance for health systems and public health programming to increase their capacity for protecting health in an unstable and changing climate. By implementing the 10 key components laid out in this framework, health organizations, authorities and programs will be better able to anticipate, prevent, prepare for and manage climate-related health risks. Least developed countries and countries in the process of developing the health components of National Adaptation Plans (NAPs) under the UN Framework Convention on Climate Change (UNFCCC) (4) may find this document particularly useful in their efforts to design a comprehensive response to the risks presented by short-term climate variability and long-term climate change.
Book Synopsis Coronaviruses and their Diseases by : David Cavanagh
Download or read book Coronaviruses and their Diseases written by David Cavanagh and published by Springer. This book was released on 2012-11-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in the coronaviruses has never been greater. Their economic impact is considerable as they infect humans, livestock, poultry and companion animals. Murine hepatitis virus (MHV) infection of the mouse and rat central nervous systems are the subject of intense study; these investigations are providing insights into the potential role of viruses in human neurological diseases and, more generally, into mechanisms causing neurological damage. The single-stranded, positive-sense RNA genomes of two species of these enveloped viruses (IBV and MHV) have been cloned completely and one of them (lBV) sequenced in its entirety, revealing a genome size of some 27000 nucleotides. This has made possible more incisive investigations into the nature of those polypeptides, encoded by more than half of the genome, which are likely to contribute, in the main, to RNA polymerase/replicase activity. Intriguingly, ribosomal frameshifting is exhibited within the mRNA coding for these polypeptides. The cloning/sequencing phase of coronavirology for which the 1980's will be partly remembered, has provided a sound framework for furthex: studies of the virus structural proteins and also some provocative insights relevant to these studies. The large spike glycoprotein(s), responsible for membrane fusion and bearing important antigenic sites, varies amazingly in length and composition both within as well as between coronavirus species. Receptors on host cells have been identified. The integral membrane glycoprotein (M) has been shown to use internal hydrophobic sequences to direct translocation within membranes.
Book Synopsis Laboratory Biosafety Guidelines by : Laboratory Centre for Disease Control (Canada)
Download or read book Laboratory Biosafety Guidelines written by Laboratory Centre for Disease Control (Canada) and published by . This book was released on 1996 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: The focus of this document is on the use of bacteria, viruses, parasites, fungi, and other infectious agents which are pathogenic to humans. The document provides guidelines for those who design, build, operate, or work in laboratories in which such pathogens are grown for research or development purposes. Sections of the document cover biohazard containment; regulations governing the import, export, and transport of pathogens; classification of biological agents according to risk; physical containment levels, and the physical and operational requirements for each level; large-scale production of micro-organisms, and related considerations regarding safety, containment, and transportation; and laboratory design. Appendices include information on safety equipment and systems for laboratories.
Book Synopsis Emergency, Crisis & Risk Management: Current Perspectives on the Development of Joint Risk Mitigation, Preparedness and Response Efforts by : Jarle Løwe Sørensen
Download or read book Emergency, Crisis & Risk Management: Current Perspectives on the Development of Joint Risk Mitigation, Preparedness and Response Efforts written by Jarle Løwe Sørensen and published by Frontiers Media SA. This book was released on 2023-01-13 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Development Dimension Innovation for Development Impact Lessons from the OECD Development Assistance Committee by : OECD
Download or read book The Development Dimension Innovation for Development Impact Lessons from the OECD Development Assistance Committee written by OECD and published by OECD Publishing. This book was released on 2020-06-23 with total page 81 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report synthesises the lessons emerging from an OECD Development Assistance Committee peer learning exercise on how innovation efforts can be strengthened, individually and collectively, to achieve the 2030 Agenda.
Book Synopsis COVID-19 Global Lessons Learned: Interactive Case Studies by : Richard Riegelman
Download or read book COVID-19 Global Lessons Learned: Interactive Case Studies written by Richard Riegelman and published by Jones & Bartlett Learning. This book was released on 2020-12-03 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: COVID-19 Global Lessons Learned is a collection of 6 interactive case studies, 6-10-page each, that is designed for online or classroom discussion or as graded assignments. The case studies include links to websites and videos, discussion and interactive questions, plus a full package of instructor resources including a helpful instructor’s guide with sample answers to discussion questions, and a test bank. The 6 Interactive Case Studies include: 1. Clinical course of COVID-19 2. Epidemiology of COVID-19 3. Testing for COVID-19 4. Population Prevention and COVID-19 5. Treatment of COVID-19 6 Health Policy and Communications for COVID-19 Available at no additional cost (excluding Inclusive Access) when bundled with a Jones & Bartlett Learning text, these case studies are designed to be used in a wide range of courses.
