Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Development Of A Novel Magnesium Doped Citrate Based Polymer Composite For Orthopedic Engineering
Download Development Of A Novel Magnesium Doped Citrate Based Polymer Composite For Orthopedic Engineering full books in PDF, epub, and Kindle. Read online Development Of A Novel Magnesium Doped Citrate Based Polymer Composite For Orthopedic Engineering ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis DEVELOPMENT OF A NOVEL MAGNESIUM DOPED CITRATE BASED POLYMER COMPOSITE FOR ORTHOPEDIC ENGINEERING. by : Kevin Rahn
Download or read book DEVELOPMENT OF A NOVEL MAGNESIUM DOPED CITRATE BASED POLYMER COMPOSITE FOR ORTHOPEDIC ENGINEERING. written by Kevin Rahn and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Current bone substitute materials vary greatly both in their manufacturing techniques and compositions, but many still lack the mechanical, biological, and fabrication properties for a clinically ready bone substitute material. The goal of this study was to develop a novel self-setting polymer/ceramic composite bone cement with improved manufacturability through the use of a citrate polymer, a calcium phosphate mineral phase, and magnesium oxide as a self-setting agent. Magnesium oxide (MgO) was shown to quickly self-set POC (poly (octamethylene citrate)) polymer and POC/hydroxyapatite (HA) composites suitable as bone tissue substitute materials. A predictive model for the setting time of the cement as a function of cement composition was developed, as well as a preliminary setting reaction mechanism model for the cement. The mechanical properties of the cement, including the peak stress, Youngs modulus, and peak strain were characterized and shown in cases of lower MgO concentrations to significantly improve the peak stress and Youngs modulus of the material. Additionally, the cytotoxicity, degradation, pH response, and swelling response of the material were shown to be either comparable, or an improvement on POC/HA control composites. Finally, and most notably, the increased ease of fabrication of porous and solid scaffolds through injection molding was demonstrated, providing a drastic improvement on current routes of fabrication for POC/HA composites. The applicability of magnesium oxide self-setting was also demonstrated in other polymers of the citrate polymer family, including crosslinked urethane doped polyester elastomers (CUPE), biodegradable photoluminescent polymer (BPLP), and POC-click.
Book Synopsis Characterization of Novel Magnesium-Doped Citrate Polymer Composites for Injection Molding by : Matthew Venable
Download or read book Characterization of Novel Magnesium-Doped Citrate Polymer Composites for Injection Molding written by Matthew Venable and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current commercial options for orthopedic biomaterials come with a plethora of shortcomings that render them unideal for clinical use. While their mechanical strength may be similar to that of bone, other properties limit their applicability and benefit to patients. The purpose of this study was to design a novel citrate-based orthopedic composite consisting of poly(octamethylene citrate) (POC) as a foundational polymer, hydroxyapatite (HA) as a bone-like mineral phase, and magnesium oxide (MgO) as a bioactive setting agent. A qualitative setting comparison was included, illustrating that MgO can set all tested POC-based polymers, suggesting niche applications beyond orthopedics with the addition of unique constituent monomers. Mechanical properties of the composites, namely viscosity, compressive strength, setting time, and injection force, were analyzed to determine fitness for orthopedic use. Viscosity and setting time were tunable with MgO, HA, and hexamethylene diisocyanate (HDI) concentrations. Moreover, in the presence of a realistic, slow-injection shear rate, POC and POC- HA exhibited intense shear-thinning on the order of 11% for the former and 96% for the latter. Compressive strength, Young's modulus, and peak strain were characterized, demonstrating MgO's significant improvements in POC-HA composite strength. Lastly, injection force measurements reflected the composites' shear thinning behavior as all break-loose and glide forces were less than 20 N at 0.5 mL/s several minutes into the setting process. A novel application of MgO-setting citrate polymers for injection molding biomaterials was explored given the mechanics of the POC composites, showing that POC-MgO/HA shows promise in this field and is worthy of further study.
Book Synopsis Fiber and Ceramic Filler-based Polymer Composites for Biomedical Engineering by : Jyotishkumar Parameswaranpillai
Download or read book Fiber and Ceramic Filler-based Polymer Composites for Biomedical Engineering written by Jyotishkumar Parameswaranpillai and published by Springer. This book was released on 2024-10-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest development of fibre/ceramic-polymer composites for biocompatible applications, with a special emphasis on the effect of different types of fibre and ceramic fillers on the characteristics of the composites. The book contains chapters that cover fundamentals, materials used for composites, fabrication, classification, and biomedical applications. The first section of the book provides a brief overview of the fibre and ceramic-based composite materials while the subsequent sections cover the numerous types of fibre and ceramic polymeric composites with emphasis on their potential biomedical applications. Increasingly sophisticated biomedical technologies, such as tissue engineering and regenerative medicine, as well as genetic therapies and controlled drug delivery, are being developed at a breakneck pace, necessitating the development of new materials to meet the specific requirements of these fields. Single-component ceramic or polymer materials that are now available do not meet their requirements. Therefore, composites and hybrid composites have an important role to play. Aside from that, to completely meet the fundamental criteria such as biocompatibility, biodegradability, and acceptable mechanical qualities, it is necessary to find materials that can perform a variety of advanced activities at the same time. This book is a road map not only for the materials scientist but also for researchers, academics, technologists, and students working in composites for biomedical engineering applications.
Book Synopsis A New Generation of Polymer/ceramic Composite Biomaterials for Bone Regeneration by : Mehrnaz Salarian
Download or read book A New Generation of Polymer/ceramic Composite Biomaterials for Bone Regeneration written by Mehrnaz Salarian and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a substantial emerging interest for fundamental and applied research on the reinforcement of polymeric materials using nanotechnology. In the biomedical industry, development of novel bone cement composite materials with enhanced mechanical properties is of tremendous potential importance. The most universally used injectable bone cement is made of poly(methyl methacrylate) (PMMA); however, the major disadvantage of PMMA is its non-biodegradability. Polymers such as poly(propylene fumarate) (PPF) and polycaprolactone (PCL) are biodegradable, but suffer from a lack of mechanical properties. The aim of this research was to test the efficacy of these biodegradable polymers integrating nanotechnology for the development of composite biomaterials with improved mechanical properties sufficient for bone cements. This goal was investigated through a range of different studies. Focusing on nanostructured titania (n-TiO2) initially, titania nanofibers (n-TiO2 fibers) and nanowires (n-TiO2 wires) were introduced into a PPF matrix for potential use as an orthopaedic biomaterial to treat skeletal bone defects and diseases such as osteonecrosis. PPF was modified with maleic anhydride to provide functionality for the coordination of PPF to the surface of TiO2 nanofibers through a ring-opening reaction. The synthesis and modification of PPF were confirmed by NMR (1H and 13C) and XPS. The reaction chemistry of the functionalized PPF and nano-TiO2 was also investigated by XPS and FTIR analyses. The PPF-grafted nano-TiO2 was further employed in the development of bone cement composites by crosslinking/polymerization in the presence of N-vinyl pyrrolidone. Mechanical testing of the resulting bone cement composites demonstrated a significant enhancement of the tensile and flexural properties attributed to the chemical bonding between the PPF matrix and TiO2 nanofibers. On the basis of the determined mechanical properties, an optimum composition was found at 5 wt% loading of n-TiO2 fiber (0.5% in the starting composition) which provided a significant increase in Young's modulus (153%), tensile strength (113%), flexural modulus (196%), and flexural strength (126%) when compared with the unfilled PPF. These improvements were attributed to the chemical linkage of the filler to the polymer matrix which enhances the transfer of a mechanical load to the n-TiO2 fiber, leading to an increase in the mechanical properties of the bone cement composite. Secondly, bone formation is an angiogenesis-dependent process, and the need for treatment modalities that enhance neovascularization is especially important for bone regeneration in necrotic bone. A bone cement system capable of delivering an angiogenic modulator in a controlled manner may have the ability to boost the angiogenic response when injected to an osteonecrotic lesion. Therefore, an angiogenic agent, ginsenoside Rg1, was incorporated into an orthopedic PPF-based cement. Additionally, Sr-doped TiO2 nanofibers synthesized in supercritical CO2 were added to the cement formulation as an alternative radiopacifier to enable visualization of the bone cement composites and potential monitoring of the healing and loosening processes. XPS analysis showed that Sr2+ was doped in the crystalline matrix of anatase with the formation of SrTiO3. The strong nterfacial adhesion between PPF and nanofibers were characterized by SEM, FTIR, XPS, and thermal analyses and mechanical testing. The Sr-doped n-TiO2 fibers were shown to provide reasonably higher radiopacity to the PPF matrix, which is 0.32 ± 0.03 mm Al, than the unmodified fibers at the same loading level (0.20 ± 0.01 mm Al). In addition, bone cement composites loaded with ginsenoside Rg1 were found to provide a high drug release without sacrificing the mechanical properties of the bone cement. Furthermore, tube formation bioassays suggested that human umbilical vein endothelial cell lines would rearrange and align into a tubular structure in the presence of ginsenoside Rg1. Consequently, the proposed cement combines the immediate mechanical support given by the chemical bonding between the filler/polymer and optimum radiopacity (0.30 ± 0.12 mm Al) due to the incorporation of the Sr-doped TiO2 nanofibers to PPF matrix. Thirdly, because of the unique biological activities of ginsenoside Rg1, upregulating in vitro proliferation, migration, chemo-invasion, and tube formation in human umbilical vein endothelial cells (HUVECs), Rg1 can be incorporated into scaffold materials for bone tissue engineering applications. This incorporation could be achieved by encapsulation of ginsenoside Rg1 in biodegradable microspheres of PPF. Rg1-loaded PPF microspheres were prepared by both a double emulsion and a microfluidic technique for the first time in this research. The size and morphology of the Rg1-loaded PPF microspheres were characterized by SEM, showing unimodal 50-65?m size diameters using the microfluidic technique, ideal for easy flowing powders required in commercial formulations. The PPF microspheres produced from the microfluidic technique gave high encapsulation efficiencies of up to 95.35 ± 0.82%, while those obtained from a conventional double emulsion method gave a much broader size distribution in the range of 2-45?m with lower encapsulation efficiencies of 78.48 ± 1.68%. Release profiles were studied and quantified by UV-Vis spectrophotometry, with the results showing a lower initial burst in the release of Rg1 from the unimodal microspheres prepared by the microfluidic technique than from the double emulsion method. The burst effect was followed by a slow release profile which can be used for long term drug delivery applications to maintain the ginsenoside Rg1 concentration for an extended time period. Moreover, the released Rg1 showed a significant stimulatory effect on angiogenesis behavior and tube formation in human umbilical vein endothelial cells (HUVECs). Therefore, PPF microspheres developed in this study have potential for next-generation biomedical agents in drug-release devices for bone tissue engineering. Finally, the use of hydroxyapatite HAp is rather limited for heavy load-bearing applications due to low mechanical reliability and poor processability. Therefore, immobilization of a biocompatible metal/metal oxide on the surface of HAp has been receiving increased attention for applications involving the enhancement of mechanical properties of biocompatible prostheses. A novel nanostructured HAp and a composite of HAp and TiO2 with ultrafine structure and significantly improved mechanical properties were prepared using combined co-precipitation and sol-gel method in the green solvent, scCO2, and incorporated into polycaprolactone (PCL) matrix to develop scaffolds with enhanced physical and mechanical properties for bone regeneration. SEM and TEM analyses were employed to examine the morphology of the HAp nanoplates and HAp-TiO2 nanocomposites. The presence of Ti, O, Ca, and P in the HAp-TiO2 nanocomposites was detected by EDX. In addition, the effect of metal alkoxide concentration, reaction temperature, and pressure on the morphology, crystallinity, and surface area of the resulting nanostructured composites was examined using SEM, XRD, and the BET method. Chemical composition of the products were characterized using FTIR, XPS, and XANES analyses. TGA analysis was performed to investigate thermal behavior of the synthesized nanomaterials. Mechanical testing revealed a significant increase in the Young's modulus (88.6%), tensile strength (122%), flexural modulus (47%), and flexural strength (59.6%) of PCL/HAp-TiO2 composites containing 20 wt % HAp-TiO2 compared to PCL/HAp composites.
Book Synopsis Calcium Doped Citrate Bound Biomaterials for Multifunctional Orthopedic Tissue Engineering Applications by : John Fadel
Download or read book Calcium Doped Citrate Bound Biomaterials for Multifunctional Orthopedic Tissue Engineering Applications written by John Fadel and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone has become the second most transplanted tissue, only behind blood, with more than $30 billion spent annually in orthopedic related medical costs [1]. Previous research has confirmed the presence of strongly bound citrate-rich molecules that serve to stabilize the apatite nanocrystals within natural bone. The regulation of apatite nanostructure and the formation of apatitic calcium phosphate crystals impart natural bone with its mechanical properties and citrate is now thought to be a critical component in bone metabolism [2]. A citrate based, biodegradable elastomer, poly (1,8-octanediol-co-citric acid) (POC), has been developed, displaying excelled in vitro and in vivo biocompatibility; however, pure POC materials display insufficient mechanical properties in hydrated conditions, rapid degradation, and insufficient osteoconductivity [3]. Multiple ions, including calcium, are present throughout the body fluid and tissues, with roles in diverse biological processes including bone regeneration [4]. Citric acid, a polycarboxylic acid present in POC, readily chelates with cationic species and thus the addition of ionic species to POC results in the formation of a secondary, reversible ionic network, capable of improving mechanical strength while maintaining elasticity. Furthermore, the addition of calcium ions to POC is capable of imparting the bioactivity of the incorporated species into the resulting material. In this study, the development of a secondary ionic network was the focus as well as expanding the versatility of POC and its functional capabilities. Through various synthesis doping modifications, ionic doping sources, and a plethora of studies to characterize and test the formulated materials, this innovative design has solidified an enhanced polymer material for orthopedic applications. Calcium doping of POC has displayed improved mechanical strength in both dry and hydrated conditions with the maintenance of elastomeric character, shortened degradation rate, decreased swelling, minimal soluble content, improved cytocompatibility, a high degree of homogeneity, and a wide versatility in scaffold fabrication and molar concentration variability.
Book Synopsis Bone Tissue Engineering by : Jeffrey O. Hollinger
Download or read book Bone Tissue Engineering written by Jeffrey O. Hollinger and published by CRC Press. This book was released on 2004-10-14 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t
Download or read book Bionanocomposites written by Carole Aimé and published by John Wiley & Sons. This book was released on 2017-09-05 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Beginning with a general overview of nanocomposites, Bionanocomposites: Integrating Biological Processes for Bio-inspired Nanotechnologies details the systems available in nature (nucleic acids, proteins, carbohydrates, lipids) that can be integrated within suitable inorganic matrices for specific applications. Describing the relationship between architecture, hierarchy and function, this book aims at pointing out how bio-systems can be key components of nanocomposites. The text then reviews the design principles, structures, functions and applications of bionanocomposites. It also includes a section presenting related technical methods to help readers identify and understand the most widely used analytical tools such as mass spectrometry, calorimetry, and impedance spectroscopy, among others.
Book Synopsis Calcium Orthophosphates by : Sergey V. Dorozhkin
Download or read book Calcium Orthophosphates written by Sergey V. Dorozhkin and published by CRC Press. This book was released on 2012-06-04 with total page 863 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to a great chemical similarity with the biological calcified tissues, many calcium orthophosphates possess remarkable biocompatibility and bioactivity. Materials scientists use this property extensively to construct artificial bone grafts that are either entirely made of or only surface-coated with the biologically relevant calcium orthophospha
Book Synopsis Natural and Synthetic Biomedical Polymers by : Sangamesh G. Kum bar
Download or read book Natural and Synthetic Biomedical Polymers written by Sangamesh G. Kum bar and published by Newnes. This book was released on 2014-01-21 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymers are important and attractive biomaterials for researchers and clinical applications due to the ease of tailoring their chemical, physical and biological properties for target devices. Due to this versatility they are rapidly replacing other classes of biomaterials such as ceramics or metals. As a result, the demand for biomedical polymers has grown exponentially and supports a diverse and highly monetized research community. Currently worth $1.2bn in 2009 (up from $650m in 2000), biomedical polymers are expected to achieve a CAGR of 9.8% until 2015, supporting a current research community of approximately 28,000+. Summarizing the main advances in biopolymer development of the last decades, this work systematically covers both the physical science and biomedical engineering of the multidisciplinary field. Coverage extends across synthesis, characterization, design consideration and biomedical applications. The work supports scientists researching the formulation of novel polymers with desirable physical, chemical, biological, biomechanical and degradation properties for specific targeted biomedical applications. Combines chemistry, biology and engineering for expert and appropriate integration of design and engineering of polymeric biomaterials Physical, chemical, biological, biomechanical and degradation properties alongside currently deployed clinical applications of specific biomaterials aids use as single source reference on field. 15+ case studies provides in-depth analysis of currently used polymeric biomaterials, aiding design considerations for the future
Book Synopsis Transport Phenomena in Biological Systems by : George A. Truskey
Download or read book Transport Phenomena in Biological Systems written by George A. Truskey and published by Prentice Hall. This book was released on 2009 with total page 889 pages. Available in PDF, EPUB and Kindle. Book excerpt: For one-semester, advanced undergraduate/graduate courses in Biotransport Engineering. Presenting engineering fundamentals and biological applications in a unified way, this text provides students with the skills necessary to develop and critically analyze models of biological transport and reaction processes. It covers topics in fluid mechanics, mass transport, and biochemical interactions, with engineering concepts motivated by specific biological problems.
Book Synopsis Nano-Antimicrobials by : Nicola Cioffi
Download or read book Nano-Antimicrobials written by Nicola Cioffi and published by Springer Science & Business Media. This book was released on 2012-02-26 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a high demand for antimicrobials for the treatment of new and emerging microbial diseases. In particular, microbes developing multidrug resistance have created a pressing need to search for a new generation of antimicrobial agents, which are effective, safe and can be used for the cure of multidrug-resistant microbial infections. Nano-antimicrobials offer effective solutions for these challenges; the details of these new technologies are presented here. The book includes chapters by an international team of experts. Chemical, physical, electrochemical, photochemical and mechanical methods of synthesis are covered. Moreover, biological synthesis using microbes, an option that is both eco-friendly and economically viable, is presented. The antimicrobial potential of different nanoparticles is also covered, bioactivity mechanisms are elaborated on, and several applications are reviewed in separate sections. Lastly, the toxicology of nano-antimicrobials is briefly assessed.
Book Synopsis Advanced Healthcare Materials by : Ashutosh Tiwari
Download or read book Advanced Healthcare Materials written by Ashutosh Tiwari and published by John Wiley & Sons. This book was released on 2014-05-09 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers a comprehensive and interdisciplinary view of cutting-edge research on advanced materials for healthcare technology and applications Advanced healthcare materials are attracting strong interest in fundamental as well as applied medical science and technology. This book summarizes the current state of knowledge in the field of advanced materials for functional therapeutics, point-of-care diagnostics, translational materials, and up-and-coming bioengineering devices. Advanced Healthcare Materials highlights the key features that enable the design of stimuli-responsive smart nanoparticles, novel biomaterials, and nano/micro devices for either diagnosis or therapy, or both, called theranostics. It also presents the latest advancements in healthcare materials and medical technology. The senior researchers from global knowledge centers have written topics including: State-of-the-art of biomaterials for human health Micro- and nanoparticles and their application in biosensors The role of immunoassays Stimuli-responsive smart nanoparticles Diagnosis and treatment of cancer Advanced materials for biomedical application and drug delivery Nanoparticles for diagnosis and/or treatment of Alzheimers disease Hierarchical modelling of elastic behavior of human dental tissue Biodegradable porous hydrogels Hydrogels in tissue engineering, drug delivery, and wound care Modified natural zeolites Supramolecular hydrogels based on cyclodextrin poly(pseudo)rotaxane Polyhydroxyalkanoate-based biomaterials Biomimetic molecularly imprinted polymers
Book Synopsis Degradation of Implant Materials by : Noam Eliaz
Download or read book Degradation of Implant Materials written by Noam Eliaz and published by Springer Science & Business Media. This book was released on 2012-08-21 with total page 521 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the current understanding of the mechanical, chemical and biological processes that are responsible for the degradation of a variety of implant materials. All 18 chapters will be written by internationally renowned experts to address both fundamental and practical aspects of research into the field. Different failure mechanisms such as corrosion, fatigue, and wear will be reviewed, together with experimental techniques for monitoring them, either in vitro or in vivo. Procedures for implant retrieval and analysis will be presented. A variety of biomaterials (stainless steels, titanium and its alloys, nitinol, magnesium alloys, polyethylene, biodegradable polymers, silicone gel, hydrogels, calcium phosphates) and medical devices (orthopedic and dental implants, stents, heart valves, breast implants) will be analyzed in detail. The book will serve as a broad reference source for graduate students and researchers studying biomedicine, corrosion, surface science, and electrochemistry.
Book Synopsis Chemicals in Surgical Periodontal Therapy by : Alexandrina Lizica Dumitrescu
Download or read book Chemicals in Surgical Periodontal Therapy written by Alexandrina Lizica Dumitrescu and published by . This book was released on 2007 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biodegradable Polymers in Clinical Use and Clinical Development by : Abraham J. Domb
Download or read book Biodegradable Polymers in Clinical Use and Clinical Development written by Abraham J. Domb and published by John Wiley & Sons. This book was released on 2011-05-12 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on biodegradable polymers that are already in clinical use or under clinical development. Synthetic and natural polymers will be included. This excludes polymers that have been investigated and did not reach clinical development. The purpose of this book is to provide updated status of the polymers that are clinical use and those that are now being developed for clinical use and hopefully will reach the clinic during the next 5 years. The book provides information that of interest to academics and practicing researchers including chemists, biologists and bioengineers and users: physicians, pharmacists.
Book Synopsis Sustainable Polymer Composites and Nanocomposites by : Inamuddin
Download or read book Sustainable Polymer Composites and Nanocomposites written by Inamuddin and published by Springer. This book was released on 2019-02-01 with total page 1424 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents emerging economical and environmentally friendly polymer composites that are free of the side effects observed in traditional composites. It focuses on eco-friendly composite materials using granulated cork, a by-product of the cork industry; cellulose pulp from the recycling of paper residues; hemp fibers; and a range of other environmentally friendly materials procured from various sources. The book presents the manufacturing methods, properties and characterization techniques of these eco-friendly composites. The respective chapters address classical and recent aspects of eco-friendly polymer composites and their chemistry, along with practical applications in the biomedical, pharmaceutical, automotive and other sectors. Topics addressed include the fundamentals, processing, properties, practicality, drawbacks and advantages of eco-friendly polymer composites. Featuring contributions by experts in the field with a variety of backgrounds and specialties, the book will appeal to researchers and students in the fields of materials science and environmental science. Moreover, it fills the gap between research work in the laboratory and practical applications in related industries.
Book Synopsis Nanotechnology Applications for Tissue Engineering by : Sabu Thomas
Download or read book Nanotechnology Applications for Tissue Engineering written by Sabu Thomas and published by William Andrew. This book was released on 2015-01-03 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tissue engineering involves seeding of cells on bio-mimicked scaffolds providing adhesive surfaces. Researchers though face a range of problems in generating tissue which can be circumvented by employing nanotechnology. It provides substrates for cell adhesion and proliferation and agents for cell growth and can be used to create nanostructures and nanoparticles to aid the engineering of different types of tissue. Written by renowned scientists from academia and industry, this book covers the recent developments, trends and innovations in the application of nanotechnologies in tissue engineering and regenerative medicine. It provides information on methodologies for designing and using biomaterials to regenerate tissue, on novel nano-textured surface features of materials (nano-structured polymers and metals e.g.) as well as on theranostics, immunology and nano-toxicology aspects. In the book also explained are fabrication techniques for production of scaffolds to a series of tissue-specific applications of scaffolds in tissue engineering for specific biomaterials and several types of tissue (such as skin bone, cartilage, vascular, cardiac, bladder and brain tissue). Furthermore, developments in nano drug delivery, gene therapy and cancer nanotechonology are described. The book helps readers to gain a working knowledge about the nanotechnology aspects of tissue engineering and will be of great use to those involved in building specific tissue substitutes in reaching their objective in a more efficient way. It is aimed for R&D and academic scientists, lab engineers, lecturers and PhD students engaged in the fields of tissue engineering or more generally regenerative medicine, nanomedicine, medical devices, nanofabrication, biofabrication, nano- and biomaterials and biomedical engineering. Provides state-of-the-art knowledge on how nanotechnology can help tackling known problems in tissue engineering Covers materials design, fabrication techniques for tissue-specific applications as well as immunology and toxicology aspects Helps scientists and lab engineers building tissue substitutes in a more efficient way
