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Development Of A High Resolution Microvascular Imaging Toolkit For Optical Coherence Tomography
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Book Synopsis Development of a High Resolution Microvascular Imaging Toolkit for Optical Coherence Tomography by : Adrian Mariampillai
Download or read book Development of a High Resolution Microvascular Imaging Toolkit for Optical Coherence Tomography written by Adrian Mariampillai and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Development of Optical Coherence Tomography for Tissue Diagnostics by : Panomsak Meemon
Download or read book Development of Optical Coherence Tomography for Tissue Diagnostics written by Panomsak Meemon and published by . This book was released on 2010 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microvasculature can be found in almost every part of the human body, including the internal organs. Importantly, abnormal changes in microvasculature are usually related to pathological development of the tissue cells. Monitoring of changes in blood flow properties in microvasculature, therefore, provides useful diagnostic information about pathological conditions in biological tissues as exemplified in glaucoma, diabetes, age related macular degeneration, port wine stains, burn-depth, and potentially skin cancer. However, the capillary network is typically only one cell in wall thickness with 5 to 10 microns in diameter and located in the dermis region of skin. Therefore, a non-invasive flow imaging technique that is capable of depth sectioning at high resolution and high speed is demanded. Optical coherence tomography (OCT), particularly after its advancement in frequency domain OCT (FD-OCT), is a promising tool for non-invasive high speed, high resolution, and high sensitivity depth-resolved imaging of biological tissues. Over the last ten years, numerous efforts have been paid to develop OCT-based flow imaging techniques. An important effort is the development of phase-resolved Doppler OCT (PR-DOCT). Phase-resolved Doppler imaging using FD-OCT is particularly of interest because of the direct access to the phase information of the depth profile signal. Furthermore, the high speed capability of FD-OCT is promising for real time flow monitoring as well as 3D flow segmentation applications. However, several challenges need to be addressed; 1) Flow in biological samples exhibits a wide dynamic range of flow velocity caused by, for example, the variation in the flow angles, flow diameters, and functionalities. However, the improvement in imaging speed of FD-OCT comes at the expense of a reduction in sensitivity to slow flow information and hence a reduction in detectable velocity range; 2) A structural ambiguity so-called 'mirror image' in FD-OCT prohibits the use of maximum sensitivity and imaging depth range; 3) The requirement of high lateral resolution to resolve capillary vessels requires the use of an imaging optics with high numerical aperture (NA) that leads to a reduction in depth of focus (DOF) and hence the imaging depth range (i.e. less than 100 microns) unless dynamic focusing is performed. Nevertheless, intrinsic to the mechanism of FD-OCT, dynamic focusing is not possible. In this dissertation, the implementation of PR-DOCT in a high speed swept-source based FD-OCT is investigated and optimized. An acquisition scheme as well as a processing algorithm that effectively extends the detectable velocity dynamic range of the PR-DOCT is presented. The proposed technique increased the overall detectable velocity dynamic range of PR-DOCT by about five times of that achieved by the conventional method. Furthermore, a novel technique of mirror image removal called 'Dual-Detection FD-OCT' (DD-FD-OCT) is presented. One of the advantages of DD-FD-OCT to Doppler imaging is that the full-range signal is achieved without manipulation of the phase relation between consecutive axial lines. Hence the full-range DD-FD-OCT is fully applicable to phase-resolved Doppler detection without a reduction in detectable velocity dynamic range as normally encountered in other full-range techniques. In addition, PR- DOCT can utilize the maximum SNR ratio provided by the full-range capability. This capability is particularly useful for imaging of blood flow that locates deep below the sample surface, such as blood flow at deep posterior human eye and blood vessels network in the dermis region of human skin. Beside high speed and functional imaging capability, another key parameter that will open path for optical diagnostics using OCT technology is high resolution imaging (i.e. in a regime of a few microns or sub-micron). Even though the lateral resolution of OCT can be independently improved by opening the NA of the imaging optics, the high lateral resolution is maintained only over a short range as limited by the depth of focus that varies inversely and quadratically with NA. Recently developed by our group, 'Gabor-Domain Optical Coherence Microscopy' (GD-OCM) is a novel imaging technique capable for invariant resolution of about 2-3 [micrometers] over a 2 mm cubic field-of-view. This dissertation details the imaging protocol as well as the automatic data fusion method of GD-OCM developed to render an in-focus high-resolution image throughout the imaging depth of the sample in real time. For the application of absolute flow measurement as an example, the precise information about flow angle is required. GD-OCM provides more precise interpretation of the tissue structures over a large field-of-view, which is necessary for accurate mapping of the flow structure and hence is promising for diagnostic applications particularly when combined with Doppler imaging. Potentially, the ability to perform high resolution OCT imaging inside the human body is useful for many diagnostic applications, such as providing an accurate map for biopsy, guiding surgical and other treatments, monitoring the functional state and/or the post-operative recovery process of internal organs, plaque detection in arteries, and early detection of cancers in the gastrointestinal tract. Endoscopic OCT utilizes a special miniature probe in the sample arm to access tubular organs inside the human body, such as the cardiovascular system, the lung, the gastrointestinal tract, the urinary tract, and the breast duct. We present an optical design of a dynamic focus endoscopic probe that is capable of about 4 to 6 [micrometers] lateral resolution over a large working distance (i.e. up to 5 mm from the distal end of the probe). The dynamic focus capability allows integration of the endoscopic probe to GD-OCM imaging to achieve high resolution endoscopic tomograms. We envision the future of this developing technology as a solution to high resolution, minimally invasive, depth-resolved imaging of not only structure but also the microvasculature of in vivo biological tissues that will be useful for many clinical applications, such as dermatology, ophthalmology, endoscopy, and cardiology. The technology is also useful for animal study applications, such as the monitoring of an embryo's heart for the development of animal models and monitoring of changes in blood circulation in response to external stimulus in small animal brains.
Book Synopsis High Resolution Imaging in Microscopy and Ophthalmology by : Josef F. Bille
Download or read book High Resolution Imaging in Microscopy and Ophthalmology written by Josef F. Bille and published by Springer. This book was released on 2019-08-13 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.
Book Synopsis Quantitative Optical Coherence Tomography Methods for Functional Microvascular Imaging by : Conrad William Merkle
Download or read book Quantitative Optical Coherence Tomography Methods for Functional Microvascular Imaging written by Conrad William Merkle and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the importance of blood flow distribution has been highlighted in a wide range of diseases that involve the cerebral microvasculature. Specifically, microvascular heterogeneity, related to the non-uniform distribution of blood flow through the microvasculature, is an important parameter that is critical to the efficacy of oxygen extraction. As increased heterogeneity may lead to oxygen insufficiency, even with blood flow above ischemic levels, heterogeneity may be an important biomarker for understanding disease progression. However, current methods of quantifying microvascular heterogeneity over large microvascular networks that extend deep into biological tissue (such as the cerebral cortical microvasculature) are limited. To address this unmet need in functional microvascular imaging, we aimed to develop new microvascular imaging methods using 1300 nm optical coherence tomography (OCT), which is uniquely capable of examining the microvasculature up to ~1 mm deep in small animal models with micron-scale resolution. While Doppler OCT and OCT angiography methods can assess flow and vascular architecture, respectively, they cannot assess microvascular heterogeneity at the single capillary level. Thus, we developed a new method called Dynamic Contrast OCT (DyC-OCT), in which an intravascular bolus of contrast agent is tracked as it passes through the microvasculature. Using the mouse neocortex as an in vivo model system, we demonstrated that DyC-OCT is capable of quantifying the transit-time kinetics of plasma flow within individual capillaries, in addition to localized, quantitative measurements of blood flow and volume within microvascular networks in different layers. Lowest microvascular transit time heterogeneity was found in the middle cortical layers, and highest blood flow and volume were found in the most metabolically active layer IV, for the first time in vivo. Measurements also suggested higher hematocrit in deeper cortical layers. These results shed light on how a single vascular supply deriving from the cortical surface manages to differentially supply oxygen and nutrients to individual cortical layers, each of which has differing metabolic needs. DyC-OCT investigations in the choriocapillaris, a difficult-to-measure microvascular network in the eye that supplies the photoreceptors, yielded the first in vivo, quantitative measurements of blood flow and volume using optical methods. Finally, as part of this thesis work, we built an ultrahigh-resolution (~0.2-1 fL focal volume) visible light optical coherence microscope which employed an asymmetric optical design to further improve lateral resolution for investigation of superficial cortical structures. This microscope was used to directly observe myelinated axons as well as cell bodies, which appeared not to be pyramidal neurons, for the first time in the mouse brain in vivo.
Book Synopsis Development of Integrated Optical Coherence Tomography - Ultrasound System for Intravascular Imaging by : Jiechen Yin
Download or read book Development of Integrated Optical Coherence Tomography - Ultrasound System for Intravascular Imaging written by Jiechen Yin and published by . This book was released on 2011 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is a noninvasive, noncontact imaging modality that uses coherent gating to obtain high-resolution cross-sectional images of the microstructure of biological tissues. Recently, OCT has been considered as a promising technique for intravascular imaging, since it provides direct visualization of vessel walls with resolutions of 1-2 orders higher than intravascular ultrasound (IVUS). However, there are two major drawbacks for OCT: limited penetration depth makes it difficult to image the whole depth of atherosclerotic plaques and clearance of blood is required since the presence of blood can seriously attenuate OCT signals. OCT and ultrasound (US) are complementary in the application of intravascular imaging. This research focuses on the development of an integrated OCT-US system for the application of intravascular imaging. By combining the two imaging modalities, the system is capable of offering simultaneous OCT and ultrasound images in real-time, thus allowing for images with both high resolution and a deep imaging depth which will significantly improve diagnostic accuracy in the detection of atherosclerosis. OCT-US probes that combine OCT optical components and US transducers have been developed. Different probe designs have been realized based on different applications; and the latest version of the miniature design aimed at human coronary artery imaging has a maximum outer diameter of only 0.69mm. A rotary joint that combines a fiber optic rotary joint and electrical slip ring has been developed, so that both optical and electrical signals can be transmitted between the stationary and rotary parts of the system. The integrated imaging system provides real-time simultaneous OCT and US data acquisition, processing and image display by using a single two-channel data acquisition board and a home-developed OCT-US program. In vitro human coronary specimen imaging and in vivo animal studies have been performed to demonstrate the feasibility of our OCT-US system in the application of intravascular imaging. Last but not least, a 3-dimensional high speed endoscopic OCT system has been developed for the application of airway imaging. In vivo animal studies of smoke-induced early airway injury were performed using this system. Image processing software has been successfully developed for motion artifact removal, image reconstruction and quantitative analysis of airway thickness.
Book Synopsis Multidimensional Data Processing for Optical Coherence Tomography Imaging by : James Patrick McLean
Download or read book Multidimensional Data Processing for Optical Coherence Tomography Imaging written by James Patrick McLean and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: High-resolution video data showing cilia motion in unprecedented detail and scale was produced. An image processing method was used to create the first 3-D fiber model of uterine tissue from OCT images. Finally, a compressed sensing approach was developed which we show to guarantee high accuracy image recovery of more complicated, clinically relevant, samples than had been previously demonstrated. The culmination of these methods represents a step forward in OCT image analysis, showing that these cutting edge tools can also be applied to OCT data and in the future be employed in a clinical setting.
Book Synopsis Speckle And Motion Based Vascular Image Analysis for Optical Coherence Tomography by : Ho Yiu Cheng
Download or read book Speckle And Motion Based Vascular Image Analysis for Optical Coherence Tomography written by Ho Yiu Cheng and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Novel Tools for Optical Coherence Imaging by : Edwin Yuan
Download or read book Novel Tools for Optical Coherence Imaging written by Edwin Yuan and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical imaging is a vital part of preventative, diagnostic, and therapeutic medical treatment, but there are surprisingly few viable clinical tools at the microscale (1 to 100 microns; from a single to dozens of cells). Optical Coherence Tomography (OCT) is a high speed and portable 3D imaging technology poised to fill this gap. This work develops on two directions that expand the capabilities of OCT imaging and set up the groundwork for new clinical applications. The first is an investigation of gold nanoparticles as contrast agents in the second near-infrared imaging window. We demonstrate that injected gold nanoprisms are highly scattering contrast agents with tune-able scattering resonances which can be used to greatly enhance the sensitivity of OCT-based vascular imaging. Postinjection OCT angiograms reveal 41% and 59% more vasculature compared to control subjects in healthy and melanoma-bearing mouse skin respectively. We then demonstrate a spectral de-mixing model for gold nanoparticles, that allows us to resolve the proportions of up to 3 different gold nanobipyramids within each voxel. With this, we demonstrate the first instance of triplex OCT contrast agent imaging, used to visualize in vivo regional dynamics within a mouse lymphatic network. The second part of this work explores a new data-centric approach to interpreting optical medical images, a task that remains challenging for clinical professionals in spite of high imaging resolution. We have developed a laser-based barcoding technology that allows us to achieve ultra-high resolution registration (down to 25 microns) of OCT images with H&E pathology images. This technology has allowed us to assemble a library of hundreds of OCT-H&E images pairs from human skin samples obtained during Mohs surgery in a dermatology clinic. We then train a generative neural network on the image library and demonstrate the ability to virtually generate realistic H&E images directly from OCT images. This opens the door to an entirely virtual and non-invasive biopsy based on OCT imaging, bypassing the traditionally labor- and time- intensive biopsy procedure.
Book Synopsis Development and Translation of Label-free Functional Microscopy Based on Optical Coherence Tomography by : Ahhyun Nam
Download or read book Development and Translation of Label-free Functional Microscopy Based on Optical Coherence Tomography written by Ahhyun Nam and published by . This book was released on 2017 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT), an imaging modality based on low coherence interferometry, can be extended to obtain various endogenous functional contrasts. This thesis focuses on the development and translation of angiographic and polarization sensitive (PS) OCT techniques for clinical and preclinical applications. This goal includes four specific aims. The first aim is to develop a clinical imaging system to image the anatomy and microvasculature of human skin. The second aim is to develop a high performance post-processing algorithm for angiographic OCT. Towards this aim, we developed a processing algorithm based on complex differential variance (CDV) and confirmed its performance by benchmarking it against other published algorithms. The third aim is to develop a new approach for achieving high spatial resolution with an extended depth of focus for angiographic imaging. To achieve this aim, we have designed and built a triband wavelength system in which each spectrum is tightly focused at displaced focal planes to yield high transverse resolution over an effectively extended depth range. The fourth aim is to provide an imaging platform for preclinical study of peripheral nerve injury and repair. The vascularization is assessed by angiographic OCT, and the degree of myelination is measured by PS-OCT. These results confirm that the OCT platform can reveal new insights into preclinical studies of nerve regeneration and may ultimately provide a means for clinical intraoperative assessment of peripheral nerve health.
Book Synopsis Using Machine Learning and Optical Coherence Tomography to Generate a Non Contact Biopsy Images by : Yonatan Winetraub
Download or read book Using Machine Learning and Optical Coherence Tomography to Generate a Non Contact Biopsy Images written by Yonatan Winetraub and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In vivo Biomedical imaging is an important part of diagnostic, therapeutic medical treatment and research. The field is constantly searching for viable clinical tools at the micro-scale (single cell resolution). Optical Coherence Tomography (OCT) enables real-time imaging of living tissues in 3D up to 1mm. In this work we develop tools and models to better quantify the OCT signal, we then apply those tools on two exciting applications in living mice brain imaging and early detection of skin cancer. We have developed a model to accurately quantify the signals produced by endogenous scattering in OCT imaging. This model predicts distinct concentration-dependent signal trends that arise from the underlying physics of OCT detection. The relation between OCT signal and particle concentration is approximately linear at low concentrations. However, at higher concentrations, interference effects cause signal to increase with a square root dependence on the number of particles within a voxel. Predictions were validated by measuring OCT signals from phantom models as well as living animals. More generally, the model described herein may inform the interpretation of detected signals in modalities that rely on coherence-based detection or are susceptible to interference effects. We then build a theoretical model for speckle noise, one of OCT's most prominent issues preventing us from experiencing the full potential of this technology. Our theoretical analysis using Monte Carlo simulations indicates that pure angular compounding (a common technology for reducing speckle) can improve the signal-to-noise ratio by no more than a factor of 1.3. We conclude that speckle reduction using angular compounding is equivalent to spatial averaging. We then shift gears and present how the above tools could be used to detect microscopic movement in living brain. We introduce a novel OCT-based neuroimaging setting and accompanied feature segmentation algorithm enabling rapid, accurate, and high-resolution imaging of 700 mu depth across the mouse cortex, in-vivo. We demonstrate 3D reconstruction of microarchitectural elements in a whole cortical column. Features as Central Nervous System cell bodies density, volume, and average distance to the nearest cell can be quantified to better study the brain by this highly transformative and versatile platform. We developed a laser-based barcoding technology that allows us to achieve precise registration of OCT images with H&E pathology images. This approach enabled us to assemble a library of > 1000 OCT - H&E images pairs from human skin samples. We then train a generative adversarial neural network on the image library and demonstrate the ability to virtually generate realistic H&E images directly from OCT images. The combination of the above technologies opens the door to a virtual biopsy allowing clinicians to examine H&E sections of a suspected area but bypassing the intensive and expensive biopsy.
Book Synopsis Optical Coherence Tomography of Ocular Diseases by : Joel S. Schuman
Download or read book Optical Coherence Tomography of Ocular Diseases written by Joel S. Schuman and published by CRC Press. This book was released on 2024-06-01 with total page 1093 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most comprehensive text and definitive guide for nearly 30 years about optical coherence tomography (OCT) imaging in ophthalmology, Optical Coherence Tomography of Ocular Diseases, Fourth Edition covers a range of subjects, from principles and operation techniques to clinical interpretation and the latest innovations in OCT. Written by the pioneers of OCT technologies and the world-renowned OCT researchers Drs. Joel S. Schuman, James G. Fujimoto, Jay S. Duker, Hiroshi Ishikawa, and Gadi Wollstein, Optical Coherence Tomography of Ocular Diseases, Fourth Edition is an essential text for imaging technology. OCT now occupies a dominant role as a diagnostic tool for retinal conditions and glaucoma. At the same time, the technology continues to show potential for emerging clinical and research applications across all the ophthalmological subspecialties. To reflect these rapid advances, this new edition of Optical Coherence Tomography of Ocular Diseases features a complete and thorough revision of the existing text as well as the addition of cutting-edge content to bring this classic resource completely up to date. New content in the Fourth Edition includes: • OCT angiography • Swept-source OCT • OCT in multimodal imaging • Clinical utility of OCT in glaucoma prediction and progression detection • OCT for neuro-ophthalmology Optical Coherence Tomography of Ocular Diseases, Fourth Edition is the one and only book needed by practitioners who use OCT for clinical eye care.
Book Synopsis Development of Photothermal Optical Coherence Tomography for in Vivo Imaging of Contrast Agents by : Jason Michael Tucker-Schwartz
Download or read book Development of Photothermal Optical Coherence Tomography for in Vivo Imaging of Contrast Agents written by Jason Michael Tucker-Schwartz and published by . This book was released on 2015 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Development of a Multi-channel Visible-light Optical Coherence Tomography Platform for Investigating Fibrotic Disease Using Optical Scattering by : Ryan Niemeier
Download or read book Development of a Multi-channel Visible-light Optical Coherence Tomography Platform for Investigating Fibrotic Disease Using Optical Scattering written by Ryan Niemeier and published by . This book was released on 2020 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical imaging and microscopy provide multi-dimensional information in both the laboratory and clinical settings. Novel imaging methods have leveraged several contrast sources in order to provide both qualitative and quantitative metrics. Optical coherence tomography (OCT) is a volumetric, micro-scale imaging modality which draws intrinsic contrast from the optical scattering of tissue. Visible-light OCT (VIS-OCT) increases the scattering contrast and is ideal for imaging thin layers of tissue with subtle changes to the optical scattering. The work contained in this dissertation is a modification of VIS-OCT to utilize simultaneous acquisition of multiple channels. Multi-channel VIS-OCT is capable of noise reduction, polarization sensitivity, and quantifying tissue optical scattering. The multi-channel system was used in several imaging applications with relevance to translational medical care and bench-top research. The system was used to image the optical scattering changes in esophageal tissue before and after microwave ablation. Measurements of optical scattering helped to identify the boundaries of the ablation which can provide valuable information both during treatment and for microwave and radiofrequency ablation antenna design. By adding polarization channels, multi-channel VIS-OCT was capable of measuring birefringence in a mouse model of pulmonary fibrosis which is being used to test novel therapeutics for lung disease. Finally, a variation of this OCT system was developed to be used in a multi-modal system which combines and co-registers several other imaging modalities and is well-suited to study fibrosis in glaucoma and cancer. The sensitivity of this VIS-OCT system to optical scattering and polarization effects make it a valuable tool with which to study fibrosis. This dissertation describes the framework of this platform and several utilities which in future work will incorporate a lens-free probe for cost-effective in vivo imaging and other bench-top variations will enable higher resolution imaging capable of capturing dynamic processes in live cells.
Book Synopsis OCT Angiography in Retinal and Macular Diseases by : F. Bandello
Download or read book OCT Angiography in Retinal and Macular Diseases written by F. Bandello and published by Karger Medical and Scientific Publishers. This book was released on 2016-03-21 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: In only a short period of time, the innovative procedure of OCT angiography has become an essential macula imaging technique. Now that it is routinely used in clinical practice, the investigation of retinal and choroidal circulation is non-invasive, which significantly changes the professional’s approach to patients. In this volume, retina specialists and renowned experts share their experience with OCT angiography. They have included numerous color images and presented current ideas to form a base for further research and discussion. This book provides retina specialists, ophthalmologists, and researchers with a first glance at original research and clinical reports on this new methodology.
Book Synopsis Fluorescence Lifetime Imaging Ophthalmoscopy by : Martin Zinkernagel
Download or read book Fluorescence Lifetime Imaging Ophthalmoscopy written by Martin Zinkernagel and published by Springer. This book was released on 2019-07-29 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the emerging non-invasive imaging technique of Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO). FLIO reveals unique information on retinal diseases, ranging from age-related macular degeneration and vascular diseases to hereditary retinal dystrophies. Fluorescence lifetimes enable the evaluation of disease progression before irreversible structural changes occur. The image acquisition is suitable for diagnostic purposes and follow-up examinations to investigate the natural course of disease, and to monitor the effects of possible therapies. This book fills the gap between available literature and gives state-of-the-art guidance on the principles of the FLIO technique, image acquisition, and data analysis. Written by a team of expert leaders within this field, this book will be relevant for scientists and clinicians with an interest in ophthalmoscopy.
Book Synopsis Neurobiological Basis of Migraine by : Turgay Dalkara
Download or read book Neurobiological Basis of Migraine written by Turgay Dalkara and published by John Wiley & Sons. This book was released on 2017-08-07 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Published with the New York Academy of Sciences A timely, broad-ranging exploration of the neurobiological basis and molecular mechanisms of migraines Migraines impact the lives of a significant portion of the world's population, afflicting sufferers with severe pain, nausea, and often visual impairment. The WHO views migraines as an important public health issue, and ranks them in its top twenty most disabling illnesses. Neurobiological Basis of Migraine reviews the latest advances made in our understanding of the primary basic mechanisms of migraine headache and provides valuable insights into how these findings are being translated into novel treatment and prevention strategies around the world. Written for researchers and clinicians alike, the book features edited contributions from distinguished experts in the field, taking a focused, yet wide-ranging approach to the subject. It begins by exploring the pathways and networks mediating migraine headaches, their underlying physiological mechanisms, characteristics of visceral pain, and the concept of dural neurogenic inflammation. From there the authors delve into the mechanisms sustaining the head pain and photophobia associated with migraines, and they review the pharmacology of newly discovered migraine treatments. These basic chapters are followed by clinical and genetic studies linking to key issues, including cortical spreading depression, ion channels, transporters, and epilepsy. Reviews of the latest advances in our understanding of the neurobiological basis of migraine Translates important research findings from around the globe into novel treatments strategies currently being investigated Provides researchers and clinicians with a deep understanding of the primary mechanisms of migraine from migraine modeling to clinical applications Includes contributions by many of the most respected researchers in the field, world-wide Discusses exciting recent developments in migraine mutations and their role in CSD, as well as the role of CSD in aura and trigeminal activation Timely, comprehensive, and authoritative, Neurobiological Basis of Migraine is an indispensable working resource for clinicians and migraine, headache, and pain researchers, including neurobiologists, neuropharmacologists, neurologists, and vascular neurobiologists, as well as graduate students in those fields who are involved in researching migraine headaches.
Book Synopsis Regenerative Medicine by : Nishant Chakravorty
Download or read book Regenerative Medicine written by Nishant Chakravorty and published by Springer Nature. This book was released on 2023-01-30 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the recent innovations and therapeutic potentials of regenerative medicine and discusses the applications of stem cells, biomaterials, and tissue engineering in regenerative medicine. The book covers essential aspects of regenerative medicine, including tissue microenvironment, immunological perspectives, stem, and non-stem cell-mediated approaches, imaging techniques, biomarkers, and 3D printing technology. It also reviews the applications of biosensing technologies in regenerative medicine, including biomanufacturing, organ-on-a-chip technologies, and as indicators of therapeutic efficacy. Further, it focuses on the regenerative medicine approaches for diseases of the central nervous system. It also provides the therapeutic potential of regenerative medicine to improve soft tissue and wound healing, cardiovascular, neural, bone, and orofacial regeneration.
