Development And Application Of An Electrospray Ionization Ion Mobility Mass Spectrometer Using An Rf Ion Funnel And Periodic Focusing Ion Guide

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Development and Application of an Electrospray Ionization Ion Mobility-mass Spectrometer Using an RF Ion Funnel and Periodic-focusing Ion Guide

Author : Junho Jeon
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (881 download)

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Book Synopsis Development and Application of an Electrospray Ionization Ion Mobility-mass Spectrometer Using an RF Ion Funnel and Periodic-focusing Ion Guide by : Junho Jeon

Download or read book Development and Application of an Electrospray Ionization Ion Mobility-mass Spectrometer Using an RF Ion Funnel and Periodic-focusing Ion Guide written by Junho Jeon and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: A novel ion mobility-mass spectrometer was designed and built in order to achieve high transmission and high resolution for observing desolvated ion conformations of chemical and biological molecules in the gas phase. The instrument incorporates a home-built electrospray ionization (ESI) source and rf ion funnel(IF) as an ion transfer interface, modular periodic-focusing ion guide (PFIG) as a drift tube (DT) for arrival time measurement, and orthogonally accelerated linear time-of-flight mass spectrometer to maximize analytical figures-of-merit of the instrument including sensitivity and separation of gas-phase ions. The rationales for implementation of each device aforementioned are discussed as enhanced ion focusing to reduce data acquisition time of the instrument, high mobility resolution (R > 56) to separate ions having a small collision cross section (CCS) difference at low-to-intermediate field strength (10 V cm−1 torr−1~19 V cm−1 torr−1), and observation of multiple conformers from isobaric ions at various operation conditions. Gate and transfer ion optic design needed to avoid detrimental gas dynamic effect is presented during hybridization of PFIG into ESI mass spectrometer. The details of instrumentation and electrode/voltage schematics are also discussed along with SIMION calculation results. The characteristic drift motions of ions inside the PFIG require a normalization procedure to compare CCS values from the instrument with the results using conventional uniform field DT ion mobility-mass spectrometry (IM-MS). Through experimental measurements and ion trajectory calculations from well known model peptides and proteins having multiple charge states, a correlation factor a which links the results from the two different types of instrumentation was derived and successfully applied (within ±4% difference). Ion heating was also investigated using ubiquitin, insulin, and substance P. Using ESI PFIG-MS, a significant variation of the arrival time distribution at different heated capillary temperature, rf amplitude, and electric field strength was observed for ubiquitin (+7) and (+8) and substance P (+3), while a substantial change was not observed for insulin owing to structural rigidity of disulfide bond cross-linking between two chains. The results imply that ESI PFIG-MS provides a window to monitor conformational variation of gas-phase ions and measure energy barriers of peptide/protein folding processes, which can allow us to reveal pathways in structural energy landscape. The electronic version of this dissertation is accessible from http://hdl.handle.net/1969.1/151673

Ion Mobility-Mass Spectrometry

Author : Alison E Ashcroft
Publisher : Royal Society of Chemistry
ISBN 13 : 1839162899
Total Pages : 621 pages
Book Rating : 4.8/5 (391 download)

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Book Synopsis Ion Mobility-Mass Spectrometry by : Alison E Ashcroft

Download or read book Ion Mobility-Mass Spectrometry written by Alison E Ashcroft and published by Royal Society of Chemistry. This book was released on 2021-11-11 with total page 621 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decade, the use of ion mobility separation in combination with mass spectrometry analysis has developed significantly. This technique adds a unique extra dimension enabling the in-depth analysis of a wide range of complex samples in the areas of the chemical and biological sciences. Providing a comprehensive guide to the technique, each chapter is written by an internationally recognised expert and with numerous different commercial platforms to choose from, this book will help the end users understand the practicalities of using different instruments for different ion mobility purposes. The first section provides a detailed account of the fundamentals behind the technique and the current range of available instrumentation. The second section focusses on the wide range of applications that have benefitted from ion mobility – mass spectrometry and includes topics taken from current research in the pharmaceutical, metabolomics, glycomics, and structural molecular biology fields. The book is primarily aimed at researchers, appealing to practising chemists and biochemists, as well as those in the pharmaceutical and medical fields.

Electrospray and MALDI Mass Spectrometry

Author : Richard B. Cole
Publisher : John Wiley & Sons
ISBN 13 : 1118211553
Total Pages : 900 pages
Book Rating : 4.1/5 (182 download)

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Book Synopsis Electrospray and MALDI Mass Spectrometry by : Richard B. Cole

Download or read book Electrospray and MALDI Mass Spectrometry written by Richard B. Cole and published by John Wiley & Sons. This book was released on 2011-09-26 with total page 900 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover how advances in mass spectrometry are fueling new discoveries across a broad range of research areas Electrospray and MALDI Mass Spectrometry brings both veteran practitioners and beginning scientists up to date with the most recent trends and findings in electrospray ionization and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. In particular, this Second Edition highlights how advances in electrospray and MALDI mass spectrometry are supporting important discoveries in new and emerging fields such as proteomics and metabolomics as well as in traditional areas of chemistry and physics research. Electrospray AND MALDI Mass Spectrometry, SECOND EDITION is divided into five parts: Part A, Fundamentals of ES, explains the fundamental phenomena underlying the electrospray process, including selectivity in ionization and inherent electrochemistry, and concludes with a chapter offering a comparative inventory of source hardware Part B, Fundamentals of MALDI, confronts ionization mechanisms, instrument development, and matrix selection, and includes a final chapter that explores the special application of MALDI to obtain two-dimensional images of spatial distributions of compounds on surfaces Part C, ES and MALDI Coupling to Mass Spectrometry Instrumentation, examines the coupling of these ionization techniques to various mass analyzers, including quadrupole ion trap, time-of-flight, Fourier transform ion cyclotron resonance, and ion mobility mass spectrometers Part D, Practical Aspects of ES and MALDI, investigates analytical issues including quantification, charge-state distributions, noncovalent interactions in solution that are preserved as gas-phase ions, and various means of ion excitation in preparation for tandem mass spectrometry, and offers a guide to the interpretation of even-electron mass spectra Part E, Biological Applications of ES and MALDI, examines the role of mass spectrometry in such areas as peptide and protein characterization, carbohydrate analysis, lipid analysis, and drug discovery Written by a team of leading experts, the book not only provides a critical review of the literature, but also presents key concepts in tutorial fashion to help readers take full advantage of the latest technological breakthroughs and applications. As a result, Electrospray and MALDI Mass Spectrometry will help researchers fully leverage the power of electrospray and MALDI mass spectrometry. The judicious compartmentalization of chapters, and the pedagogic presentation style throughout, render the book highly suitable for use as a text for graduate-level courses in advanced mass spectrometry.

Ion Mobility Spectrometry - Mass Spectrometry

Author : Charles L. Wilkins
Publisher : CRC Press
ISBN 13 : 1439813256
Total Pages : 374 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Ion Mobility Spectrometry - Mass Spectrometry by : Charles L. Wilkins

Download or read book Ion Mobility Spectrometry - Mass Spectrometry written by Charles L. Wilkins and published by CRC Press. This book was released on 2010-12-14 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: The analytical power of ion mobility spectrometry-mass spectrometry (IMS-MS) instruments is poised to advance this technology from research to analytical laboratories. Exploring these developments at this critical juncture, Ion Mobility Spectrometry-Mass Spectrometry: Theory and Applications covers the tools, techniques, and applications involved w

Development and Application of Electrospray Ionization-high Resolution Ion Mobility Spectrometry-mass Spectrometry

Author : Ching Wu
Publisher :
ISBN 13 :
Total Pages : 560 pages
Book Rating : 4.:/5 (397 download)

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Book Synopsis Development and Application of Electrospray Ionization-high Resolution Ion Mobility Spectrometry-mass Spectrometry by : Ching Wu

Download or read book Development and Application of Electrospray Ionization-high Resolution Ion Mobility Spectrometry-mass Spectrometry written by Ching Wu and published by . This book was released on 1997 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Differential Ion Mobility Spectrometry

Author : Alexandre A. Shvartsburg
Publisher : CRC Press
ISBN 13 : 9781420051070
Total Pages : 322 pages
Book Rating : 4.0/5 (51 download)

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Book Synopsis Differential Ion Mobility Spectrometry by : Alexandre A. Shvartsburg

Download or read book Differential Ion Mobility Spectrometry written by Alexandre A. Shvartsburg and published by CRC Press. This book was released on 2008-12-24 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decade, scientific and engineering interests have been shifting from conventional ion mobility spectrometry (IMS) to field asymmetric waveform ion mobility spectrometry (FAIMS). Differential Ion Mobility Spectrometry: Nonlinear Ion Transport and Fundamentals of FAIMS explores this new analytical technology that separates and characterizes ions by the difference between their mobility in gases at high and low electric fields. It also covers the novel topics of higher-order differential IMS and IMS with alignment of dipole direction. The book relates the fundamentals of FAIMS and other nonlinear IMS methods to the physics of gas-phase ion transport. It begins with the basics of ion diffusion and mobility in gases, covering the main attributes of conventional IMS that are relevant to all IMS approaches. Building on this foundation, the author reviews diverse high-field transport phenomena that underlie differential IMS. He discusses the conceptual implementation and first-principles optimization of FAIMS as a filtering technique, emphasizing the dependence of FAIMS performance metrics on instrumental parameters and properties of ion species. He also explores ion reactions in FAIMS caused by field heating and the effects of inhomogeneous electric field in curved FAIMS gaps. Written by an accomplished scientist in the field, this state-of-the-art book supplies the foundation to understand the new technology of nonlinear IMS methods.

Ion Mobility Spectrometry

Author : G.A. Eiceman
Publisher : CRC Press
ISBN 13 : 1420038974
Total Pages : 367 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Ion Mobility Spectrometry by : G.A. Eiceman

Download or read book Ion Mobility Spectrometry written by G.A. Eiceman and published by CRC Press. This book was released on 2005-06-23 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: Key Developments for Faster, More Precise Detection Capabilities Driven by the demand for the rapid and advanced detection of explosives, chemical and biological warfare agents, and narcotics, ion mobility spectrometry (IMS) undergone significant refinements in technology, computational capabilities, and understanding of the principles of gas phase

Fundamentals of Electric Propulsion

Author : Dan M. Goebel
Publisher : John Wiley & Sons
ISBN 13 : 0470436263
Total Pages : 528 pages
Book Rating : 4.4/5 (74 download)

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Book Synopsis Fundamentals of Electric Propulsion by : Dan M. Goebel

Download or read book Fundamentals of Electric Propulsion written by Dan M. Goebel and published by John Wiley & Sons. This book was released on 2008-12-22 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Throughout most of the twentieth century, electric propulsion was considered the technology of the future. Now, the future has arrived. This important new book explains the fundamentals of electric propulsion for spacecraft and describes in detail the physics and characteristics of the two major electric thrusters in use today, ion and Hall thrusters. The authors provide an introduction to plasma physics in order to allow readers to understand the models and derivations used in determining electric thruster performance. They then go on to present detailed explanations of: Thruster principles Ion thruster plasma generators and accelerator grids Hollow cathodes Hall thrusters Ion and Hall thruster plumes Flight ion and Hall thrusters Based largely on research and development performed at the Jet Propulsion Laboratory (JPL) and complemented with scores of tables, figures, homework problems, and references, Fundamentals of Electric Propulsion: Ion and Hall Thrusters is an indispensable textbook for advanced undergraduate and graduate students who are preparing to enter the aerospace industry. It also serves as an equally valuable resource for professional engineers already at work in the field.

Applied Electrospray Mass Spectrometry

Author : Birendra N. Pramanik
Publisher : CRC Press
ISBN 13 : 1135560439
Total Pages : 478 pages
Book Rating : 4.1/5 (355 download)

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Book Synopsis Applied Electrospray Mass Spectrometry by : Birendra N. Pramanik

Download or read book Applied Electrospray Mass Spectrometry written by Birendra N. Pramanik and published by CRC Press. This book was released on 2002-02-28 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discussing strategies to determine the structure and machanisms of numerous compound classics, this book covers new chemical and elctrophoretic techniques for rapid sample preconcentration and separation. It summarizes breakthroughs in the theory and instrumentation of electrospray mass spectrometry in pharmaceutical and biomedical applications, provides practical examples for the characterization of peptides, proteins, and glycoproteins, includes applications in proteomics, combinatorial chemistry, and drug characterization. Topics include chemical and electrophoretic techniques for rapid sample preconcentration and separation, screening processes for proteins from libraries of compounds, protein folding and dynamics, and more.

Development and Applications of an Electrospray Ionization Ion Trap/linear Time-of-flight Mass Spectrometer

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (654 download)

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Book Synopsis Development and Applications of an Electrospray Ionization Ion Trap/linear Time-of-flight Mass Spectrometer by :

Download or read book Development and Applications of an Electrospray Ionization Ion Trap/linear Time-of-flight Mass Spectrometer written by and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Analyzing Biomolecular Interactions by Mass Spectrometry

Author : Jeroen Kool
Publisher : John Wiley & Sons
ISBN 13 : 3527334645
Total Pages : 402 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Analyzing Biomolecular Interactions by Mass Spectrometry by : Jeroen Kool

Download or read book Analyzing Biomolecular Interactions by Mass Spectrometry written by Jeroen Kool and published by John Wiley & Sons. This book was released on 2015-05-04 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph reviews all relevant technologies based on mass spectrometry that are used to study or screen biological interactions in general. Arranged in three parts, the text begins by reviewing techniques nowadays almost considered classical, such as affinity chromatography and ultrafiltration, as well as the latest techniques. The second part focusses on all MS-based methods for the study of interactions of proteins with all classes of biomolecules. Besides pull down-based approaches, this section also emphasizes the use of ion mobility MS, capture-compound approaches, chemical proteomics and interactomics. The third and final part discusses other important technologies frequently employed in interaction studies, such as biosensors and microarrays. For pharmaceutical, analytical, protein, environmental and biochemists, as well as those working in pharmaceutical and analytical laboratories.

Electrospray Ionization Mass Spectrometry

Author : Richard B. Cole
Publisher : Wiley-Interscience
ISBN 13 :
Total Pages : 610 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Electrospray Ionization Mass Spectrometry by : Richard B. Cole

Download or read book Electrospray Ionization Mass Spectrometry written by Richard B. Cole and published by Wiley-Interscience. This book was released on 1997-05-06 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive, up-to-date coverage of a revolutionary technique Electrospray ionization mass spectrometry (ESI-MS) has completely changed the way physicists, chemists, and biologists view the study of large molecules. The technique derives detailed information about molecular weights and structures from extremely small sample quantities. ESI-MS can create highly charged forms of very high molecular weight compounds, it is naturally compatible with many types of separation techniques, and it allows noncovalent interactions between molecules in solution to be preserved in the gas phase. But many researchers may not use the technique to its full potential because they are unfamiliar with the different perspectives of its underlying processes, the varied approaches to implementation, and the wide-ranging utility of the technique. In this book, Richard B. Cole and an assemblage of leading researchers present a single-volume compilation of different approaches to the understanding and exploitation of ESI-MS. This comprehensive guide: * Examines the physical and chemical aspects of the electrospray process and describes the events involved in ion formation as well as the electro-chemical phenomena that are central to charged droplet formation during the process * Explores the coupling of electrospray ionization to various mass spectrometers, including quadrupole, magnetic, time-of-flight, quadrupole ion trap, and Fourier transform ion cyclotron resonance instruments * Describes recent progress in interfacing ESI with solution-based separation techniques, including liquid chromatography and capillary electrophoresis * Charts the rapid development of ESI applications and categorizes them by compound type: peptides and proteins, nucleic acids and their constituents, carbohydrates and lipids, small molecules related to pharmacology and drug metabolism, and organometallics and inorganic compounds Electrospray Ionization Mass Spectrometry is the indispensable handbook and reference for anyone who wishes to understand, implement, or apply this technique, including researchers in chemistry, metallochemistry, biochemistry, biology, pharmacology, and physics.

Practical Aspects of Ion Trap Mass Spectrometry

Author : Raymond E. March
Publisher : CRC Press
ISBN 13 : 9780849344527
Total Pages : 452 pages
Book Rating : 4.3/5 (445 download)

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Book Synopsis Practical Aspects of Ion Trap Mass Spectrometry by : Raymond E. March

Download or read book Practical Aspects of Ion Trap Mass Spectrometry written by Raymond E. March and published by CRC Press. This book was released on 1995-09-18 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamentals of Ion Trap Mass Spectrometry presents an account of the development and theory of the quadrupole ion trap and its utilization as an ion storage device, a reactor for ion/molecular reactions, and a mass spectrometer. It also expands the appreciation of ion traps from that of a unique arrangement of electrodes of hyperbolic form (and having a pure quadrupole field) to a series of ion traps having fields with hexapole and octopole components and introduces the practical ion trapping device in which electrode spacing has been increased. The fundamentals of ion trap are covered in four chapters, beginning with the origin of the ion trap, its development and operating principles, and improvements in performance. The second part focuses on the environment within the ion trap -- the movement of ions within the trap -- and how this movement is modified by repeated collisions of the ions with buffer gas atoms of helium, and on the collisions of ions with molecules that lead to chemical change. The critical role of collisions in focusing the ion cloud for subsequent operations is emphasized. This important reference presents a coherent picture of the present status of research in the ion trapping field to facilitate the entree of potential ion trappers and provide a backdrop for ion trap research and development in the future.

Plasma Chromatography

Author : T.W. Carr
Publisher : Springer
ISBN 13 :
Total Pages : 284 pages
Book Rating : 4.:/5 (44 download)

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Book Synopsis Plasma Chromatography by : T.W. Carr

Download or read book Plasma Chromatography written by T.W. Carr and published by Springer. This book was released on 1984-03-31 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mass Spectrometry

Author : Jürgen H Gross
Publisher : Springer Science & Business Media
ISBN 13 : 3540407391
Total Pages : 534 pages
Book Rating : 4.5/5 (44 download)

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Book Synopsis Mass Spectrometry by : Jürgen H Gross

Download or read book Mass Spectrometry written by Jürgen H Gross and published by Springer Science & Business Media. This book was released on 2006-04-05 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mass Spectrometry is an ideal textbook for students and professionals as well as newcomers to the field. Starting from the very first principles of gas-phase ion chemistry and isotopic properties, the textbook takes the reader through the design of mass analyzers and ionization methods all the way to mass spectral interpretation and coupling techniques. Step-by-step, the reader learns how mass spectrometry works and what it can do. The book comprises a balanced mixture of practice-oriented information and theoretical background. It features a clear layout and a wealth of high-quality figures. Exercises and solutions are located on the Springer Global Web.

Development of Ion Mobility Mass Spectrometry Instrumentation to Investigate the Gas-phase Structures of Protein and Protein Complex Ions

Download Development of Ion Mobility Mass Spectrometry Instrumentation to Investigate the Gas-phase Structures of Protein and Protein Complex Ions PDF Online Free

Author : Samuel J. Allen
Publisher :
ISBN 13 :
Total Pages : 193 pages
Book Rating : 4.:/5 (988 download)

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Book Synopsis Development of Ion Mobility Mass Spectrometry Instrumentation to Investigate the Gas-phase Structures of Protein and Protein Complex Ions by : Samuel J. Allen

Download or read book Development of Ion Mobility Mass Spectrometry Instrumentation to Investigate the Gas-phase Structures of Protein and Protein Complex Ions written by Samuel J. Allen and published by . This book was released on 2017 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation reports the development of new ion mobility mass spectrometry (IM-MS) instrumentation to analyze protein and protein complex ions. IM-MS is a gas-phase analytical technique that separate ions based on their collision cross section (a description of ion shape) and mass-to-charge ratio. Electrospray ionization of samples from buffered solutions at biologically relevant pH generates “native-like” protein ions, which retain noncovalent interactions and compact conformations. IM-MS analysis enables the determination of the shape and assembly of native-like ions, which can be used to infer information about the solution conformations of biomolecules. New IM devices were developed to improve the informational content obtained from IM-MS experiments. First, an RF-confining drift cell was developed and implemented in a commercial mass spectrometer. Experimental results and ion trajectories implemented using SIMION were used to describe the separation principles of ions in RF-confining drift cells. Those results show that RF-confining drift cells separate ions similarly to traditional IM devices and that applied RF potentials have minimal effects on the effective temperatures of gas-phase ions. The RF-confining drift cells was used to report collision cross sections for 349 ions, 155 of which are for ions that have not been characterized previously using IM. The effects of ionization conditions and analyte solutions on the charge states and collision cross sections of ions was also investigated. An additional IM device based on Structures for Lossless Ion Manipulations (SLIM) was developed. SLIM is an emerging IM technology that can be implemented as modular platforms to perform ion separations, filtering, and trapping. The first collision cross sections determined using SLIM are reported. IM analysis of native-like protein ions shows that those ions exhibit significant structural heterogeneity in the gas-phase. To evaluate the stability and dynamics of native-like protein ions, IM-IM-MS functionality was implemented into the SLIM device. Dynamic gas-phase conformations were observed for native-like protein ions, which has significant implications for the broader community’s interpretation of IM-MS results. The stability of structural subpopulations of native-like ions was investigated as a function of gas-phase ion lifetime at near-ambient temperatures. The conformations of subpopulations evolve continuously in the gas-phase, but even after 4 seconds, the subpopulations exhibit different distributions of collision cross sections. This suggests that native-like ions in IM-MS experiments can retain some memory of their initial gas-phase structures for up to seconds at near-ambient temperature.

Practical Aspects of Trapped Ion Mass Spectrometry

Author : Raymond E. March
Publisher : CRC Press
ISBN 13 : 1420083716
Total Pages : 950 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Practical Aspects of Trapped Ion Mass Spectrometry by : Raymond E. March

Download or read book Practical Aspects of Trapped Ion Mass Spectrometry written by Raymond E. March and published by CRC Press. This book was released on 2010-05-25 with total page 950 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reflecting the substantial increase in popularity of quadrupole ion traps and Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometers, Practical Aspects of Trapped Ion Mass Spectrometry, Volume IV: Theory and Instrumentation explores the historical origins of the latest advances in this expanding field. It covers new methods for trapping ions, such as the OrbitrapTM, the digital ion trap (DIT), the rectilinear ion trap (RIT), and the toroidal ion trap; the development and application of the quadrupole ion trap (QIT) and the quadrupole linear ion trap (LIT); and the introduction of high-field asymmetric waveform ion mobility spectrometry (FAIMS). After a combined appreciation and historical survey of mass spectrometry and a discussion of how improved capabilities for microfabrication have led to interest in arrays of ion traps, the book examines the theory and practice of the Orbitrap mass analyzer, the rectangular waveform-driven DIT mass spectrometer, FAIMS, and ion traps with circular geometries. It next discusses ion accumulation for increasing sensitivity in FT-ICR spectrometry, a radio frequency-only-mode event for Penning traps in FT MS, and an FT operating mode applied to a 3D-QIT. The text then presents three behavioral aspects of quadrupole rod sets, before illustrating the development of the 3D-QIT in recent years. The final chapters explore photodissociation in ion traps and the chemical and photochemical studies of metal dication complexes in a 3D-QIT. In this volume that spans twenty-one chapters, a stellar panel of leading experts and up-and-coming researchers presents a cohesive, global, and up-to-date view of the practical aspects of using trapped ion devices. A companion to Volume V: Applications of Ion Trapping Devices, the book authoritatively covers the theory involved as well as the instrumentation currently used in this dynamic field.