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Developing Techniques To Understand Increased Ion Complexity In The Gas Phase
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Book Synopsis Developing Techniques to Understand Increased Ion Complexity in the Gas Phase by : Matthew Kusinski
Download or read book Developing Techniques to Understand Increased Ion Complexity in the Gas Phase written by Matthew Kusinski and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: While ions are held in the volume of a quadrupole ion trap mass spectrometer it is possible to use gas-phase optical spectroscopy to extract intrinsic information from the trapped species. This information is unencumbered by influences and interferences that populate the condensed phase. Under these conditions, it is possible to develop an understanding of the intersection of the intra- and intermolecular influences on a molecule. Doing so by beginning at the baseline of a bare ion and building up complexity in a controlled and calculated fashion. This research aims to fill in existing knowledge gaps by monitoring the effect of discrete changes on trapped ions. Chapters 2 and 3 of this thesis focus on examining intrinsic photophysical properties from groups of common fluorescent dyes (oxazines and rhodamines). The subtle structural change of the deuteration exchange of labile hydrogens resulted in significant changes in the measured fluorescence of oxazines but minimally affected structurally related rhodamine dyes. These may function as benchmark results and enable a better understanding of the interplay between structure and quantum efficiency. In combination with computation, the new insights promise to aid the effective and deliberate design of new fluorescent probes. The fourth chapter of this thesis describes the effects of increasing the internal energy of interrogated systems; via the design, implementation, and application of an intra-vacuum heating system. Effects were monitored using optical probing in combination with heating for several systems. These effects were varied, from the subtle shifting of rhodamine emission spectra to a rejection of the gas phase effectiveness of fluorescence thermometer molecule rhodamine B, and inducing a FRET monitored conformational change in a mutant variant of ubiquitin. Using this method of purposefully added complexity (deuteration and increased internal energy) it is possible to better understand how and why these effects occur. The work in these chapters represents essential steps in taking mass spectrometry from an important tool for sensitive and selective detection to an expanded role as an important investigative space to determine the nature of the molecules we use every day.
Book Synopsis Gas-Phase IR Spectroscopy and Structure of Biological Molecules by : Anouk M. Rijs
Download or read book Gas-Phase IR Spectroscopy and Structure of Biological Molecules written by Anouk M. Rijs and published by Springer. This book was released on 2015-06-03 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. Review articles for the individual volumes are invited by the volume editors. Readership: research chemists at universities or in industry, graduate students.
Book Synopsis Mass Spectrometry in Environmental Sciences by : O. Hutzinger
Download or read book Mass Spectrometry in Environmental Sciences written by O. Hutzinger and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past ten years a variety of methods involving mass spectrom etry have been developed for the analysis of environmentally important compounds. Much has been accomplished in that period to solve some of the important problems in the field. Growth of this methodology and its accomplishments has reached the point where an individual scientist can no longer have an in-depth knowledge of all the areas involved. We have attempted to provide this in-depth picture to those scientists con cerned by having the important topics treated by experts in the subject matter. In order to provide all the relevant material in one volume we begin with the general topics which provide the basic background material necessary to understand the techniques discussed in the in-depth topics. These general chapters are kept brief, containing only the essentials needed by the working scientist to deal with the practical applications. References in these chapters are chosen to permit a more complete study of each chapter. The concept for this book was developed during the activities of two of the editors under a NATO travel grant. These editors gratefully acknowledge this support which made the initial planning of this book possible. The editors would like to thank the individual authors of each chap ter for their cooperation and generously giving of their time for this project.
Book Synopsis Nucleic Acids in the Gas Phase by : Valérie Gabelica
Download or read book Nucleic Acids in the Gas Phase written by Valérie Gabelica and published by Springer. This book was released on 2014-07-28 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives physical chemists a broader view of potential biological applications of their techniques for the study of nucleic acids in the gas phase. It provides organic chemists, biophysicists, and pharmacologists with an introduction to new techniques they can use to find the answers to yet unsolved questions. Laboratory sciences have bloomed with a variety of techniques to decipher the properties of the molecules of life. This volume introduces techniques used to investigate the properties of nucleic acids in the absence of solvent. It highlights the specificities pertaining to the studies of nucleic acids, although some of the techniques can similarly be applied to the study of other biomolecules, like proteins. The first part of the book introduces the techniques, from the transfer of nucleic acids to the gas-phase, to their detailed physico-chemical investigation. Each chapter is devoted to a specific molecular property, and illustrates how various approaches (experimental and theoretical) can be combined for the interpretation. The second part of the book is devoted to applying the gas-phase approaches to solve specific questions related to the biophysics, biochemistry or pharmacology of nucleic acids.
Book Synopsis Expanding the Vision of Sensor Materials by : National Research Council
Download or read book Expanding the Vision of Sensor Materials written by National Research Council and published by National Academies Press. This book was released on 1995-06-22 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in materials science and engineering have paved the way for the development of new and more capable sensors. Drawing upon case studies from manufacturing and structural monitoring and involving chemical and long wave-length infrared sensors, this book suggests an approach that frames the relevant technical issues in such a way as to expedite the consideration of new and novel sensor materials. It enables a multidisciplinary approach for identifying opportunities and making realistic assessments of technical risk and could be used to guide relevant research and development in sensor technologies.
Book Synopsis Ion Mobility Spectrometry - Mass Spectrometry by : Charles L. Wilkins
Download or read book Ion Mobility Spectrometry - Mass Spectrometry written by Charles L. Wilkins and published by CRC Press. This book was released on 2010-12-14 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: The analytical power of ion mobility spectrometry-mass spectrometry (IMS-MS) instruments is poised to advance this technology from research to analytical laboratories. Exploring these developments at this critical juncture, Ion Mobility Spectrometry-Mass Spectrometry: Theory and Applications covers the tools, techniques, and applications involved w
Book Synopsis Mass Spectrometry Handbook by : Mike S. Lee
Download or read book Mass Spectrometry Handbook written by Mike S. Lee and published by John Wiley & Sons. This book was released on 2012-04-16 with total page 1362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to its enormous sensitivity and ease of use, mass spectrometry has grown into the analytical tool of choice in most industries and areas of research. This unique reference provides an extensive library of methods used in mass spectrometry, covering applications of mass spectrometry in fields as diverse as drug discovery, environmental science, forensic science, clinical analysis, polymers, oil composition, doping, cellular research, semiconductor, ceramics, metals and alloys, and homeland security. The book provides the reader with a protocol for the technique described (including sampling methods) and explains why to use a particular method and not others. Essential for MS specialists working in industrial, environmental, and clinical fields.
Download or read book Comprehensive Biotechnology written by and published by Elsevier. This book was released on 2019-07-17 with total page 4876 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Biotechnology, Third Edition, Six Volume Set unifies, in a single source, a huge amount of information in this growing field. The book covers scientific fundamentals, along with engineering considerations and applications in industry, agriculture, medicine, the environment and socio-economics, including the related government regulatory overviews. This new edition builds on the solid basis provided by previous editions, incorporating all recent advances in the field since the second edition was published in 2011. Offers researchers a one-stop shop for information on the subject of biotechnology Provides in-depth treatment of relevant topics from recognized authorities, including the contributions of a Nobel laureate Presents the perspective of researchers in different fields, such as biochemistry, agriculture, engineering, biomedicine and environmental science
Book Synopsis Techniques for the Study of Ion-Molecule Reactions by : James M. Farrar
Download or read book Techniques for the Study of Ion-Molecule Reactions written by James M. Farrar and published by Wiley-Interscience. This book was released on 1988-08-12 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first comprehensive collection of all the major techniques used to study gas phase interactions is presented in this volume. With complete coverage of what a given technique can accomplish, its advantages and disadvantages, the book is designed to teach advanced students and researchers entering the field how to investigate a broad range of topics. Included is coverage of traditional topics such as ion cyclotron resonance, as well as more recent innovations, including Fourier transform mass spectrometry and ionic cluster studies. Several diagrams of instrumentation and examples of experimental data are also provided.
Book Synopsis Atmospheric Chemistry in a Changing World by : Guy P. Brasseur
Download or read book Atmospheric Chemistry in a Changing World written by Guy P. Brasseur and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praise for Guy P. Brasseur's Atmospheric Chemistry in a Changing World American Meteorological Society "This volume summarizes and integrates more than a decade of atmospheric chemistry research. During the period under consideration, great progress has been made in computing, modeling, and observational techniques, and methods have also improved. Here, suggestions for the highest priority research for the next decade are made, and important information is related regarding impacts on the environment."
Book Synopsis Scientific and Technical Aerospace Reports by :
Download or read book Scientific and Technical Aerospace Reports written by and published by . This book was released on 1989 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lists citations with abstracts for aerospace related reports obtained from world wide sources and announces documents that have recently been entered into the NASA Scientific and Technical Information Database.
Book Synopsis Summaries of Projects Completed in Fiscal Year ... by :
Download or read book Summaries of Projects Completed in Fiscal Year ... written by and published by . This book was released on 1979 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Summaries of Projects Completed in Fiscal Year ... by : National Science Foundation (U.S.)
Download or read book Summaries of Projects Completed in Fiscal Year ... written by National Science Foundation (U.S.) and published by . This book was released on 1979 with total page 720 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Summaries of Projects Completed by : National Science Foundation (U.S.)
Download or read book Summaries of Projects Completed written by National Science Foundation (U.S.) and published by . This book was released on with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Approximate Analytical Methods for Solving Ordinary Differential Equations by : T.S.L Radhika
Download or read book Approximate Analytical Methods for Solving Ordinary Differential Equations written by T.S.L Radhika and published by CRC Press. This book was released on 2014-10-31 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: Approximate Analytical Methods for Solving Ordinary Differential Equations (ODEs) is the first book to present all of the available approximate methods for solving ODEs, eliminating the need to wade through multiple books and articles. It covers both well-established techniques and recently developed procedures, including the classical series solution method, diverse perturbation methods, pioneering asymptotic methods, and the latest homotopy methods. The book is suitable not only for mathematicians and engineers but also for biologists, physicists, and economists. It gives a complete description of the methods without going deep into rigorous mathematical aspects. Detailed examples illustrate the application of the methods to solve real-world problems. The authors introduce the classical power series method for solving differential equations before moving on to asymptotic methods. They next show how perturbation methods are used to understand physical phenomena whose mathematical formulation involves a perturbation parameter and explain how the multiple-scale technique solves problems whose solution cannot be completely described on a single timescale. They then describe the Wentzel, Kramers, and Brillown (WKB) method that helps solve both problems that oscillate rapidly and problems that have a sudden change in the behavior of the solution function at a point in the interval. The book concludes with recent nonperturbation methods that provide solutions to a much wider class of problems and recent analytical methods based on the concept of homotopy of topology.
Book Synopsis AEC Authorizing Legislation Fiscal Year 1966 by : United States. Congress. Joint Committee on Atomic Energy
Download or read book AEC Authorizing Legislation Fiscal Year 1966 written by United States. Congress. Joint Committee on Atomic Energy and published by . This book was released on 1965 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Encyclopedia of Mass Spectrometry by :
Download or read book The Encyclopedia of Mass Spectrometry written by and published by Newnes. This book was released on 2015-12-04 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 9: Historical Perspectives, Part A: The Development of Mass Spectrometry of The Encyclopedia of Mass Spectrometry describes and analyzes the development of many aspects of Mass Spectrometry. Beginning with the earliest types of Mass Analyzers, Historical Perspectives explores the development of many different forms of analytical processes and methods. The work follows various instruments and interfaces, to the current state of detectors and computerization. It traces the use of Mass Spectrometry across many different disciplines, including Organic Chemistry, Biochemistry, and Proteomics; Environmental Mass Spectrometry; Forensic Science; Imaging; Medical Monitoring and Diagnosis; Earth and Planetary Sciences; and Nuclear Science. Finally, the book covers the history of manufacturers and societies as well as the professionals who form the Mass Spectrometry community. Also available: Volume 9: Historical Perspectives, Part B: Notable People in Mass Spectrometry briefly reviews the lives and works of many of the major people who carried out this development. Preserves the history and development of Mass Spectrometry for use across scientific fields Written and edited by Mass Spectrometry experts Coordinates with Volume 9: Historical Perspectives, Part B: Notable People in Mass Spectrometry, a collection of short biographies on many of the major people who carried out this development
