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Author : Tanya Kurosky
Publisher :
ISBN 13 :
Total Pages : 150 pages
Book Rating : 4.:/5 (14 download)
Download or read book Design of Proteins and a Protein Folding Potential written by Tanya Kurosky and published by . This book was released on 1997 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Kenneth M.Jr. Merz
Publisher : Springer Science & Business Media
ISBN 13 : 1468468316
Total Pages : 585 pages
Book Rating : 4.4/5 (684 download)
Download or read book The Protein Folding Problem and Tertiary Structure Prediction written by Kenneth M.Jr. Merz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: A solution to the protein folding problem has eluded researchers for more than 30 years. The stakes are high. Such a solution will make 40,000 more tertiary structures available for immediate study by translating the DNA sequence information in the sequence databases into three-dimensional protein structures. This translation will be indispensable for the analy sis of results from the Human Genome Project, de novo protein design, and many other areas of biotechnological research. Finally, an in-depth study of the rules of protein folding should provide vital clues to the protein fold ing process. The search for these rules is therefore an important objective for theoretical molecular biology. Both experimental and theoretical ap proaches have been used in the search for a solution, with many promising results but no general solution. In recent years, there has been an exponen tial increase in the power of computers. This has triggered an incredible outburst of theoretical approaches to solving the protein folding problem ranging from molecular dynamics-based studies of proteins in solution to the actual prediction of protein structures from first principles. This volume attempts to present a concise overview of these advances. Adrian Roitberg and Ron Elber describe the locally enhanced sam pling/simulated annealing conformational search algorithm (Chapter 1), which is potentially useful for the rapid conformational search of larger molecular systems.
Author : Sheldon J. Park
Publisher : CRC Press
ISBN 13 : 1420076590
Total Pages : 434 pages
Book Rating : 4.4/5 (2 download)
Download or read book Protein Engineering and Design written by Sheldon J. Park and published by CRC Press. This book was released on 2009-09-25 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental protein engineering and computational protein design are broad but complementary strategies for developing proteins with altered or novel structural properties and biological functions. By describing cutting-edge advances in both of these fields, Protein Engineering and Design aims to cultivate a synergistic approach to protein science
Author : Eugene I. Shakhnovich
Publisher : IOS Press
ISBN 13 : 9781586031695
Total Pages : 364 pages
Book Rating : 4.0/5 (316 download)
Download or read book Protein Folding, Evolution and Design written by Eugene I. Shakhnovich and published by IOS Press. This book was released on 2001 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text presents the results of broad, interdisciplinary effort to study proteins in physical and evolutionary perpective. Among authors are physicists, computational, chemists, crystallographers and evolutionary biologists. Experimental and theoretical developments from molecules to cells are presented, providing a broad picture of modern biophysical chemistry.
Author : Andrzej Koliński
Publisher : Landes Bioscience
ISBN 13 :
Total Pages : 224 pages
Book Rating : 4.3/5 (91 download)
Download or read book Lattice Models of Protein Folding, Dynamics, and Thermodynamics written by Andrzej Koliński and published by Landes Bioscience. This book was released on 1996 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Alexei V. Finkelstein
Publisher : Elsevier
ISBN 13 : 0081012365
Total Pages : 530 pages
Book Rating : 4.0/5 (81 download)
Download or read book Protein Physics written by Alexei V. Finkelstein and published by Elsevier. This book was released on 2016-06-22 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Physics: A Course of Lectures covers the most general problems of protein structure, folding and function. It describes key experimental facts and introduces concepts and theories, dealing with fibrous, membrane, and water-soluble globular proteins, in both their native and denatured states. The book systematically summarizes and presents the results of several decades of worldwide fundamental research on protein physics, structure, and folding, describing many physical models that help readers make estimates and predictions of physical processes that occur in proteins. New to this revised edition is the inclusion of novel information on amyloid aggregation, natively disordered proteins, protein folding in vivo, protein motors, misfolding, chameleon proteins, advances in protein engineering & design, and advances in the modeling of protein folding. Further, the book provides problems with solutions, many new and updated references, and physical and mathematical appendices. In addition, new figures (including stereo drawings, with a special appendix showing how to use them) are added, making this an ideal resource for graduate and advanced undergraduate students and researchers in academia in the fields of biophysics, physics, biochemistry, biologists, biotechnology, and chemistry. Fully revised and expanded new edition based on the latest research developments in protein physics Written by the world's top expert in the field Deals with fibrous, membrane, and water-soluble globular proteins, in both their native and denatured states Summarizes, in a systematic form, the results of several decades of worldwide fundamental research on protein physics and their structure and folding Examines experimental data on protein structure in the post-genome era
Author : Richard A. Friesner
Publisher : John Wiley & Sons
ISBN 13 : 0471465232
Total Pages : 544 pages
Book Rating : 4.4/5 (714 download)
Download or read book Computational Methods for Protein Folding, Volume 120 written by Richard A. Friesner and published by John Wiley & Sons. This book was released on 2004-04-07 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first attempts to model proteins on a computer began almost thirty years ago, our understanding of protein structure and dynamics has dramatically increased. Spectroscopic measurement techniques continue to improve in resolution and sensitivity, allowing a wealth of information to be obtained with regard to the kinetics of protein folding and unfolding, and complementing the detailed structural picture of the folded state. Concurrently, algorithms, software, and computational hardware have progressed to the point where both structural and kinetic problems may be studied with a fair degree of realism. Despite these advances, many major challenges remain in understanding protein folding at both the conceptual and practical levels. Computational Methods for Protein Folding seeks to illuminate recent advances in computational modeling of protein folding in a way that will be useful to physicists, chemists, and chemical physicists. Covering a broad spectrum of computational methods and practices culled from a variety of research fields, the editors present a full range of models that, together, provide a thorough and current description of all aspects of protein folding. A valuable resource for both students and professionals in the field, the book will be of value both as a cutting-edge overview of existing information and as a catalyst for inspiring new studies. Computational Methods for Protein Folding is the 120th volume in the acclaimed series Advances in Chemical Physics, a compilation of scholarly works dedicated to the dissemination of contemporary advances in chemical physics, edited by Nobel Prize-winner Ilya Prigogine.
Author : Paul Wrede
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110874245
Total Pages : 396 pages
Book Rating : 4.1/5 (18 download)
Download or read book Concepts in Protein Engineering and Design written by Paul Wrede and published by Walter de Gruyter GmbH & Co KG. This book was released on 2020-10-12 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: No detailed description available for "Concepts in Protein Engineering and Design".
Author : Serafin Fraga
Publisher : Springer Science & Business Media
ISBN 13 : 3642514995
Total Pages : 296 pages
Book Rating : 4.6/5 (425 download)
Download or read book Computer Simulations of Protein Structures and Interactions written by Serafin Fraga and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein engineering endeavors to design new peptides and proteins or to change the structural and/or functional characteristics of existing ones for specific purposes, opening the way for the development of new drugs. This work develops in a comprehensive way the theoretical formulation for the methods used in computer-assisted modeling and predictions, starting from the basic concepts and proceeding to the more sophisticated methods, such as Monte Carlo and molecular dynamics. An evaluation of the approximations inherent to the simulations will allow the reader to obtain a perspective of the possible deficiencies and difficulties and approach the task with realistic expectations. Examples from the authors laboratories, as well as from the literature provide useful information.
Author : StoryBuddiesPlay
Publisher : StoryBuddiesPlay
ISBN 13 :
Total Pages : 69 pages
Book Rating : 4./5 ( download)
Download or read book Alphafold 3 Understanding Protein Structures written by StoryBuddiesPlay and published by StoryBuddiesPlay. This book was released on 2024-06-09 with total page 69 pages. Available in PDF, EPUB and Kindle. Book excerpt: AlphaFold 3: Unveiling the Protein Universe and Revolutionizing Healthcare Proteins are the fundamental building blocks of life, playing a critical role in every physiological process. But understanding their complex structures has been a longstanding challenge. Enter AlphaFold 3, a revolutionary artificial intelligence system that has unlocked a new era of protein science. This comprehensive guide delves into the fascinating world of proteins and explores how AlphaFold 3 is transforming our understanding and manipulation of these essential molecules. Unveiling Protein Structures with Unprecedented Accuracy AlphaFold 3 utilizes the power of deep learning to predict protein structures with remarkable accuracy, surpassing even the most advanced experimental methods. This breakthrough allows scientists to visualize the intricate three-dimensional shapes of proteins, providing crucial insights into their function and potential roles in health and disease. The Future of Medicine: Personalized Treatments and Early Disease Detection With the ability to predict protein structures, AlphaFold 3 holds immense potential for personalized medicine. By analyzing an individual's unique protein profile, doctors can potentially tailor treatments and identify those at risk for developing certain protein-related diseases. This personalized approach could lead to more effective therapies, earlier intervention, and improved patient outcomes. Beyond Medicine: A Protein-Powered Future The impact of AlphaFold 3 extends far beyond the realm of medicine. Its ability to predict protein structures can benefit various fields, including: Biotechnology and Agriculture: Design of crops with improved resistance to pests and diseases, development of biofuels, and bioremediation strategies. Materials Science and Engineering: Creation of biomimetic materials with unique properties and design of next-generation electronics. Energy Production and Storage: Development of novel enzymes for efficient biocatalysis and exploration of protein-based energy storage solutions. A New Era of Discovery: Unveiling Protein Dynamics and Designing the Future The future of protein science promises even more exciting advancements. By incorporating protein dynamics – how these molecules move and interact – into predictions, AlphaFold 3 can offer a more complete picture of protein function. Additionally, the field of protein design aims to create proteins with entirely new properties, paving the way for groundbreaking innovations in various sectors. Join the Exploration: A Deep Dive into the World of Proteins This guide is just the beginning of your journey into the fascinating world of proteins and AlphaFold 3. As research continues to unlock the secrets of these remarkable molecules, the possibilities for a healthier, more sustainable future are truly limitless.
Author : Henrik Bohr
Publisher :
ISBN 13 :
Total Pages : 366 pages
Book Rating : 4.:/5 (89 download)
Download or read book Protein Structure by Distance Analysis written by Henrik Bohr and published by . This book was released on 1994 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction (Henrik Bohr and Soren Brunak). Protein structure prediction (Shankar Subramaniam). Structures from X-Ray Crystallography illustrated by proteins with prosthetic groups (Sine Larsen, Anders Kadziola and Jens F. W. Petersen). Function and three-dimensional structure odf proteins using nuclear magnetic resonance spectroscopy (Flemming M. Poulsen). Experimental aspects of ultr-violet and circular dichroism methods for protein folding (Hans E. M. Christensen, Jan M. Hammerstad-Pedersen, arne Holm, Gitte Iversen and Jens Ulstrup). Probing protein structure by solvent perturbation of NMR spectra: III. Combination of experiment and theory (Gennaro esposito, Arthur M. Lesk, Henriette Molinari Andrea Motta, Neri Niccolai and Annalisa Pastore). Comparative protein modeling by satisfaction of spatial restraints (Andrej Sali and Tom Blundell). Recurrent Neural Networks for protein distance matrix prediction (Martin Reczko and Henrik Bohr). Growth of domains in distance geometry through protein folding (Henry Bohr, Jin Wang and Peter Wolynes). Predictive power of mean force pair potentials (Manfred J. Sippl and Markus Jaritz). Optimized energy functions for tertiary structure prediction and recognition (Richard A. Goldstein, Zan A. Luthey-Schulten and Peter G. Wolynes). Prediction of 3D structures of globular proteins based on self-consistent molecular field theory (Alexei V. Finkelstein, Rumen A. Dimitrov, Aza Ya, Badretdinov and Boris A. Reva). A potential function that identifies correct protein folds (Gordon M. Crippen and Vladimir N. Maiorov). Genetic algorithm codings used in protein structure prediction by energy minimization (Frank Hermann). Super-secondary structures in proteins (Alexander V. Efimov). Design of model fast-folding proteins (Eugene I. Shakhnovich). Modelling and predicting protein structure using distance geometry (Willian R. taylor and András Aszódi). Modelling secondary structure formation by distance geometry techniques (András Aszódi and Willian R. taylor). A library of signature pentapeptides for the protein data bank (Ikuo Uchiyama, Atsushi Ogiwara, and Minoru Kanehisa). Glycosylation and protein conformation ( Jan E. Hansen, Ole Lund, Khistoffer Rapacki, Henrik Clausen, Erik Mosekilde, Jens O. Nielsen and John-Erik S. Hansen). 1D secondary structure prediction through evolutionary profiles (Burkhard Rost and Chris Sander). Fold-class prediction by neural network (Martin Reczko, Henrik Bohr, Shankar Subramaniam, Sudhakar Pamidighantam and Artemis Hatzigeorgiou). Distance-based approaches to protein structure-function analysis (Michael N. Liebman). Quantification odf secondary structure prediction improvement using distantly related proteins (Jonathan M. Levin, Steffano Pascarella, Patrick Argos and Jean Garnier). Delineating the mainchain topology of four-helix bundle proteins using the genetic algorithm and knowledge based on the amino acid sequence alone ( Patrick Argos and Thomas Dandekar). Correlation between protein secondary structure and the nRNA nucleotide sequence (Soren Brunak, Jacob Engelbrecht and Can Kesmir).
Author : Ilan Samish
Publisher : Humana
ISBN 13 : 9781493966356
Total Pages : 0 pages
Book Rating : 4.9/5 (663 download)
Download or read book Computational Protein Design written by Ilan Samish and published by Humana. This book was released on 2016-12-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim this volume is to present the methods, challenges, software, and applications of this widespread and yet still evolving and maturing field. Computational Protein Design, the first book with this title, guides readers through computational protein design approaches, software and tailored solutions to specific case-study targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Computational Protein Design aims to ensure successful results in the further study of this vital field.
Author : Jeffrey L. Cleland
Publisher : Wiley-Liss
ISBN 13 :
Total Pages : 558 pages
Book Rating : 4.3/5 (91 download)
Download or read book Protein Engineering written by Jeffrey L. Cleland and published by Wiley-Liss. This book was released on 1996-02-07 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: This systematic approach to protein engineering provides a thorough introduction to protein biophysics via chapters dealing with the experimental and theoretical determination of protein structure. Separate chapters discuss each of the expression systems c
Author : John Joseph Langone
Publisher : Gulf Professional Publishing
ISBN 13 : 9780121821036
Total Pages : 864 pages
Book Rating : 4.8/5 (21 download)
Download or read book Molecular Design and Modeling written by John Joseph Langone and published by Gulf Professional Publishing. This book was released on 1991 with total page 864 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computer-based design and modeling, computational approaches, and instrumental methods for elucidating molecular mechanisms of protein folding and ligand-acceptor interactions are included in Volumes 202 and 203, as are genetic and chemical methods for the production of functional molecules including antibodies and antigens, enzymes, receptors, nucleic acids and polysaccharides, and drugs.
Author : Raphael Guerois
Publisher : Springer Science & Business Media
ISBN 13 : 1597451169
Total Pages : 303 pages
Book Rating : 4.5/5 (974 download)
Download or read book Protein Design written by Raphael Guerois and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Design: Methods and Applications presents the most up-to-date protein design and engineering strategies so that readers can undertake their own projects with a maximum chance of success. The authors present integrated computational approaches that require various degrees of computational complexity, and the major accomplishments that have been achieved in the design and structural characterization of helical peptides and proteins.
Author : Saran A. Narang
Publisher : Butterworth-Heinemann
ISBN 13 : 1483161285
Total Pages : 285 pages
Book Rating : 4.4/5 (831 download)
Download or read book Protein Engineering written by Saran A. Narang and published by Butterworth-Heinemann. This book was released on 2013-10-22 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Engineering: Approaches to the Manipulation of Protein Folding outlines the complexity of the protein-folding problem and the potential of using genetic tools which, in combination with physical techniques, are expected to shed new light. The book begins with an overview of the basic concepts of protein folding, along with prediction methods and protein-folding models. Separate chapters cover experimental approaches to in vitro protein folding; general approaches used to characterize the folding reaction, equilibrium and kinetic experiments; and strategies employed to elucidate structure/function relationships in proteins of unknown tertiary structure. Subsequent chapters cover the structural and functional features of the HIV envelope protein; x-ray diffraction of proteins; application of Fourier transform infrared (FT-IR) spectroscopy to probe the secondary structure and orientation of membrane-associated proteins; and fluorescence measurements of proteins. The final chapters discuss nuclear magnetic resonance studies of proteins and the potential of the synthetic gene approach applied to the problem of protein folding.
