Design And Synthesis Of Gd3 Based Mri Contrast Agents

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Design and Synthesis of Gd(3+) Based MRI Contrast Agents

Author : Haroon Ur Rashid
Publisher : LAP Lambert Academic Publishing
ISBN 13 : 9783659632822
Total Pages : 136 pages
Book Rating : 4.6/5 (328 download)

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Book Synopsis Design and Synthesis of Gd(3+) Based MRI Contrast Agents by : Haroon Ur Rashid

Download or read book Design and Synthesis of Gd(3+) Based MRI Contrast Agents written by Haroon Ur Rashid and published by LAP Lambert Academic Publishing. This book was released on 2014-11-04 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic Resonance Imaging (MRI) has become a prominent imaging technique in medicine.MRI contrast agents are used to increase the sensitivity of this technique.1,4,7,10-teraazacyclododecane (cyclen) is a key macrocycle used for the synthesis of Magnetic Resonance Imaging (MRI) contrast agents. Substituting the hydrogen atoms (attached to the nitrogen atoms in the ring) of cyclen with suitable groups produce stable ligands. These ligands on complexation with Ln3+ ions lead to the formation of useful chelates. Cyclen is widely synthesized via Richman and Atkins method.Recently, a new method for cancer treatment with a less side effect called photodynamic therapy (PDT) has been introduced. In this method cancer tissues are selectively destroyed without injuring the surrounding healthy cells. However, for the successful use of this method, the selection of an appropriate photosensitizer is important. Hence, it diagnosis-treat union of MRI and PDT will be significantly promoted if a new family of bi-functional agents is found, which would combine the effects of a contrast agent in MRI and of a photosensitizer in PDT. It will bring great improvement to the cancer diagnosis and treatment

The Design and Synthesis of MRI Contrast Agents for Imaging Cancer and Hypoxia

Author : Eleanor F. Grimes
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (16 download)

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Book Synopsis The Design and Synthesis of MRI Contrast Agents for Imaging Cancer and Hypoxia by : Eleanor F. Grimes

Download or read book The Design and Synthesis of MRI Contrast Agents for Imaging Cancer and Hypoxia written by Eleanor F. Grimes and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Design, Synthesis, and Physico-chemical Studies of Mri Contrast Agents

Author : Alan Kazunari Marumoto
Publisher :
ISBN 13 :
Total Pages : 258 pages
Book Rating : 4.:/5 (313 download)

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Book Synopsis The Design, Synthesis, and Physico-chemical Studies of Mri Contrast Agents by : Alan Kazunari Marumoto

Download or read book The Design, Synthesis, and Physico-chemical Studies of Mri Contrast Agents written by Alan Kazunari Marumoto and published by . This book was released on 1994 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Lanthanide and Other Transition Metal Ion Complexes and Nanoparticles in Magnetic Resonance Imaging

Author : Carlos F.G.C. Geraldes
Publisher : CRC Press
ISBN 13 : 1040098797
Total Pages : 427 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Lanthanide and Other Transition Metal Ion Complexes and Nanoparticles in Magnetic Resonance Imaging by : Carlos F.G.C. Geraldes

Download or read book Lanthanide and Other Transition Metal Ion Complexes and Nanoparticles in Magnetic Resonance Imaging written by Carlos F.G.C. Geraldes and published by CRC Press. This book was released on 2024-08-21 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the development of the first clinical MRI contrast agent, Gd(DTPA) (or Magnevist®) in the early 1980s, another three linear and three macrocyclic (eg. Gd(DOTA) (Dotarem®) have been introduced in the clinic and inspired a huge number of researchers worldwide to perform preclinical research to obtain contrast agents for many kinds of clinical applications, which are described in this book. The most current research has been assembled here and can be used by the scientific community to continue increasing the relevance of metal-containing molecules and nanomaterials for MRI-based diagnosis and thus increase the practical use of these systems. Presents the importance of metal-containing molecules and nanomaterials for MRI-based diagnosis and the practical use of these systems. Discusses the structure and dynamics of Ln-based contrast agents as well as computational studies related to these agents. Endorses and stimulates research in the vibrant field of biological inorganic chemistry. Reviews the most current research supporting the relevance of metal-containing molecules and nanomaterials for diagnosis and therapy. The authors are preeminent bioinorganic and medicinal inorganic chemists and review the most current research in this field.

MRI

Author : Brian M. Dale
Publisher : John Wiley & Sons
ISBN 13 : 1119013038
Total Pages : 246 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis MRI by : Brian M. Dale

Download or read book MRI written by Brian M. Dale and published by John Wiley & Sons. This book was released on 2015-08-06 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fifth edition of the most accessible introduction to MRI principles and applications from renowned teachers in the field provides an understandable yet comprehensive update. Accessible introductory guide from renowned teachers in the field Provides a concise yet thorough introduction for MRI focusing on fundamental physics, pulse sequences, and clinical applications without presenting advanced math Takes a practical approach, including up-to-date protocols, and supports technical concepts with thorough explanations and illustrations Highlights sections that are directly relevant to radiology board exams Presents new information on the latest scan techniques and applications including 3 Tesla whole body scanners, safety issues, and the nephrotoxic effects of gadolinium-based contrast media

The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging

Author : Andre S. Merbach
Publisher : John Wiley & Sons
ISBN 13 : 1118503678
Total Pages : 514 pages
Book Rating : 4.1/5 (185 download)

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Book Synopsis The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging by : Andre S. Merbach

Download or read book The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging written by Andre S. Merbach and published by John Wiley & Sons. This book was released on 2013-02-19 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic Resonance Imaging (MRI) is one of the most important tools in clinical diagnostics and biomedical research. The number of MRI scanners operating around the world is estimated to be approximately 20,000, and the development of contrast agents, currently used in about a third of the 50 million clinical MRI examinations performed every year, has largely contributed to this significant achievement. This completely revised and extended second edition: Includes new chapters on targeted, responsive, PARACEST and nanoparticle MRI contrast agents. Covers the basic chemistries, MR physics and the most important techniques used by chemists in the characterization of MRI agents from every angle from synthesis to safety considerations. Is written for all of those involved in the development and application of contrast agents in MRI. Presented in colour, it provides readers with true representation and easy interpretation of the images. A word from the Authors: Twelve years after the first edition published, we are convinced that the chemistry of MRI agents has a bright future. By assembling all important information on the design principles and functioning of magnetic resonance imaging probes, this book intends to be a useful tool for both experts and newcomers in the field. We hope that it helps inspire further work in order to create more efficient and specific imaging probes that will allow materializing the dream of seeing even deeper and better inside the living organisms. Reviews of the First Edition: "...attempts, for the first time, to review the whole spectrum of involved chemical disciplines in this technique..."—Journal of the American Chemical Society "...well balanced in its scope and attention to detail...a valuable addition to the library of MR scientists..."—NMR in Biomedicine

Nanoplatform-Based Molecular Imaging

Author : Xiaoyuan Chen
Publisher : John Wiley & Sons
ISBN 13 : 1118110021
Total Pages : 848 pages
Book Rating : 4.1/5 (181 download)

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Book Synopsis Nanoplatform-Based Molecular Imaging by : Xiaoyuan Chen

Download or read book Nanoplatform-Based Molecular Imaging written by Xiaoyuan Chen and published by John Wiley & Sons. This book was released on 2011-04-20 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cutting-edge guide on advancing the science of molecular imaging using nanoparticles Nanoplathform-Based Molecular Imaging provides rationale for using nanoparticle-based probes for molecular imaging, then discusses general strategies for this underutilized, yet promising, technology. It addresses general strategies of particle synthesis and surface chemistry, applications in computed tomography optical imaging, magnetic resonance imaging, ultrasound, multimodality imaging, theranostics, and finally, the clinical perspectives of nanoimaging. This comprehensive volume summarizes the opinions of those in the forefront of research and describes the latest developments by emphasizing fundamentals and initiating hands-on application.

Magnetic Nanomaterials

Author :
Publisher : John Wiley & Sons
ISBN 13 : 3527321543
Total Pages : 673 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Magnetic Nanomaterials by :

Download or read book Magnetic Nanomaterials written by and published by John Wiley & Sons. This book was released on 2009-09-15 with total page 673 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book series Nanomaterials for the Life Sciences, provides an in-depth overview of all nanomaterial types and their uses in the life sciences. Each volume is dedicated to a specific material class and covers fundamentals, synthesis and characterization strategies, structure-property relationships and biomedical applications. The series brings nanomaterials to the Life Scientists and life science to the Materials Scientists so that synergies are seen and developed to the fullest. Written by international experts of various facets of this exciting field of research, the series is aimed at scientists of the following disciplines: biology, chemistry, materials science, physics, bioengineering, and medicine, together with cell biology, biomedical engineering, pharmaceutical chemistry, and toxicology, both in academia and fundamental research as well as in pharmaceutical companies. VOLUME 4 - Magnetic Nanomaterials This volume takes the reader on a tour showing how magnetic nanomaterials are used in the fields of diagnosis and therapy, as well as in tissue engineering and environmental applications.

Nanotechnology for Biomedical Imaging and Diagnostics

Author : Mikhail Y. Berezin
Publisher : John Wiley & Sons
ISBN 13 : 1118873149
Total Pages : 534 pages
Book Rating : 4.1/5 (188 download)

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Book Synopsis Nanotechnology for Biomedical Imaging and Diagnostics by : Mikhail Y. Berezin

Download or read book Nanotechnology for Biomedical Imaging and Diagnostics written by Mikhail Y. Berezin and published by John Wiley & Sons. This book was released on 2015-02-02 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology for Biomedical Imaging and Diagnostics: From Nanoparticle Design to Clinical Applications reflects upon the increasing role of nanomaterials in biological and medical imaging, presenting a thorough description of current research as well as future directions. With contributions from experts in nanotechnology and imaging from academia, industry, and healthcare, this book provides a comprehensive coverage of the field, ranging from the architectural design of nanomaterials to their broad imaging applications in medicine. Grouped into three sections, the book: Elucidates all major aspects of nanotechnology and bioimaging Provides comprehensive coverage of the field, ranging from the architectural design of nanomaterials to their broad imaging applications in medicine Written by well-recognized experts in academia, industry, and healthcare, will be an excellence source of reference With a multidisciplinary approach and a balance of research and diagnostic topics, this book will appeal to students, scientiests, and healthcare professionals alike

Targeted Molecular Imaging in Oncology

Author : E. Edmund Kim
Publisher : Springer Science & Business Media
ISBN 13 : 9780387950280
Total Pages : 322 pages
Book Rating : 4.9/5 (52 download)

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Book Synopsis Targeted Molecular Imaging in Oncology by : E. Edmund Kim

Download or read book Targeted Molecular Imaging in Oncology written by E. Edmund Kim and published by Springer Science & Business Media. This book was released on 2001 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer cells dedifferentiate with repect to cell function; their vascularity is more leaky, but perfusion is heterogenerously reduced, and interstitial fluid pressure is high, severely retarding delivery of agents from the blood. Targeted imaging is designed to produce a detectable difference between tissue that is visualized with single photon and positron emission tomography, magnetic resonance imaging, computed tomography, or ultrasonography. This book uniquely reports strategies for the application of molecular targeted imaging agents such as antibodies, peptides, receptors and contrast agents in the biologic grading of tumors, differential diagnosis of tumors, prediction of therapeutic response and monitoring tumor response to treatment. This book also describes updated information about the imaging of tumor angiogenesis, hypoxia, apoptosis and gene delivery as well as expression in the understanding and utility of tumor molecular biology for better cancer management.

Nanotoxicity

Author : Joshua Reineke
Publisher : Humana Press
ISBN 13 : 9781627030014
Total Pages : 0 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Nanotoxicity by : Joshua Reineke

Download or read book Nanotoxicity written by Joshua Reineke and published by Humana Press. This book was released on 2012-09-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of nanotechnology has developed very rapidly over the past decade lending great promise to medical applications in drug delivery, therapeutics, and biological imaging. Due to the great promise, rapid development, and broad application of nanomaterials, it is imperative that researchers from development through application seek a thorough understanding of nanotoxicity. Nanotoxicity: Methods and Protocols address the special considerations when applying toxicity studies to nanomaterials and detail newly developed methods for the study of nanotoxicity. These diverse methods span in vitro cell culture, model tissues, in situ exposure, in vivo models, analysis in plants, and mathematical modeling, proving to be relevant to pharmaceutical scientists, material scientists, bioengineers, toxicologists, environmentalists, immunologists, and cellular and molecular biologists, to name a few. As part of the highly successful Methods in Molecular BiologyTM, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Nanotoxicity: Methods and Protocols aims to diversify the capabilities of current researchers involved in nanotoxicology and to enable researchers in related fields to expand their knowledge of how nanomaterials interface with the biological environment.

Design, Synthesis and Characterization of Dendritic Macromolecules and Their Potential Applications in Drug Delivery

Author : Mingjun Liu
Publisher :
ISBN 13 :
Total Pages : 358 pages
Book Rating : 4.:/5 (34 download)

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Book Synopsis Design, Synthesis and Characterization of Dendritic Macromolecules and Their Potential Applications in Drug Delivery by : Mingjun Liu

Download or read book Design, Synthesis and Characterization of Dendritic Macromolecules and Their Potential Applications in Drug Delivery written by Mingjun Liu and published by . This book was released on 1999 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Hybrid Nanomaterials

Author : Weibo Cai
Publisher : CRC Press
ISBN 13 : 1498720943
Total Pages : 451 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Hybrid Nanomaterials by : Weibo Cai

Download or read book Hybrid Nanomaterials written by Weibo Cai and published by CRC Press. This book was released on 2017-05-25 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decade, an unprecedented expansion in the field of nanomedicine has resulted in the development of new nanomaterials for diagnosis and therapy of various diseases such as cancer. This book covers the design, synthesis and applications of various functionally-hybridized nanomaterials for biomedical applications. It includes strategies for design and synthesis of hybrid nanomaterials, surface engineering of various nanoparticle-based hybrid nanosystems for cancer imaging and therapy, toxicity aspects of nanomaterials and the challenges in translation research of hybrid nanomaterials.

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 030916785X
Total Pages : 223 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research by : National Research Council

Download or read book Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research written by National Research Council and published by National Academies Press. This book was released on 2003-08-22 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.

Trends in Contrast Media

Author : Henrik S. Thomsen
Publisher : Springer Science & Business Media
ISBN 13 : 3642598145
Total Pages : 471 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Trends in Contrast Media by : Henrik S. Thomsen

Download or read book Trends in Contrast Media written by Henrik S. Thomsen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: A different approach to contrast media, discussed primarily from the point of view of the radiologist. Comprehensive sections are devoted to iodinated contrast media and to the contrast media employed in magnetic resonance imaging and ultrasonography. The latest agents available receive due attention, as do adverse reactions. A final section considers the use of contrast media in nuclear medicine.

A Report for the Year ... on the Research and Other Activities of the Division of Biology

Author : California Institute of Technology. Division of Biology
Publisher :
ISBN 13 :
Total Pages : 402 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis A Report for the Year ... on the Research and Other Activities of the Division of Biology by : California Institute of Technology. Division of Biology

Download or read book A Report for the Year ... on the Research and Other Activities of the Division of Biology written by California Institute of Technology. Division of Biology and published by . This book was released on 1999 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Chemistry of Molecular Imaging

Author : Nicholas Long
Publisher : John Wiley & Sons
ISBN 13 : 1118093275
Total Pages : 431 pages
Book Rating : 4.1/5 (18 download)

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Book Synopsis The Chemistry of Molecular Imaging by : Nicholas Long

Download or read book The Chemistry of Molecular Imaging written by Nicholas Long and published by John Wiley & Sons. This book was released on 2014-12-31 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular imaging is primarily about the chemistry of novel biological probes, yet the vast majority of practitioners are not chemists or biochemists. This is the first book, written from a chemist's point of view, to address the nature of the chemical interaction between probe and environment to help elucidate biochemical detail instead of bulk anatomy. Covers all of the fundamentals of modern imaging methodologies, including their techniques and application within medicine and industry Focuses primarily on the chemistry of probes and imaging agents, and chemical methodology for labelling and bioconjugation First book to investigate the chemistry of molecular imaging Aimed at students as well as researchers involved in the area of molecular imaging