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Author : Mitchell Huot
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (692 download)
Download or read book Design and Synthesis of Bicyclic Peptidomimetic Scaffolds written by Mitchell Huot and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Mitchell Huot
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (13 download)
Download or read book Design and Synthesis of Peptidomimetic Scaffolds written by Mitchell Huot and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Antonio Guarna
Publisher : John Wiley & Sons
ISBN 13 : 1118683145
Total Pages : 334 pages
Book Rating : 4.1/5 (186 download)
Download or read book Peptidomimetics in Organic and Medicinal Chemistry written by Antonio Guarna and published by John Wiley & Sons. This book was released on 2014-03-14 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery.
Author : Elisa Danieli
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (14 download)
Download or read book Synthesis and Applications of Cyclic and Bicyclic Molecular Scaffolds as Peptidomimetics written by Elisa Danieli and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Aaron R. Minter
Publisher :
ISBN 13 :
Total Pages : 410 pages
Book Rating : 4.3/5 (91 download)
Download or read book Towards the Design, Synthesis, and Structural Characteristics of Peptidomimetic Scaffolds written by Aaron R. Minter and published by . This book was released on 2005 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 604 pages
Book Rating : 4.:/5 (659 download)
Download or read book PART I. DESIGN AND SYNTHESIS OF BICYCLIC INTERNAL BETA-TURN MIMETICS AND THEIR INCORPORATION INTO BIOLOGICALLY ACTIVE LIGANDS; PART II. SYNTHESIS OF CYCLIC PEPTIDES BY RING. written by and published by . This book was released on 2010 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt: Beta-Turns in many biologically active peptides are important secondary structural elements which are critical for their biological activities. Hence, it is not surprising that beta-turn based pharmacophore design including beta-turn mimetics has become a central topic in medicinal chemistry in addition to alpha-helix or helical peptides. One of the advantages of such beta-turn mimetics is that they can better control torsion angles of the backbone of peptides and to some degree dihedral angles chi (X). These beta-turn mimicking scaffolds are designed to have a higher avidity for the acceptor by overcoming what otherwise is the inherent entropic cost paid for beta-turn formation upon binding to the acceptor. Among different synthetic strategies to bicyclic structures as beta-turn mimetics, consecutive formation of bicyclic structures using tandem acid-catalyzed N-acyliminium ion cyclization is attractive since this methodology was well established in the synthesis of natural product alkaloids. 1,3,6,8-Substituted tetrahydro-2H-pyrazino[1,2-a]pyrimidine-4,7-diones were designed and synthesized as internal beta-turn mimetics through an acid-catalyzed tandem acyliminium ion cyclization. Its development and synthesis are decribed in Chapter 2 to Chapter 4. Its application toward the development and synthesis of a small molecule ligand for melanocortin receptors is described in Chapter 5. In addition, the development of peptidomimetics for opioid receptors is explained in Chapter 6. On the other hand, a dicarba analogue having opioid receptor agonist, and dicarba analogues for MCRs were synthesized through solid phase synthesis including a ring closing metathesis reaction using Grubbs' catalyst (I) in Chapter 8.
Author : Sergey Nicholaevitch Savinov
Publisher :
ISBN 13 :
Total Pages : 610 pages
Book Rating : 4.:/5 (819 download)
Download or read book Design, Synthesis and Application of a Hetero-bicycle-based Peptidomimetic Scaffold written by Sergey Nicholaevitch Savinov and published by . This book was released on 2000 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt:
![Download The Design and Synthesis of Non-peptide Peptidomimetics Based on the [beta]-D-glucose Scaffold and the Development of Rigid Tricyclic Biological Platforms for Ligand Design PDF Online Free](https://books.google.com/books/content/images/frontcover/_5dLNwAACAAJ?fife=w200-h370)
Author : John Hynes
Publisher :
ISBN 13 :
Total Pages : 603 pages
Book Rating : 4.:/5 (187 download)
Download or read book The Design and Synthesis of Non-peptide Peptidomimetics Based on the [beta]-D-glucose Scaffold and the Development of Rigid Tricyclic Biological Platforms for Ligand Design written by John Hynes and published by . This book was released on 1996 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Stina Saitton
Publisher :
ISBN 13 : 9789162865245
Total Pages : 70 pages
Book Rating : 4.8/5 (652 download)
Download or read book Design and Synthesis of a Tripeptidomimetic Scaffold Based on Pyridine written by Stina Saitton and published by . This book was released on 2005 with total page 70 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Daniela Stranges
Publisher :
ISBN 13 :
Total Pages : 169 pages
Book Rating : 4.:/5 (14 download)
Download or read book Synthesis of Bicyclic Scaffolds Derived from Natural Compounds and Their Pharmacological Applications written by Daniela Stranges and published by . This book was released on 2005 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Hui Shao
Publisher :
ISBN 13 :
Total Pages : 326 pages
Book Rating : 4.:/5 (318 download)
Download or read book Stereoisomeric Design and Synthesis of Peptidomimetic Building Blocks and Biologically Active Molecules written by Hui Shao and published by . This book was released on 1996 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jaimie K. Rueter
Publisher :
ISBN 13 :
Total Pages : 502 pages
Book Rating : 4.:/5 (318 download)
Download or read book The Design and Synthesis of Peptidomimetics for the Study of Biological Activity written by Jaimie K. Rueter and published by . This book was released on 1998 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Shawn Earle Richard Schiller
Publisher :
ISBN 13 :
Total Pages : 304 pages
Book Rating : 4.:/5 (433 download)
Download or read book Design and Synthesis of Nuclear Localization Sequence Peptidomimetics Utilizing Glycoside Scaffolding written by Shawn Earle Richard Schiller and published by . This book was released on 1999 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : William D. Lubell
Publisher : Springer
ISBN 13 : 3319491199
Total Pages : 322 pages
Book Rating : 4.3/5 (194 download)
Download or read book Peptidomimetics I written by William D. Lubell and published by Springer. This book was released on 2017-06-29 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field. All chapters from Topics in Heterocyclic Chemistry are published Online First with an individual DOI. In references, Topics in Heterocyclic Chemistry is abbreviated as Top Heterocycl Chem and cited as a journal.
Author : Hannah Lindsey Stewart
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (18 download)
Download or read book Synthesis of Partially Saturated Bicyclic Heteroaromatics written by Hannah Lindsey Stewart and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Yansong Wang
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (956 download)
Download or read book Design and Synthesis of Bicyclic Ligands for the FK506-binding Proteins 51 and 52 written by Yansong Wang and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Joanna Duncan
Publisher :
ISBN 13 :
Total Pages : 544 pages
Book Rating : 4.:/5 (11 download)
Download or read book Design and Synthesis and Testing of Conformationally Constrained Peptidomimetics written by Joanna Duncan and published by . This book was released on 2013 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt:
