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Delivery Of Fluorouracil And Sirna By Mesoporous Silica Nanoparticles To Drug Resistant Colorectal Cancer
Download Delivery Of Fluorouracil And Sirna By Mesoporous Silica Nanoparticles To Drug Resistant Colorectal Cancer full books in PDF, epub, and Kindle. Read online Delivery Of Fluorouracil And Sirna By Mesoporous Silica Nanoparticles To Drug Resistant Colorectal Cancer ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Delivery of Fluorouracil and SiRNA by Mesoporous Silica Nanoparticles to Drug Resistant Colorectal Cancer by : Lijue Chen
Download or read book Delivery of Fluorouracil and SiRNA by Mesoporous Silica Nanoparticles to Drug Resistant Colorectal Cancer written by Lijue Chen and published by . This book was released on 2015 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesoporous silica nanoparticle based drug and gene delivery system was developed to overcome the acquired drug resistance in colorectal cancer by targeted delivery of anti-cancer drug in the cytoplasm of the cancer cells and silencing the gene expression related to drug resistance.
Book Synopsis Nanotechnology for Efficient Delivery of Short Therapeutic Oligonucleotides (antisense ODN and SiRNA) and Codelivery with Chemical Anticancer Drugs for Effective Cancer Therapy by : Minhua Chen
Download or read book Nanotechnology for Efficient Delivery of Short Therapeutic Oligonucleotides (antisense ODN and SiRNA) and Codelivery with Chemical Anticancer Drugs for Effective Cancer Therapy written by Minhua Chen and published by . This book was released on 2009 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite great progress in recent years, efficient delivery of gene therapy or chemotherapy drugs into their target sites with minimal side effects remains one of the biggest challenges for effective cancer therapy. Co-delivery of siRNA targeted for proteins responsible for drug resistance and chemical anticancer drugs represents a promising new approach to overcome drug resistance and to make cancer therapy more effective. However, efficient co-delivery systems that can deliver siRNA and anti-cancer drugs simultaneously into cancer cells have rarely been developed. This thesis is aimed at developing novel non-viral nanocarriers for efficient delivery of antisense ODN and siRNA and codelivery with chemical anticancer drugs for effective cancer therapy. We began by performing a systematic investigation on the efficacy of five generations of polypropyleneimine (PPI) dendrimers to provoke nanoparticle formation from antisense ODNs and then deliver the ODN nanoparticles into cancer cells (Chapter 2). We then developed a novel approach to efficiently package and deliver siRNAs into cancer cells with low generation non-toxic PPI dendrimers by using gold nanoparticles as a "labile catalytic" packaging agent (Chapter 3). Relying on the fundamental understanding gained from Chapters 2 and 3, we then continued the utilization of dendrimers and developed polyamidoamine (PAMAM) dendrimer-modified mesoporous silica nanoparticles (MSNs) as a stimuli-responsive controlled-release delivery system for a chemotherapy drug (Chapter 4). By using a non-gatekeeping approach, we demonstrated nearly zero release of doxorubicin in H2O and complete release once delivered into cancer cells. In Chapter 5, we further utilized MSNs as a codelivery system to simultaneously deliver Doxorubicin and a Bcl-2-targeted siRNA into A2780/AD human ovarian cancer cells for enhanced chemotherapy efficacy. We then investigated the effect of each component in the PAMAM-dendrimer modified MSN-based codelivery system on the cell uptake efficiency of siRNA and its intracellular release and localization (Chapter 6). We further studied the effect of temperature and different inhibitors on the cell uptake efficiency of MSN-Dox-G2 and found that MSN-Dox-G2 might internalize into cells through a non-endocytic process (Chapter 7). Finally, we demonstrated a specific cancer cell-targeted delivery by PEGylating the MSN-Dox-G2/siRNA complex and tagging it with a specific cancer-targeting group (Chapter 8).
Book Synopsis Silica Nanoparticles for the Delivery of DNA and RNAi in Cancer Treatment by : Michael Aaron Vrolijk
Download or read book Silica Nanoparticles for the Delivery of DNA and RNAi in Cancer Treatment written by Michael Aaron Vrolijk and published by . This book was released on 2017 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA and interfering RNA (RNAi) -- short interfering RNA (siRNA) and micro RNA (miRNA) -- are promising new cancer therapies, especially for drug resistant lines. However, they require a delivery system in vivo to prevent degradation and off target effects. Silica based nanoparticles, both solid and mesoporous, are a promising option due to their biocompatibility, ease of preparation and morphology control, reproducibility, and facile addition of functional groups including targeting ligands. After a brief introduction to cancer treatment and review of the current nanoparticle treatments undergoing clinical trials, this thesis details the many methods explored over the past ten years to fine-tune particle preparation, pore size, functionalization, and delivery strategies. The majority of both solid and mesoporous silica nanoparticles are synthesized using the sol-gel method and then various functionalization techniques are employed to load and protect the oligonucleotides. Externally loaded systems generally use a combination of polyethylenimine (PEI) and polyethylene glycol (PEG). Mesoporous silica nanoparticles internally load the DNA or RNAi, resulting in the added variable of pore size. Several groups have investigated how pore size alters loading and release kinetics to perfect this variable. Many groups have also tested ligands targeting for over expressed proteins on the intended cancer, triggered release techniques, cell-penetrating peptides in order to create a viable in vivo delivery system. By compiling the techniques employed by researchers over the past ten years, this thesis will elucidate which approaches are most promising for future research. Furthermore, overall strategies within the field are suggested to more easily compare studies and evaluate methods.
Book Synopsis Industrial Applications for Intelligent Polymers and Coatings by : Majid Hosseini
Download or read book Industrial Applications for Intelligent Polymers and Coatings written by Majid Hosseini and published by Springer. This book was released on 2016-05-14 with total page 715 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive collaboration on intelligent polymers and coatings for industrial applications by worldwide researchers and specialists. The authors cover the basis and fundamental aspects of intelligent polymers and coatings, challenges, and potential mechanisms and properties. They include recent and emerging industrial applications in medical, smart textile design, oil and gas, electronic, aerospace, and automobile industries as well as other applications including microsystems, sensors, and actuators, among others. The authors discuss the potential for future research in these areas for improvement and growth of marketable applications of intelligent polymers and coatings.
Book Synopsis A Cancer Source Book for Nurses by : American Cancer Society
Download or read book A Cancer Source Book for Nurses written by American Cancer Society and published by Jones & Bartlett Learning. This book was released on 2004 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers the most common cancers and strategies for nursing care.
Author :Kevin M. Haigis, Ph.D. Publisher :Springer Science & Business Media ISBN 13 :146148412X Total Pages :319 pages Book Rating :4.4/5 (614 download)
Book Synopsis Molecular Pathogenesis of Colorectal Cancer by : Kevin M. Haigis, Ph.D.
Download or read book Molecular Pathogenesis of Colorectal Cancer written by Kevin M. Haigis, Ph.D. and published by Springer Science & Business Media. This book was released on 2013-10-02 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. The book will focus on the progression from the identification of mutations that drive colorectal cancer initiation and progression to the search for novel therapies to treat the disease.
Book Synopsis Smart Nanovesicles for Drug Targeting and Delivery by : Maria Carafa
Download or read book Smart Nanovesicles for Drug Targeting and Delivery written by Maria Carafa and published by MDPI. This book was released on 2019-05-20 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: We can use the short text on the SI page for the description, or you make slight modifications on it. The description/summary is only for promotion (flyer, distribution channels), and will not be included in the book You can use the short text on the SI page for the description Nanovesicles are highly-promising systems for the delivery and/or targeting of drugs, biomolecules and contrast agents. Despite the fact that initial studies in this area were performed on phospholipid vesicles, there is an ever-increasing interest in the use of other molecules to obtain smart vesicular carriers focusing on strategies for targeted delivery. These systems can be obtained using newly synthesized smart molecules, or by intelligent design of opportune carriers to achieve specific delivery to the site of action. The drug/contrast agent-containing vesicles need to be directed to precise locations within the body to obtain desired magnitude and duration of the therapeutic or diagnostic effect. This spatial control in the delivery might open new avenues to modulate drug activity while avoiding side-effects and to optimize contrast agent properties while avoiding a broad distribution in the organism. However, delivering and targeting active substances into specific tissues and cells is still a challenge in designing novel therapeutic approaches against untreatable disorders, such as tumors and degenerative diseases.
Book Synopsis Silk-based Drug Delivery Systems by : Elia Bari
Download or read book Silk-based Drug Delivery Systems written by Elia Bari and published by Royal Society of Chemistry. This book was released on 2020-10-07 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering spider silk and silk worm cocoons, the editors elucidate the extraction, structure and properties of silk sericin and silk fibroin.
Book Synopsis Combination Drug Delivery Approach as an Effective Therapy for Various Diseases by : Prashant Kesharwani
Download or read book Combination Drug Delivery Approach as an Effective Therapy for Various Diseases written by Prashant Kesharwani and published by Academic Press. This book was released on 2022-03-27 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: Combination Drug Delivery Approach as an Effective Therapy for Various Diseases explores the use of bioengineering tools in combination drug delivery approaches to control various diseases at different clinical stages of synergistic action, varying mechanisms of action, and during the suppression of drug resistance. The book presents fundamental knowledge on the experiential and experimental aspects of drug combination approaches in order to equip rational applications in preventing the emergence of resistance during the treatment of various diseases. It provides a holistic understanding of the principles behind formation, characterization, applications, regulations, toxicity, challenges and future perspectives of combination drug delivery approaches. It will be of interest to researchers and advanced graduate students in pharmaceutical science, chemistry, biology and medicine, as well as pharmaceutical companies and scientific organizations. Provides an accounting of vital aspects on various combination drug delivery approaches, presenting next generation diagnostics and therapeutics Discusses the perspectives of current technologies in highly organized tables, illustrative figures and flow charts Defines major gaps in knowledge that can lead to significant scientific discoveries
Book Synopsis Drug Delivery of SiRNA Therapeutics by : Gaetano Lamberti
Download or read book Drug Delivery of SiRNA Therapeutics written by Gaetano Lamberti and published by . This book was released on 2020-06-15 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new frontier of pharmaceutical sciences is gene therapy, which is the use of molecules able to interact directly with the expression of the genetic material of the patient as well as of the disease-causing guest (bacteria, virus, parasites, and tumor cells). Among the molecules of interest for gene therapy, a relevant role is played by small interfering RNA (siRNA) molecules able to interfere with the expression of genes of interest for some diseases. However, siRNA molecules, even if they are powerful as drugs, are difficult to deliver since they are sensitive to enzymes present in plasma and they are large and negatively charged, so are difficult to administer into the cell nuclei, since the cell walls are scarcely permeable to large molecules and are also negatively charged. Therefore, the focus of research on siRNA-based therapies is their delivery, which can be performed by chemical modification, association with aptamers or polycations, or embedding them into properly designed liposomes. This book is centered on the more recent development in siRNA delivery techniques toward the clinical applications of this potent class of drugs.
Book Synopsis Smart Drug Delivery System by : Ali Demir Sezer
Download or read book Smart Drug Delivery System written by Ali Demir Sezer and published by BoD – Books on Demand. This book was released on 2016-02-10 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different smart drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, diabetic, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.
Download or read book Cancer Nanotechnology written by and published by Academic Press. This book was released on 2018-06-23 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research, Volume 139, provides invaluable information on the exciting and fast-moving field of cancer research. Original reviews are presented on a variety of topics relating to the rapidly developing intersection between nanotechnology and cancer research, with unique sections in the new release focusing on Exosomes as a theranostic for lung cancer, Nanotechnology and cancer immunotherapy, Ultrasound imaging agents and delivery systems, Dendronized systems for the delivery of chemotherapeutics, Thermosensitive liposomes for image-guided drug delivery, Supramolecular Chemistry in Tumor Analysis and Drug Delivery, Gold nanoparticles for delivery of cancer therapeutics, and Single cell barcode microchip for cancer research and therapy. Provides the latest information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike
Book Synopsis Drug-delivery systems of phytochemicals as therapeutic strategies in cancer therapy by : Akhileshwar Kumar Srivastava
Download or read book Drug-delivery systems of phytochemicals as therapeutic strategies in cancer therapy written by Akhileshwar Kumar Srivastava and published by Elsevier. This book was released on 2023-11-07 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phytochemicals and derivatives have become promising alternatives to increase treatment potential in cancer patients with minimal side effects. Drug-delivery Systems of Phytochemicals as Therapeutic Strategies in Cancer Therapy elucidates the importance of various phytochemicals in cancer therapy and explains various routes/methods to deliver phytochemicals for overcoming the problems associated with delivery system in cancer treatment. Several nanotechnological methods are followed to enhance drug solubility, sustainability, bioavailability and gastrointestinal permeability of these phytochemicals. The advanced field of drug-delivery systems explains that combination therapy for cancer treatment has important benefits over mono-delivery therapeutics. Natural compounds, because of their biobased origin, have drawn higher attention than synthetic drugs. Synthesis of nano-phytomedicines has impacted the bioavailability of phytochemicals. Novel formulations have been synthesized loaded with phytochemicals and have revealed extraordinary results in treatment of various cancers. Current understanding of the relevant information presented in Drug-delivery systems of phytochemicals as therapeutic strategies in cancer therapy fulfils the requirements of oncologists, molecular biologists, pharmacologist and related researchers, who want to work in the areas of drug development targeting phytochemicals for cancer therapy Explains the significance of phytochemicals in cancer therapy, along with their pharmacologic action Elucidates the importance of various phytochemicals in cancer therapy Explains the emerging need of drug-delivery system for plant metabolites Deciphers the various drug-delivery systems for phytomedicines involved in cancer treatments Describes the crucial role of nanotechnology in the development of drug-delivery systems for anticancer phytochemicals Explores the challenges associated with developing drug-delivery systems for phytochemicals to cure cancer
Book Synopsis Colon Cancer Diagnosis and Therapy by : Naveen Kumar Vishvakarma
Download or read book Colon Cancer Diagnosis and Therapy written by Naveen Kumar Vishvakarma and published by Springer Nature. This book was released on 2021-06-04 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis. This book is the second of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutics, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.
Book Synopsis Targeted Drug Delivery : Concepts and Design by : Padma V. Devarajan
Download or read book Targeted Drug Delivery : Concepts and Design written by Padma V. Devarajan and published by Springer. This book was released on 2014-12-08 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative volume explores the fundamental concepts and numerous applications of targeted delivery of drugs to the body. This compilation has been divided into eight sections comprised of the basic principles of drug targeting, disease and organ/organelle-based targeting, passive and active targeting strategies, and various advanced drug delivery tools such as functionalized lipidic, polymeric and inorganic nanocarriers. Together, the twenty-three chapters cover a wide range of topics in the field, including tumor and hepatic targeting, polymer-drug conjugates, nanoemulsion, physical and biophysical characteristics of nanoparticles, and in vivo imaging techniques, among others. The book also examines advanced characterization techniques, regulatory hurdles and toxicity-related issues that are key features for successful commercialization of targeted drug delivery system products. Targeted Drug Delivery is a comprehensive reference guide for drug delivery researchers, both beginners and those already working in the field.
Book Synopsis Intracellular Delivery III by : Aleš Prokop
Download or read book Intracellular Delivery III written by Aleš Prokop and published by Springer. This book was released on 2016-10-31 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: A critical review is attempted to assess the status of nanomedicine entry onto the market. The emergence of new potential therapeutic entities such as DNA and RNA fragments requires that these new “drugs” will need to be delivered in a cell-and organelle-specific manner. Although efforts have been made over the last 50 years or so to develop such delivery technology, no effective and above all clinically approved protocol for cell-specific drug delivery in humans exists as yet. Various particles, macromolecules, liposomes and most recently “nanomaterials” have been said to “show promise” but none of these promises have so far been “reduced” to human clinical practice. The focus of this volume is on cancer indication since the majority of published research relates to this application; within that, we focus on solid tumors (solid malignancies). Our aim is critically to evaluate whether nanomaterials, both non-targeted and targeted to specific cells, could be of therapeutic benefit in clinical practice. The emphasis of this volume will be on pharmacokinetics (PK) and pharmacodynamics (PD) in animal and human studies. Apart from the case of exquisitely specific antibody-based drugs, the development of target-specific drug–carrier delivery systems has not yet been broadly successful at the clinical level. It can be argued that drugs generated using the conventional means of drug development (i.e., relying on facile biodistribution and activity after (preferably) oral administration) are not suitable for a target-specific delivery and would not benefit from such delivery even when a seemingly perfect delivery system is available. Therefore, successful development of site-selective drug delivery systems will need to include not only the development of suitable carriers, but also the development of drug entities that meet the required PK/PD profile.
Book Synopsis Bioactivity of Engineered Nanoparticles by : Bing Yan
Download or read book Bioactivity of Engineered Nanoparticles written by Bing Yan and published by Springer. This book was released on 2017-08-17 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together reviews from international experts who are exploring the biological activities of nanomaterials for medical applications or to better understand nanotoxicity. Topics include but are not limited to the following: 1) mechanistic understanding of nanostructure-bioactivity relationships; 2) the regulation of nanoparticles’ bioactivity by means of chemical modification; 3) the new methodologies and standard methods used to assess nanoparticles’ bioactivity; 4) the mechanisms involved in nanoparticle-biomolecule interactions and nanoparticle-cell interactions; and 5) biomedical applications of nanotechnology. The book will be a valuable resource for a broad readership in various subfields of chemical science, engineering, biology, environment, and medicine.
