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Dehydroepiandrosterone And Its Metabolites
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Book Synopsis Effects of Dehydroepiandrosterone (DHEA) and Its Metabolites in a Murine Cutaneous Wound Healing Model by : Stuart James Mills
Download or read book Effects of Dehydroepiandrosterone (DHEA) and Its Metabolites in a Murine Cutaneous Wound Healing Model written by Stuart James Mills and published by . This book was released on 2004 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Handbook of Neuroendocrinology by : George Fink
Download or read book Handbook of Neuroendocrinology written by George Fink and published by Academic Press. This book was released on 2012 with total page 895 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroendocrinology underpins fundamental physiological, molecular, biological, and genetic principles such as the regulation of gene transcription and translation. This handbook highlights the experimental and technical foundations of each area's major concepts and principles.
Book Synopsis Dehydroepiandrosterone and Its Metabolites by : Qianxing Mo
Download or read book Dehydroepiandrosterone and Its Metabolites written by Qianxing Mo and published by . This book was released on 2005 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dehydroepiandrosterone (DHEA) is a multi-functional neurosteroid that has been implicated in a variety of biological effects in humans and other mammals. The mechanism of action of DHEA has not been fully elucidated, although it is under investigation as a replacement therapy for humans with DHEA Insufficiency based on reports suggesting beneficial effects ranging from anti-depression to neuroprotection. Controversy remains about the relative contribution of DHEA and its metabolites in its biological effects. This dissertation focuses on a comparative study of the genomic effects of DHEA and its metabolites in vitro, and identification of genes regulated by DHEA in vivo. The results indicated that DHEA, androstenediol and androstenedione produced typical genomic effects, including promoting AR-GFP intracellular trafficking and formation of nuclear clusters in COS-7 cells, and conferred AR transcriptional activity in a dose-dependent manner in transiently transfected CV-1 cells. In contrast, DHEAS, 7alpha-OH-DHEA, 7beta-OH-DHEA, and 7-oxo-DHEA were essentially without androgenic activity. The results confirmed that DHEA is intrinsically androgenic and demonstrated significant differences in androgenic activity among DHEA and its metabolites. In the hypothalamus, DHEA, like the strongest androgen DHT, significantly up-regulated the expression of two important neuropeptides: hypocretin (Orexin) and pro-melanin concentrating hormone precursor (Prepro-MCH), and delta type protein kinase C (PKCdelta), and down-regulated the expression of deleted in bladder cancer chromosome region candidate 1 (DBCCR1) and chitinase 3-like 3 (Chi3l3). Interestingly, DHT down-regulated the expression of PKCS in the hippocampus. The differential expression of Prepro-MCH, orexin, and PKCdelta was further confirmed by real-time RT-PCR. MCH and orexin are involved in the regulation of appetite and energy homeostasis, and PKCdelta and DBCC1 are involved in regulation of cell growth, proliferation or survival. More importantly, the functions of these genes may explain the multiple effects of DHEA in humans and rodents. The findings may be of clinical significance and provide a new level of detail concerning the mechanism of action of DHEA in the central nervous system.
Book Synopsis Contemporary Practice in Clinical Chemistry by : William Clarke
Download or read book Contemporary Practice in Clinical Chemistry written by William Clarke and published by Academic Press. This book was released on 2020-06-11 with total page 1070 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contemporary Practice in Clinical Chemistry, Fourth Edition, provides a clear and concise overview of important topics in the field. This new edition is useful for students, residents and fellows in clinical chemistry and pathology, presenting an introduction and overview of the field to assist readers as they in review and prepare for board certification examinations. For new medical technologists, the book provides context for understanding the clinical utility of tests that they perform or use in other areas in the clinical laboratory. For experienced laboratorians, this revision continues to provide an opportunity for exposure to more recent trends and developments in clinical chemistry. Includes enhanced illustration and new and revised color figures Provides improved self-assessment questions and end-of-chapter assessment questions
Book Synopsis Treatment of the Postmenopausal Woman by : Rogerio A. Lobo
Download or read book Treatment of the Postmenopausal Woman written by Rogerio A. Lobo and published by Elsevier. This book was released on 2007-06-05 with total page 902 pages. Available in PDF, EPUB and Kindle. Book excerpt: For anyone who treats postmenopausal women, this latest edition of Rogerio Lobo's classic work combines the best from two well-known references: Menopause, and the second edition of Treatment of the Postmenopausal Woman. By adding significant discussions of the basic science behind menopause, it is possible to objectively assess the clinical value and limitations of current approaches to treatment and provide a basis and rationale for strategies that will result in better individualized and specialized care. Not only does the third edition discuss diagnosis and treatment of menopause but it covers biological, anatomical, physiological, pathobiological, and pharmacological aspects as well bringing together, in one source, all of the information needed to understand and treat postmenopausal conditions. Over 50% new material representing the vast amount of information available since the Women's Health Initiative (WHI) clinical trials were completed making this the most up-to-date reference on postmenopausal women Includes several new sections on comparisons between clinical trials and observational data, urology, and pelvic support Each section is preceded by a preface to put the area into context with many chapters having suggested treatment regimens
Book Synopsis Dehydroepiandrosterone (DHEA) Metabolism and Its Role in Preadipocyte Growth and Differentiation by : Yolanda Renee Lea-Currie
Download or read book Dehydroepiandrosterone (DHEA) Metabolism and Its Role in Preadipocyte Growth and Differentiation written by Yolanda Renee Lea-Currie and published by . This book was released on 1999 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Use of Dietary Supplements by Military Personnel by : Institute of Medicine
Download or read book Use of Dietary Supplements by Military Personnel written by Institute of Medicine and published by National Academies Press. This book was released on 2008-10-31 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dietary supplements are widely available through a rapidly expanding market of products commonly advertised as beneficial for health, performance enhancement, and disease prevention. Given the importance and frequent evaluation of physical performance and health as a criteria to join and remain in the military, the use of these products by military personnel has raised concern regarding over-all and long-term efficacy and safety. This evaluation is especially difficult, as many of these supplements contain multiple ingredients, have a changing composition over time, or are used intermittently at doses difficult to measure. This book analyzes the patterns of dietary supplement use among military personnel, examines published reviews of the scientific evidence, and identifies those dietary supplements that are beneficial and/or warrant concern due to risks to health or performance. The book also recommends a system to monitor adverse health effects and a framework to identify the need for active management of dietary supplements by military personnel. Military policy makers, personnel, and recruits will find this book useful, as will nutritionists, athletes, and others working in strenuous environments.
Book Synopsis Nutritional and Herbal Therapies for Children and Adolescents by : George M. Kapalka
Download or read book Nutritional and Herbal Therapies for Children and Adolescents written by George M. Kapalka and published by Academic Press. This book was released on 2009-11-06 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume assists practicing mental health professionals in expanding their knowledge about nutritional and herbal interventions that can be attempted as alternatives to prescription medications. Designed to provide guidance for non-medical caregivers treating children and adolescents who present with emotional and/or behavioral difficulties such as such as depression, anxiety, ADHD, sleep difficulties, impulsivity, distractibility, and other psychological and psychiatric disorders, the volume provides a comprehensive discussion of naturopathic solutions based on existing research. In areas where research is not extensive, conclusions are provided about potentially beneficial effects based on the specific pharmacologic action of the compounds. Dosage for specific age groups, schedules of administration, dietary considerations (i.e., whether or not to take the supplement with food), monitoring for response and adverse effects, signs of dangerous reactions, and the need to control interactions with other compounds (i.e., prescription medications) are thoroughly reviewed with regard to each supplement discussed in the book. Reviews specific psychological disorders (i.e. ADHD, depression, mania, anxiety, sleep difficulties, tic behaviors and autism) and the available data about their treatment with the use of nutritional and herbal supplements Provides rationale for the use of every specific compound with detailed recommendations tailored for each age group with regard to the dosage, frequency of administration, possible dangers and monitoring for side effects Discusses claims of efficacy used to market various products and ground those claims within fully vetted scientific research Discusses neurobiology, pharmacodynamics and pharmokinetics in detailed but accessible language *Non-medical clinicians with limited knowledge of medicine and pharmacology come away with understanding of key issues involved in Fully covers assessment, diagnosis & treatment of children and adolescents, focusing on evidence-based practices *Consolidates broadly distributed literature into single source and specifically relates evidence-based tools to practical treatment, saving clinicians time in obtaining and translating information and improving the level of care they can provide Detailed how-to explanation of practical evidence-based treatment techniques *Gives reader firm grasp of how to more effectively treat patients Material related to diversity (including race, ethnicity, gender and social class) integrated into each chapter *Prepares readers for treating the wide range of youth they will encounter in practice
Book Synopsis Mass Spectrometry for the Clinical Laboratory by : Hari Nair
Download or read book Mass Spectrometry for the Clinical Laboratory written by Hari Nair and published by Academic Press. This book was released on 2016-11-02 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mass Spectrometry for the Clinical Laboratory is an accessible guide to mass spectrometry and the development, validation, and implementation of the most common assays seen in clinical labs. It provides readers with practical examples for assay development, and experimental design for validation to meet CLIA requirements, appropriate interference testing, measuring, validation of ion suppression/matrix effects, and quality control. These tools offer guidance on what type of instrumentation is optimal for each assay, what options are available, and the pros and cons of each. Readers will find a full set of tools that are either directly related to the assay they want to adopt or for an analogous assay they could use as an example. Written by expert users of the most common assays found in a clinical laboratory (clinical chemists, toxicologists, and clinical pathologists practicing mass spectrometry), the book lays out how experts in the field have chosen their mass spectrometers, purchased, installed, validated, and brought them on line for routine testing. The early chapters of the book covers what the practitioners have learned from years of experience, the challenges they have faced, and their recommendations on how to build and validate assays to avoid problems. These chapters also include recommendations for maintaining continuity of quality in testing. The later parts of the book focuses on specific types of assays (therapeutic drugs, Vitamin D, hormones, etc.). Each chapter in this section has been written by an expert practitioner of an assay that is currently running in his or her clinical lab. Provides readers with the keys to choosing, installing, and validating a mass spectrometry platform Offers tools to evaluate, validate, and troubleshoot the most common assays seen in clinical pathology labs Explains validation, ion suppression, interference testing, and quality control design to the detail that is required for implementation in the lab
Book Synopsis DHEA and the Brain by : Robert Morfin
Download or read book DHEA and the Brain written by Robert Morfin and published by CRC Press. This book was released on 2002-04-25 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: DHEA and the Brain reviews a range of existing studies regarding DHEA administration to animals and humans. Chapter authors evaluate DHEA metabolism in tissues and organs, explore DHEA effects in the liver that may be of importance to the brain, and discuss recent findings regarding how DHEA is made in the brain. New perspectives about the neuropro
Book Synopsis DHEA in Human Health and Aging by : Ronald Ross Watson
Download or read book DHEA in Human Health and Aging written by Ronald Ross Watson and published by CRC Press. This book was released on 2011-07-22 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reduced production of DHEA associated with the diseases that accompany aging has led to its use as a nutritional supplement for antiaging, metabolic support, and other purposes. While animal studies have clearly shown substantial benefits of DHEA in combating various disease states, the effect of low levels of DHEA in humans is less established, an
Book Synopsis Basic Medical Endocrinology by : H. Maurice Goodman
Download or read book Basic Medical Endocrinology written by H. Maurice Goodman and published by Lippincott Williams & Wilkins. This book was released on 1994 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Androgens in Gynecological Practice by : Leo Plouffe (Jr.)
Download or read book Androgens in Gynecological Practice written by Leo Plouffe (Jr.) and published by Cambridge University Press. This book was released on 2015-06-25 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical approach to the field of androgen excess or deprivation in women's health. The content includes multiple viewpoints on the most common disorders in this class, such as polycystic ovary disease, hirsutism and menopausal issues. Each chapter provides a combination of long-lasting clinical principles in the diagnosis and management of these patients along with a state-of-the-art review. This text takes an innovative approach to uncommon conditions (such as congenital adrenal hyperplasia, transgender conditions). In addition to presenting clinical insights, and a review of the basic science underpinning these conditions, it focuses on key concepts that can be derived from these rare conditions to the entire field. This book is an essential addition to the library for any busy clinician who is looking for a practical reference guide but also for the sub-specialist who is looking for new and thought-provoking insights in this complex scientific area.
Book Synopsis Goodman's Basic Medical Endocrinology by : Elizabeth H. Holt
Download or read book Goodman's Basic Medical Endocrinology written by Elizabeth H. Holt and published by Academic Press. This book was released on 2021-02-21 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: Goodman's Basic Medical Endocrinology, Fifth Edition, has been student tested and approved for decades. This essential textbook provides up-to-date coverage of rapidly unfolding advances in the understanding of hormones involved in regulating most aspects of bodily functions. It is richly illustrated in full color with both descriptive schematic diagrams and laboratory findings obtained in clinical studies. This is a classic reference for moving forward into advanced study. Clinical case studies in every chapter E-book version available with every copy for obtaining images and tables for lectures or notes Clinicians added as co-authors to enhance usefulness by physicians and medical students and residents Detailed molecular biology of hormones and hormone action for graduate and advanced undergraduate students Expanded and updated color images emphasizing hormone action at the molecular level In-depth molecular biology and clinical sections boxed for ease of access
Book Synopsis Handbook of Hormones by : Yoshio Takei
Download or read book Handbook of Hormones written by Yoshio Takei and published by Academic Press. This book was released on 2015-08-26 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research collates fundamental information about the structure and function of hormones from basic biology to clinical use. The handbook offers a rapid way to obtain specific facts about the chemical and molecular characteristics of hormones, their receptors and signalling pathways, and the biological activities they regulate. The evolution of hormones and gene families is also covered both in the text and in online ancillaries. Users will find simple and visual ways to learn key molecular information. Chapters and online ancillary resources integrate additional sections, providing a comparative molecular, functional, and evolutionary consideration. Provides the only single resource available with concise, yet informative descriptions of hormones in vertebrates, invertebrates, and plants Presents hormones in groups according to their origin, so that readers can easily understand their inter-relation Includes comparative information on the structures and functions of hormones enabling readers to understand both general and specific actions in and across species Ancillary website hosts additional information, including sequence data, comparative data, figures, and tables
Book Synopsis The Hypothalamus-Pituitary-Adrenal Axis by :
Download or read book The Hypothalamus-Pituitary-Adrenal Axis written by and published by Elsevier. This book was released on 2008-09-12 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: The hypothalamic-pituitary-adrenal axis controls reactions to stress and regulates various body processes such as digestion, the immune system, mood and sexuality, and energy usage. This volume focuses on the role it plays in the immune system and provides substantive experimental and clinical data to support current understanding in the field, and potential applications of this knowledge in the treatment of disease. Evidence presented in this book suggests that the nervous, endocrine, and immune systems form the Neuroendoimmune Supersystem, which integrates all the biological functions of higher organisms both in health and disease for their entire life cycle Contributors include both the scientists who initiated the work on the HPA axis and on the autonomic nervous system, and those who joined the field later
Book Synopsis Clinical Gynecology by : Eric J. Bieber
Download or read book Clinical Gynecology written by Eric J. Bieber and published by Cambridge University Press. This book was released on 2015-04-23 with total page 1127 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written with the busy practice in mind, this book delivers clinically focused, evidence-based gynecology guidance in a quick-reference format. It explores etiology, screening, tests, diagnosis, and treatment for a full range of gynecologic health issues. The coverage includes the full range of gynecologic malignancies, reproductive endocrinology and infertility, infectious diseases, urogynecologic problems, gynecologic concerns in children and adolescents, and surgical interventions including minimally invasive surgical procedures. Information is easy to find and absorb owing to the extensive use of full-color diagrams, algorithms, and illustrations. The new edition has been expanded to include aspects of gynecology important in international and resource-poor settings.
