Dancing Protein Clouds Intrinsically Disordered Proteins In Health And Disease Part A

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Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology

Author : Vladimir Uversky
Publisher : Academic Press
ISBN 13 : 012816851X
Total Pages : 426 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology by : Vladimir Uversky

Download or read book Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology written by Vladimir Uversky and published by Academic Press. This book was released on 2019-09-15 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain. Provides some recent studies on the intrinsically disordered proteins and their functions, as well as on the involvement of intrinsically disordered proteins in pthogenesis of various diseases Contains numerous illustrative materials (color figures, diagrams, and tables) to help the readers to delve in the information provided Includes contributions from recognized experts in the field

Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B

Author :
Publisher : Academic Press
ISBN 13 : 0128226048
Total Pages : 406 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B by :

Download or read book Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B written by and published by Academic Press. This book was released on 2020-08-19 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B, represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain. - Provides some recent studies on the intrinsically disordered proteins and their functions, as well as on the involvement of intrinsically disordered proteins in pthogenesis of various diseases - Contains numerous illustrative materials (color figures, diagrams, and tables) to help the readers to delve in the information provided - Includes contributions from recognized experts in the field

Dancing protein clouds: Intrinsically disordered proteins in health and disease, Part A

Author :
Publisher : Academic Press
ISBN 13 : 9780128168516
Total Pages : 0 pages
Book Rating : 4.1/5 (685 download)

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Book Synopsis Dancing protein clouds: Intrinsically disordered proteins in health and disease, Part A by :

Download or read book Dancing protein clouds: Intrinsically disordered proteins in health and disease, Part A written by and published by Academic Press. This book was released on 2019-09-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain.

Dancing protein clouds: Intrinsically disordered proteins in health and disease, Part A

Author :
Publisher : Academic Press
ISBN 13 : 0128168528
Total Pages : 428 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Dancing protein clouds: Intrinsically disordered proteins in health and disease, Part A by :

Download or read book Dancing protein clouds: Intrinsically disordered proteins in health and disease, Part A written by and published by Academic Press. This book was released on 2019-09-11 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain. Provides some recent studies on the intrinsically disordered proteins and their functions, as well as on the involvement of intrinsically disordered proteins in pthogenesis of various diseases Contains numerous illustrative materials (color figures, diagrams, and tables) to help the readers to delve in the information provided Includes contributions from recognized experts in the field

Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C

Author :
Publisher : Academic Press
ISBN 13 : 0323853005
Total Pages : 438 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C by :

Download or read book Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C written by and published by Academic Press. This book was released on 2021-10-14 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C, Volume 183 represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this volume include discussions on the evolution of disorder, consideration of the peculiarities of phase separation of the prion protein, a general discussion of the relationships between intrinsic disorder and protein functions, coverage of the structural and functional characterization of several important intrinsically disordered proteins, such as transcription factors, outer membrane porins, trans-membrane and membrane associated proteins with ID regions, discussion of molecular simulations of IDPs, and much more. Provides recent studies on the intrinsically disordered proteins and their functions, along with the involvement of intrinsically disordered proteins in the pathogenesis of various diseases Contains numerous illustrative materials (color figures, diagrams and tables) to help readers delve into the information provided Includes contributions from recognized experts in the field

Amino Acids, Peptides and Proteins

Author : Maxim Ryadnov
Publisher : Royal Society of Chemistry
ISBN 13 : 1788017005
Total Pages : 189 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Amino Acids, Peptides and Proteins by : Maxim Ryadnov

Download or read book Amino Acids, Peptides and Proteins written by Maxim Ryadnov and published by Royal Society of Chemistry. This book was released on 2020-12-07 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Amino Acids, Peptides and Proteins is a broad ranging title comprising comprehensive and critical reviews of significant developments at the biology and chemistry interface. Compiled by leading researchers in their subject, this volume incorporates current trends and emerging areas in topics ranging from enzymatic halogenation, unnatural amino acids in peptide and protein chemistry and detection of protein post-translational modifications by mass spectrometry. Appealing broadly to researchers in academia and industry, it will be of great benefit to any researcher wanting a succinct reference in this field and looking at the future.

Amino Acids, Peptides and Proteins Volume 44

Author : Maxim Ryadnov
Publisher : Royal Society of Chemistry
ISBN 13 : 1788016890
Total Pages : 189 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Amino Acids, Peptides and Proteins Volume 44 by : Maxim Ryadnov

Download or read book Amino Acids, Peptides and Proteins Volume 44 written by Maxim Ryadnov and published by Royal Society of Chemistry. This book was released on 2020-12-08 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Compiled by leading researchers, Amino Acids, Peptides and Proteins is a broad ranging title comprising comprehensive and critical reviews of significant developments at the biology and chemistry interface.

Intrinsically Disordered Proteins

Author : Vladimir N. Uversky
Publisher : Springer
ISBN 13 : 3319089218
Total Pages : 73 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Intrinsically Disordered Proteins by : Vladimir N. Uversky

Download or read book Intrinsically Disordered Proteins written by Vladimir N. Uversky and published by Springer. This book was released on 2014-08-05 with total page 73 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on to describe the peculiar amino acid sequences of IDPs, their structural heterogeneity, typical functions and disorder-based binding modes. In the final sections, Uversky discusses IDPs in human diseases and as potential drug targets. This volume provides a snapshot to researchers entering the field as well as providing a current overview for more experienced scientists in related areas.

Intrinsically Disordered Proteins

Author :
Publisher : Academic Press
ISBN 13 : 0128156503
Total Pages : 756 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Intrinsically Disordered Proteins by :

Download or read book Intrinsically Disordered Proteins written by and published by Academic Press. This book was released on 2018-11-21 with total page 756 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intrinsically Disordered Proteins, Volume 611, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics of interest, including the Characterization of Structure-Function relationships in the intrinsically disordered protein complexin, Distances, distance distributions, and ensembles of IDPs from single-molecule FRET, Biophysical characterization of disordered protein liquid phases, The Use of Mass Spectrometry to Examine IDPs – Unique Insights and Caveats, Fluorescence Depolarization Kinetics to Study Conformational Preference, Structural Plasticity and Membrane Binding of Intrinsically Disordered Proteins, Characterizing the Function of Intrinsically Disordered Proteins in the Circadian Clock, and more. - Breadth of experimental approaches and systems that will be covered - The expertise of the contributors writing the articles

Intrinsically Disordered Proteins (IDPs)

Author : Violet Weber
Publisher : Nova Science Publishers
ISBN 13 : 9781634844079
Total Pages : 0 pages
Book Rating : 4.8/5 (44 download)

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Book Synopsis Intrinsically Disordered Proteins (IDPs) by : Violet Weber

Download or read book Intrinsically Disordered Proteins (IDPs) written by Violet Weber and published by Nova Science Publishers. This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intrinsically disordered proteins (IDPs) are biomolecules that do not have a definite 3D structure; their role in the biochemical network of a cell relates to their ability to switch rapidly among different secondary and tertiary structures. The emergence of IDPs has challenged the classical protein structure-function paradigm. IDPs play an important role in cellular regulation, signaling and control in health and disease. However, the unusual biophysics of these proteins makes structural characterisation of IDPs and their complexes not only challenging but often resulting in opposite conclusions. This book studies the structural characterisation and future directions of IDPs. Chapter One focuses on the DNA-binding IDPs and how intrinsic disorder affects their function. Chapter Two discusses the use of a computer atomistic simulation for the structural analysis of IDPs. The final chapter, Chapter Three, examines two long-standing contradictions concerning dimerisation and membrane-binding activities of IDPs; provides an explanation of these discrepancies; and demonstrates how the resolution of these critical issues in the field results in the expanded understanding of cell function with multiple applications in biology and medicine.

Structure and Function of Intrinsically Disordered Proteins

Author : Peter Tompa
Publisher : CRC Press
ISBN 13 : 1420078933
Total Pages : 362 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Structure and Function of Intrinsically Disordered Proteins by : Peter Tompa

Download or read book Structure and Function of Intrinsically Disordered Proteins written by Peter Tompa and published by CRC Press. This book was released on 2009-11-18 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: The existence and functioning of intrinsically disordered proteins (IDPs) challenge the classical structure-function paradigm that equates function with a well-defined 3D structure. Uncovering the disordered complement of proteomes and understanding their functioning can extend the structure-function paradigm to herald new breakthroughs in drug dev

Flexible Viruses

Author : Vladimir Uversky
Publisher : John Wiley & Sons
ISBN 13 : 0470618310
Total Pages : 532 pages
Book Rating : 4.4/5 (76 download)

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Book Synopsis Flexible Viruses by : Vladimir Uversky

Download or read book Flexible Viruses written by Vladimir Uversky and published by John Wiley & Sons. This book was released on 2012-02-07 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides up-to-date information on experimental and computational characterization of the structural and functional properties of viral proteins, which are widely involved in regulatory and signaling processes. With chapters by leading research groups, it features current information on the structural and functional roles of intrinsic disorders in viral proteomes. It systematically addresses the measles, HIV, influenza, potato virus, forest virus, bovine virus, hepatitis, and rotavirus as well as viral genomics. After analyzing the unique features of each class of viral proteins, future directions for research and disease management are presented.

Biodiversity and Human Health

Author : Francesca Grifo
Publisher : Island Press
ISBN 13 : 9781559635004
Total Pages : 0 pages
Book Rating : 4.6/5 (35 download)

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Book Synopsis Biodiversity and Human Health by : Francesca Grifo

Download or read book Biodiversity and Human Health written by Francesca Grifo and published by Island Press. This book was released on 1997-02-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The implications of biodiversity loss for the global environment have been widely discussed, but only recently has attention been paid to its direct and serious effects on human health. Biodiversity loss affects the spread of human diseases, causes a loss of medical models, diminishes the supplies of raw materials for drug discovery and biotechnology, and threatens food production and water quality. Biodiversity and Human Health brings together leading thinkers on the global environment and biomedicine to explore the human health consequences of the loss of biological diversity. Based on a two-day conference sponsored by the National Institutes of Health, the National Science Foundation, and the Smithsonian Institution, the book opens a dialogue among experts from the fields of public health, biology, epidemiology, botany, ecology, demography, and pharmacology on this vital but often neglected concern. Contributors discuss the uses and significance of biodiversity to the practice of medicine today, and develop strategies for conservation of these critical resources. Topics examined include: the causes and consequences of biodiversity loss emerging infectious diseases and the loss of biodiversity the significance and use of both prescription and herbal biodiversity-derived remedies indigenous and local peoples and their health care systems sustainable use of biodiversity for medicine an agenda for the future In addition to the editors, contributors include Anthony Artuso, Byron Bailey, Jensa Bell, Bhaswati Bhattacharya, Michael Boyd, Mary S. Campbell, Eric Chivian, Paul Cox, Gordon Cragg, Andrew Dobson, Kate Duffy-Mazan, Robert Engelman, Paul Epstein, Alexandra S. Fairfield, John Grupenhoff, Daniel Janzen, Catherine A. Laughin, Katy Moran, Robert McCaleb, Thomas Mays, David Newman, Charles Peters, Walter Reid, and John Vandermeer. The book provides a common framework for physicians and biomedical researchers who wish to learn more about environmental concerns, and for members of the environmental community who desire a greater understanding of biomedical issues.

The Lives of a Cell

Author : Lewis Thomas
Publisher : Penguin
ISBN 13 : 1101667052
Total Pages : 162 pages
Book Rating : 4.1/5 (16 download)

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Book Synopsis The Lives of a Cell by : Lewis Thomas

Download or read book The Lives of a Cell written by Lewis Thomas and published by Penguin. This book was released on 1978-02-23 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Elegant, suggestive, and clarifying, Lewis Thomas's profoundly humane vision explores the world around us and examines the complex interdependence of all things. Extending beyond the usual limitations of biological science and into a vast and wondrous world of hidden relationships, this provocative book explores in personal, poetic essays to topics such as computers, germs, language, music, death, insects, and medicine. Lewis Thomas writes, "Once you have become permanently startled, as I am, by the realization that we are a social species, you tend to keep an eye out for the pieces of evidence that this is, by and large, good for us."

Sophie's World

Author : Jostein Gaarder
Publisher : Farrar, Straus and Giroux
ISBN 13 : 1466804270
Total Pages : 735 pages
Book Rating : 4.4/5 (668 download)

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Book Synopsis Sophie's World by : Jostein Gaarder

Download or read book Sophie's World written by Jostein Gaarder and published by Farrar, Straus and Giroux. This book was released on 2007-03-20 with total page 735 pages. Available in PDF, EPUB and Kindle. Book excerpt: A page-turning novel that is also an exploration of the great philosophical concepts of Western thought, Jostein Gaarder's Sophie's World has fired the imagination of readers all over the world, with more than twenty million copies in print. One day fourteen-year-old Sophie Amundsen comes home from school to find in her mailbox two notes, with one question on each: "Who are you?" and "Where does the world come from?" From that irresistible beginning, Sophie becomes obsessed with questions that take her far beyond what she knows of her Norwegian village. Through those letters, she enrolls in a kind of correspondence course, covering Socrates to Sartre, with a mysterious philosopher, while receiving letters addressed to another girl. Who is Hilde? And why does her mail keep turning up? To unravel this riddle, Sophie must use the philosophy she is learning—but the truth turns out to be far more complicated than she could have imagined.

The Emperor of All Maladies

Author : Siddhartha Mukherjee
Publisher : Simon and Schuster
ISBN 13 : 1439170916
Total Pages : 624 pages
Book Rating : 4.4/5 (391 download)

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Book Synopsis The Emperor of All Maladies by : Siddhartha Mukherjee

Download or read book The Emperor of All Maladies written by Siddhartha Mukherjee and published by Simon and Schuster. This book was released on 2011-08-09 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: Winner of the Pulitzer Prize and a documentary from Ken Burns on PBS, this New York Times bestseller is “an extraordinary achievement” (The New Yorker)—a magnificent, profoundly humane “biography” of cancer—from its first documented appearances thousands of years ago through the epic battles in the twentieth century to cure, control, and conquer it to a radical new understanding of its essence. Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with—and perished from—for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.

The 2030 Spike

Author : Colin Mason
Publisher : Routledge
ISBN 13 : 1136555110
Total Pages : 256 pages
Book Rating : 4.1/5 (365 download)

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Book Synopsis The 2030 Spike by : Colin Mason

Download or read book The 2030 Spike written by Colin Mason and published by Routledge. This book was released on 2013-06-17 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: The clock is relentlessly ticking! Our world teeters on a knife-edge between a peaceful and prosperous future for all, and a dark winter of death and destruction that threatens to smother the light of civilization. Within 30 years, in the 2030 decade, six powerful 'drivers' will converge with unprecedented force in a statistical spike that could tear humanity apart and plunge the world into a new Dark Age. Depleted fuel supplies, massive population growth, poverty, global climate change, famine, growing water shortages and international lawlessness are on a crash course with potentially catastrophic consequences. In the face of both doomsaying and denial over the state of our world, Colin Mason cuts through the rhetoric and reams of conflicting data to muster the evidence to illustrate a broad picture of the world as it is, and our possible futures. Ultimately his message is clear; we must act decisively, collectively and immediately to alter the trajectory of humanity away from catastrophe. Offering over 100 priorities for immediate action, The 2030 Spike serves as a guidebook for humanity through the treacherous minefields and wastelands ahead to a bright, peaceful and prosperous future in which all humans have the opportunity to thrive and build a better civilization. This book is powerful and essential reading for all people concerned with the future of humanity and planet earth.