Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases

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Publisher : Springer Science & Business Media
ISBN 13 : 3540376739
Total Pages : 225 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases by : R. Numerof

Download or read book Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases written by R. Numerof and published by Springer Science & Business Media. This book was released on 2007-01-19 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytokines and cytokine receptors remain an area of great interest for the development of targeted therapies for cutaneous inflammatory diseases. Anti-TNF therapeutics have proven to be effective in the treatment of psoriasis, and clinical investigations have now begun for other cytokine-directed therapies, such as those targeting IFN-g, IL-12p40, and IL-18. In addition to therapeutics that target cytokines directly, strategies that target cytokine signaling pathways are in development. This book summarizes the findings of the 56th International Workshop of the Ernst Schering Research Foundation that focused on "Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases".

Targeting Human Inflammatory Skin Diseases With Natural Products: Exploring Potential Mechanisms and Regulatory Pathways

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Publisher : Frontiers Media SA
ISBN 13 : 2889719936
Total Pages : 157 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Targeting Human Inflammatory Skin Diseases With Natural Products: Exploring Potential Mechanisms and Regulatory Pathways by : Bey Hing Goh

Download or read book Targeting Human Inflammatory Skin Diseases With Natural Products: Exploring Potential Mechanisms and Regulatory Pathways written by Bey Hing Goh and published by Frontiers Media SA. This book was released on 2022-01-07 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Clinical Applications of Cytokines

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Publisher : Oxford University Press, USA
ISBN 13 : 9780195071290
Total Pages : 406 pages
Book Rating : 4.0/5 (712 download)

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Book Synopsis Clinical Applications of Cytokines by : Joost J. Oppenheim

Download or read book Clinical Applications of Cytokines written by Joost J. Oppenheim and published by Oxford University Press, USA. This book was released on 1993 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: The driving force for research on cytokines has always been their clinical promise. Their biological properties suggested a key role in hematopoiesis, immunity, tumor genesis, hemostasis, vascularization, repair of connective tissues and integration of the immune system with the neuroendocrine system. Animal studies have shown that cytokines could be used as effective biotherapeutics with easily manageable and reversible toxicities. Clinical trials have confirmed these findings, culminating in the licensing of a number of the cytokines such as interferon alpha, interferon gamma, interleukin 2, erythropoietin, granulocyte colony stimulating factor, and granulocyte-macrophage colony stimulating factor. Many other cytokines are in clinical trials. This is the first comprehensive volume on the cytokines written primarily from a medical perspective. After presenting background information about the structure, production, assays and systemic effects of cytokines and their receptors, it is organized around diseases and organ systems. Infectious diseases, autoimmunity, immunodeficiency states, defective hematopoiesis, allergies, injury repair, cancer, vascular and skin diseases, and neurological disorders are all covered. This work reviews the role that cytokines play in the pathogenesis, diagnosis and therapy of each disease. The authors assess both the current state of the art and the potential for future applications.

Cytokine Frontiers

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Publisher : Springer Science & Business Media
ISBN 13 : 4431544429
Total Pages : 398 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Cytokine Frontiers by : Takayuki Yoshimoto

Download or read book Cytokine Frontiers written by Takayuki Yoshimoto and published by Springer Science & Business Media. This book was released on 2013-10-28 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book guides the reader through the latest research on the cytokine network, covering signaling pathways, control of the immune response, and potential therapeutics. Different cytokines stimulate diverse responses in various phases of inflammation and immunity, including the innate immune response, the generation of effector T cells, and the development of antibodies by the humoral immune system. It is now clear that the pathophysiology of many infectious, autoimmune, allergic, and malignant diseases can be largely explained by which cytokines are induced and subsequently regulate the cellular responses. In clinical medicine, cytokines are involved in a wide spectrum of diseases. This book describes in three parts the properties and roles of 15 key cytokines under physiological and pathological conditions. Part I presents nine cytokines associated with inflammatory disorders, pro-inflammatory cytokines, and the recently identified new helper T (Th) subset: Th17 cells. Part II gives details of three cytokines associated with allergic disorders, including Th2 responses and recently identified types of innate cells. Part III describes three cytokines that are associated with immunological tolerance and anti-inflammation, including regulatory T (Treg) cells, IL-10-producing Treg (Tr1) cells, and inducible IL-35-producing Treg (iTr35) cells. Cytokines are considered to be important as therapeutic targets for specific agonists or antagonists in numerous immune and inflammatory diseases. The ultimate goal of this book is to facilitate the development of therapeutic treatments for such diseases which has been limited by an insufficient understanding of the biology of cytokines and the complicated network that they create.

Itch

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Publisher : CRC Press
ISBN 13 : 1466505435
Total Pages : 482 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Itch by : E. Carstens

Download or read book Itch written by E. Carstens and published by CRC Press. This book was released on 2014-02-25 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.

Innovative Medicine

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Publisher : Springer
ISBN 13 : 4431556516
Total Pages : 330 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Innovative Medicine by : Kazuwa Nakao

Download or read book Innovative Medicine written by Kazuwa Nakao and published by Springer. This book was released on 2015-10-13 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Moderate to Severe Psoriasis, Fourth Edition

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Publisher : CRC Press
ISBN 13 : 1482215160
Total Pages : 422 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Moderate to Severe Psoriasis, Fourth Edition by : John Y. M. Koo

Download or read book Moderate to Severe Psoriasis, Fourth Edition written by John Y. M. Koo and published by CRC Press. This book was released on 2014-03-18 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by experts in the dermatology field, this new fourth edition of Moderate-to-Severe Psoriasis discusses the current use of biologics and other pharmacologic and phototherapy treatments for moderate-to-severe psoriasis. Illustrated with high quality color figures, this standalone text emphasizes safe and effective treatments for the psoriasis patient that are perfect for the dermatologist in daily practice. New to this edition are chapters on day treatment programs, new agents, erythrodermic and pustular psoriasis, special populations, and pharmacogenetics.

Skin Autoimmunity

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Publisher : Frontiers Media SA
ISBN 13 : 2889668096
Total Pages : 754 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Skin Autoimmunity by : Ralf J. Ludwig

Download or read book Skin Autoimmunity written by Ralf J. Ludwig and published by Frontiers Media SA. This book was released on 2021-05-25 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Altered Expression of Proteins in Cancer: Function and Potential Therapeutic Targets, Volume II

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Publisher : Frontiers Media SA
ISBN 13 : 283253144X
Total Pages : 224 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Altered Expression of Proteins in Cancer: Function and Potential Therapeutic Targets, Volume II by : João Pessoa

Download or read book Altered Expression of Proteins in Cancer: Function and Potential Therapeutic Targets, Volume II written by João Pessoa and published by Frontiers Media SA. This book was released on 2023-08-02 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:

TNF-alpha Inhibitors

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Publisher : Springer Science & Business Media
ISBN 13 : 3764374381
Total Pages : 136 pages
Book Rating : 4.7/5 (643 download)

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Book Synopsis TNF-alpha Inhibitors by : Jeffrey M. Weinberg

Download or read book TNF-alpha Inhibitors written by Jeffrey M. Weinberg and published by Springer Science & Business Media. This book was released on 2006-08-08 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a comprehensive overview of the development, pharmacology, efficacy, and safety of the currently available TNF-alpha inhibitors. It is the first volume that summarizes this material for all available TNF-alpha inhibitors. Elevated levels of TNF-alpha have been demonstrated in Crohn's disease, psoriasis, psoriatic arthritis, and rheumatoid arthritis, suggesting a role for TNF-alpha in their pathogenesis. The most recent preclinical and clinical data is presented in this book.

Cooperation of Liver Cells in Health and Disease

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Publisher : Springer Science & Business Media
ISBN 13 : 3642565530
Total Pages : 154 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Cooperation of Liver Cells in Health and Disease by : Z. Kmiec

Download or read book Cooperation of Liver Cells in Health and Disease written by Z. Kmiec and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.

Interleukins in Cancer Biology

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Publisher : Academic Press
ISBN 13 : 0128013338
Total Pages : 361 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Interleukins in Cancer Biology by : Arseniy Yuzhalin

Download or read book Interleukins in Cancer Biology written by Arseniy Yuzhalin and published by Academic Press. This book was released on 2014-06-27 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interleukins in Cancer Biology responds to the growing need for credible and up-to-date information about the impact of interleukins on occurrence, development and progression of cancer. It provides reliable information about all known interleukins (38), describes recent discoveries in the field, and moreover, suggests further directions of research on the most promising aspects of this topic. The structure and presentation of the work is very understandable and clear with attention to detail maintained throughout. There are multiple illustrations throughout to help in comprehending and remembering the most important facts. . Summarizes and discusses existing facts on the impact of all known interleukins in occurrence, development, and progression of cancer Categorizes and clarifies all interleukins based on their role in cancer Contains comprehensive and exhaustive information on each molecule

Pharmacology of Immunotherapeutic Drugs

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Publisher : Springer Nature
ISBN 13 : 3030199223
Total Pages : 399 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Pharmacology of Immunotherapeutic Drugs by : Clinton B. Mathias

Download or read book Pharmacology of Immunotherapeutic Drugs written by Clinton B. Mathias and published by Springer Nature. This book was released on 2019-10-18 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicine has entered a golden age in which therapeutic agents are becoming widely available due to advances in basic science and technology. As such, many drugs have been developed that target inflammatory processes and/or the immune system. This book is intended for health professionals examining the modulation of inflammation by immunotherapeutic drugs. The immune system fills the primordial role of host defense and resistance to infections with pathogenic microorganisms. Several hematopoietic-derived cells constituting the innate and adaptive immune systems cooperate to provide barriers for microbial colonization and/or promote pathogen destruction within the host. Conversely, many immune cells are also involved in the pathogenesis and propagation of chronic inflammatory diseases. The beginning of this book details various components of the immune system including the cell types, lymphoid tissues, soluble cytokines and surface molecules that are essential for host defense. Breakdowns in immune tolerance, or dysregulated immune responses to antigens derived from self tissues or innocuous sources, can lead to the development of autoimmunity or chronic inflammatory diseases. Pathophysiologic roles for the immune system are detailed in corresponding chapters on autoimmunity, epithelial surfaces (lungs, skin, intestine), and transplantation, with special emphasis placed on immunotherapeutic drug targets. The last section of the book focuses on treatments that stimulate our immune system to specifically target and fight infectious diseases and cancer. In each chapter, the medications used to treat various diseases/conditions in terms of their mechanism of action and other pharmacologic properties are detailed. Chapters begin with a table showing drug names and classifications. The importance of basic science and clinical trials cannot be understated in the context of drug development. As such, the discovery of certain medications that had a lasting impact in medicine and pharmacy are highlighted in chapter subsections named “Bench to Bedside.” Several clinical applications of immunotherapeutic drugs are described within end-of -chapter case studies including practice questions. The Pharmacology of Immunotherapeutic Drugs is a reference for immunologists and clinicians (medical doctors, pharmacists, nurses) examining the modulation of inflammatory processes by a variety of medications targeting the cells and mediators of our immune system.​

Adipose tissue and skeletal muscle as endocrine organs: role of cytokines in health and disease

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2832509878
Total Pages : 165 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Adipose tissue and skeletal muscle as endocrine organs: role of cytokines in health and disease by : Ana Cláudia Garcia De Oliveira Duarte

Download or read book Adipose tissue and skeletal muscle as endocrine organs: role of cytokines in health and disease written by Ana Cláudia Garcia De Oliveira Duarte and published by Frontiers Media SA. This book was released on 2022-12-29 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Principles of Cancer Biotherapy

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Publisher : Springer Science & Business Media
ISBN 13 : 9048122899
Total Pages : 743 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Principles of Cancer Biotherapy by : Robert K. Oldham

Download or read book Principles of Cancer Biotherapy written by Robert K. Oldham and published by Springer Science & Business Media. This book was released on 2009-08-29 with total page 743 pages. Available in PDF, EPUB and Kindle. Book excerpt: At the time of the first edition of Principles of Cancer Biotherapy in 1987, this book represented the first comprehensive textbook on biological therapy. In 1991, when the second edition was published, there was still some doubt on the part of many oncologists and cancer researchers as to the therapeutic value of these new approaches. By 2003 and the fourth edition, it was generally agreed that biopharmaceuticals were producing major opportunities for new cancer therapies. Cancer biotherapy has now truly matured into the fourth modality of cancer treatment. This fifth revised edition describes the tremendous progress that has been made in recent years using biologicals in cancer treatment. This book summarizes an evolving science and a rapidly changing medical practice in biotherapy. In this new millennium, it is now possible to envision a much more diversified system of cancer research and treatment that will afford greater opportunities for a patient’s personalized cancer treatment. This was first envisioned in the 1987 initial edition of this textbook and is now a “new” and popular approach to cancer treatment. Some forms of cancer biotherapy use the strategy of tumor stabilization and control through continued biological therapy, akin to the use of insulin in the treatment of diabetes. This textbook illustrates new methods of thinking and new strategies for control of cancer. It is always difficult to move from past dogma to future opportunity, but this fifth edition of Principles of Cancer Biotherapy illustrates why it is so important to the patients for researchers and clinicians to explore and quickly apply these new opportunities in cancer biotherapy.

Clinical Diagnosis: Chronic Inflammatory Skin Diseases

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Author :
Publisher : Rila Publications Ltd
ISBN 13 : 9781899839032
Total Pages : 76 pages
Book Rating : 4.8/5 (39 download)

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Book Synopsis Clinical Diagnosis: Chronic Inflammatory Skin Diseases by :

Download or read book Clinical Diagnosis: Chronic Inflammatory Skin Diseases written by and published by Rila Publications Ltd. This book was released on 1998 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Insights in Dermatology: 2021

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Publisher : Frontiers Media SA
ISBN 13 : 2889763455
Total Pages : 203 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Insights in Dermatology: 2021 by : Robert Gniadecki

Download or read book Insights in Dermatology: 2021 written by Robert Gniadecki and published by Frontiers Media SA. This book was released on 2022-07-06 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: