Cyclic Nucleotides

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Cyclic Nucleotides

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Author : J. A. Nathanson
Publisher : Springer Science & Business Media
ISBN 13 : 3642681115
Total Pages : 570 pages
Book Rating : 4.6/5 (426 download)

Book Synopsis Cyclic Nucleotides by : J. A. Nathanson

Download or read book Cyclic Nucleotides written by J. A. Nathanson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of the present volume, the first of two on the pharmacology, biochemistry, and physiology of cyclic nucleotides, is to provide a comprehensive and up-to-date anthology on the nature and role of these important chemical regulators. Each of the chapters is the work of internationally known researchers who present a lucid and detailed review of their subject and not merely a single laboratory's viewpoint. The chapters emphasize critical assessments of the field rather than mere listings of experimental findings. By so doing, the contributors present the role of cyclic nucleotides in relationship to other intracellular regulators. Each chapter begins with a detailed summary to allow the reader to obtain a rapid overview of subsequent material. In addition, there are extensive bibliographies and a detailed subject index. Wherever pertinent, the chapters contain sections on drug mechanisms, physiological relevance, and disease processes. The Volume is divided into two sections, each beginning with an overview written by Professors T. W. RALL and P. GREENGARD, respectively. The first section focuses on the detailed pharmacology and chemistry of cyclic nucleotides, including their formation, degradation, measurement, and interaction with various modulatory agents, such as receptors and calcium. The second section is concerned with the biochemistry of protein phosphorylation, a process which appears to be one of the most important mechanisms for the intracellular expression of cyclic nucleotide action in eukaryotic cells.

Non-canonical Cyclic Nucleotides

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Author : Roland Seifert
Publisher : Springer
ISBN 13 : 3319526731
Total Pages : 387 pages
Book Rating : 4.3/5 (195 download)

Book Synopsis Non-canonical Cyclic Nucleotides by : Roland Seifert

Download or read book Non-canonical Cyclic Nucleotides written by Roland Seifert and published by Springer. This book was released on 2017-04-28 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cyclic purine nucleotides 3’,5’-cAMP and 3’,5’-cGMP are well-established second messengers. cGMP has recently been covered in a volume of the Handbook of Experimental Pharmacology (volume 191). In addition to 3’,5’-cAMP and 3’,5’-cGMP, so-called non-canonical cyclic nucleotides exist. These comprise the cyclic pyrimidine nucleotides 3’,5’-cCMP and 3’,5’-cUMP, the purine nucleotide 3’,5’-cIMP, the 2’,3’-nucleoside monophosphates and cyclic dinucleotides. In this volume of the Handbook of Pharmacology, word-leading experts in the field summarize our current knowledge on these non-canonical cyclic nucleotides, discuss open questions, future research directions and the pharmacotherapeutic implications. Special emphasis will be given to the emerging roles of 3’,5’-cCMP and 3’,5’-cUMP as second messengers with regard to generators, effectors, biological functions, inactivation and bacterial toxins. The role of 3’,5’-cIMP as potential second messenger will also be critically discussed. Furthermore, we will consider transport of cyclic nucleotides and their potential role as first messengers. The role of the cyclic dinucleotide cGAMP in the immune system will covered, too. Lastly, the book will present important methodological aspects ranging from mass-spectrometric methods for cyclic nucleotide detection to the synthesis of nucleotide analogs as experimental tools and holistic methods for analysis of cyclic nucleotide effects.

Cyclic Nucleotides in Disease

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Author : Medical College of Pennsylvania
Publisher :
ISBN 13 :
Total Pages : 416 pages
Book Rating : 4.3/5 (91 download)

Book Synopsis Cyclic Nucleotides in Disease by : Medical College of Pennsylvania

Download or read book Cyclic Nucleotides in Disease written by Medical College of Pennsylvania and published by . This book was released on 1975 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cyclic Nucleotides

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Author : P. D. Kebabian
Publisher : Springer Science & Business Media
ISBN 13 : 3642683932
Total Pages : 907 pages
Book Rating : 4.6/5 (426 download)

Book Synopsis Cyclic Nucleotides by : P. D. Kebabian

Download or read book Cyclic Nucleotides written by P. D. Kebabian and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 907 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cyclic nucleotides are intimately involved in the consequences of either stimulation or blockade of receptors; therefore, an understanding of the biochemistry of cyclic nucleotides ought to be important for pharmacologists. Pharmacology is a science that among other things investigates chemical compounds that affect the physiology of cells, tissues and organs. Frequently pharmacologists account for the effect of low concentrations of a drug upon a tissue by invoking the presence of a receptor upon the surface of the cell. Traditional pharmacologists excelled at identifying and classifying the properties of receptors. A. J. CLARK'S monograph in the earlier series of the Handbook of Experimental Pharmacology (CLARK 1937) summarized the mathematics underlying the traditional pharmacological approach towards receptors. By its nature, however, classic pharmacology provided little useful information about the intracellular events occurring as a consequence of occupying a receptor; for example, ALQUIST (1948) identified the beta-adrenocep tor, but he did not provide any insight into how stimulation of the receptor produces tissue-specific physiological responses. The discovery of cyclic AMP by RALL and SUTHERLAND (see RALL, Vol. I) led to biochemical investigations of many different receptors (including ALQUIST'S beta-adrenoceptor) that share a cyclic nucleotide as a common factor in the biochemical mechanisms that translate the occupancy of receptors into physiological effects. Ten years ago, in the introduction to their monograph on cyclic nucleotides, ROBISON et al. (1971) commented on the rapid growth of interest in cyclic nucleotides over the preceding years.

Methods in Cyclic Nucleotide Research

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Author : Mark Chasin
Publisher :
ISBN 13 :
Total Pages : 344 pages
Book Rating : 4.:/5 (319 download)

Book Synopsis Methods in Cyclic Nucleotide Research by : Mark Chasin

Download or read book Methods in Cyclic Nucleotide Research written by Mark Chasin and published by . This book was released on 1972 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cyclic Nucleotide Signaling

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Author : Xiaodong Cheng
Publisher : CRC Press
ISBN 13 : 1482235579
Total Pages : 282 pages
Book Rating : 4.4/5 (822 download)

Book Synopsis Cyclic Nucleotide Signaling by : Xiaodong Cheng

Download or read book Cyclic Nucleotide Signaling written by Xiaodong Cheng and published by CRC Press. This book was released on 2015-05-07 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Showcasing the recent progresses of the field, Cyclic Nucleotide Signaling covers the major tools and methodologies used in various areas of research. The majority of the chapters are protocol oriented, with the goal of providing clear directions for laboratory use. Students and investigators new to the field will find this book particularly inform

Cyclic Nucleotides in the Nervous System

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Author : John Daly
Publisher : Springer Science & Business Media
ISBN 13 : 1461341272
Total Pages : 408 pages
Book Rating : 4.4/5 (613 download)

Book Synopsis Cyclic Nucleotides in the Nervous System by : John Daly

Download or read book Cyclic Nucleotides in the Nervous System written by John Daly and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: The elucidation of the cellular and molecular bases underlying the inte grated function of the central nervous system, both in disease and in health, must ultimately come from the combined efforts of scientists from many disciplines, including biology, chemistry, histology, pathology, physiology, pharmacology, and psychology. Communication between scientists from these various disciplines-vital to the advancement of our understanding of the function of the nervous system-has become more and more difficult in recent years. Both increasing specialization and the incredible increases in publications pertinent to brain research in a wide spectrum of journals, in symposium volumes, in monographs, in abstracts, and in reviews contrib ute to the problems of cross-communication and even of communication within a scientific discipline. Research on the significance of cyclic nucleo tides to the function of nervous systems is particularly illustrative of the communication problem. Since the initial publications by Sutherland, Rall, and Butcher in the late fifties and early sixties on high levels of adenylate cyclase, phosphodiesterases, and cyclic AMP in brain, the ensuing litera ture of this field has expanded exponentially. At the present time, from five to ten publications relevant to cyclic nucleotides and the nervous system appear each week. Indeed, these are minimal numbers based mainly on examination of literature titles and key index words. Many articles concerned with some aspect of central function contain, buried within their text, experiments with or related to cyclic nucleotides.

Microbial Cyclic Di-nucleotide Signaling

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Author :
Publisher :
ISBN 13 : 9783030333096
Total Pages : 640 pages
Book Rating : 4.3/5 (33 download)

Book Synopsis Microbial Cyclic Di-nucleotide Signaling by :

Download or read book Microbial Cyclic Di-nucleotide Signaling written by and published by . This book was released on 2020 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the broad and diverse biological and physiological impacts of established and newly discovered cyclic di-nucleotide second messenger signaling systems, while also providing descriptions of the intriguing biochemical characteristics of multiple turnover enzymes and receptors. The respective chapters discuss the commonalities and diversity of cyclic di-GMP, cyclic di-AMP and recently discovered cyclic GMP-AMP signaling systems in manifold Gram-negative and Gram-positive bacteria. The global human pathogens Mycobacterium tuberculosis, Vibrio cholerae, Salmonella typhimurium, Escherichia coli and Streptococcus pneumoniae, the facultative human pathogen Pseudomonas aeruginosa, global plant pathogens as exemplified by Xanthomonas campestris and Burkholderia spp., and the omnipresent probiotic Lactobacilli, as well as environmentally important photoautotrophic cyanobacteria, the multicellular Myxococcus xanthus, and chemolithotrophic Acidithiobacillus are among the representatives of the microbial kingdom that are described. In turn, the various aspects of bacterial physiology affected by these signaling systems- e.g. biofilm formation and dispersal, the cell cycle, motility, virulence, production of antimicrobials, fundamental metabolism and osmohomeostasis - are discussed in detail in the context of different microorganisms. Dedicated chapters focus on the population diversity of cyclic dinucleotide signaling systems, their tendency to be horizontally transferred, the cyclic di-GMP signaling system in the social amoeba Dictyostelium, honorary cyclic (di)nucleotides, and the development of strategies for interfering with cyclic dinucleotide signaling in order to manipulate microbial behavior. Taken together, the chapters provide an authoritative source of information for a broad readership: beginners and advanced researchers from various disciplines; individuals seeking a broad overview of cyclic di-nucleotide signaling; and those who want to learn more about specific aspects. Also featuring reviews with a forward-looking perspective, the book offers a valuable source of inspiration for future research directions.

Cyclic Nucleotide Phosphodiesterases in Health and Disease

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Author : Joseph A. Beavo
Publisher : CRC Press
ISBN 13 : 1420020846
Total Pages : 728 pages
Book Rating : 4.4/5 (2 download)

Book Synopsis Cyclic Nucleotide Phosphodiesterases in Health and Disease by : Joseph A. Beavo

Download or read book Cyclic Nucleotide Phosphodiesterases in Health and Disease written by Joseph A. Beavo and published by CRC Press. This book was released on 2006-12-05 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research. Cyclic Nucleotide Phosph

ICRDB Cancergram

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Author :
Publisher :
ISBN 13 :
Total Pages : 24 pages
Book Rating : 4.:/5 (3 download)

Book Synopsis ICRDB Cancergram by :

Download or read book ICRDB Cancergram written by and published by . This book was released on 1978 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cyclic Nucleotides

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Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (99 download)

Book Synopsis Cyclic Nucleotides by :

Download or read book Cyclic Nucleotides written by and published by . This book was released on 1982 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cyclic Nucleotides

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Author : J W Kebabian
Publisher :
ISBN 13 : 9783642681127
Total Pages : 584 pages
Book Rating : 4.6/5 (811 download)

Book Synopsis Cyclic Nucleotides by : J W Kebabian

Download or read book Cyclic Nucleotides written by J W Kebabian and published by . This book was released on 1982-03-01 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cyclic Nucleotide Signaling in Plants

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Author : Chris Gehring
Publisher : Humana Press
ISBN 13 : 9781627034401
Total Pages : 0 pages
Book Rating : 4.0/5 (344 download)

Book Synopsis Cyclic Nucleotide Signaling in Plants by : Chris Gehring

Download or read book Cyclic Nucleotide Signaling in Plants written by Chris Gehring and published by Humana Press. This book was released on 2013-05-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last two decades there has been a growing interest in cyclic nucleotide research in plants with an emphasis on the elucidation of the roles of cGMP and cAMP. In Cyclic Nucleotide Signaling in Plants: Methods and Protocols, expert researchers in the field detail many approaches to better understand the biological role of this important signaling system. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cyclic Nucleotide Signaling in Plants: Methods and Protocols seeks to aid scientist in further understanding signal transduction and the molecular mechanisms underlying cellular signaling.

Cell Physiology Source Book

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Author : Nicholas Sperelakis
Publisher : Elsevier
ISBN 13 : 0080574556
Total Pages : 1262 pages
Book Rating : 4.0/5 (85 download)

Book Synopsis Cell Physiology Source Book by : Nicholas Sperelakis

Download or read book Cell Physiology Source Book written by Nicholas Sperelakis and published by Elsevier. This book was released on 2012-12-02 with total page 1262 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative book gathers together a broad range of ideas and topics that define the field. It provides clear, concise, and comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics. The Third Edition contains substantial new material. Most chapters have been thoroughly reworked. The book includes chapters on important topics such as sensory transduction, the physiology of protozoa and bacteria, the regulation of cell division, and programmed cell death. Completely revised and updated - includes 8 new chapters on such topics as membrane structure, intracellular chloride regulation, transport, sensory receptors, pressure, and olfactory/taste receptors Includes broad coverage of both animal and plant cells Appendixes review basics of the propagation of action potentials, electricity, and cable properties Authored by leading experts in the field Clear, concise, comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics

From Neuroscience to Neurology

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Author : Stephen Waxman
Publisher : Elsevier
ISBN 13 : 0080506984
Total Pages : 552 pages
Book Rating : 4.0/5 (85 download)

Book Synopsis From Neuroscience to Neurology by : Stephen Waxman

Download or read book From Neuroscience to Neurology written by Stephen Waxman and published by Elsevier. This book was released on 2004-11-05 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of neurology is being transformed, from a therapeutically nihilistic discipline with few effective treatments, to a therapeutic specialty which offers new, effective treatments for disorders of the brain and spinal cord. This remarkable transformation has bridged neuroscience, molecular medicine, and clinical investigation, and represents a major triumph for biomedical research. This book, which contains chapters by more than 29 internationally recognized authorities who have made major contributions to neurotherapeutics, tells the stories of how new treatments for disabling disorders of the nervous system, such as stroke, multiple sclerosis, Parkinson’s disease, and migraine, were developed, and explores evolving themes and technologies that offer hope for even more effective treatments and ultimately cures for currently untreatable disorders of the brain and spinal cord. The first part of this book reviews the development of new therapies in neurology, from their inception in terms of basic science to their introduction into the clinical world. It also explores evolving themes and new technologies. This book will be of interest to everyone – clinicians and basic scientists alike – interested in diseases of the brain and spinal cord, and in the quest for new treatments for these disorders. * Presents the evolution of the field of neurology into a therapeutic discipline * Discusses lessons learned from past successes and applications to ongoing work * Explores the future of this field

Cyclic 3', 5'- Nucleotides

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Author : Hinrich Cramer
Publisher : John Wiley & Sons
ISBN 13 :
Total Pages : 576 pages
Book Rating : 4.:/5 (45 download)

Book Synopsis Cyclic 3', 5'- Nucleotides by : Hinrich Cramer

Download or read book Cyclic 3', 5'- Nucleotides written by Hinrich Cramer and published by John Wiley & Sons. This book was released on 1977 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cyclic Nucleotides in the Nervous System

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Author : George I. Drummond
Publisher : New York : Raven Press
ISBN 13 :
Total Pages : 142 pages
Book Rating : 4.3/5 (91 download)

Book Synopsis Cyclic Nucleotides in the Nervous System by : George I. Drummond

Download or read book Cyclic Nucleotides in the Nervous System written by George I. Drummond and published by New York : Raven Press. This book was released on 1984 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: