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Current Protocols In Toxicology Supplement 21
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Book Synopsis Toxicology and Epigenetics by : Saura C. Sahu
Download or read book Toxicology and Epigenetics written by Saura C. Sahu and published by John Wiley & Sons. This book was released on 2012-08-23 with total page 822 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics is the study of both heritable and non-heritable changes in the regulation of gene activity and expression that occur without an alteration in the DNA sequence. This dynamic and rapidly developing discipline is making its impact across the biomedical sciences, in particular in toxicology where epigenetic differences can mean that different individuals respond differently to the same drug or chemical. Toxicology and Epigenetics reflects the multidimensional character of this emerging area of toxicology, describing cutting-edge molecular technologies to unravel epigenetic changes, the use of in vivo and in vitro models, as well as the potential use of toxicological epigenetics in regulatory environments. An international team of experts consider the interplay between epigenetics and toxicology in a number of areas, including environmental, nutritional, pharmacological, and computational toxicology, nanomaterials, proteomics and metabolomics, and cancer research. Topics covered include: environment, epigenetics and diseases DNA methylation and toxicogenomics chromatin at the intersection of disease and therapy epigenomic actions of environmental arsenicals environment, epigenetics and cardiovascular health toxicology, epigenetics and autoimmunity ocular epigenomics: potential sites of environmental impact in development and disease nuclear RNA silencing and related phenomena in animals epigenomics – impact for drug safety sciences methods of global epigenomic profiling transcriptomics: applications in epigenetic toxicology Toxicology and Epigenetics is an essential insight into the current trends and future directions of research in this rapidly expanding field for investigators, toxicologists, risk assessors and regulators in academia, industry and government.
Book Synopsis Advances in Molecular Toxicology by :
Download or read book Advances in Molecular Toxicology written by and published by Elsevier. This book was released on 2012-12-06 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of both progress on the molecular level and on advances in technological approaches employed. - Cutting-edge reviews by leading workers in the discipline - In-depth dissection of molecular aspects of interest to a broad range of scientists, physicians and any student in the allied disciplines - Leading edge applications of technological innovations in chemistry, biochemistry and molecular medicine
Book Synopsis Molecular, Clinical and Environmental Toxicology by : Andreas Luch
Download or read book Molecular, Clinical and Environmental Toxicology written by Andreas Luch and published by Springer Science & Business Media. This book was released on 2012-06-07 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental Toxicology is the third volume of a three-volume set on molecular, clinical and environmental toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals of daily life. By providing intriguing insights far down to the molecular level, this three-volume work covers the entire range of modern toxicology with special emphasis on recent developments and achievements. It is written for students and professionals in medicine, science, public health or engineering who are demanding reliable information on toxic or potentially harmful agents and their adverse effects on the human body.
Book Synopsis Cyclin Dependent Kinase 5 (Cdk5) by : Nancy Y. Ip
Download or read book Cyclin Dependent Kinase 5 (Cdk5) written by Nancy Y. Ip and published by Springer Science & Business Media. This book was released on 2009-02-28 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during both developmental stages and in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may serve as therapeutic treatment for a number of neurodegenerative diseases.
Book Synopsis Insight on Genotoxicity by : Shiv Shankar Shukla
Download or read book Insight on Genotoxicity written by Shiv Shankar Shukla and published by CRC Press. This book was released on 2020-10-14 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic toxicology is considered to be an important assessment tool as there is genetic impact of artificial chemicals. Insight on Genotoxicity discusses testing, mechanism, prediction, and bioindicator of genotoxicity taking into consideration recent advances in nano-engineered particles. Corollary of DNA dent is also discussed in detail taking into consideration the impact of ICH guidelines on genotoxicity testing, which is important for drug discovery innovation and development. Perspective review of genotoxicity evaluation in phytopharmaceuticals has been mentioned along with the prevention of genotoxicity in brief viewpoint. Salient Features Presents methods, standard protocols, and guidelines for genotoxicity testing Examines the impact of ICH Guidelines on genetic toxicity testing which is a regulatory requirement for drug discovery and development Defines appropriate strategies about advances in in vivo genotoxicity testing which have been listed along with progress and prospects Discusses advancement in the high-throughput approaches for genotoxicity testing Details computational prediction of genotoxicity with consideration of mutagenicity, chromosomal damage caused and strategies for computational prediction in drug development
Book Synopsis Small Animal Toxicology Essentials by : Robert H. Poppenga
Download or read book Small Animal Toxicology Essentials written by Robert H. Poppenga and published by John Wiley & Sons. This book was released on 2011-05-31 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a ready reference for the initial triage, collection of diagnostic samples, and management of a poisoning case, Small Animal Toxicology Essentials focuses on the most common poisons encountered by companion animals. From prevention to evaluation, monitoring, and treatment, the book is a guide for veterinary technicians to differentiate between significant and insignificant exposures and effectively manage animal poisonings. Emphasizing clinical signs, differential diagnoses, and case management, the book begins with the principles of veterinary toxicology, such as terminology, history-taking, and decontamination. The second half of the book is devoted to specific toxicants, including plants, metals, drugs, and household poisons. A companion website at www.wiley.com/go/poppenga provides review questions in Word and color images available for download into PowerPoint. Small Animal Toxicology Essentials is a useful resource for veterinary technicians, especially those with a interest in emergency and critical care, and veterinary technician students, as well as practicing veterinarians looking for an introduction to toxicology.
Book Synopsis Handbook of Toxicology by : Michael J. Derelanko
Download or read book Handbook of Toxicology written by Michael J. Derelanko and published by CRC Press. This book was released on 2014-03-07 with total page 1016 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Toxicology, Third Edition provides an updated practical reference source for practicing toxicologists in the pharmaceutical and chemical industries, contract laboratories, regulatory agencies, and academia. Written by experts in their specific toxicology fields, the chapters provide both fundamental and applied information. Topics r
Book Synopsis Using the Pharmaceutical Literature by : Sharon Srodin
Download or read book Using the Pharmaceutical Literature written by Sharon Srodin and published by CRC Press. This book was released on 2006-02-16 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gathering information of critical importance for professionals in the pharmaceutical and medical device industries, this guide provides a comprehensive overview of key resources, such as databases, on-line directories, reports, and periodicals-providing at-a-glance guidance and collection development tools for information professionals in this fiel
Book Synopsis Toxicological Profile for Cobalt by :
Download or read book Toxicological Profile for Cobalt written by and published by . This book was released on 1992 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Arsenic Contamination in the Environment by : Dharmendra Kumar Gupta
Download or read book Arsenic Contamination in the Environment written by Dharmendra Kumar Gupta and published by Springer. This book was released on 2017-05-23 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview to researchers, graduate, and undergraduate students, as well as academicians who are interested in arsenic. It covers human health risks and established cases of human ailments and sheds light on prospective control measures, both biological and physico-chemical. Arsenic (As) is a widely distributed element in the environment having no known useful physiological function in plants or animals. Historically, this metalloid has been known to be used widely as a poison. Effects of arsenic have come to light in the past few decades due to its increasing contamination in several parts of world, with the worst situation being in Bangladesh and West Bengal, India. The worrying issue is the ingestion of arsenic through water and food and associated health risks due to its carcinogenic and neurotoxic nature. The impact of the problem is widespread, and it has led to extensive research on finding both the causes and solutions. These attempts have allowed us to understand the various probable causes of arsenic contamination in the environment, and at the same time, have provided a number of possible solutions. It is reported that more than 200 mineral species contain As. Generally, As binds with iron and sulfur to form arsenopyrite. According to one estimate from the World Health Organization (WHO), contextual levels of As in soil ranges from 1 to 40 mg kg-1. Arsenic toxicity is related to its oxidation state which is present in the medium. As is a protoplastic toxin, due to its consequence on sulphydryl group it interferes in cell enzymes, cell respiration and in mitosis. Exposure of As may occur to humans via several industries, such as refining or smelting of metal ores, microelectronics, wood preservation, battery manufacturing, and also to those who work in power plants that burn arsenic-rich coal.
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309459575 Total Pages :483 pages Book Rating :4.3/5 (94 download)
Book Synopsis Pain Management and the Opioid Epidemic by : National Academies of Sciences, Engineering, and Medicine
Download or read book Pain Management and the Opioid Epidemic written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-09-28 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.
Book Synopsis Decellularized Extracellular Matrix by : Takashi Hoshiba
Download or read book Decellularized Extracellular Matrix written by Takashi Hoshiba and published by Royal Society of Chemistry. This book was released on 2019-12-05 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using this book, the reader will gain a good foundation to the field complemented with a broad overview of characterisation, microfabrication and applications.
Book Synopsis Statin-Associated Muscle Symptoms by : Paul D. Thompson
Download or read book Statin-Associated Muscle Symptoms written by Paul D. Thompson and published by Springer Nature. This book was released on 2020-01-25 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of statin-associated muscle symptoms (SAMS) from clinical presentation to treatment and possible metabolic causes. It examines the risk factors, presentations, diagnosis and differential diagnosis, clinical management, and financial costs of SAMS. The book also highlights patients’ perspectives on SAMS such as the psychosocial, emotional, and societal factors influencing their perceptions and experiences. Finally, the book presents the results of observational and clinical trials on the prevalence of SAMS, clinical trials for treatments, and potential future research approaches for improving the understanding and treatment of SAMS. A key addition to the Contemporary Cardiology series, Statin-Associated Muscle Symptoms is an essential resource for physicians, medical students, residents, fellows, and allied health professionals in cardiology, endocrinology, pharmacotherapy, primary care, and health promotion and disease prevention.
Book Synopsis Carbon Monoxide and Cardiovascular Functions by : Rui Wang
Download or read book Carbon Monoxide and Cardiovascular Functions written by Rui Wang and published by CRC Press. This book was released on 2001-10-30 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Akin to nitric oxide, carbon monoxide (CO) was initially viewed as a pure toxic gas, yet it has been recently demonstrated to be an important endogenous molecule of gas that has profound physiological and pathophysiological effects on the cardiovascular system. In spite of the growing understanding achieved in this field, until now a comprehensive
Book Synopsis Toxicological Principles for the Safety Assessment of Direct Food Additives and Color Additives Used in Food by :
Download or read book Toxicological Principles for the Safety Assessment of Direct Food Additives and Color Additives Used in Food written by and published by . This book was released on 1993 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Herbal Supplements and the Brain by : S.J. Enna
Download or read book Herbal Supplements and the Brain written by S.J. Enna and published by FT Press. This book was released on 2012-05-07 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today, many manufacturers of plant-based "neuroceuticals" claim their products can offer powerful benefits in brain function. However, the US government does not require these manufacturers to demonstrate their products’ effectiveness, leaving it difficult for consumers and health professionals to make decisions about the benefits and risks. In Herbal Supplements and the Brain: Understanding their Health Benefits and Hazards, two leading researchers provide this crucial information in clear language any intelligent reader can understand and use. They begin by introducing the fundamental principles of pharmacology, explaining how drugs and natural products can affect the body’s organs and organ systems. Using examples, they show how to determine whether an ingested substance can enter the bloodstream and reach its target at a concentration sufficient to have an effect. They also explain how natural products may influence blood levels of other substances, and discuss whether such interactions may diminish the effectiveness of prescription medications or alter normal body chemistry. Throughout, the authors emphasize factors relating especially to neuroceuticals and the brain. Individual chapters are devoted to nutritional supplements which promise to enhance memory, relieve pain, safely promote sleep, and aid in the treatment of depression or anxiety. Specifically, readers will find research-based coverage of Ginkgo biloba; St. John’s Wort; Valerian; Lemon Balm; Kava; Lavender; Kudzu, Daffodil, Passion Flower, and Camellia Tea and other caffeinated beverages.
Book Synopsis Current Protocols Essential Laboratory Techniques by : Sean R. Gallagher
Download or read book Current Protocols Essential Laboratory Techniques written by Sean R. Gallagher and published by John Wiley & Sons. This book was released on 2012-03-19 with total page 679 pages. Available in PDF, EPUB and Kindle. Book excerpt: The latest title from the acclaimed Current Protocols series, Current Protocols Essential Laboratory Techniques, 2e provides the new researcher with the skills and understanding of the fundamental laboratory procedures necessary to run successful experiments, solve problems, and become a productive member of the modern life science laboratory. From covering the basic skills such as measurement, preparation of reagents and use of basic instrumentation to the more advanced techniques such as blotting, chromatography and real-time PCR, this book will serve as a practical reference manual for any life science researcher. Written by a combination of distinguished investigators and outstanding faculty, Current Protocols Essential Laboratory Techniques, 2e is the cornerstone on which the beginning scientist can develop the skills for a successful research career.
