Current Concepts In Drug Metabolism And Toxicology

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Current Concepts in Drug Metabolism and Toxicology

Author :
Publisher : Academic Press
ISBN 13 : 0123983592
Total Pages : 301 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Current Concepts in Drug Metabolism and Toxicology by :

Download or read book Current Concepts in Drug Metabolism and Toxicology written by and published by Academic Press. This book was released on 2012-11-27 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Advances in Pharmacology explores the current concepts in drug metabolism and toxicology. Chapters cover the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike. Explores the current concepts in drug metabolism and toxicology Chapters cover such areas as the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity An essential resource for pharmacologists, immunologists and biochemists alike

Drug Metabolism

Author : Corina Ionescu
Publisher : Springer Science & Business Media
ISBN 13 : 9781402041419
Total Pages : 444 pages
Book Rating : 4.0/5 (414 download)

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Book Synopsis Drug Metabolism by : Corina Ionescu

Download or read book Drug Metabolism written by Corina Ionescu and published by Springer Science & Business Media. This book was released on 2006-02-28 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.

Drug Metabolism

Author : Mino R. Caira
Publisher : Springer
ISBN 13 : 9781402041419
Total Pages : 422 pages
Book Rating : 4.0/5 (414 download)

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Book Synopsis Drug Metabolism by : Mino R. Caira

Download or read book Drug Metabolism written by Mino R. Caira and published by Springer. This book was released on 2006-02-28 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.

Drug Metabolism Handbook

Author : Ala F. Nassar
Publisher : John Wiley & Sons
ISBN 13 : 0470439254
Total Pages : 1059 pages
Book Rating : 4.4/5 (74 download)

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Book Synopsis Drug Metabolism Handbook by : Ala F. Nassar

Download or read book Drug Metabolism Handbook written by Ala F. Nassar and published by John Wiley & Sons. This book was released on 2009-01-28 with total page 1059 pages. Available in PDF, EPUB and Kindle. Book excerpt: A valuable reference tool for professionals involved in the industry, Drug Metabolism in Pharmaceuticals covers new tools such as LC-MS and LC-MS-NMR along with experimental aspects of drug metabolism. This work fills a gap in the literature by covering the concepts and applications of pharmaceutical research, development, and assessment from the point of view of drug metabolism. By providing both a solid conceptual understanding of the drug metabolism system, and a well illustrated, detailed demonstration and explanation of cutting edge tools and techniques, this book serves as a valuable reference tool for bench scientists, medical students, and students of general health sciences.

Issues in Drug Management, Toxicology, Monitoring, Resistance, and Safety: 2011 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464967083
Total Pages : 552 pages
Book Rating : 4.4/5 (649 download)

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Book Synopsis Issues in Drug Management, Toxicology, Monitoring, Resistance, and Safety: 2011 Edition by :

Download or read book Issues in Drug Management, Toxicology, Monitoring, Resistance, and Safety: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues in Drug Management, Toxicology, Monitoring, Resistance, and Safety: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Drug Management, Toxicology, Monitoring, Resistance, and Safety. The editors have built Issues in Drug Management, Toxicology, Monitoring, Resistance, and Safety: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Drug Management, Toxicology, Monitoring, Resistance, and Safety in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Drug Management, Toxicology, Monitoring, Resistance, and Safety: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Concepts in Drug Metabolism

Author : Peter Jenner
Publisher : CRC Press
ISBN 13 : 9780824769062
Total Pages : 424 pages
Book Rating : 4.7/5 (69 download)

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Book Synopsis Concepts in Drug Metabolism by : Peter Jenner

Download or read book Concepts in Drug Metabolism written by Peter Jenner and published by CRC Press. This book was released on 1980-04-01 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Concepts in Drug Metabolism

Author : Peter Jenner
Publisher : CRC Press
ISBN 13 : 9780824769062
Total Pages : 424 pages
Book Rating : 4.7/5 (69 download)

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Book Synopsis Concepts in Drug Metabolism by : Peter Jenner

Concepts in Drug Metabolism

Author : Peter Jenner
Publisher :
ISBN 13 :
Total Pages : 409 pages
Book Rating : 4.:/5 (174 download)

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Book Synopsis Concepts in Drug Metabolism by : Peter Jenner

Download or read book Concepts in Drug Metabolism written by Peter Jenner and published by . This book was released on with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Drug Metabolism in Drug Design and Development

Author : Donglu Zhang
Publisher : Wiley-Interscience
ISBN 13 : 9780471733133
Total Pages : 0 pages
Book Rating : 4.7/5 (331 download)

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Book Synopsis Drug Metabolism in Drug Design and Development by : Donglu Zhang

Download or read book Drug Metabolism in Drug Design and Development written by Donglu Zhang and published by Wiley-Interscience. This book was released on 2007-11-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The essentials of drug metabolism vital to developing new therapeutic entities Information on the metabolism and disposition of candidate drugs is a critical part of all aspects of the drug discovery and development process. Drug metabolism, as practiced in the pharmaceutical industry today, is a complex, multidisciplinary field that requires knowledge of sophisticated analytical technologies and expertise in mechanistic and kinetic enzymology, organic reaction mechanism, pharmacokinetic analysis, animal physiology, basic chemical toxicology, preclinical pharmacology, and molecular biology. With chapters contributed by experts in their specific areas, this reference covers: * Basic concepts of drug metabolism * The role of drug metabolism in the pharmaceutical industry * Analytical techniques in drug metabolism * Common experimental approaches and protocols Drug Metabolism in Drug Design and Development emphasizes practical considerations such as the data needed, the experiments and analytical methods typically employed, and the interpretation and application of data. Chapters highlight facts, common protocols, detailed experimental designs, applications, and limitations of techniques. This is a comprehensive, hands-on reference for drug metabolism researchers as well as other professionals involved in pre-clinical drug discovery and development.

Drug Metabolism in Diseases

Author : Wen Xie
Publisher : Academic Press
ISBN 13 : 0128029633
Total Pages : 294 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Drug Metabolism in Diseases by : Wen Xie

Download or read book Drug Metabolism in Diseases written by Wen Xie and published by Academic Press. This book was released on 2016-09-12 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. The book contains valuable insights into mechanistic effects and examples of how to accurately predict drug metabolism during these different pathophysiological states. Each chapter clearly presents the effects of changes in drug metabolism and drug transporters on pharmacokinetics and disposition. This is a unique and useful approach for all those involved in drug discovery and development, and for clinicians and researchers in drug metabolism, pharmacology, and clinical pharmacology. Written and edited by leaders in drug metabolism from academia and industry Covers important topics, such as pharmacogenomics, drug metabolism in transplant patients, xenobiotic receptors, drug metabolism in geriatric and pediatric populations, and more Highlights topics of importance in drug discovery and development, and for safe and effective drug use in the clinic

Holland-Frei Cancer Medicine

Author : Robert C. Bast, Jr.
Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2008 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.

Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2008 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Drug Metabolism and Pharmacokinetics Quick Guide

Author : Siamak Cyrus Khojasteh
Publisher : Springer Science & Business Media
ISBN 13 : 1441956298
Total Pages : 222 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Drug Metabolism and Pharmacokinetics Quick Guide by : Siamak Cyrus Khojasteh

Download or read book Drug Metabolism and Pharmacokinetics Quick Guide written by Siamak Cyrus Khojasteh and published by Springer Science & Business Media. This book was released on 2011-04-07 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.

Pharmaceutical Toxicology

Author : Gerard J. Mulder
Publisher :
ISBN 13 :
Total Pages : 284 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Pharmaceutical Toxicology by : Gerard J. Mulder

Download or read book Pharmaceutical Toxicology written by Gerard J. Mulder and published by . This book was released on 2006 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicology studies are carried out on all drug substances to ensure safety. This book provides an overview of the methodology andrequirements of pre-clinical safety assessments of new medicines. with the focus on medicinal drugs - the most important safety issues of drugs are covered, including registration requirements of new drugs and pharmacovigilance. This is an introductory text for students at BSc, MSc and PhD levels,and will be an excellent companion to pharmacology textbooks, combining a broad treatment of the issues relevant for assessing the safety/efficacy balance of a new drug wit

Drug Metabolism

Author : Mino R. Caira
Publisher :
ISBN 13 : 9788184891478
Total Pages : 420 pages
Book Rating : 4.8/5 (914 download)

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Book Synopsis Drug Metabolism by : Mino R. Caira

Download or read book Drug Metabolism written by Mino R. Caira and published by . This book was released on 2009-02-01 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topics 1. Drug Metabolism In Context 2. Pathways Of Biotransformation Phase I Reactions 3. Pathways Of Biotransformation Phase Ii Reactions 4. Enzymatic Systems Involved In Drug Biotransformation 5. Induction And Inhibition Of Drug-Metabolising Enzymes 6. Factors That Infuence Drug Biotransformation 7. Impact Of Gene Variability On Drug Metabolism 8. Drug Interactions And Adverse Reactions 9. Strategies For Drug Design

Human Drug Metabolism

Author : Michael D. Coleman
Publisher : John Wiley & Sons
ISBN 13 : 9780470689349
Total Pages : 360 pages
Book Rating : 4.6/5 (893 download)

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Book Synopsis Human Drug Metabolism by : Michael D. Coleman

Download or read book Human Drug Metabolism written by Michael D. Coleman and published by John Wiley & Sons. This book was released on 2010-03-30 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Drug Metabolism, An Introduction, Second Edition provides an accessible introduction to the subject and will be particularly invaluable to those who already have some understanding of the life sciences. Completely revised and updated throughout, the new edition focuses only on essential chemical detail and includes patient case histories to illustrate the clinical consequences of changes in drug metabolism and its impact on patient welfare. After underlining the relationship between efficacy, toxicity and drug concentration, the book then considers how metabolizing systems operate and how they impact upon drug concentration, both under drug pressure and during inhibition. Factors affecting drug metabolism, such as genetic polymorphisms, age and diet are discussed and how metabolism can lead to toxicity is explained. The book concludes with the role of drug metabolism in the commercial development of therapeutic agents as well as the pharmacology of some illicit drugs.

Transporters and Drug-Metabolizing Enzymes in Drug Toxicity

Author : Albert P. Li
Publisher : John Wiley & Sons
ISBN 13 : 1119170842
Total Pages : 530 pages
Book Rating : 4.1/5 (191 download)

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Book Synopsis Transporters and Drug-Metabolizing Enzymes in Drug Toxicity by : Albert P. Li

Download or read book Transporters and Drug-Metabolizing Enzymes in Drug Toxicity written by Albert P. Li and published by John Wiley & Sons. This book was released on 2021-07-27 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: TRANSPORTERS AND DRUG-METABOLIZING ENZYMES IN DRUG TOXICITY Explore up-to-date coverage on the interaction between drug metabolism enzymes, transporters, and drug toxicity with this leading resources Transporters and Drug-Metabolizing Enzymes in Drug Toxicity delivers a comprehensive and updated review of the relationship between drug metabolism, transporters, and toxicity, providing insights into a major challenge in drug development – accurate assessment of human drug toxicity. Combining two disciplines frequently considered independently of one another, the book combines drug metabolism and toxicology with a focus on the role of biotransformation on drug toxicity and as a major factor for species and individual differences. Mechanism and species differences in drug metabolizing enzymes and transporters are discussed, as are the methods used to investigate the role of drug metabolizing enzymes and transporters in drug toxicity. Finally, the distinguished authors describe promising new experimental approaches to accurately assessing human drug toxicity via the consideration of human-specific drug metabolism in toxicity assays. In addition to topics as diverse as extended clearance models, experimental approaches for the estimation of DILI potential of drug candidates and roles of transporters in renal drug toxicity, readers will also enjoy the inclusion of such subjects as: A thorough overview of and introduction to drug metabolism and transporters and drug toxicity An exploration of drug metabolism enzymes and transporter activities as risk factors of marketed drugs associated with drug-induced fatalities A discussion of human-based in vitro experimental models for the evaluation of metabolism-dependent drug toxicity A treatment of mechanism-based experimental models for the evaluation of BSEP inhibition and DILI An examination of transporters and cochlea toxicity Perfect for scientists, students, and practitioners with interests in metabolism, toxicology, and drug development in the pharmaceutical industry, Transporters and Drug-Metabolizing Enzymes in Drug Toxicity will also earn a place in the libraries of medicinal chemists, pharmacologists, biochemists, toxicologists, and regulators in the pharmaceutical and health industries.

Drug-like Properties: Concepts, Structure Design and Methods

Author : Li Di
Publisher : Elsevier
ISBN 13 : 0080557619
Total Pages : 549 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Drug-like Properties: Concepts, Structure Design and Methods by : Li Di

Download or read book Drug-like Properties: Concepts, Structure Design and Methods written by Li Di and published by Elsevier. This book was released on 2010-07-26 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. Serves as an essential working handbook aimed at scientists and students in medicinal chemistry Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies Discusses improvements in pharmacokinetics from a practical chemist's standpoint