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Author :
Publisher : Elsevier
ISBN 13 : 0443159270
Total Pages : 404 pages
Book Rating : 4.4/5 (431 download)
Download or read book Crystallography of Protein Dynamics written by and published by Elsevier. This book was released on 2023-09-25 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Approx.400 pages Approx.400 pages
Author : Elena J. Levin
Publisher :
ISBN 13 :
Total Pages : 190 pages
Book Rating : 4.:/5 (891 download)
Download or read book Using X-ray Crystallography for the Analysis of Protein Dynamics written by Elena J. Levin and published by . This book was released on 2008 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : T. L. Blundell
Publisher : Academic Press
ISBN 13 :
Total Pages : 592 pages
Book Rating : 4.:/5 ( download)
Download or read book Protein Crystallography written by T. L. Blundell and published by Academic Press. This book was released on 1976-01-28 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jan Drenth
Publisher : Springer Science & Business Media
ISBN 13 : 0387337466
Total Pages : 332 pages
Book Rating : 4.3/5 (873 download)
Download or read book Principles of Protein X-Ray Crystallography written by Jan Drenth and published by Springer Science & Business Media. This book was released on 2007-04-05 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: X-ray crystallography is an established method for studying the structure of proteins and other macromolecules. As the importance of proteins grows, researchers in many fields have found that a working knowledge of X-ray diffraction is an indispensable tool. In this new edition of his essential work, the internationally recognized researcher Dr. Jan Drenth offers an up-to-date and technically rigorous introduction to the subject, providing the theoretical background necessary to understand how the structure of proteins is determined at atomic resolution. New material in the 3rd edition includes a section on twinning, an additional chapter on crystal growth and a discussion of single-wavelength anomalous dispersion.
Author : Isabel Moraes
Publisher : Springer
ISBN 13 : 3319350722
Total Pages : 184 pages
Book Rating : 4.3/5 (193 download)
Download or read book The Next Generation in Membrane Protein Structure Determination written by Isabel Moraes and published by Springer. This book was released on 2016-08-23 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews current techniques used in membrane protein structural biology, with a strong focus on practical issues. The study of membrane protein structures not only provides a basic understanding of life at the molecular level but also helps in the rational and targeted design of new drugs with reduced side effects. Today, about 60% of the commercially available drugs target membrane proteins and it is estimated that nearly 30% of proteins encoded in the human genome are membrane proteins. In recent years much effort has been put towards innovative developments to overcome the numerous obstacles associated with the structure determination of membrane proteins. This book reviews a variety of recent techniques that are essential to any modern researcher in the field of membrane protein structural biology. The topics that are discussed are not commonly found in textbooks. The scope of this book includes: Expression screening using fluorescent proteins The use of detergents in membrane protein research The use of NMR Synchrotron developments in membrane protein structural biology Visualisation and X-ray data collection of microcrystals X-ray diffraction data analysis from multiple crystals Serial millisecond crystallography Serial femtosecond crystallography Membrane protein structures in drug discovery The information provided in this book should be of interest to anyone working in the area of structural biology. Students will find carefully prepared overviews of basic ideas and advanced protein scientists will find the level of detail required to apply the material directly to their day to day work. Chapters 4, 5, 6, 8 and 9 of this book are published open access under a CC BY 4.0 license at link.springer.com.
Author : Herman Winick
Publisher : World Scientific
ISBN 13 : 9814571199
Total Pages : 528 pages
Book Rating : 4.8/5 (145 download)
Download or read book Synchrotron Radiation Sources — A Primer written by Herman Winick and published by World Scientific. This book was released on 1995-02-28 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Specialists in the technical components of a synchrotron light source are usually well versed in their field and in the associated technical literature. However, with the rapid and continuing growth of synchrotron radiation research, and with new facilities coming online and being authorized for design and construction around the world, there is a need for a reference book that describes the various technical components of a synchrotron light source in a manner that will be useful to those who lack specialized technical background, but who have responsibility for some part of the design, construction, operation or development of such a facility. This would include technicians, engineers and physicists who have technical background in related fields but no specific experience with a synchrotron light source, and also project managers, laboratory directors, and government officials involved with synchrotron light facilities. College level scientific or engineering training or the equivalent experience is assumed and appropriate mathematics is used throughout. However, the basic concepts in each chapter are given in less technical language and a glossary of terms as well as an index will make the book useful for those with less technical training or experience. Contents: Introduction and Overview (H Winick)Lattices (M Cornacchia)Injector Systems (G Mülhaupt)RF Systems (D J Thompson & D M Dykes)Magnet Design (N Marks)Magnet Power Supplies (R Richter)Magnetic Measurements (R P Walker)Vacuum Systems (J Noonan & D Walters)Accelerator Controls and Modeling (J Corbett & C Wermelskirchen)Beam Diagnostics (P Kuske)Magnet Support and Alignment (R E Ruland)Beam Instabilities (M Furman, J Byrd & S Chattopadhyay)Orbit Stabilizing and Multibunch Feedback Systems (J N Galayda, L-J Chung & R O Hettel)Wiggler and Undulator Insertion Devices (R D Schlueter)Conventional Facilities (V Saile & J D Scott)Safety (T Dickinson) Readership: Scientists and engineers. Keywords:Accelerators;Synchrotron Radiation;Storage Rings;Synchrotrons;Magnets;Rf Systems;Vacuum Systems;Control Systems;Insertion Devices;Wigglers;Undulators;Power SuppliesReviews:“Herman Winick is to be commended for organizing and editing a comprehensive selection of articles (chapters) written by leading specialists and covering all aspects of synchrotron radiation production in this excellent new book … Its swift publication makes it fully up-to-date at the time of going to press … It is extremely beneficial in allowing SR specialists from specific areas to learn about related areas. The level has been carefully monitored by the editor and is useful in providing a sound basis for further study in each area.”Gwyn Williams Synchrotron Radiation News
Author : Maria Armenia Carrondo
Publisher : Springer
ISBN 13 : 9400725302
Total Pages : 208 pages
Book Rating : 4.4/5 (7 download)
Download or read book Macromolecular Crystallography written by Maria Armenia Carrondo and published by Springer. This book was released on 2011-12-01 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a collection of the contributions presented at the 42nd Erice Crystallographic Course whose main objective was to train the younger generation on advanced methods and techniques for examining structural and dynamic aspects of biological macromolecules. The papers review the techniques used to study protein assemblies and their dynamics, including X-ray diffraction and scattering, electron cryo-electron microscopy, electro nanospray mass spectrometry, NMR, protein docking and molecular dynamics. A key theme throughout the book is the dependence of modern structural science on multiple experimental and computational techniques, and it is the development of these techniques and their integration that will take us forward in the future.
Author : Eaton E. Lattman
Publisher : JHU Press
ISBN 13 : 0801896843
Total Pages : 149 pages
Book Rating : 4.8/5 (18 download)
Download or read book Protein Crystallography written by Eaton E. Lattman and published by JHU Press. This book was released on 2008-04-28 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: The proteome remains a mysterious realm. Researchers have determined the structures of only a small fraction of the proteins encoded by the human genome. Crystallography continues to be the primary method used to determine the structures of the remaining unknown proteins. This imaging technique uses the diffraction of X-rays to determine a protein’s three-dimensional molecular structure. Drawing on years of research and teaching experience, Eaton E. Lattman and Patrick J. Loll use clear examples and abundant illustrations to provide a concise and accessible primer on protein crystallography. Discussing the basics of diffraction, the behavior of two- and three-dimensional crystals, phase determination (including MIR and MAD phasing and molecular replacement), the Patterson function, and refinement, Lattman and Loll provide a complete overview of this important technique, illuminated by physical insights. The crisp writing style and simple illustrations will provide beginner crystallographers with a guide to the process of unraveling protein structure.
Author : Jean-Paul Renaud
Publisher : John Wiley & Sons
ISBN 13 : 1118900502
Total Pages : 1367 pages
Book Rating : 4.1/5 (189 download)
Download or read book Structural Biology in Drug Discovery written by Jean-Paul Renaud and published by John Wiley & Sons. This book was released on 2020-01-09 with total page 1367 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins
Author : Timir Tripathi
Publisher : Academic Press
ISBN 13 : 0323902650
Total Pages : 716 pages
Book Rating : 4.3/5 (239 download)
Download or read book Advances in Protein Molecular and Structural Biology Methods written by Timir Tripathi and published by Academic Press. This book was released on 2022-01-14 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Protein Molecular and Structural Biology Methods offers a complete overview of the latest tools and methods applicable to the study of proteins at the molecular and structural level. The book begins with sections exploring tools to optimize recombinant protein expression and biophysical techniques such as fluorescence spectroscopy, NMR, mass spectrometry, cryo-electron microscopy, and X-ray crystallography. It then moves towards computational approaches, considering structural bioinformatics, molecular dynamics simulations, and deep machine learning technologies. The book also covers methods applied to intrinsically disordered proteins (IDPs)followed by chapters on protein interaction networks, protein function, and protein design and engineering. It provides researchers with an extensive toolkit of methods and techniques to draw from when conducting their own experimental work, taking them from foundational concepts to practical application. Presents a thorough overview of the latest and emerging methods and technologies for protein study Explores biophysical techniques, including nuclear magnetic resonance, X-ray crystallography, and cryo-electron microscopy Includes computational and machine learning methods Features a section dedicated to tools and techniques specific to studying intrinsically disordered proteins
Author : Terese M. Bergfors
Publisher : Internat'l University Line
ISBN 13 : 0972077448
Total Pages : 505 pages
Book Rating : 4.9/5 (72 download)
Download or read book Protein Crystallization written by Terese M. Bergfors and published by Internat'l University Line. This book was released on 2009 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Bernhard Rupp
Publisher : Garland Science
ISBN 13 : 1134064195
Total Pages : 832 pages
Book Rating : 4.1/5 (34 download)
Download or read book Biomolecular Crystallography written by Bernhard Rupp and published by Garland Science. This book was released on 2009-10-20 with total page 832 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesizing over thirty years of advances into a comprehensive textbook, Biomolecular Crystallography describes the fundamentals, practices, and applications of protein crystallography. Illustrated in full-color by the author, the text describes mathematical and physical concepts in accessible and accurate language. Biomolecular Crystallography will be a valuable resource for advanced undergraduate and graduate students and practitioners in structural biology, crystallography, and structural bioinformatics.
Author : Charles W. Carter
Publisher : Gulf Professional Publishing
ISBN 13 : 9780121827779
Total Pages : 752 pages
Book Rating : 4.8/5 (277 download)
Download or read book Macromolecular Crystallography written by Charles W. Carter and published by Gulf Professional Publishing. This book was released on 1997 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation Accurate molecular structures is vital for rational drug design and for structure based functional studies directed toward the development of effective therapeutic agents and drugs. Crystallography can reliably predict structure, both in terms of folding and atomic details of bonding. * Phases * Map interpretation and refinement * Analysis and software.
Author : Gwyndaf Evans
Publisher : Royal Society of Chemistry
ISBN 13 : 1782627286
Total Pages : 244 pages
Book Rating : 4.7/5 (826 download)
Download or read book Protein Crystallography written by Gwyndaf Evans and published by Royal Society of Chemistry. This book was released on 2018-06-21 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein crystallography has become vital to further understanding the structure and function of many complex biological systems. In recent years, structure determination has progressed tremendously however the quality of crystals and data sets can prevent the best results from being obtained. With contributions from world leading researchers whose software are used worldwide, this book provides a coherent approach on how to handle difficult crystallographic data and how to assess its quality. The chapters will cover all key aspects of protein crystallography, from instrumentation and data processing through to model building. This book also addresses challenges that protein crystallographers will face such as dealing with data from microcrystals and multi protein complexes. This book is ideal for both academics and researchers in industry looking for a comprehensive guide to protein crystallography.
Author : Reinhard B. Neder
Publisher : Oxford University Press
ISBN 13 : 0199233691
Total Pages : 239 pages
Book Rating : 4.1/5 (992 download)
Download or read book Diffuse Scattering and Defect Structure Simulations written by Reinhard B. Neder and published by Oxford University Press. This book was released on 2008-11-20 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the atomic structure of complex and time disordered materials relies upon computer simulations of these structures. This cook book provides a unique mixture of simulation know-how and hands on examples. All related files and the program DISCUS are included on a CDROM with the book.
Author : Sukarno Ferreira
Publisher : BoD – Books on Demand
ISBN 13 : 9535110101
Total Pages : 436 pages
Book Rating : 4.5/5 (351 download)
Download or read book Advanced Topics on Crystal Growth written by Sukarno Ferreira and published by BoD – Books on Demand. This book was released on 2013-02-20 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: Crystal growth is the key step of a great number of very important applications. The development of new devices and products, from the traditional microelectronic industry to pharmaceutical industry and many others, depends on crystallization processes. The objective of this book is not to cover all areas of crystal growth but just present, as specified in the title, important selected topics, as applied to organic and inorganic systems. All authors have been selected for being key researchers in their field of specialization, working in important universities and research labs around the world. The first section is mainly devoted to biological systems and covers topics like proteins, bone and ice crystallization. The second section brings some applications to inorganic systems and describes more general growth techniques like chemical vapor crystallization and electrodeposition. This book is mostly recommended for students working in the field of crystal growth and for scientists and engineers in the fields of crystalline materials, crystal engineering and the industrial applications of crystallization processes.
Author : Angeles Canales
Publisher : Royal Society of Chemistry
ISBN 13 : 1788012860
Total Pages : 336 pages
Book Rating : 4.7/5 (88 download)
Download or read book Biophysical Techniques in Drug Discovery written by Angeles Canales and published by Royal Society of Chemistry. This book was released on 2017-11-14 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biophysical techniques are used in many key stages of the drug discovery process including in screening for new receptor ligands, in characterising drug mechanisms, and in validating data from biochemical and cellular assays. This book provides an overview of the biophysical methods applied in drug discovery today, including traditional techniques and newer developments. Perspectives from academia and industry across a spectrum of techniques are brought together in a single volume. Small and biotherapeutic approaches are covered and strengths and limitations of each technique are presented. Case studies illustrate the application of each technique in real applied examples. Finally, the book covers recent developments in areas such as electron microscopy with discussions of their possible impact on future drug discovery. This is a go-to volume for biophysicists, analytical chemists and medicinal chemists providing a broad overview of techniques of contemporary interest in drug discovery.
